| 727933 | Rnasel | ribonuclease L | ENCODES a protein that exhibits RNA nuclease activity; rRNA binding; identical protein binding (ortholog); INVOLVED IN rRNA processing; fat cell differentiation (ortholog); negative regulation of viral genome replication (ortholog); PARTICIPATES IN hepatitis C pathway; influenza A pathway; ASSOCIATE D WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN nuclear matrix; cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide | 13 | 68446641 | 68460804 | Rat | 142 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1346643 | RNASEL | ribonuclease L | This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this g ene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021] | 1 | 182573634 | 182589256 | Human | 174 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553469 | Rnasel | ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) | Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of D-glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in several structures, including brain and retina nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 153625089 | 153644441 | Mouse | 167 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8910622 | Rnasel | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); negative regulation of viral genome replication (ortholog); positive regulation of D-glucose import across plas ma membrane (ortholog); ASSOCIATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN cytosol (ortholog); nuclear matrix (ortholog) | NW_004955406 | 21413950 | 21424860 | Chinchilla | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11718598 | RNASEL | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); RNA nuclease activity (ortholog); rRNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); regulation of mRNA stability (ortholog); ASSOCI ATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN nuclear matrix (ortholog) | 1 | 158092346 | 158108026 | Bonobo | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12350950 | RNASEL | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); RNA nuclease activity (ortholog); rRNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); regulation of mRNA stability (ortholog); ASSOCI ATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN nuclear matrix (ortholog); INTERACTS WITH bisphenol A | 7 | 15978055 | 16001604 | Dog | 57 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12693275 | Rnasel | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); RNA nuclease activity (ortholog); rRNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); regulation of mRNA stability (ortholog); ASSOCI ATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN nuclear matrix (ortholog) | NW_004936481 | 7165400 | 7177342 | Squirrel | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626035657 | Rnasel | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); negative regulation of viral genome replication (ortholog); positive regulation of D-glucose import across plas ma membrane (ortholog); ASSOCIATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN cytosol (ortholog); nuclear matrix (ortholog) | | | | Black Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18735261 | RNASEL | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); RNA nuclease activity (ortholog); rRNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); regulation of mRNA stability (ortholog); ASSOCI ATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN nuclear matrix (ortholog) | | | | Green Monkey | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922536 | Rnasel | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA nuclease activity (ortholog); INVOLVED IN fat cell differentiation (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); positive regulation of tra nscription by RNA polymerase II (ortholog); ASSOCIATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN cytosol (ortholog); nuclear matrix (ortholog) | | | | Naked Mole-Rat | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14075774 | RNASEL | ribonuclease L | ENCODES a protein that exhibits identical protein binding (ortholog); RNA nuclease activity (ortholog); rRNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); regulation of mRNA stability (ortholog); ASSOCI ATED WITH Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); Cardiovirus Infections (ortholog); FOUND IN nuclear matrix (ortholog) | | | | Pig | 57 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313249 | ABCE1 | ATP binding cassette subfamily E member 1 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This p rotein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | 4 | 145098311 | 145129524 | Human | 171 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313250 | Abce1 | ATP-binding cassette, sub-family E member 1 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, G CN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008] | 8 | 80410071 | 80438369 | Mouse | 198 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |