| 69423 | Srebf1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein-containing complex binding; INVOLVED IN cellular response to fatty acid; cellular response to insulin stimulus; cellular response to starvation; PARTICIPATES IN triacy lglycerol metabolic pathway; mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; ASSOCIATED WITH abnormal triglyceride level; decreased cholesterol level; ASSOCIATED WITH alcoholic hepatitis; Diabetic Nephropathies; diabetic neuropathy; FOUND IN protein-containing complex; cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH (+)-catechin; (-)-cotinine; (-)-epigallocatechin 3-gallate | 10 | 45507152 | 45529164 | Rat | 1099 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 69473 | SREBF1 | sterol regulatory element binding transcription factor 1 | This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded pro tein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017] | 17 | 17811334 | 17836986 | Human | 1143 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 69474 | Srebf1 | sterol regulatory element binding transcription factor 1 | This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017] | 11 | 60089910 | 60113407 | Mouse | 1104 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9062386 | Srebf1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); cellular response to st arvation (ortholog); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; triacylglycerol metabolic pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); coronary artery disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog) | NW_004955577 | 171425 | 183669 | Chinchilla | 159 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12018202 | SREBF1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); protein-containing complex binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); cholesterol metabolic process (ortholog); P ARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; triacylglycerol metabolic pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); coronary artery disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); protein-containing complex (ortholog) | 17 | 33458196 | 33484643 | Bonobo | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12142397 | SREBF1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); protein-containing complex binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); cholesterol metabolic process (ortholog); P ARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; triacylglycerol metabolic pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); coronary artery disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); protein-containing complex (ortholog) | 5 | 41663809 | 41686764 | Dog | 157 | symbol | gene, protein-coding, INFERRED [RefSeq] |
| 12465536 | Srebf1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); protein-containing complex binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); cholesterol metabolic process (ortholog); P ARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; triacylglycerol metabolic pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); coronary artery disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); protein-containing complex (ortholog) | NW_004936741 | 1408669 | 1419717 | Squirrel | 157 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14144399 | SREBF1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); cholesterol metabolic proc ess (ortholog); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; triacylglycerol metabolic pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); coronary artery disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); nucleus (ortholog); INTERACTS WITH aldehydo-D-glucose; cadmium atom; D-glucose | | | | Pig | 178 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18932912 | Srebf1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (orth olog); cellular response to starvation (ortholog); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; triacylglycerol metabolic pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); coronary artery disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog) | | | | Naked Mole-Rat | 161 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232998 | srebf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18627568 | SREBF1 | sterol regulatory element binding transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); protein-containing complex binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); cholesterol metabolic process (ortholog); P ARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; triacylglycerol metabolic pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); coronary artery disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); protein-containing complex (ortholog) | | | | Green Monkey | 159 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626177538 | srebf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860048 | srebf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865451 | srebf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863520 | srebf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861736 | srebf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245916 | srebf1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1552516 | Tom1l2 | target of myb1-like 2 (chicken) | Predicted to enable clathrin binding activity and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division and signal transduction. Predicted to be active in endosome and membrane. Orthologous to human TOM1L2 (target of myb1 like 2 membrane traffic king protein). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 60114622 | 60243766 | Mouse | 135 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 407574739 | LNCHR1 | lncRNA induced by HCV, regulator of SREBF1 | | 12 | 94491546 | 94496442 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |
| 16561304 | LNCHR1 | lncRNA induced by HCV, regulator of SREBF1 | | | | | Human | | name | gene, lncrna |
| 728302 | Srebf1_v1 | sterol regulatory element binding factor 1, variant 1 | an alternative transcript of Srebf1 that is associated with diabetes | | | | Rat | | symbol , description | gene, splice |
| 728328 | Srebf1_v2 | sterol regulatory element binding factor 1, variant 2 | ENCODES an splice that exhibits chromatin binding; protein-containing complex binding; INVOLVED IN cellular response to insulin stimulus; cholesterol metabolic process; lung development; ASSOCIATED WITH decreased cholesterol level; ASSOCIATED WITH Fetal Growth Retardation; Insulin Resistance; type 2 diabetes mellitus; FOUND IN protein-containing complex | | | | Rat | 19 | symbol | gene, splice |