| 3184 | Nos1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding; cadmium ion binding; calcium-dependent protein binding; INVOLVED IN behavioral response to cocaine; cellular response to epinephrine stimulus; cellular response to mechanical stimulus; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metab olic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH acute kidney failure; acute necrotizing pancreatitis; alcoholic cardiomyopathy; FOUND IN azurophil granule; cell periphery; cytoplasm; INTERACTS WITH (+)-pilocarpine; (S)-colchicine; 1,2-dimethylhydrazine | 12 | 44276011 | 44456371 | Rat | 713 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10991 | Nos1 | nitric oxide synthase 1, neuronal | Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 118004904 | 118096905 | Mouse | 902 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 619551 | NOS1 | nitric oxide synthase 1 | The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011] | 12 | 117208142 | 117361626 | Human | 694 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8804517 | Nos1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to growth factor stimulus (ortholog) ; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN neuron projection terminus; perikaryon; azurophil granule (ortholog) | NW_004955455 | 13797557 | 13978402 | Chinchilla | 256 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12045312 | NOS1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to mechanical stimulus (ortholog); P ARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); cell periphery (ortholog); cytoplasm (ortholog) | 12 | 114784232 | 114938385 | Bonobo | 259 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12378424 | NOS1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to mechanical stimulus (ortholog); P ARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); cell periphery (ortholog); cytoplasm (ortholog) | 26 | 13787341 | 13895176 | Dog | 270 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12566457 | Nos1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to mechanical stimulus (ortholog); P ARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); cell periphery (ortholog); cytoplasm (ortholog) | NW_004936558 | 5162471 | 5302488 | Squirrel | 254 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14245546 | NOS1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to mechanical stimulus (ortholog); P ARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); cell periphery (ortholog); cytoplasm (ortholog); INTERACTS WITH bisphenol A | | | | Pig | 271 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18789965 | NOS1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to growth factor stimulus (ortholog) ; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); calyx of Held (ortholog); caveola (ortholog) | | | | Green Monkey | 254 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928719 | Nos1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to growth factor stimulus (ortholog) ; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); calyx of Held (ortholog); caveola (ortholog) | | | | Naked Mole-Rat | 259 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865819 | NOS1 | nitric oxide synthase 1 | ENCODES a protein that exhibits arginine binding (inferred); calmodulin binding (inferred); FMN binding (inferred); INVOLVED IN cellular response to growth factor stimulus (inferred); multicellular organismal response to stress (inferred); negative regulation of serotonin uptake (inferred); FOUND IN calyx of Held (inferred); caveola (inferred); cell projection (inferred) | | | | Green Monkey | 40 | symbol | gene, protein-coding |
| 155235001 | nos1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626049975 | Nos1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to growth factor stimulus (ortholog) ; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); calyx of Held (ortholog); caveola (ortholog) | | | | Black Rat | 254 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256500 | nos1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236614 | nos1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1578795 | Nos1m1Mcwi | nitric oxide synthase 1; mutation 1, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); L72Stop mutation is generated. | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1317831 | NANOS1 | nanos C2HC-type zinc finger 1 | This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015] | 10 | 119029714 | 119033730 | Human | 132 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 620106 | Nos1ap | nitric oxide synthase 1 adaptor protein | ENCODES a protein that exhibits mitogen-activated protein kinase kinase binding; nitric-oxide synthase binding; PDZ domain binding; INVOLVED IN negative regulation of cellular process; neuron projection regeneration; regulation of calcium ion transmembrane transport via high voltage-gated calcium ch annel; ASSOCIATED WITH congestive heart failure; depressive disorder; Pathologic Constriction; FOUND IN cytosol; glutamatergic synapse; nuclear membrane; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; all-trans-retinoic acid | 13 | 85080558 | 85353741 | Rat | 109 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732118 | NOS1AP | nitric oxide synthase 1 adaptor protein | This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009] | 1 | 162069691 | 162370475 | Human | 148 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1619996 | Nos1ap | nitric oxide synthase 1 (neuronal) adaptor protein | Enables nitric-oxide synthase binding activity. Predicted to be involved in postsynaptic actin cytoskeleton organization; regulation of heart rate by chemical signal; and regulation of ventricular cardiac muscle cell membrane repolarization. Located in Z disc; mitochondrion; and sarcoplasmic reticul um membrane. Colocalizes with T-tubule and caveola. Is expressed in several structures, including brain; gallbladder; genitourinary system; spinal cord; and trachea. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 170143039 | 170417371 | Mouse | 132 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 12100501 | NOS1AP | nitric oxide synthase 1 adaptor protein | ENCODES a protein that exhibits mitogen-activated protein kinase kinase binding (ortholog); nitric-oxide synthase binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN negative regulation of cellular process (ortholog); neuron projection regeneration (ortholog); postsynaptic actin cytoskele ton organization (ortholog); ASSOCIATED WITH Cardiac Arrhythmias (ortholog); congestive heart failure (ortholog); depressive disorder (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | 38 | 20353341 | 20614684 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249997 | nos1ap | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596936191 | NOS1AP | nitric oxide synthase 1 adaptor protein | | | | | Pig | | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155250307 | nos1ap.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253929 | nos1ap.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2320873 | C13h1orf226 | similar to human chromosome 1 open reading frame 226 | ENCODES a protein that exhibits nitric-oxide synthase binding (inferred); FOUND IN filopodium (inferred); podosome (inferred); INTERACTS WITH 17beta-estradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog); acrylamide (ortholog) | 13 | 85063350 | 85071435 | Rat | 45 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14234344 | C4H1orf226 | chromosome 4 C1orf226 homolog | ENCODES a protein that exhibits mitogen-activated protein kinase kinase binding (ortholog); nitric-oxide synthase binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN negative regulation of cellular process (ortholog); neuron projection regeneration (ortholog); postsynaptic actin cytoskele ton organization (ortholog); ASSOCIATED WITH Cardiac Arrhythmias (ortholog); congestive heart failure (ortholog); depressive disorder (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 40 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18914836 | CUNH1orf226 | chromosome unknown C1orf226 homolog | ENCODES a protein that exhibits nitric-oxide synthase binding (inferred); FOUND IN podosome (inferred) | | | | Naked Mole-Rat | 4 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11736599 | LOC100983469 | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | ENCODES a protein that exhibits nitric-oxide synthase binding (inferred); INVOLVED IN postsynaptic actin cytoskeleton organization (inferred); regulation of heart rate by chemical signal (inferred); regulation of ventricular cardiac muscle cell membrane repolarization (inferred); FOUND IN caveola (i nferred); glutamatergic synapse (inferred); mitochondrion (inferred) | 1 | 137487845 | 137800242 | Bonobo | 12 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12480160 | LOC101960259 | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | ENCODES a protein that exhibits nitric-oxide synthase binding (inferred); INVOLVED IN postsynaptic actin cytoskeleton organization (inferred); regulation of heart rate by chemical signal (inferred); regulation of ventricular cardiac muscle cell membrane repolarization (inferred); FOUND IN caveola (i nferred); glutamatergic synapse (inferred); mitochondrion (inferred) | NW_004936831 | 271604 | 591461 | Squirrel | 14 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8962726 | LOC102014428 | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | | NW_004955462 | 13941877 | 14243305 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18534438 | LOC103223662 | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | ENCODES a protein that exhibits nitric-oxide synthase binding (inferred) | | | | Green Monkey | 1 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16570836 | AL450163.1 | Novel transcript, antisense to NOS1AP | | | | | Human | | name | gene, lncrna |
