| 3078 | Men1 | menin 1 | ENCODES a protein that exhibits chromatin binding; DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN cellular response to glucose stimulus; cellular response to peptide hormone stimulus; decidualization; PARTICIPATES IN histone modification pathway; ASSOCIA TED WITH abnormal intestinal epithelium morphology; ASSOCIATED WITH Colonic Neoplasms; Hyperalgesia; adenoma (ortholog); FOUND IN nucleus; chromatin (ortholog); chromosome, telomeric region (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; ammonium chloride | 1 | 213068166 | 213074132 | Rat | 275 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736443 | MEN1 | menin 1 | This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin struc ture through the modification of histones. [provided by RefSeq, May 2019] | 11 | 64803516 | 64811294 | Human | 1279 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736444 | Men1 | multiple endocrine neoplasia 1 | Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in transcription initiation-coupled chromatin remodeling. Acts upstream of or within several processes, including negative regulation of cell populatio n proliferation; regulation of osteoblast differentiation; and regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 6385009 | 6390924 | Mouse | 474 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8995322 | Men1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodeling (ortholog); PART ICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); cleavage furrow (ortholog) | NW_004955422 | 20356491 | 20363374 | Chinchilla | 192 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11918071 | MEN1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodelin g (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog) | 11 | 60159009 | 60166222 | Bonobo | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12358230 | MEN1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodelin g (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog) | 18 | 52346747 | 52352884 | Dog | 193 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12704440 | Men1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodelin g (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog) | NW_004936599 | 4504489 | 4510085 | Squirrel | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625942448 | Men1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodeling (ortholog); PART ICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); cleavage furrow (ortholog) | | | | Black Rat | 170 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13929784 | MEN1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodelin g (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog) | | | | Pig | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234585 | men1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18901791 | Men1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodeling (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cleavage furrow (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18586046 | MEN1 | menin 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); chromatin remodelin g (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog) | | | | Green Monkey | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241160 | men1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1346504 | SF1 | splicing factor 1 | This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] | 11 | 64764606 | 64778542 | Human | 176 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1551753 | Sf1 | splicing factor 1 | Enables RNA binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and nuclear body organization. Located in nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary syst em; limb; and sensory organ. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 6413952 | 6428060 | Mouse | 177 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1350269 | ZFPL1 | zinc finger protein like 1 | Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 65084222 | 65088398 | Human | 56 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 69115 | CDKN1B | cyclin dependent kinase inhibitor 1B | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this pr otein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] | 12 | 12717368 | 12722369 | Human | 1166 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |