Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Vars2 | Rat | combined oxidative phosphorylation deficiency 20 | | ISO | VARS2 (Homo sapiens) | 7240710 | | OMIM | | |
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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Vars2 | Rat | combined oxidative phosphorylation deficiency 20 | | ISO | VARS2 (Homo sapiens) | 7240710 | | OMIM | | |
KEGG Pathway | Valine, leucine and isoleucine biosynthesis |
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KEGG Pathway | Valine, leucine and isoleucine biosynthesis |
# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
3. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
4. | GOA pipeline | RGD automated data pipeline |
5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
6. | Information Derived from GenBank Report | RGD, Sept. 2003 |
Vars2 (Rattus norvegicus - Norway rat) |
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VARS2 (Homo sapiens - human) |
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Vars2 (Mus musculus - house mouse) |
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Vars2 (Chinchilla lanigera - long-tailed chinchilla) |
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VARS2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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VARS2 (Canis lupus familiaris - dog) |
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Vars2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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VARS2 (Sus scrofa - pig) |
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VARS2 (Chlorocebus sabaeus - green monkey) |
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Vars2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Vars2
144 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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9 | 11 | 49 | 113 | 91 | 90 | 59 | 25 | 59 | 6 | 218 | 97 | 93 | 45 | 60 | 31 |
RefSeq Transcripts | NM_001429116 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_001429117 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NM_213563 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NR_190585 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006255932 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006255933 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006255934 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063279089 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063279090 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063279091 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063279092 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063279093 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_010060661 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_010060662 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_010060663 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | BX883047 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
FQ219325 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000020 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000048103 ⟹ ENSRNOP00000046565 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000091232 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_213563 ⟹ NP_998728 | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_063279089 ⟹ XP_063135159 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063279090 ⟹ XP_063135160 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063279091 ⟹ XP_063135161 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063279092 ⟹ XP_063135162 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063279093 ⟹ XP_063135163 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_010060661 | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_010060662 | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_010060663 | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001416045 | (Get FASTA) | NCBI Sequence Viewer |
NP_001416046 | (Get FASTA) | NCBI Sequence Viewer | |
NP_998728 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063135159 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063135160 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063135161 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063135162 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063135163 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | CAE84026 | (Get FASTA) | NCBI Sequence Viewer |
Q6MG21 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_998728 ⟸ NM_213563 |
- Peptide Label: | precursor |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000046565 ⟸ ENSRNOT00000048103 |
RefSeq Acc Id: | XP_063135159 ⟸ XM_063279089 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_063135163 ⟸ XM_063279093 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | XP_063135161 ⟸ XM_063279091 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_063135162 ⟸ XM_063279092 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_063135160 ⟸ XM_063279090 |
- Peptide Label: | isoform X2 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q6MG21-F1-model_v2 | AlphaFold | Q6MG21 | 1-1065 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13701307 | ||||||||
Promoter ID: | EPDNEW_R11831 | ||||||||
Type: | initiation region | ||||||||
Name: | Vars2_1 | ||||||||
Description: | valyl-tRNA synthetase 2, mitochondrial | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1303122 | AgrOrtholog |
BioCyc Gene | G2FUF-4764 | BioCyc |
BioCyc Pathway | TRNA-CHARGING-PWY [tRNA charging] | BioCyc |
BioCyc Pathway Image | TRNA-CHARGING-PWY | BioCyc |
Ensembl Genes | ENSRNOG00000000833 | Ensembl |
Gene3D-CATH | 3.40.50.620 | UniProtKB/Swiss-Prot |
3.90.740.10 | UniProtKB/Swiss-Prot | |
HUPs | UniProtKB/TrEMBL | |
Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain | UniProtKB/TrEMBL | |
InterPro | aa-tRNA-synth_I_CS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
aa-tRNA-synth_Ia | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Anticodon_Ia_Val | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
M/V/L/I-tRNA-synth_anticd-bd | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Rossmann-like_a/b/a_fold | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
tRNAsynth_Ia_anticodon-bd | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Val/Leu/Ile-tRNA-synth_edit | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Valyl-tRNA_ligase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:309596 | UniProtKB/Swiss-Prot |
NCBI Gene | 309596 | ENTREZGENE |
PANTHER | PTHR11946 | UniProtKB/Swiss-Prot |
VALINE--TRNA LIGASE, MITOCHONDRIAL | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
VALYL-TRNA SYNTHETASES | UniProtKB/TrEMBL | |
Pfam | Anticodon_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
tRNA-synt_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Vars2 | PhenoGen |
PRINTS | TRNASYNTHVAL | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | AA_TRNA_LIGASE_I | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000000833 | RatGTEx |
Superfamily-SCOP | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | UniProtKB/TrEMBL |
Nucleotidylyl transferase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF47323 | UniProtKB/Swiss-Prot | |
SSF50677 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A6KTA4_RAT | UniProtKB/TrEMBL |
Q6MG21 | ENTREZGENE, UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2012-11-07 | Vars2 | valyl-tRNA synthetase 2, mitochondrial | Vars2 | valyl-tRNA synthetase 2, mitochondrial (putative) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-03-07 | Vars2 | valyl-tRNA synthetase 2, mitochondrial (putative) | Varsl | valyl-tRNA synthetase-like | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-02-15 | Varsl | valyl-tRNA synthetase-like | Vars2l | valyl-tRNA synthetase 2-like | Symbol and Name updated | 1299863 | APPROVED |
2006-03-30 | Vars2l | valyl-tRNA synthetase 2-like | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2005-02-14 | Vars2l | valyl-tRNA synthetase 2-like | Symbol and Name status set to provisional | 70820 | PROVISIONAL |