| 2887 | Il15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN cellular response to vitamin D; hyaluronan metabolic process; negative regulation of smooth muscle cell proliferation; PARTICIPATES IN Jak-Stat signaling pathway; cytokine mediated signaling pathway; rheumatoid arthritis pathw ay; ASSOCIATED WITH abnormal placenta junctional zone morphology; abnormal uterine spiral artery morphology; decreased NK cell number; ASSOCIATED WITH Experimental Autoimmune Myasthenia Gravis; Inflammation; listeriosis; FOUND IN cell surface; extracellular space; cytoplasm (ortholog); INTERACTS WITH (+)-taxifolin; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 19 | 42536160 | 42611349 | Rat | 298 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10786 | Il15 | interleukin 15 | This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proli feration of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016] | 8 | 83058253 | 83129883 | Mouse | 360 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737535 | IL15 | interleukin 15 | The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus nega tively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011] | 4 | 141636583 | 141733987 | Human | 298 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8798402 | Il15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); arteri osclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | NW_004955471 | 1496352 | 1583919 | Chinchilla | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11796365 | IL15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respirator y distress syndrome (ortholog); arteriosclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | 4 | 133693995 | 134115470 | Bonobo | 102 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12420146 | IL15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respirator y distress syndrome (ortholog); arteriosclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | 19 | 1339607 | 1364762 | Dog | 102 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12691336 | Il15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respirator y distress syndrome (ortholog); arteriosclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | NW_004936535 | 6344348 | 6358803 | Squirrel | 99 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626019982 | Il15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); arteri osclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | | | | Black Rat | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18756911 | IL15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respirator y distress syndrome (ortholog); arteriosclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | | | | Green Monkey | 102 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18928979 | Il15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respirator y distress syndrome (ortholog); arteriosclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13924523 | IL15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN cell maturation (ortholog); cellular response to vitamin D (ortholog); extrathymic T cell selection (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH adult respirator y distress syndrome (ortholog); arteriosclerosis (ortholog); aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); INTERACTS WITH hydrogen peroxide; oleanolic acid | | | | Pig | 108 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12910491 | Il15em1Soar | interleukin 15; ZFN induced mutant 1, Soar | ASSOCIATED WITH abnormal placenta junctional zone morphology; abnormal uterine spiral artery morphology; decreased NK cell number | | | | Rat | 4 | symbol , description , old_gene_symbol | gene, allele |
| 1313009 | IL15RA | interleukin 15 receptor subunit alpha | This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping bio logical activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010] | 10 | 5948900 | 5978741 | Human | 129 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1305149 | Il15ra | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits interleukin-15 receptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT; negative regulation of neuron projection development; response to nutrient levels; PARTICIPATES IN Jak-Stat signaling path way; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atrazine | 17 | 71712141 | 71742072 | Rat | 121 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313010 | Il15ra | interleukin 15 receptor, alpha chain | Predicted to enable interleukin-15 receptor activity and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell differentiation. Located in cytoplasmic vesicle. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to hu man IL15RA (interleukin 15 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 11709992 | 11739129 | Mouse | 167 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8884637 | Il15ra | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits interleukin-15 receptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); interleukin-15-mediated signaling pathway (ortholog); negative regulation of neuron projection development (ort holog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); plasma membrane (ortholog) | NW_004955421 | 22590168 | 22612835 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11796651 | IL15RA | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits interleukin-15 receptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); interleukin-15-mediated signaling pathway (ortholog); negative regulation of neuron projection development (ort holog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); plasma membrane (ortholog) | 10 | 5993583 | 6019967 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12434397 | IL15RA | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); negative regulation of neuron projection development (ortholog); positive regulation of natural killer cell differentiation (ortholog); PARTICIPATES IN Jak- Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (inferred); cytoplasmic vesicle (inferred); extracellular region (inferred) | 2 | 29981385 | 30034364 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12557938 | Il15ra | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits interleukin-15 receptor activity (inferred); protein kinase binding (inferred); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); negative regulation of neuron projection development (ortholog); positive regulation of natural killer cell dif ferentiation (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (inferred); cytoplasmic vesicle (inferred); extracellular region (inferred) | NW_004936484 | 8590945 | 8623478 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626174163 | il15ra | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14249314 | IL15RA | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); negative regulation of neuron projection development (ortholog); positive regulation of natural killer cell differentiation (ortholog); PARTICIPATES IN Jak- Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (inferred); cytoplasmic vesicle (inferred); extracellular region (inferred) | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18392399 | IL15RA | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits interleukin-15 receptor activity (inferred); protein kinase binding (inferred); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); negative regulation of neuron projection development (ortholog); positive regulation of natural killer cell dif ferentiation (ortholog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (inferred); cytoplasmic vesicle (inferred); extracellular region (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625889445 | Il15ra | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits interleukin-15 receptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); interleukin-15-mediated signaling pathway (ortholog); negative regulation of neuron projection development (ort holog); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); plasma membrane (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921949 | Il15ra | interleukin 15 receptor subunit alpha | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); negative regulation of neuron projection development (ortholog); positive regulation of natural killer cell differentiation (ortholog); PARTICIPATES IN Jak- Stat signaling pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); Human Influenza (ortholog); Pneumococcal Pneumonia (ortholog); FOUND IN cell surface (inferred); cytoplasmic vesicle (inferred); extracellular region (inferred) | | | | Naked Mole-Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 732849 | Il2rb | interleukin 2 receptor, beta chain | The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008] | 15 | 78363456 | 78396569 | Mouse | 252 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737611 | IL2RB | interleukin 2 receptor subunit beta | The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an al pha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016] | 22 | 37125838 | 37175118 | Human | 255 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 730858 | IL2 | interleukin 2 | This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is i mportant for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020] | 4 | 122451470 | 122456725 | Human | 907 | description | gene, protein-coding, REVIEWED [RefSeq] |