| 619707 | Ptgdr | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity; prostaglandin J receptor activity (ortholog); INVOLVED IN negative regulation of cytosolic calcium ion concentration; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of circadian sleep/wake cycle , REM sleep; PARTICIPATES IN eicosanoid signaling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH hypertension; pulmonary hypertension; allergic asthma (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid | 15 | 19790499 | 19797873 | Rat | 99 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1349248 | PTGDR | prostaglandin D2 receptor | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a recep tor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] | 14 | 52267698 | 52280914 | Human | 103 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1551031 | Ptgdr | prostaglandin D receptor | Enables prostaglandin D receptor activity and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenosine metabolic process; cellular response to prostaglandin D stimulus; and male sex determination. Located in plasma membrane. Is expressed in several structu res, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and respiratory system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 45088692 | 45096832 | Mouse | 127 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8951421 | Ptgdr | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); prostaglandin J receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signa ling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955409 | 10801370 | 10810161 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12024852 | PTGDR | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); prostaglandin J receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signa ling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 14 | 32863852 | 32873492 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12305575 | PTGDR | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); prostaglandin J receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signa ling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 8 | 28480446 | 28491331 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12524804 | Ptgdr | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signaling pathway; prostaglandin D2 signaling pathw ay; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936697 | 2481340 | 2488868 | Squirrel | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14123122 | PTGDR | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); prostaglandin J receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signa ling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Pig | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287318146 | ptgdr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18903326 | Ptgdr | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); prostaglandin J receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signa ling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18416847 | PTGDR | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); prostaglandin J receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signa ling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626088322 | Ptgdr | prostaglandin D2 receptor | ENCODES a protein that exhibits prostaglandin D receptor activity (ortholog); prostaglandin J receptor activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); cellular response to prostaglandin D stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN eicosanoid signa ling pathway; prostaglandin D2 signaling pathway; ASSOCIATED WITH allergic asthma (ortholog); asthma (ortholog); COVID-19 (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1565108 | Ptgdrl1 | prostaglandin D2 receptor-like 1 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); prostaglandin D receptor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (inferred); mast cell degranulation (inferred); signal transduction (inferred); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH trichloroethene | 15 | 20552125 | 20561220 | Rat | 15 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1311986 | Ptgdr2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits prostaglandin binding; G protein-coupled receptor activity (ortholog); prostaglandin D receptor activity (ortholog); INVOLVED IN positive regulation of eosinophil migration; positive regulation of lymphocyte migration; positive regulation of release of sequestered cal cium ion into cytosol; ASSOCIATED WITH allergic asthma; aspergillosis; pulmonary eosinophilia; FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH 13,14-dihydro-15-ketoprostaglandin D2; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 1 | 217010183 | 217015044 | Rat | 121 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323730 | PTGDR2 | prostaglandin D2 receptor 2 | This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Si ngle nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011] | 11 | 60850933 | 60855950 | Human | 121 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323731 | Ptgdr2 | prostaglandin D2 receptor 2 | Enables prostaglandin D receptor activity; prostaglandin F receptor activity; and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; calcium-mediated signaling; and negative regulation of male germ cell proliferation. Predicted to be active in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 10901883 | 10919875 | Mouse | 136 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9014812 | Ptgdr2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); prostaglandin binding (ortholog); prostaglandin D receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); che motaxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog) | NW_004955511 | 5536602 | 5539944 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11803164 | PTGDR2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits prostaglandin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); chemotaxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 11 | 56114166 | 56153820 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12386912 | PTGDR2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits prostaglandin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); chemotaxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 18 | 55426632 | 55431916 | Dog | 54 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12669128 | Ptgdr2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits prostaglandin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); chemotaxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936581 | 2069355 | 2072535 | Squirrel | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 152177957 | PTGDR2 | prostaglandin D2 receptor 2 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding |
| 18452614 | PTGDR2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits prostaglandin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); chemotaxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13933927 | PTGDR2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits prostaglandin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); chemotaxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625986516 | Ptgdr2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); prostaglandin binding (ortholog); prostaglandin D receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); che motaxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934228 | Ptgdr2 | prostaglandin D2 receptor 2 | ENCODES a protein that exhibits prostaglandin binding (ortholog); prostaglandin D receptor activity (ortholog); prostaglandin F receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); chemo taxis (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic asthma (ortholog); aspergillosis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1563234 | Ptgdrl1-ps1 | prostaglandin D2 receptor-like 1, pseudogene 1 | | X | 46260716 | 46279422 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |