RHOBTB1 (Rho related BTB domain containing 1) - Rat Genome Database

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Gene: RHOBTB1 (Rho related BTB domain containing 1) Sus scrofa
Analyze
Symbol: RHOBTB1
Name: Rho related BTB domain containing 1
RGD ID: 14000113
Description: ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN cortical cytoskeleton organization (inferred); engulfment of apoptotic cell (inferred); establishment or maintenance of cell polarity (inferred); ASSOCIATED WITH Autosomal Dominant Intellectual Developmental Disorder 70 (ortholog); genetic disease (ortholog); juvenile rheumatoid arthritis (ortholog); FOUND IN cell projection (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rho-related BTB domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1464,326,461 - 64,465,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,326,461 - 64,465,331 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,414,894 - 69,473,132 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RHOBTB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1464,326,461 - 64,465,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,326,461 - 64,465,331 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,414,894 - 69,473,132 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOBTB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381060,860,860 - 61,001,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1060,869,438 - 61,001,440 (-)EnsemblGRCh38hg38GRCh38
GRCh371062,629,196 - 62,761,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,299,202 - 62,431,204 (-)NCBINCBI36Build 36hg18NCBI36
Build 341062,299,205 - 62,430,735NCBI
Celera1055,895,951 - 56,028,156 (-)NCBICelera
Cytogenetic Map10q21.2NCBI
HuRef1056,618,425 - 56,750,282 (-)NCBIHuRef
CHM1_11062,911,408 - 63,043,385 (-)NCBICHM1_1
T2T-CHM13v2.01061,726,193 - 61,858,729 (-)NCBIT2T-CHM13v2.0
Rhobtb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391068,987,106 - 69,127,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1068,987,264 - 69,127,621 (+)EnsemblGRCm39 Ensembl
GRCm381069,151,058 - 69,291,791 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1069,151,434 - 69,291,791 (+)EnsemblGRCm38mm10GRCm38
MGSCv371068,675,405 - 68,754,539 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361068,546,791 - 68,687,148 (+)NCBIMGSCv36mm8
Celera1070,309,641 - 70,381,742 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.04NCBI
Rhobtb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82019,326,197 - 19,455,182 (-)NCBIGRCr8
mRatBN7.22019,327,142 - 19,456,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2019,327,155 - 19,403,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2020,056,110 - 20,131,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02019,408,581 - 19,484,447 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02019,883,789 - 19,959,657 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02020,638,579 - 20,715,437 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2020,638,579 - 20,713,128 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02022,756,929 - 22,837,644 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,089,811 - 20,166,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12020,105,716 - 20,146,672 (-)NCBI
Celera2020,702,887 - 20,778,657 (-)NCBICelera
Cytogenetic Map20p11NCBI
Rhobtb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542514,299,035 - 14,360,759 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542514,299,128 - 14,366,732 (-)NCBIChiLan1.0ChiLan1.0
RHOBTB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2873,078,236 - 73,219,435 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11073,083,558 - 73,224,757 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01057,410,347 - 57,541,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11059,740,656 - 59,872,612 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1059,740,662 - 59,815,536 (-)Ensemblpanpan1.1panPan2
RHOBTB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1412,971,624 - 13,089,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl412,973,412 - 13,035,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha413,177,476 - 13,295,404 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0413,237,185 - 13,355,077 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl413,237,195 - 13,301,063 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1413,214,849 - 13,332,726 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0413,332,783 - 13,450,635 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0413,643,870 - 13,761,776 (-)NCBIUU_Cfam_GSD_1.0
Rhobtb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721368,014,268 - 68,142,246 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366142,103,101 - 2,230,444 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366142,101,175 - 2,230,441 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOBTB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1970,266,735 - 70,398,839 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl970,356,290 - 70,396,791 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604831,156,539 - 31,288,910 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhobtb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247912,747,931 - 2,827,614 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247912,695,173 - 2,824,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RHOBTB1
2580 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 3 2 2 1
Low 8 2 3 2 23 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026831   ⟹   ENSSSCP00000019246
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1464,326,453 - 64,465,281 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000058157   ⟹   ENSSSCP00000044587
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1464,326,461 - 64,465,281 (-)Ensembl
RefSeq Acc Id: XM_021073597   ⟹   XP_020929256
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,326,498 - 64,400,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073598   ⟹   XP_020929257
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,326,498 - 64,465,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073599   ⟹   XP_020929258
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,326,498 - 64,399,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073600   ⟹   XP_020929259
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,326,498 - 64,400,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073601   ⟹   XP_020929260
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,326,461 - 64,399,883 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073602   ⟹   XP_020929261
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,326,498 - 64,399,783 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020929260   ⟸   XM_021073601
- Peptide Label: isoform X1
- UniProtKB: A0A287AL07 (UniProtKB/TrEMBL),   A0A4X1TW38 (UniProtKB/TrEMBL),   A0A8D0QPH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020929257   ⟸   XM_021073598
- Peptide Label: isoform X1
- UniProtKB: A0A287AL07 (UniProtKB/TrEMBL),   A0A4X1TW38 (UniProtKB/TrEMBL),   A0A8D0QPH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020929259   ⟸   XM_021073600
- Peptide Label: isoform X1
- UniProtKB: A0A287AL07 (UniProtKB/TrEMBL),   A0A4X1TW38 (UniProtKB/TrEMBL),   A0A8D0QPH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020929256   ⟸   XM_021073597
- Peptide Label: isoform X1
- UniProtKB: A0A287AL07 (UniProtKB/TrEMBL),   A0A4X1TW38 (UniProtKB/TrEMBL),   A0A8D0QPH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020929261   ⟸   XM_021073602
- Peptide Label: isoform X2
- UniProtKB: F1RFZ1 (UniProtKB/TrEMBL),   A0A4X1TTG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020929258   ⟸   XM_021073599
- Peptide Label: isoform X1
- UniProtKB: A0A287AL07 (UniProtKB/TrEMBL),   A0A4X1TW38 (UniProtKB/TrEMBL),   A0A8D0QPH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000044587   ⟸   ENSSSCT00000058157
RefSeq Acc Id: ENSSSCP00000019246   ⟸   ENSSSCT00000026831
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028327 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015003085 UniProtKB/TrEMBL
  ENSSSCG00025004923 UniProtKB/TrEMBL
  ENSSSCG00030064630 UniProtKB/TrEMBL
  ENSSSCG00035066492 UniProtKB/TrEMBL
  ENSSSCG00040070748 UniProtKB/TrEMBL
  ENSSSCG00045025664 UniProtKB/TrEMBL
  ENSSSCG00050044168 UniProtKB/TrEMBL
  ENSSSCG00055002772 UniProtKB/TrEMBL
  ENSSSCG00060075774 UniProtKB/TrEMBL
  ENSSSCG00065020448 UniProtKB/TrEMBL
  ENSSSCG00070012073 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000058157 ENTREZGENE
  ENSSSCT00000058157.3 UniProtKB/TrEMBL
  ENSSSCT00015003888.1 UniProtKB/TrEMBL
  ENSSSCT00015003927.1 UniProtKB/TrEMBL
  ENSSSCT00025006665.1 UniProtKB/TrEMBL
  ENSSSCT00030090333.1 UniProtKB/TrEMBL
  ENSSSCT00030090371.1 UniProtKB/TrEMBL
  ENSSSCT00035089581.1 UniProtKB/TrEMBL
  ENSSSCT00035089597.1 UniProtKB/TrEMBL
  ENSSSCT00040097182.1 UniProtKB/TrEMBL
  ENSSSCT00040097312.1 UniProtKB/TrEMBL
  ENSSSCT00040097428.1 UniProtKB/TrEMBL
  ENSSSCT00045043714.1 UniProtKB/TrEMBL
  ENSSSCT00050060129.1 UniProtKB/TrEMBL
  ENSSSCT00050060138.1 UniProtKB/TrEMBL
  ENSSSCT00055005299.1 UniProtKB/TrEMBL
  ENSSSCT00055005306.1 UniProtKB/TrEMBL
  ENSSSCT00055005313.1 UniProtKB/TrEMBL
  ENSSSCT00055005316.1 UniProtKB/TrEMBL
  ENSSSCT00060103824.1 UniProtKB/TrEMBL
  ENSSSCT00065027249.1 UniProtKB/TrEMBL
  ENSSSCT00070023736.1 UniProtKB/TrEMBL
  ENSSSCT00070023746.1 UniProtKB/TrEMBL
  ENSSSCT00070023757.1 UniProtKB/TrEMBL
  ENSSSCT00070023771.1 UniProtKB/TrEMBL
  ENSSSCT00070023780.1 UniProtKB/TrEMBL
  ENSSSCT00070023788.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
NCBI Gene RHOBTB1 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
  PTHR24413:SF233 UniProtKB/TrEMBL
  RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  SPECKLE-TYPE POZ PROTEIN UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A287AL07 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TTG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TW38 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TW71_PIG UniProtKB/TrEMBL
  A0A8D0QPH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1FUY3_PIG UniProtKB/TrEMBL
  F1RFZ1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92285 ENTREZGENE