| 2872 | Igfbp1 | insulin-like growth factor binding protein 1 | ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN insulin receptor signaling pathway; positive regulation of cell growth; tissue regeneration; PARTICIPATES IN f orkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH Burns; Endotoxemia; Experimental Diabetes Mellitus; FOUND IN extracellular space; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate | 14 | 86261277 | 86266344 | Rat | 414 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69038 | IGFBP1 | insulin like growth factor binding protein 1 | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGF s) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017] | 7 | 45888488 | 45893660 | Human | 422 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 69039 | Igfbp1 | insulin-like growth factor binding protein 1 | Enables insulin-like growth factor binding activity. Acts upstream of or within response to insulin. Located in extracellular space. Is expressed in several structures, including early embryo; jaw; liver; mandible primordium; and secondary oocyte. Human ortholog(s) of this gene implicated in diabeti c angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 7147787 | 7152546 | Mouse | 428 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8909655 | Igfbp1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insu lin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Burns (ortholog); Colonic Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | NW_004955456 | 6810461 | 6814944 | Chinchilla | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11921338 | IGFBP1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits growth factor binding (inferred); insulin-like growth factor binding (inferred); insulin-like growth factor I binding (inferred); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insulin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); breast cancer (ortholog); Burns (ortholog); FOUND IN extracellular space (ortholog) | 7 | 46538566 | 46545536 | Bonobo | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12149945 | IGFBP1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insulin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); breast cancer (ortholog); Burns (ortholog); FOUND IN extracellular space (ortholog) | 16 | 1037169 | 1040996 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12613189 | Igfbp1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits growth factor binding (inferred); insulin-like growth factor binding (inferred); insulin-like growth factor I binding (inferred); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insulin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); breast cancer (ortholog); Burns (ortholog); FOUND IN extracellular space (ortholog) | NW_004936478 | 20494190 | 20499001 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244129 | igfbp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13920114 | IGFBP1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits growth factor binding (inferred); insulin-like growth factor binding (inferred); insulin-like growth factor I binding (inferred); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insulin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Burns (ortholog); Colonic Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | | | | Pig | 39 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626044896 | Igfbp1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insu lin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Burns (ortholog); Colonic Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921837 | Igfbp1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits growth factor binding (inferred); insulin-like growth factor binding (inferred); insulin-like growth factor I binding (inferred); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insulin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); breast cancer (ortholog); Burns (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18608636 | IGFBP1 | insulin like growth factor binding protein 1 | ENCODES a protein that exhibits growth factor binding (inferred); insulin-like growth factor binding (inferred); insulin-like growth factor I binding (inferred); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insulin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); breast cancer (ortholog); Burns (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231761 | igfbp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244128 | igfbp1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 731720 | CCN1 | cellular communication network factor 1 | The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apopto sis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] | 1 | 85580761 | 85583950 | Human | 499 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731721 | Ccn1 | cellular communication network factor 1 | Enables extracellular matrix binding activity and integrin binding activity. Acts upstream of or within several processes, including chondroblast differentiation; circulatory system development; and regulation of apoptotic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; embryo mesenchyme; extraembryonic component; heart; and sensory organ. Used to study atrial heart septal defect 1 and atrioventricular septal defect. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human CCN1 (cellular communication network factor 1). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 145352726 | 145355740 | Mouse | 540 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |