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Gene: Elf5 (E74 like ETS transcription factor 5) Rattus norvegicus

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Symbol:

Elf5

Name:

E74 like ETS transcription factor 5

RGD ID:

1305859

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including ectodermal cell fate commitment; mammary gland epithelial cell differentiation; and negative regulation of cell differentiation involved in embryonic placenta development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human ELF5 (E74 like ETS transcription factor 5); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E74-like factor 5; ETS-related transcription factor Elf-5; LOC366142

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ELF5 (E74 like ETS transcription factor 5)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Elf5 (E74-like factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Elf5 (E74 like ETS transcription factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ELF5 (E74 like ETS transcription factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ELF5 (E74 like ETS transcription factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Elf5 (E74 like ETS transcription factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ELF5 (E74 like ETS transcription factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ELF5 (E74 like ETS transcription factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Elf5 (E74 like ETS transcription factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ELF5 (E74 like ETS transcription factor 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|PANTHER)
Mus musculus (house mouse):	Elf5 (E74-like factor 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	svh-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	elf5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	110,264,460 - 110,291,926 (+)	NCBI		GRCr8
mRatBN7.2	3	89,808,837 - 89,836,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	89,797,880 - 89,836,973 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	93,303,076 - 93,330,417 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	101,902,134 - 101,929,483 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	99,732,989 - 99,760,479 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	93,333,514 - 93,374,454 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	93,351,619 - 93,371,656 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	99,988,281 - 100,016,439 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	88,691,632 - 88,720,167 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	88,589,258 - 88,616,545 (-)	NCBI
Celera	3	88,877,696 - 88,905,823 (+)	NCBI		Celera
Cytogenetic Map	3	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

ciglitazone (ISO)

cobalt dichloride (EXP)

coumestrol (ISO)

crocidolite asbestos (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

Enterolactone (ISO)

ethanol (ISO)

folic acid (ISO)

genistein (EXP,ISO)

GW 4064 (ISO)

hydroquinone (ISO)

lead diacetate (ISO)

mercaptopurine (EXP)

mercury dibromide (ISO)

methapyrilene (ISO)

methimazole (EXP)

mifepristone (ISO)

nickel atom (ISO)

panobinostat (ISO)

phenylmercury acetate (ISO)

promegestone (ISO)

purine-6-thiol (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sulfadimethoxine (EXP)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ectoderm development (ISO)

ectodermal cell fate commitment (ISO)

mammary gland epithelial cell differentiation (ISO)

negative regulation of cell differentiation involved in embryonic placenta development (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IBA)

somatic stem cell population maintenance (ISO)

trophoblast giant cell differentiation (ISO)

Cellular Component

cytoplasm (ISO)

nucleus (IBA,ISO)

Molecular Function

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9840936	PMID:15829518	PMID:16469767	PMID:24190884	PMID:24859262	PMID:25446535

Genomics

Comparative Map Data

Elf5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	110,264,460 - 110,291,926 (+)	NCBI		GRCr8
mRatBN7.2	3	89,808,837 - 89,836,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	89,797,880 - 89,836,973 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	93,303,076 - 93,330,417 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	101,902,134 - 101,929,483 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	99,732,989 - 99,760,479 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	93,333,514 - 93,374,454 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	93,351,619 - 93,371,656 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	99,988,281 - 100,016,439 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	88,691,632 - 88,720,167 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	88,589,258 - 88,616,545 (-)	NCBI
Celera	3	88,877,696 - 88,905,823 (+)	NCBI		Celera
Cytogenetic Map	3	q32	NCBI

ELF5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	34,478,791 - 34,513,794 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	34,478,791 - 34,525,193 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	34,500,338 - 34,535,341 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	34,456,918 - 34,491,906 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	34,456,917 - 34,489,922	NCBI
Celera	11	34,647,528 - 34,682,543 (-)	NCBI		Celera
Cytogenetic Map	11	p13	NCBI
HuRef	11	34,197,704 - 34,232,735 (-)	NCBI		HuRef
CHM1_1	11	34,499,338 - 34,534,346 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	34,615,634 - 34,650,642 (-)	NCBI		T2T-CHM13v2.0

Elf5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	103,242,443 - 103,281,334 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	103,242,033 - 103,281,334 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	103,412,098 - 103,450,989 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	103,411,688 - 103,450,989 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	103,252,255 - 103,291,146 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	103,224,916 - 103,251,824 (+)	NCBI		MGSCv36	mm8
Celera	2	104,658,179 - 104,697,597 (+)	NCBI		Celera
Cytogenetic Map	2	E2	NCBI
cM Map	2	54.43	NCBI

Elf5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	11,750,774 - 11,780,310 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	11,751,073 - 11,779,313 (+)	NCBI	ChiLan1.0	ChiLan1.0

ELF5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	36,701,083 - 36,734,109 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	36,705,954 - 36,738,909 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	34,453,550 - 34,486,519 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	34,329,889 - 34,364,852 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	34,329,889 - 34,362,770 (-)	Ensembl	panpan1.1		panPan2

ELF5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	33,342,962 - 33,376,012 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	33,332,324 - 33,374,828 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	32,948,821 - 32,981,834 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	33,953,670 - 33,986,711 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	33,942,913 - 33,986,698 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	33,513,404 - 33,546,418 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	33,105,247 - 33,138,256 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	33,740,636 - 33,773,663 (+)	NCBI		UU_Cfam_GSD_1.0

Elf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	30,444,654 - 30,471,208 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936533	3,569,452 - 3,596,004 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936533	3,569,435 - 3,595,991 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ELF5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	26,443,977 - 26,485,903 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	26,443,979 - 26,486,802 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	28,811,152 - 28,852,566 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ELF5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	30,746,054 - 30,785,670 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	127,867,510 - 127,896,312 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Elf5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	12,649,643 - 12,675,711 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	12,648,420 - 12,675,727 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Elf5
117 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	50
Interacting mature miRNAs:	51
Transcripts:	ENSRNOT00000011035
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	84091273	129091273	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat

Markers in Region

D3Rat205

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	89,812,437 - 89,812,635 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	93,348,243 - 93,348,440	NCBI	Rnor6.0
Rnor_5.0	3	99,991,132 - 99,991,329	UniSTS	Rnor5.0
RGSC_v3.4	3	88,717,118 - 88,717,316	RGD	RGSC3.4
RGSC_v3.4	3	88,717,119 - 88,717,316	UniSTS	RGSC3.4
RGSC_v3.1	3	88,613,546 - 88,613,744	RGD
Celera	3	88,880,547 - 88,880,743	UniSTS
FHH x ACI Map	3	53.96	UniSTS
FHH x ACI Map	3	53.96	RGD
Cytogenetic Map	3	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	9	31	57	54	60	30	21	30	6	158	68	44	45	55	30

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011035 ⟹ ENSRNOP00000011035

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	89,797,880 - 89,836,973 (+)	Ensembl
Rnor_6.0 Ensembl	3	93,351,619 - 93,371,656 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095913 ⟹ ENSRNOP00000087846

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	89,809,433 - 89,836,973 (+)	Ensembl

RefSeq Acc Id:

NM_001108956 ⟹ NP_001102426

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	110,264,503 - 110,291,926 (+)	NCBI
mRatBN7.2	3	89,809,587 - 89,836,977 (+)	NCBI
Rnor_6.0	3	93,345,392 - 93,374,454 (+)	NCBI
Rnor_5.0	3	99,988,281 - 100,016,439 (+)	NCBI
RGSC_v3.4	3	88,691,632 - 88,720,167 (-)	RGD
Celera	3	88,877,696 - 88,905,823 (+)	RGD

Sequence:

show sequence

ATCACAAGGCTACAGGTGCCTTTATTTCTACCGTCCGCTGGTGCTGGGAGCGCGCCTGCCTTCT
CTTGCCTTGAAAGCCTTCTGTCTGGACCTAGCCACCACTTGTCTTCACGGTGATGTTGGACTCT
GTAACCCATAGCACCTTCCTGCCCAACGCTTCCTTCTGTGACCCCCTGATGTCTTGGACCGATC
TGTTCAACAATGAAGAATATTACCCTGCCTTTGAGCATCAGACAGCCTGTGATTCCTACTGGAC
ATCAGTGCACCCTGAATACTGGACCAAGCGCCATGTCTGGGAATGGCTCCAGTTCTGCTGTGAC
CAGTACAAGCTCGACGCCAACTGCATCTCCTTCTGTCACTTCAACATCAGCGGTCTGCAGCTGT
GCAGCATGACGCAGGAGGAGTTCATTGAGGCAGCCGGCATCTGTGGGGAGTACCTGTACTTCAT
CCTCCAGAACATTCGCTCACAAGGTTATTCCTTTTTCAACGATGCTGAAGAGACTAAGACCGCC
ATCAAAGATTATGCTGATTCCAGTTGCTTGAAAACAAGTGGCATCAAGAGTCAAGACTGTCACA
CCCGAACAAACCTCCAAAGTTCTCACCTGTGGGAATTTGTCAGAGACTTGCTTCTGTCTCCTGA
AGAAAACTGTGGCATCTTGGAGTGGGAAGACAGGGAGCAGGGCATCTTCCGAGTGGTTAAGTCA
GAAGCCCTGGCAAAGATGTGGGGACAAAGGAAGAAAAACGACAGGATGACGTATGAAAAGTTGA
GCCGAGCCCTGAGATACTACTATAAAACGGGAATTTTGGAGCGGGTTGACCGGCGGTTAGTGTA
CAAATTTGGAAAAAATGCGCACGGGTGGCAGGAAGAGAAACTATGATCTACACCGGACACCAGG
CTCACTTGATGGATTGCTGTTGTTTGAAACAATCAGATCAAACTAGACATTTGAAACCTCCTCC
TTTCCCTCCTCCCCCTCCTCCTCTTCAAAACCTACAAACACACTGATAAAATTTCTGGTGTCTC
AGCTTACATTTGAATTCAGTTGTTGTCTATTGGGGTGATGGCATCAGCCCTTAAGCAATGGTCT
TCATCCCTAGGGGGAGGAAGGGATGGTCTTGTGGCAACTTGGTGGGACATTGTTTTCTTAATGA
AGTGTTTGGAGCCAAGGTAGCCAGTGTTATGGGTGCTGTTTCAAAAGAGGGCCCTGTTACGCCG
TTAAGGACACATGATCCTCCCATTCCAGAGGTTCTGAACCCTCAACTGAGGCAGCTCACCCGTG
GTTAGTTTTTAGGAGAGGGTGAGATGTATGACTTACTTACTTTAGGTTTGAAATTATCACAATT
ATATTCCATAGAAATTTATAATAAAAATAAAAAGCTAAGCCACTAAACTGGGACCTAATTGGAT
ATAGCCTAAGTTAGTAATAAGTTTCTTAGCCAGATCACCATTTTTGACCACTTAGCCACACCCA
CTTAATCCATGGCCAATCCTTCTGAACTTAACATGCTTGTAATTAGTCACATTGGGACTGAAAC
TGTTGCCCCCTTCTCCTCACTGGTGGCTAGTGTCAGATCTATAGAGACCAAGTCAACAGGCATG
TGCATTCATTTCTAAATCACTGCTGTGCCTATGATTCAAACTGTCAATGTGTTCAAATAGAATT
TATTGATTCTCTCTGAGGCTAAGATGTTAAACCTTTACAGAGCAGAAAATGTCCTGACAAGCCA
TGACAGGCGAACATGTCAATCTCTTTCCTGATTTGTCCTGATGAATACTCAAACATCCCAACAT
ATTCTCTTCACAAAAATAAGAACAGTGAATTTACATCAATAACTGCTCATGGGTTAAAGTCTGC
ACTGACATTTCCTCGTCTGCCGTTGGCATACACGCAAGGTGTTAATGACCTGCAACATGGTAGA
GTGCCCTGAACCCTAACTTCCCCAGAACTGGGACTGTCTAGCGACAGGCACTGAATAGCAATGC
AGGCTGAAGACCTCCATGTTTAGAGTTTAACCTCAAAAGTTAACTTGTTTTTTTTTTTAAATGT
GAATTACTGTAACATAATCTATTTTTGGATTCGTGTGTTTTCCAGGTGGACATAGTTTATAAAC
AATGTGAATAAAATATTTAACATGTT

hide sequence

RefSeq Acc Id:

XM_008762070 ⟹ XP_008760292

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	110,264,460 - 110,291,926 (+)	NCBI
mRatBN7.2	3	89,808,837 - 89,836,977 (+)	NCBI
Rnor_6.0	3	93,344,103 - 93,371,686 (+)	NCBI

Sequence:

show sequence

CCTCCTGAGTGCTGGGATAAAAGGCATTGTTACATCCATTTTCTCCTATTGCTGCTGGGAGAAT
TCTGACCCAGGAAAGCCGGCTCTCCTGACTGAGGTCCCAGAGCCAAGCCAGTGCCTCAACAGTC
CACTTATCTTTCCCCAACTATTTTTCCATGATGACACATAACTCCTCACATGAACTGCCTTTTG
TTTCTTCACGCCATTCATGTGTTTGGATTTGAGTGTTTGTGCCGGTGCCCAGTGTTCCCAAGAA
AACCTAACCAACCAGTCTCTGCTTTCCACTTCAAGCTCAAGAGTCTGCAGTTTGGGCATTTTGG
TGTCTCAGCTGCCTGAGACTGAGGGAGGAACAGAACACACGAGAGGGGTTACCAGCACTCCTCC
CAGAGCACCGCATCTGTCATCATTTAAATTTGAGAGGTGTCCGAGAGAGTGGGTAGTTCTCAGG
GAGTCAACTGAGAGTTTGCAAGCAAAGTCAGGACCCCCGTGTGTGGTTCTGGACACTGGAAGCT
GGGGCCACAAGGTCCCTTCATATCTCCATCTGTAAAACGGAGGACACAGGGAAAAGGAGAAAGC
AGTCATGAGGCTCCTGCACTCAAACGTGATGCCCTTTGGGCACTTAGAGTGAACAAGCCAAGTA
ACTGCCCCCTGATCAGAAGGTCCCCACCAGGATCAATAGAAGGAAGGGAATTCTGACTAGCGAC
CAGCGTGCTTTATGAAGGAAGCATGTAGCATATAAGGACAGACTTCCAGGATTTGCTGACATTC
CCAAGTGTGCCTTCCCAGCAGACCAAGGACAGTTTCCATTATTGCATTAATCTGATGAATCCCG
GATATGCTCATTAACTTATTCACAGTAACACAGCCAGAAAATGATGGGCTCAGAATTTGATCCC
TGAAGCATCTTTCTTCTTTACCACTACTTGGCACGGCTCTTCTTTCACACAGAAAGGGGATGAC
ACTACACACAGAGGTTCAGGACTTGTCCAGCCCAGGCAAAGCTGCAATAAACAGACACCGGGCC
TGAATTTCCCTCCAGCTTGCTCCAAGGAGAATGCTCCAGCCAGCCCTCCACTTATCTCCCGGGG
GCAAGAATTCTCAGCTTGTTTCCTGGGTCCCCTCGGTGGGTGGTGGGAGCTGGGCACAAAAGCA
GGAGAAAGGTAAAGTTTTTGCATGTGAAAACCACCCCCCACCCCCGAGGAGCCGTGTCACACCG
TATGTCACCGTCATCAAAGGGGCTGTGCATAAACCTGAAAAACCAAACGGACCTGTCTGTAGGT
GTCACTTATATCACAAGGCTACAGGTGCCTTTATTTCTACCGTCCGCTGGTGCTGGGAGCGCGC
CTGCCTTCTCTTGCCTTGAAAGCCTTCTGTCTGGACCTAGCCACCACTTGTCTTCACGGTGATG
TTGGACTCTGTAACCCATAGCACCTTCCTGCCCAACGCTTCCTTCTGTGACCCCCTGATGTCTT
GGACCGATCTGTTCAACAATGAAGAATATTACCCTGCCTTTGAGCATCAGACAGCAGCCTGTGA
TTCCTACTGGACATCAGTGCACCCTGAATACTGGACCAAGCGCCATGTCTGGGAATGGCTCCAG
TTCTGCTGTGACCAGTACAAGCTCGACGCCAACTGCATCTCCTTCTGTCACTTCAACATCAGCG
GTCTGCAGCTGTGCAGCATGACGCAGGAGGAGTTCATTGAGGCAGCCGGCATCTGTGGGGAGTA
CCTGTACTTCATCCTCCAGAACATTCGCTCACAAGGTTATTCCTTTTTCAACGATGCTGAAGAG
ACTAAGACCGCCATCAAAGATTATGCTGATTCCAGTTGCTTGAAAACAAGTGGCATCAAGAGTC
AAGACTGTCACACCCGAACAAACCTCCAAAGTTCTCACCTGTGGGAATTTGTCAGAGACTTGCT
TCTGTCTCCTGAAGAAAACTGTGGCATCTTGGAGTGGGAAGACAGGGAGCAGGGCATCTTCCGA
GTGGTTAAGTCAGAAGCCCTGGCAAAGATGTGGGGACAAAGGAAGAAAAACGACAGGATGACGT
ATGAAAAGTTGAGCCGAGCCCTGAGATACTACTATAAAACGGGAATTTTGGAGCGGGTTGACCG
GCGGTTAGTGTACAAATTTGGAAAAAATGCGCACGGGTGGCAGGAAGAGAAACTATGATCTACA
CCGGACACCAGGCTCACTTGATGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102426	(Get FASTA)	NCBI Sequence Viewer
	XP_008760292	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL79665	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011035.5
	ENSRNOP00000087846.1

