| 621309 | Rhob | ras homolog family member B | ENCODES a protein that exhibits GDP binding (ortholog); INVOLVED IN cell adhesion (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to ionizing radiation (ortholog); ASSOCIATED WITH Avian Sarcoma; melanoma; breast cancer (ortholog); FOUND IN cytosol; membrane; synapse; INTERACTS WITH (S)-(-)-perillyl alcohol; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine | 6 | 37083030 | 37085204 | Rat | 378 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1351195 | RHOB | ras homolog family member B | Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer. [pro vided by Alliance of Genome Resources, Jul 2025] | 2 | 20447074 | 20449440 | Human | 355 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1552942 | Rhob | ras homolog family member B | Enables GDP binding activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of apoptotic process; and regulation of modification of postsynaptic structure. Acts upstream of or within intracellular protein transport. Located in endosome; nucleus; an d plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including branchial arch; central nervous system; embryo ectoderm; heart; and sensory organ. Orthologous to human RHOB (ras homolog family member B). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 8547661 | 8550009 | Mouse | 374 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8979326 | Rhob | ras homolog family member B | ENCODES a protein that exhibits GDP binding (ortholog); INVOLVED IN cell adhesion (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to ionizing radiation (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cleavage furrow (ortholog); cytosol (ortholog); early endosome (ortholog) | NW_004955469 | 2964968 | 2966998 | Chinchilla | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12023306 | RHOB | ras homolog family member B | ENCODES a protein that exhibits GDP binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN intracellular protein transport (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cytosol (ortholog); synapse (ort holog) | 2A | 20433576 | 20435986 | Bonobo | 45 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12408952 | RHOB | ras homolog family member B | ENCODES a protein that exhibits GDP binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN intracellular protein transport (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cytosol (ortholog); synapse (ort holog) | 17 | 15438744 | 15439793 | Dog | 44 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12723868 | Rhob | ras homolog family member B | ENCODES a protein that exhibits GDP binding (ortholog); INVOLVED IN cell adhesion (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to ionizing radiation (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cytosol (ortholog); early endosome (ortholog); endosome membrane (ortholog) | NW_004936493 | 10987801 | 10990207 | Squirrel | 44 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14270086 | RHOB | ras homolog family member B | ENCODES a protein that exhibits GDP binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN intracellular protein transport (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cytosol (ortholog); synapse (ort holog) | | | | Pig | 49 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18670013 | RHOB | ras homolog family member B | ENCODES a protein that exhibits GDP binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN intracellular protein transport (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cytosol (ortholog); synapse (ort holog) | | | | Green Monkey | 45 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18933336 | Rhob | ras homolog family member B | ENCODES a protein that exhibits GDP binding (ortholog); INVOLVED IN cell adhesion (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to ionizing radiation (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cytosol (ortholog); early endosome (ortholog); endosome membrane (ortholog) | | | | Naked Mole-Rat | 44 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155231849 | rhob | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625850961 | Rhob | ras homolog family member B | ENCODES a protein that exhibits GDP binding (ortholog); INVOLVED IN cell adhesion (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to ionizing radiation (ortholog); ASSOCIATED WITH Avian Sarcoma (ortholog); breast cancer (ortholog); cerebral palsy (ortholog); FOUND IN cleavage furrow (ortholog); cytosol (ortholog); early endosome (ortholog) | | | | Black Rat | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155231848 | rhob.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240302 | rhob.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12544152 | LOC101956215 | rho-related GTP-binding protein RhoB-like | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); FOUND IN cleavage furrow (inferred); plasma membrane (inferred) | NW_004936471 | 31247593 | 31248901 | Squirrel | 7 | name | gene, protein-coding, MODEL [RefSeq] |
| 16560730 | AP000857.1 | ras homolog gene family, member B (RHOB) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1318093 | RHPN2 | rhophilin Rho GTPase binding protein 2 | This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009] | 19 | 32978592 | 33064888 | Human | 106 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12412387 | RHPN2 | rhophilin Rho GTPase binding protein 2 | INVOLVED IN glomerular filtration (ortholog); negative regulation of stress fiber assembly (ortholog); ASSOCIATED WITH Colorectal Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); perinuclear region of cytoplasm (inferred) | 1 | 119061637 | 119119470 | Dog | 10 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14388379 | RhoBTB | | | | | | Fly | | symbol | gene, null |
| 1306871 | Rhobtb1 | Rho-related BTB domain containing 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); FOU ND IN endosome membrane (inferred); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 20 | 19326197 | 19455182 | Rat | 157 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315735 | RHOBTB1 | Rho related BTB domain containing 1 | The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] | 10 | 60860860 | 61001967 | Human | 156 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315736 | Rhobtb1 | Rho-related BTB domain containing 1 | Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and stomach. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 68987106 | 69127621 | Mouse | 162 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8958132 | Rhobtb1 | Rho related BTB domain containing 1 | ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog) | NW_004955425 | 14299128 | 14366732 | Chinchilla | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11993923 | RHOBTB1 | Rho related BTB domain containing 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); FOUND IN endosome membrane (inferred) | 10 | 57410347 | 57541038 | Bonobo | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12076166 | RHOBTB1 | Rho related BTB domain containing 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); FOUND IN endosome membrane (inferred); INTERACTS WITH bisphen ol A | 4 | 12971624 | 13089520 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12589967 | Rhobtb1 | Rho related BTB domain containing 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); FOUND IN endosome membrane (inferred) | NW_004936614 | 2101175 | 2230441 | Squirrel | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14000113 | RHOBTB1 | Rho related BTB domain containing 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); FOUND IN endosome membrane (inferred); INTERACTS WITH deoxyni valenol | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18676759 | RHOBTB1 | Rho related BTB domain containing 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); FOUND IN endosome membrane (inferred) | | | | Green Monkey | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905561 | Rhobtb1 | Rho related BTB domain containing 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); FOUND IN endosome membrane (inferred) | | | | Naked Mole-Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232963 | rhobtb1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626146111 | Rhobtb1 | Rho related BTB domain containing 1 | ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog) | | | | Black Rat | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1309924 | Rhobtb2 | Rho-related BTB domain containing 2 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH (+)-schisandrin B; 1-nitropropane; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 51278024 | 51298209 | Rat | 121 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320529 | RHOBTB2 | Rho related BTB domain containing 2 | The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript va riants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] | 8 | 22950813 | 23020199 | Human | 252 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320530 | Rhobtb2 | Rho-related BTB domain containing 2 | Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 64. Orthologous to human RHOBTB2 (Rho related BTB domain containing 2). