MEN1 (menin 1) - Rat Genome Database

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Gene: MEN1 (menin 1) Pan paniscus
Analyze
Symbol: MEN1
Name: menin 1
RGD ID: 11918071
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN brain development (ortholog); cellular response to DNA damage stimulus (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoma (ortholog); adrenocortical carcinoma (ortholog); Angiofibroma (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); cleavage furrow (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: menin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11163,499,954 - 63,507,164 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,499,962 - 63,507,164 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01160,159,009 - 60,166,222 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
chromatin remodeling  (ISO)
decidualization  (ISO)
embryonic skeletal system morphogenesis  (ISO)
hemopoiesis  (ISO)
histone H3-K4 methylation  (ISO)
histone methylation  (ISO)
leukocyte homeostasis  (ISO)
MAPK cascade  (ISO)
maternal process involved in female pregnancy  (ISO)
mitotic cell cycle  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of JNK cascade  (ISO)
negative regulation of organ growth  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of telomerase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
ossification  (ISO)
osteoblast development  (ISO)
osteoblast fate commitment  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell division  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of histone methylation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of activin receptor signaling pathway  (ISO)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of gene expression  (ISO)
regulation of type B pancreatic cell proliferation  (ISO)
response to gamma radiation  (ISO)
response to transforming growth factor beta  (ISO)
response to UV  (ISO)
roof of mouth development  (ISO)
type B pancreatic cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MEN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11163,499,954 - 63,507,164 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,499,962 - 63,507,164 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01160,159,009 - 60,166,222 (-)NCBIMhudiblu_PPA_v0panPan3
MEN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1164,803,510 - 64,811,294 (-)EnsemblGRCh38hg38GRCh38
GRCh381164,803,514 - 64,811,294 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,570,986 - 64,578,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,327,564 - 64,335,342 (-)NCBINCBI36hg18NCBI36
Build 341164,327,571 - 64,335,342NCBI
Celera1161,897,163 - 61,904,940 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,898,267 - 60,932,150 (-)NCBIHuRef
CHM1_11164,454,762 - 64,462,538 (-)NCBICHM1_1
Men1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,385,009 - 6,390,924 (+)NCBIGRCm39mm39
GRCm39 Ensembl196,385,009 - 6,390,921 (+)Ensembl
GRCm38196,334,979 - 6,340,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,334,979 - 6,340,891 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,334,979 - 6,340,894 (+)NCBIGRCm37mm9NCBIm37
MGSCv36196,335,039 - 6,340,889 (+)NCBImm8
Celera196,207,959 - 6,213,874 (+)NCBICelera
Cytogenetic Map19ANCBI
Men1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21203,638,905 - 203,644,871 (+)NCBI
Rnor_6.0 Ensembl1221,704,493 - 221,710,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01221,704,394 - 221,710,343 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01228,692,520 - 228,698,433 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,114,987 - 209,120,837 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11209,273,349 - 209,279,258 (+)NCBI
Celera1201,172,444 - 201,178,294 (+)NCBICelera
Cytogenetic Map1q43NCBI
Men1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,356,491 - 20,363,575 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,356,491 - 20,363,374 (+)NCBIChiLan1.0ChiLan1.0
MEN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,346,747 - 52,352,884 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,346,933 - 52,353,340 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,954,682 - 50,959,679 (+)NCBI
ROS_Cfam_1.01853,387,971 - 53,394,108 (+)NCBI
UMICH_Zoey_3.11852,483,508 - 52,488,505 (+)NCBI
UNSW_CanFamBas_1.01852,069,239 - 52,074,237 (+)NCBI
UU_Cfam_GSD_1.01852,853,531 - 52,858,531 (+)NCBI
Men1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,062,038 - 8,068,200 (+)NCBI
SpeTri2.0NW_0049365994,504,489 - 4,510,085 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,357,951 - 7,365,128 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,358,130 - 7,364,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,490,697 - 6,497,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,423,885 - 9,431,123 (+)NCBI
ChlSab1.1 Ensembl19,423,917 - 9,431,104 (+)Ensembl
Vero_WHO_p1.0NW_023666038106,810,667 - 106,817,860 (+)NCBI
Men1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476721,579,084 - 21,585,380 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000030414   ⟹   ENSPPAP00000007805
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1163,499,962 - 63,507,164 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000030420   ⟹   ENSPPAP00000007811
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1163,500,773 - 63,506,533 (-)Ensembl
RefSeq Acc Id: XM_003828589   ⟹   XP_003828637
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11163,499,954 - 63,507,164 (-)NCBI
Mhudiblu_PPA_v01160,159,009 - 60,166,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003828591   ⟹   XP_003828639
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11163,499,954 - 63,507,031 (-)NCBI
Mhudiblu_PPA_v01160,159,009 - 60,166,163 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954013   ⟹   XP_008952261
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11163,499,954 - 63,507,109 (-)NCBI
Mhudiblu_PPA_v01160,159,009 - 60,166,158 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954014   ⟹   XP_008952262
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11163,499,954 - 63,506,967 (-)NCBI
Mhudiblu_PPA_v01160,159,009 - 60,166,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954015   ⟹   XP_008952263
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11163,499,954 - 63,507,109 (-)NCBI
Mhudiblu_PPA_v01160,159,009 - 60,166,157 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954016   ⟹   XP_008952264
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11163,499,954 - 63,507,030 (-)NCBI
Mhudiblu_PPA_v01160,159,009 - 60,166,162 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_008952262   ⟸   XM_008954014
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003828637   ⟸   XM_003828589
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008952263   ⟸   XM_008954015
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008952261   ⟸   XM_008954013
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003828639   ⟸   XM_003828591
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008952264   ⟸   XM_008954016
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000007811   ⟸   ENSPPAT00000030420
RefSeq Acc Id: ENSPPAP00000007805   ⟸   ENSPPAT00000030414


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027099 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000007805 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000007811 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000030414 UniProtKB/TrEMBL
  ENSPPAT00000030420 UniProtKB/TrEMBL
InterPro Menin UniProtKB/TrEMBL
KEGG Report pps:100995950 UniProtKB/TrEMBL
NCBI Gene MEN1 ENTREZGENE
PANTHER PTHR12693 UniProtKB/TrEMBL
Pfam Menin UniProtKB/TrEMBL
UniProt A0A2R8ZTC6_PANPA UniProtKB/TrEMBL
  A0A2R8ZVC2_PANPA UniProtKB/TrEMBL