RefSeq Acc Id:

NP_001102426 ⟸ NM_001108956

- UniProtKB:

D4A3N9 (UniProtKB/TrEMBL), A6HNR4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLDSVTHSTFLPNASFCDPLMSWTDLFNNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQ
FCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEE
TKTAIKDYADSSCLKTSGIKSQDCHTRTNLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFR
VVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEEKL

hide sequence

RefSeq Acc Id:	XP_008760292 ⟸ XM_008762070
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A588 (UniProtKB/TrEMBL), D4A3N9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLDSVTHSTFLPNASFCDPLMSWTDLFNNEEYYPAFEHQTAACDSYWTSVHPEYWTKRHVWEWL QFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAE ETKTAIKDYADSSCLKTSGIKSQDCHTRTNLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIF RVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEEKL hide sequence

Ensembl Acc Id:

ENSRNOP00000011035 ⟸ ENSRNOT00000011035

Ensembl Acc Id:

ENSRNOP00000087846 ⟸ ENSRNOT00000095913

Protein Domains

ETS PNT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3N9-F1-model_v2	AlphaFold	D4A3N9	1-253	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305859	AgrOrtholog
BioCyc Gene	G2FUF-48582	BioCyc
Ensembl Genes	ENSRNOG00000008282	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011035.6	UniProtKB/TrEMBL
	ENSRNOT00000095913.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	1.10.150.50	UniProtKB/TrEMBL
InterPro	Ets	UniProtKB/TrEMBL
	ETS_fam	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
	SAM_type	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:366142	UniProtKB/TrEMBL
NCBI Gene	366142	ENTREZGENE
PANTHER	PTHR11849	UniProtKB/TrEMBL
	PTHR11849:SF15	UniProtKB/TrEMBL
Pfam	Ets	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
PhenoGen	Elf5	PhenoGen
PRINTS	ETSDOMAIN	UniProtKB/TrEMBL
PROSITE	ETS_DOMAIN_2	UniProtKB/TrEMBL
	ETS_DOMAIN_3	UniProtKB/TrEMBL
	PNT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008282	RatGTEx
SMART	ETS	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
Superfamily-SCOP	SAM_homology	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
UniProt	A0A8I6A588	ENTREZGENE, UniProtKB/TrEMBL
	A6HNR4	ENTREZGENE, UniProtKB/TrEMBL
	D4A3N9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-07	Elf5	E74 like ETS transcription factor 5	Elf5	E74-like factor 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Elf5	E74-like factor 5	Elf5_predicted	E74-like factor 5 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Elf5_predicted	E74-like factor 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar