Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Creb3l2 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of CREB3L2 mRNA | CTD | PMID:22206623 | Creb3l2 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of CREB3L2 mRNA | CTD | PMID:17555576 | Creb3l2 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of CREB3L2 mRNA | CTD | PMID:26496021 | Creb3l2 | Rat | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of CREB3L2 mRNA | CTD | PMID:29581250 | Creb3l2 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Creb3l2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | Creb3l2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CREB3L2 mRNA | CTD | PMID:24058054 | Creb3l2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CREB3L2 mRNA | CTD | PMID:33387578 | Creb3l2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CREB3L2 mRNA | CTD | PMID:32109520 | Creb3l2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CREB3L2 mRNA | CTD | PMID:26290441 and PMID:33956508 | Creb3l2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of CREB3L2 mRNA | CTD | PMID:25975270 | Creb3l2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CREB3L2 mRNA | CTD | PMID:21570461 | Creb3l2 | Rat | 2-butoxyethanol | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | n-butoxyethanol results in decreased expression of CREB3L2 mRNA | CTD | PMID:19812364 | Creb3l2 | Rat | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 and PMID:32119087 | Creb3l2 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of CREB3L2 mRNA | CTD | PMID:20188158 | Creb3l2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of CREB3L2 mRNA | CTD | PMID:30951980 | Creb3l2 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Fenretinide results in increased expression of CREB3L2 mRNA | CTD | PMID:28973697 | Creb3l2 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of CREB3L2 mRNA | CTD | PMID:30047161 | Creb3l2 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of CREB3L2 mRNA | CTD | PMID:31881176 | Creb3l2 | Rat | all-trans-retinoic acid | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of CREB3L2 mRNA | CTD | PMID:30951980 | Creb3l2 | Rat | all-trans-retinoic acid | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of CREB3L2 mRNA | CTD | PMID:33167477 | Creb3l2 | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of CREB3L2 mRNA | CTD | PMID:30047161 | Creb3l2 | Rat | aristolochic acid A | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of CREB3L2 mRNA | CTD | PMID:33212167 | Creb3l2 | Rat | arsenite(3-) | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to CREB3L2 mRNA] | CTD | PMID:32406909 | Creb3l2 | Rat | arsenous acid | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA] | CTD | PMID:29095437 | Creb3l2 | Rat | arsenous acid | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Arsenic Trioxide results in increased expression of CREB3L2 mRNA | CTD | PMID:29095437 | Creb3l2 | Rat | atrazine | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Atrazine results in increased expression of CREB3L2 mRNA | CTD | PMID:22378314 | Creb3l2 | Rat | benzo[a]pyrene | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CREB3L2 mRNA | CTD | PMID:19770486 | Creb3l2 | Rat | benzo[a]pyrene | decreases methylation | ISO | CREB3L2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of CREB3L2 3' UTR | CTD | PMID:27901495 | Creb3l2 | Rat | benzo[a]pyrene | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of CREB3L2 mRNA | CTD | PMID:20106945 and PMID:21632981 | Creb3l2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | Creb3l2 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of CREB3L2 mRNA | CTD | PMID:26496021 | Creb3l2 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CREB3L2 mRNA | CTD | PMID:32145629 | Creb3l2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CREB3L2 mRNA | CTD | PMID:30816183 more ... | Creb3l2 | Rat | bisphenol A | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CREB3L2 mRNA | CTD | PMID:30951980 | Creb3l2 | Rat | bisphenol A | affects methylation | ISO | Creb3l2 (Mus musculus) | 6480464 | bisphenol A affects the methylation of CREB3L2 promoter | CTD | PMID:27334623 | Creb3l2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CREB3L2 mRNA | CTD | PMID:25181051 and PMID:33296240 | Creb3l2 | Rat | bisphenol F | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of CREB3L2 mRNA | CTD | PMID:30951980 | Creb3l2 | Rat | bisphenol F | increases methylation | ISO | CREB3L2 (Homo sapiens) | 6480464 | bisphenol F results in increased methylation of CREB3L2 gene | CTD | PMID:31601247 | Creb3l2 | Rat | bisphenol F | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of CREB3L2 mRNA | CTD | PMID:30951980 | Creb3l2 | Rat | cadmium atom | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB3L2 mRNA | CTD | PMID:35301059 | Creb3l2 | Rat | cadmium dichloride | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB3L2 mRNA | CTD | PMID:35301059 | Creb3l2 | Rat | caffeine | affects phosphorylation | ISO | CREB3L2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of CREB3L2 protein | CTD | PMID:35688186 | Creb3l2 | Rat | carbon nanotube | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of CREB3L2 mRNA | CTD | PMID:25620056 | Creb3l2 | Rat | ciguatoxin CTX1B | affects expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of CREB3L2 mRNA | CTD | PMID:18353800 | Creb3l2 | Rat | clofibrate | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of CREB3L2 mRNA | CTD | PMID:23811191 | Creb3l2 | Rat | clotrimazole | increases expression | EXP | | 6480464 | Clotrimazole results in increased expression of CREB3L2 mRNA | CTD | PMID:30047161 | Creb3l2 | Rat | cobalt dichloride | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of CREB3L2 mRNA | CTD | PMID:19320972 | Creb3l2 | Rat | copper atom | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of CREB3L2 mRNA and [Chelating Agents binds to Copper] which results in increased expression of CREB3L2 mRNA | CTD | PMID:30911355 | Creb3l2 | Rat | copper(0) | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of CREB3L2 mRNA and [Chelating Agents binds to Copper] which results in increased expression of CREB3L2 mRNA | CTD | PMID:30911355 | Creb3l2 | Rat | cyclosporin A | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CREB3L2 mRNA | CTD | PMID:20106945 | Creb3l2 | Rat | cyclosporin A | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CREB3L2 mRNA | CTD | PMID:25562108 | Creb3l2 | Rat | diallyl trisulfide | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | diallyl trisulfide results in decreased expression of CREB3L2 mRNA | CTD | PMID:34995734 | Creb3l2 | Rat | diarsenic trioxide | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Arsenic Trioxide results in increased expression of CREB3L2 mRNA | CTD | PMID:29095437 | Creb3l2 | Rat | diarsenic trioxide | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA] | CTD | PMID:29095437 | Creb3l2 | Rat | dibutyl phthalate | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of CREB3L2 mRNA | CTD | PMID:21266533 | Creb3l2 | Rat | dichloromethane | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Methylene Chloride results in decreased expression of CREB3L2 mRNA | CTD | PMID:28392392 | Creb3l2 | Rat | diclofenac | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Diclofenac results in increased expression of CREB3L2 mRNA | CTD | PMID:26934552 | Creb3l2 | Rat | dicrotophos | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of CREB3L2 mRNA | CTD | PMID:28302478 | Creb3l2 | Rat | dorsomorphin | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Creb3l2 | Rat | ethanol | affects expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Ethanol affects the expression of CREB3L2 mRNA | CTD | PMID:30319688 | Creb3l2 | Rat | ethanol | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Ethanol results in increased expression of CREB3L2 mRNA | CTD | PMID:30319688 | Creb3l2 | Rat | folic acid | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of CREB3L2 mRNA | CTD | PMID:25629700 | Creb3l2 | Rat | FR900359 | decreases phosphorylation | ISO | CREB3L2 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of CREB3L2 protein | CTD | PMID:37730182 | Creb3l2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of CREB3L2 mRNA | CTD | PMID:33387578 | Creb3l2 | Rat | geraniol | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | geraniol results in increased expression of CREB3L2 mRNA | CTD | PMID:27683099 | Creb3l2 | Rat | glyphosate | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of CREB3L2 mRNA | CTD | PMID:31295307 | Creb3l2 | Rat | isobutanol | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of CREB3L2 mRNA | CTD | PMID:29432896 | Creb3l2 | Rat | lead(0) | multiple interactions | EXP | | 6480464 | Lead results in decreased expression of and results in increased methylation of CREB3L2 mRNA | CTD | PMID:37269892 | Creb3l2 | Rat | metformin | increases expression | EXP | | 6480464 | Metformin results in increased expression of CREB3L2 mRNA | CTD | PMID:31324951 | Creb3l2 | Rat | metformin | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA] | CTD | PMID:29095437 | Creb3l2 | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of CREB3L2 mRNA | CTD | PMID:30047161 | Creb3l2 | Rat | methotrexate | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of CREB3L2 mRNA | CTD | PMID:24449571 | Creb3l2 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of CREB3L2 gene | CTD | PMID:35440735 | Creb3l2 | Rat | methyl methanesulfonate | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of CREB3L2 mRNA | CTD | PMID:23649840 | Creb3l2 | Rat | paracetamol | affects expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of CREB3L2 mRNA | CTD | PMID:17562736 | Creb3l2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CREB3L2 mRNA | CTD | PMID:33387578 | Creb3l2 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of CREB3L2 mRNA | CTD | PMID:32680482 | Creb3l2 | Rat | pirinixic acid | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CREB3L2 mRNA | CTD | PMID:19710929 | Creb3l2 | Rat | pirinixic acid | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of CREB3L2 mRNA | CTD | PMID:17426115 and PMID:23811191 | Creb3l2 | Rat | propiconazole | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | propiconazole results in increased expression of CREB3L2 mRNA | CTD | PMID:21278054 | Creb3l2 | Rat | quercetin | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of CREB3L2 mRNA | CTD | PMID:21632981 | Creb3l2 | Rat | resveratrol | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | Resveratrol inhibits the reaction [titanium dioxide results in increased expression of CREB3L2 mRNA] | CTD | PMID:31298478 | Creb3l2 | Rat | rimonabant | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CREB3L2 mRNA] | CTD | PMID:19030233 | Creb3l2 | Rat | SB 431542 | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Creb3l2 | Rat | silicon dioxide | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of CREB3L2 mRNA | CTD | PMID:23221170 | Creb3l2 | Rat | silver atom | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Silver results in increased expression of CREB3L2 mRNA | CTD | PMID:27131904 | Creb3l2 | Rat | silver(0) | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Silver results in increased expression of CREB3L2 mRNA | CTD | PMID:27131904 | Creb3l2 | Rat | starch | multiple interactions | EXP | | 6480464 | Starch analog inhibits the reaction [Rapeseed Oil metabolite results in decreased expression of CREB3L2 mRNA] | CTD | PMID:27363782 | Creb3l2 | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of CREB3L2 mRNA | CTD | PMID:30047161 | Creb3l2 | Rat | tamoxifen | affects expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of CREB3L2 mRNA | CTD | PMID:17555576 | Creb3l2 | Rat | temozolomide | decreases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of CREB3L2 mRNA | CTD | PMID:31758290 | Creb3l2 | Rat | tetrachloromethane | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of CREB3L2 mRNA | CTD | PMID:31919559 | Creb3l2 | Rat | thapsigargin | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of CREB3L2 mRNA | CTD | PMID:22378314 and PMID:29453283 | Creb3l2 | Rat | titanium dioxide | multiple interactions | ISO | Creb3l2 (Mus musculus) | 6480464 | Resveratrol inhibits the reaction [titanium dioxide results in increased expression of CREB3L2 mRNA] | CTD | PMID:31298478 | Creb3l2 | Rat | titanium dioxide | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of CREB3L2 mRNA | CTD | PMID:31298478 | Creb3l2 | Rat | trichostatin A | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of CREB3L2 mRNA | CTD | PMID:24935251 and PMID:26272509 | Creb3l2 | Rat | trichostatin A | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREB3L2 mRNA | CTD | PMID:27188386 | Creb3l2 | Rat | triphenyl phosphate | affects expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CREB3L2 mRNA | CTD | PMID:37042841 | Creb3l2 | Rat | tungsten | decreases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Tungsten results in decreased expression of CREB3L2 mRNA | CTD | PMID:30912803 | Creb3l2 | Rat | tunicamycin | increases expression | ISO | Creb3l2 (Mus musculus) | 6480464 | Tunicamycin results in increased expression of CREB3L2 mRNA | CTD | PMID:17127020 | Creb3l2 | Rat | tunicamycin | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of CREB3L2 mRNA | CTD | PMID:22378314 and PMID:29453283 | Creb3l2 | Rat | valproic acid | affects expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CREB3L2 mRNA | CTD | PMID:25979313 | Creb3l2 | Rat | valproic acid | increases expression | ISO | CREB3L2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CREB3L2 mRNA | CTD | PMID:23179753 more ... | Creb3l2 | Rat | valproic acid | multiple interactions | ISO | CREB3L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREB3L2 mRNA | CTD | PMID:27188386 | |