| 621260 | Msn | moesin | ENCODES a protein that exhibits actin binding; cell adhesion molecule binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN response to alcohol; establishment of endothelial barrier (ortholog); establishment of epithelial cell apical/basal polarity (ortholog); PARTICIPATES IN measl es pathway; ASSOCIATED WITH primary biliary cholangitis; autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface; cell tip; cytoplasmic side of plasma membrane; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | X | 65005546 | 65073512 | Rat | 292 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732547 | MSN | moesin | Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008] | X | 65588377 | 65741931 | Human | 289 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732548 | Msn | moesin | Predicted to enable several functions, including actin binding activity; double-stranded RNA binding activity; and protein kinase binding activity. Acts upstream of or within positive regulation of podosome assembly. Located in several cellular components, including basolateral plasma membrane; micr ovillus; and uropod. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 50. Orthologous to human MSN (moesin). [provided by Alliance of Genome Resources, Jul 2025] | X | 95139651 | 95212159 | Mouse | 304 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8791785 | Msn | moesin | ENCODES a protein that exhibits actin binding (ortholog); cell adhesion molecule binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN establishment of endothelial barrier (ortholog); establishment of epithelial cell apical/basal polarity (ortholog); gland morphogenesis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | NW_004955475 | 5301856 | 5370378 | Chinchilla | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11937997 | MSN | moesin | ENCODES a protein that exhibits actin binding (ortholog); INVOLVED IN positive regulation of podosome assembly (ortholog); response to alcohol (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN basolateral plasma me mbrane (ortholog); cell surface (ortholog); cell tip (ortholog) | X | 54785309 | 54859364 | Bonobo | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12324284 | MSN | moesin | ENCODES a protein that exhibits actin binding (ortholog); double-stranded RNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN establishment of endothelial barrier (ortholog); establishment of epithelial cell apical/basal polarity (ortholog); gland morphogenesis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | X | 50708913 | 50775404 | Dog | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12533745 | Msn | moesin | ENCODES a protein that exhibits actin binding (ortholog); INVOLVED IN positive regulation of podosome assembly (ortholog); response to alcohol (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholo g); cell tip (ortholog); cytoplasmic side of plasma membrane (ortholog) | NW_004936635 | 2390390 | 2461870 | Squirrel | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625947822 | Msn | moesin | ENCODES a protein that exhibits actin binding (ortholog); cell adhesion molecule binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN establishment of endothelial barrier (ortholog); establishment of epithelial cell apical/basal polarity (ortholog); gland morphogenesis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Black Rat | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909037 | Msn | moesin | ENCODES a protein that exhibits actin binding (ortholog); cell adhesion molecule binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN establishment of endothelial barrier (ortholog); establishment of epithelial cell apical/basal polarity (ortholog); gland morphogenesis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Naked Mole-Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14380315 | msn | | | | | | Fly | | symbol | gene, null |
| 13872721 | MSN | moesin | ENCODES a protein that exhibits actin binding (ortholog); INVOLVED IN immunological synapse formation (ortholog); positive regulation of podosome assembly (ortholog); response to alcohol (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic diseas e (ortholog); FOUND IN cell surface (ortholog); cell tip (ortholog); cytoplasmic side of plasma membrane (ortholog); INTERACTS WITH graphene oxide | | | | Pig | 91 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18435425 | MSN | moesin | ENCODES a protein that exhibits actin binding (ortholog); INVOLVED IN positive regulation of podosome assembly (ortholog); response to alcohol (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholo g); cell tip (ortholog); cytoplasmic side of plasma membrane (ortholog) | | | | Green Monkey | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247737 | msn | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155258692 | msn.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238968 | msn.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1314611 | Dclre1a | DNA cross-link repair 1A | Predicted to enable 5'-3' DNA exonuclease activity; beta-lactamase activity; and damaged DNA binding activity. Acts upstream of or within nucleotide-excision repair. Predicted to be located in fibrillar center and nucleoplasm. Orthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by All iance of Genome Resources, Apr 2025] | 19 | 56517593 | 56536716 | Mouse | 98 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14380858 | MSN2 | | | | | | Yeast | | symbol | gene, null |
| 14380860 | MSN4 | | | | | | Yeast | | symbol | gene, null |
| 14380861 | MSN5 | | | | | | Yeast | | symbol | gene, null |
| 1353422 | MSNP1 | moesin pseudogene 1 | INTERACTS WITH aristolochic acid A | 5 | 25909315 | 25913278 | Human | 1 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1321193 | Dclre1b | DNA cross-link repair 1B | Enables 5'-3' exonuclease activity. Involved in protection from non-homologous end joining at telomere; telomeric 3' overhang formation; and telomeric loop formation. Located in chromosome, telomeric region. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene imp licated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 103707921 | 103716703 | Mouse | 126 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320658 | Sbno1 | strawberry notch 1 | Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in negative regulation of neuroinflammatory response; positive regulation of neural precursor cell proliferation; and regulation of signal transduction. Located in nucleus. Is expressed in several structures, i ncluding brain; cardiovascular system; genitourinary system; gut; and liver. Orthologous to human SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 124506765 | 124564059 | Mouse | 117 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1318722 | Smarcb1 | SWI/SNF related BAF chromatin remodeling complex subunit B1 | Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Acts upstream of or within blastocyst hatching; hepatocyte differentiation; and negative regulation of cell population proliferation. Located in XY body and ge rm cell nucleus. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb primordium; and sensory organ. Used to study atypical teratoid rhabdoid tumor. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; meningioma; rhabdoid cancer; rhabdoid tumor predisposition syndrome 1; and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 75732603 | 75757448 | Mouse | 312 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1623060 | Smarca5 | SNF2 related chromatin remodeling ATPase 5 | Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and nucleosome array spacer activity. Predicted to contribute to histone binding activity. Involved in negative regulation of macromolecule biosynthetic process and positive regulation of DNA replication. Acts upstream of or within cellular response to leukemia inhibitory factor; chromatin organization; and positive regulation of DNA-templated transcription. Located in nucleus and pericentric heterochromatin. Part of CERF complex; NoRC complex; and chromatin silencing complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SMARCA5 (SNF2 related chromatin remodeling ATPase 5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 81426572 | 81466088 | Mouse | 224 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1353820 | ALK | ALK receptor tyrosine kinase | This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the developme nt of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] | 2 | 29192774 | 29921586 | Human | 593 | description | gene, protein-coding, REVIEWED [RefSeq] |