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Gene: ZNRF2 (zinc and ring finger 2) Homo sapiens
Symbol: ZNRF2
Name: zinc and ring finger 2
Description: Exhibits ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Localizes to the cytoplasmic vesicle membrane; plasma membrane; and protein-containing complex; INTERACTS WITH aflatoxin B1; antirheumatic drug; bortezomib.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase ZNRF2; protein Ells2; RING finger protein 202; RING-type E3 ubiquitin transferase ZNRF2; RNF202; zinc and ring finger 2, E3 ubiquitin protein ligase; zinc finger/RING finger 2; zinc/RING finger protein 2
Mus musculus (house mouse) : Znrf2 (zinc and ring finger 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Znrf2 (zinc and ring finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Znrf2 (zinc and ring finger 2)
Canis lupus familiaris (dog) : ZNRF2 (zinc and ring finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Znrf2 (zinc and ring finger 2)
Sus scrofa (pig) : ZNRF2 (zinc and ring finger 2)
Chlorocebus sabaeus (African green monkey) : ZNRF2 (zinc and ring finger 2)
Heterocephalus glaber (naked mole-rat) : Znrf2 (zinc and ring finger 2)
more info ...
Related Pseudogenes: ZNRF2P1   ZNRF2P2   ZNRF2P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl730,284,597 - 30,367,689 (+)EnsemblGRCh38hg38GRCh38
GRCh38730,284,597 - 30,367,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,323,923 - 30,407,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,290,448 - 30,373,833 (+)NCBINCBI36hg18NCBI36
Build 34730,097,162 - 30,180,547NCBI
Celera730,313,247 - 30,396,631 (+)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,206,083 - 30,289,579 (+)NCBIHuRef
CHM1_1730,324,010 - 30,407,338 (+)NCBICHM1_1
CRA_TCAGchr7v2730,373,689 - 30,457,078 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ZNRF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352531
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.