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 70022439 | 70062296 | Mouse | 124 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8750635 | Rhobtb2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog) | NW_004955403 | 46367390 | 46390551 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11900734 | RHOBTB2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein ubiquitination (inferred); small GTPase-mediated signal transduction (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH developmen tal and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); endosome membrane (inferred) | 8 | 22246075 | 22269443 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12083521 | RHOBTB2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein ubiquitination (inferred); small GTPase-mediated signal transduction (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH developmen tal and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); endosome membrane (inferred) | 25 | 34299363 | 34329052 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12661001 | Rhobtb2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein ubiquitination (inferred); small GTPase-mediated signal transduction (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH developmen tal and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); endosome membrane (inferred) | NW_004936555 | 6664811 | 6684756 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14137613 | RHOBTB2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein ubiquitination (inferred); small GTPase-mediated signal transduction (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH developmen tal and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); endosome membrane (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18361568 | RHOBTB2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein ubiquitination (inferred); small GTPase-mediated signal transduction (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH developmen tal and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); endosome membrane (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914685 | Rhobtb2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242543 | rhobtb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626107905 | Rhobtb2 | Rho related BTB domain containing 2 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1311683 | Rhobtb3 | Rho-related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); small GTPase binding (ortholog); INVOLVED IN male gonad development (ortholog); retrograde transport, endosome to Golgi (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); INTERACT S WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 7094972 | 7201507 | Rat | 152 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323267 | RHOBTB3 | Rho related BTB domain containing 3 | Enables ATP binding activity; ATP hydrolysis activity; and small GTPase binding activity. Involved in retrograde transport, endosome to Golgi. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 95717624 | 95796361 | Human | 153 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1323268 | Rhobtb3 | Rho-related BTB domain containing 3 | Predicted to enable ATP binding activity; ATP hydrolysis activity; and enzyme binding activity. Acts upstream of or within male gonad development. Located in cytoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; respiratory system; and ske letal musculature. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 76017656 | 76092054 | Mouse | 173 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8715172 | Rhobtb3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); small GTPase binding (ortholog); INVOLVED IN male gonad development (ortholog); retrograde transport, endosome to Golgi (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog) | NW_004955418 | 16772363 | 16839347 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11756490 | RHOBTB3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); GTP binding (inferred); INVOLVED IN male gonad development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); Golgi apparatus (inferred) | 5 | 19552740 | 19618055 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12172432 | RHOBTB3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); GTP binding (inferred); INVOLVED IN male gonad development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); Golgi apparatus (inferred) | 3 | 13823607 | 13879663 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12692428 | Rhobtb3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); GTP binding (inferred); INVOLVED IN male gonad development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); Golgi apparatus (inferred) | NW_004936523 | 7562054 | 7618380 | Squirrel | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14018770 | RHOBTB3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); GTP binding (inferred); INVOLVED IN male gonad development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); Golgi apparatus (inferred) | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18574655 | RHOBTB3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); GTP binding (inferred); INVOLVED IN male gonad development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); Golgi apparatus (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18923800 | Rhobtb3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); small GTPase binding (ortholog); INVOLVED IN male gonad development (ortholog); retrograde transport, endosome to Golgi (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244593 | rhobtb3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625834614 | Rhobtb3 | Rho related BTB domain containing 3 | ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); small GTPase binding (ortholog); INVOLVED IN male gonad development (ortholog); retrograde transport, endosome to Golgi (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog) | | | | Black Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242345 | rhobtb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232964 | rhobtb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242544 | rhobtb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256705 | rhobtb2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247365 | rhobtb3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 38620675 | RHOBTB2-AS1 | RHOBTB2 antisense RNA 1 | | 8 | 22953619 | 22999805 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1312227 | Arhgef2 | Rho/Rac guanine nucleotide exchange factor 2 | Enables guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including asymmetric neuroblast division; establishment of mitotic spindle orientation; and positive regulation of neuron migration. Acts upstream of or within several processes, inclu ding actin filament organization; negative regulation of podosome assembly; and regulation of Rho protein signal transduction. Located in several cellular components, including dendritic shaft; podosome; and postsynaptic density. Is expressed in several structures, including brain; dorsal root ganglion; liver; and testis. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 88500427 | 88556839 | Mouse | 264 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1321712 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 3 | 56727420 | 57079268 | Human | 136 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16557946 | AC107959.1 | novel transcript, antisense to RHOBTB2 | | | | | Human | | name | gene, lncrna |
