| 1311936 | Rnf20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2B C-terminal K residue ubiquitin ligase activity (ortholog); INVOLVED IN negative regulation of cell migration (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regul ation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (ortholog); nucleolus (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; diuron | 5 | 68771507 | 68797240 | Rat | 119 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323649 | RNF20 | ring finger protein 20 | The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tum or suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012] | 9 | 101533853 | 101563344 | Human | 113 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323650 | Rnf20 | ring finger protein 20 | Enables chromatin binding activity and histone H2B C-terminal K residue ubiquitin ligase activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predic ted to be located in nucleolus and nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 49632005 | 49656887 | Mouse | 139 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9062141 | Rnf20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2B C-terminal K residue ubiquitin ligase activity (ortholog); INVOLVED IN negative regulation of cell migration (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regul ation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | NW_004955419 | 24273714 | 24299454 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11794717 | RNF20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2B C-terminal K residue ubiquitin ligase activity (inferred); INVOLVED IN regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (inferred); nucleolus (inferred); nucleoplasm (inferred) | 9 | 72738132 | 72767868 | Bonobo | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12241122 | RNF20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2B C-terminal K residue ubiquitin ligase activity (inferred); INVOLVED IN regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (inferred); nucleolus (inferred); nucleoplasm (inferred) | 11 | 58239245 | 58266637 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12685749 | Rnf20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2B C-terminal K residue ubiquitin ligase activity (inferred); INVOLVED IN regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (inferred); nucleolus (inferred); nucleoplasm (inferred) | NW_004936524 | 9690611 | 9715579 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13980563 | RNF20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2B C-terminal K residue ubiquitin ligase activity (inferred); INVOLVED IN regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (inferred); nucleolus (inferred); nucleoplasm (inferred) | | | | Pig | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18484894 | RNF20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2B C-terminal K residue ubiquitin ligase activity (inferred); INVOLVED IN regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (inferred); nucleolus (inferred); nucleoplasm (inferred) | | | | Green Monkey | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902764 | Rnf20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of cell migration (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulation of transcription by RNA pol ymerase II (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); ubiquitin ligase complex (ortholog) | | | | Naked Mole-Rat | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236055 | rnf20 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626036883 | Rnf20 | ring finger protein 20 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2B C-terminal K residue ubiquitin ligase activity (ortholog); INVOLVED IN negative regulation of cell migration (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regul ation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH acute biphenotypic leukemia (ortholog); Arsenic Poisoning (ortholog); breast cancer (ortholog); FOUND IN HULC complex (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236056 | rnf20.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1323007 | Rnf207 | ring finger protein 207 | Predicted to enable Hsp70 protein binding activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of delayed rectifier potassium channel activity; regulation of cardiac muscle contraction; and regulation of heart looping. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human RNF207 (ring finger protein 207). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 152391475 | 152403686 | Mouse | 100 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1586262 | Rnf207 | ring finger protein 207 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); protein-folding chaperone binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of membrane repolarization during ventricular cardiac muscl e cell action potential (ortholog); ASSOCIATED WITH long QT syndrome (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 5 | 168098074 | 168112585 | Rat | 100 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1603826 | RNF207 | ring finger protein 207 | Enables Hsp70 protein binding activity and transmembrane transporter binding activity. Involved in positive regulation of gene expression. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 6206119 | 6221299 | Human | 99 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 11814278 | RNF207 | ring finger protein 207 | ENCODES a protein that exhibits Hsp70 protein binding (inferred); metal ion binding (inferred); protein-folding chaperone binding (inferred); INVOLVED IN positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (ortholog); ASSOCIATED WITH long QT syndrom e (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN cytoplasm (inferred); perinuclear region of cytoplasm (inferred) | 1 | 4972787 | 4986992 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12406483 | RNF207 | ring finger protein 207 | ENCODES a protein that exhibits Hsp70 protein binding (inferred); metal ion binding (inferred); protein-folding chaperone binding (inferred); INVOLVED IN positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (ortholog); ASSOCIATED WITH long QT syndrom e (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN cytoplasm (inferred); perinuclear region of cytoplasm (inferred) | 5 | 60105200 | 60119902 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12460524 | Rnf207 | ring finger protein 207 | ENCODES a protein that exhibits Hsp70 protein binding (inferred); metal ion binding (inferred); protein-folding chaperone binding (inferred); INVOLVED IN positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (ortholog); ASSOCIATED WITH long QT syndrom e (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN cytoplasm (inferred); perinuclear region of cytoplasm (inferred) | NW_004936623 | 1065260 | 1079918 | Squirrel | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14077333 | RNF207 | ring finger protein 207 | ENCODES a protein that exhibits Hsp70 protein binding (inferred); metal ion binding (inferred); protein-folding chaperone binding (inferred); INVOLVED IN positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (ortholog); ASSOCIATED WITH long QT syndrom e (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN cytoplasm (inferred); perinuclear region of cytoplasm (inferred) | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18539280 | RNF207 | ring finger protein 207 | ENCODES a protein that exhibits Hsp70 protein binding (inferred); metal ion binding (inferred); protein-folding chaperone binding (inferred); INVOLVED IN positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (ortholog); ASSOCIATED WITH long QT syndrom e (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN cytoplasm (inferred); perinuclear region of cytoplasm (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930199 | Rnf207 | ring finger protein 207 | ENCODES a protein that exhibits protein-folding chaperone binding (ortholog); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (ortholog); ASSOCIATED WITH long QT syndrome (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN cytoplasm (inferred); perinuclear region of cytoplasm (inferred) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865646 | RNF207 | ring finger protein 207 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 285102966 | rnf207 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625975884 | Rnf207 | ring finger protein 207 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); protein-folding chaperone binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of membrane repolarization during ventricular cardiac muscl e cell action potential (ortholog); ASSOCIATED WITH long QT syndrome (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog) | | | | Black Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1557929 | Rnf208 | ring finger protein 208 | Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination. Predicted to be located in cytosol and nucleoplasm. Is expressed in nervous system and neural retina. Orthologous to human RNF208 (ring finger protein 208). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 25132941 | 25134273 | Mouse | 75 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1565957 | Rnf208 | ring finger protein 208 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 3 | 28455836 | 28457879 | Rat | 52 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1603720 | RNF208 | ring finger protein 208 | Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 137220259 | 137223408 | Human | 55 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8812686 | Rnf208 | ring finger protein 208 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955513 | 5219250 | 5223043 | Chinchilla | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11686667 | RNF208 | ring finger protein 208 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein autoubiquitination (inferred); protein ubiquitination (inferred); FOUND IN nucleoplasm (inferred) | 9 | 108279801 | 108281695 | Bonobo | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12085571 | RNF208 | ring finger protein 208 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin-protein transferase activity (inferred); zinc ion binding (inferred); INVOLVED IN protein autoubiquitination (inferred); FOUND IN nucleoplasm (inferred) | 9 | 48452147 | 48453585 | Dog | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12526349 | Rnf208 | ring finger protein 208 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004936669 | 769076 | 770772 | Squirrel | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14007834 | RNF208 | ring finger protein 208 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin-protein transferase activity (inferred); zinc ion binding (inferred); INVOLVED IN protein autoubiquitination (inferred); FOUND IN nucleoplasm (inferred) | | | | Pig | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18669192 | RNF208 | ring finger protein 208 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein autoubiquitination (inferred); protein ubiquitination (inferred); FOUND IN nucleoplasm (inferred) | | | | Green Monkey | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934524 | Rnf208 | ring finger protein 208 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626044095 | Rnf208 | ring finger protein 208 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein autoubiquitination (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626187485 | rnf208 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 287901963 | rnf207.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 285314258 | rnf207.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 21410035 | RNF207-AS1 | RNF207 antisense RNA 1 | | 1 | 6204840 | 6205780 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1346229 | COP1 | COP1 E3 ubiquitin ligase | Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 175944831 | 176207286 | Human | 82 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1314835 | RAPSN | receptor associated protein of the synapse | This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic si tes by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011] | 11 | 47437764 | 47449136 | Human | 939 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1349611 | RFWD3 | ring finger and WD repeat domain 3 | Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of double-str and break. Implicated in Fanconi anemia complementation group W. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 74621399 | 74666877 | Human | 246 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1601884 | TRAIP | TRAF interacting protein | This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear fac tor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008] | 3 | 49828601 | 49856564 | Human | 250 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1605231 | TRIML1 | tripartite motif family like 1 | The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the bla stocyst development stage. [provided by RefSeq, Sep 2016] | 4 | 188137229 | 188150767 | Human | 30 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352531 | ZNRF2 | zinc and ring finger 2 | Enables ubiquitin protein ligase activity. Involved in positive regulation of autophagosome-lysosome fusion. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. Is active in intracellular membrane-bounded organelle. [provided by Alliance o f Genome Resources, Apr 2025] | 7 | 30284597 | 30367689 | Human | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1342950 | ZNRF3 | zinc and ring finger 3 | Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 22 | 28883572 | 29057488 | Human | 138 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1345671 | ZNRF4 | zinc and ring finger 4 | Enables ubiquitin protein ligase activity. Involved in negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 5455417 | 5456856 | Human | 50 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |