| 1302992 | Cchcr1 | coiled-coil alpha-helical rod protein 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN protein export from nucleus (ortholog); ASSOCIATED WITH alopecia areata (ortholog); amphetamine abuse (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN centriole (ortholog); cytoplasm (ortholog); cytos ol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 20 | 3210383 | 3223187 | Rat | 82 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1344859 | CCHCR1 | coiled-coil alpha-helical rod protein 1 | This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017] | 6 | 31142439 | 31158197 | Human | 88 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1617323 | Cchcr1 | coiled-coil alpha-helical rod protein 1 | Predicted to enable identical protein binding activity. Acts upstream of or within protein export from nucleus. Located in cytoplasm. Is expressed in brain ventricular layer; inferior colliculus; and pancreas epithelium. Used to study alopecia areata. Orthologous to human CCHCR 700;'>HCR1 (coiled-coil alpha-helical rod protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 35827914 | 35841912 | Mouse | 90 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12006443 | CCHCR1 | coiled-coil alpha-helical rod protein 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN protein export from nucleus (ortholog); ASSOCIATED WITH alopecia areata (ortholog); amphetamine abuse (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN centriole (ortholog) | 6 | 30888542 | 30904382 | Bonobo | 25 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14297491 | CCHCR1 | coiled-coil alpha-helical rod protein 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN protein export from nucleus (ortholog); ASSOCIATED WITH alopecia areata (ortholog); amphetamine abuse (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN centriole (ortholog); cytosol (ortholog); INTERAC TS WITH deoxynivalenol | | | | Pig | 25 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1323460 | CCRL2 | C-C motif chemokine receptor like 2 | This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene i s expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008] | 3 | 46407259 | 46409523 | Human | 123 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 70883 | Eif2ak1 | eukaryotic translation initiation factor 2 alpha kinase 1 | ENCODES a protein that exhibits eukaryotic translation initiation factor 2alpha kinase activity; heme binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN acute inflammatory response (ortholog); HRI-mediated signaling (ortholog); integrated stress response signaling (ortholo g); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Chemical and Drug Induced Liver Injury (ortholog); hemolytic anemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride | 12 | 15824431 | 15858266 | Rat | 154 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 737179 | Eif2ak1 | eukaryotic translation initiation factor 2 alpha kinase 1 | Enables heme binding activity; protein homodimerization activity; and protein kinase activity. Involved in negative regulation of cell population proliferation; negative regulation of hemoglobin biosynthetic process; and protein autophosphorylation. Acts upstream of or within several processes, incl uding macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Located in cytoplasm. Is expressed in alimentary system; central nervous system; liver; nervous system; and spinal cord. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 143803586 | 143839535 | Mouse | 157 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1354333 | EIF2AK1 | eukaryotic translation initiation factor 2 alpha kinase 1 | The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefS eq, Aug 2008] | 7 | 6022247 | 6059175 | Human | 147 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1604264 | NTPCR | nucleoside-triphosphatase, cancer-related | The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activit y. [provided by RefSeq, Jul 2016] | 1 | 232950611 | 232983882 | Human | 91 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 14377132 | HCR1 | | | | | | Yeast | | symbol | gene, null |
| 2786 | Hcrt | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide hormone activity; type 1 orexin receptor binding; type 2 orexin receptor binding; INVOLVED IN behavioral response to ethanol; drinking behavior; eating behavior; PARTICIPATES IN orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/ hypocretin signaling pathway via orexin/hypocretin receptor 2; orexin/hypocretin signaling pathway; ASSOCIATED WITH alcohol use disorder; hyperglycemia; Hyperphagia; FOUND IN neuronal dense core vesicle lumen; secretory granule; perinuclear region of cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 86190289 | 86191524 | Rat | 147 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731040 | HCRT | hypocretin neuropeptide precursor | This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCR ight:700;'>HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010] | 17 | 42184060 | 42185452 | Human | 208 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731041 | Hcrt | hypocretin | This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcr ight:700;'>Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015] | 11 | 100652519 | 100653757 | Mouse | 210 | symbol , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 8895758 | Hcrt | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); perinuclear region of cytoplasm (ortholog); secretory granule (ortholog) | NW_004955451 | 16235819 | 16237457 | Chinchilla | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11759550 | HCRT | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog) | 17 | 15130581 | 15132024 | Bonobo | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12151352 | HCRT | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog) | 9 | 20729616 | 20732074 | Dog | 78 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12455574 | Hcrt | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog) | NW_004936490 | 17007001 | 17008363 | Squirrel | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14082490 | HCRT | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog) | | | | Pig | 78 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18340833 | HCRT | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog) | | | | Green Monkey | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927659 | Hcrt | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog) | | | | Naked Mole-Rat | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083136 | hcrt | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625951795 | Hcrt | hypocretin neuropeptide precursor | ENCODES a protein that exhibits neuropeptide activity (ortholog); neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); drinking behavior (ortholog); eating behavior (ortholog); PARTICIPATES IN orexin/hypocretin si gnaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH alcohol use disorder (ortholog); cannabis dependence (ortholog); cocaine abuse (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); perinuclear region of cytoplasm (ortholog); secretory granule (ortholog) | | | | Black Rat | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083138 | hcrt.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856016 | hcrt.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860940 | hcrt.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862162 | hcrt.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864164 | hcrt.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359207 | hcrt.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2787 | Hcrtr1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity; peptide hormone binding; INVOLVED IN feeding behavior; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride | 5 | 147761392 | 147771846 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 734418 | HCRTR1 | hypocretin receptor 1 | The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009] | 1 | 31617689 | 31634492 | Human | 101 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737545 | Hcrtr1 | hypocretin (orexin) receptor 1 | Predicted to enable orexin receptor activity and peptide hormone binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and li ver and biliary system. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 130024010 | 130033389 | Mouse | 108 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8831366 | Hcrtr1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); PARTICIPATES IN G protein mediated signaling pathway v ia Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955452 | 10026464 | 10036267 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11798553 | HCRTR1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 1 | 30901772 | 30913633 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12351240 | HCRTR1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 2 | 69484776 | 69493956 | Dog | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12695370 | Hcrtr1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936474 | 14735654 | 14744112 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14131536 | HCRTR1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN plasma membrane (ortholog) | | | | Pig | 36 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18703489 | HCRTR1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911746 | Hcrtr1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625947242 | Hcrtr1 | hypocretin receptor 1 | ENCODES a protein that exhibits orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); PARTICIPATES IN G protein mediated signaling pathway v ia Galphaq family; orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); withdrawal disorder (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 2788 | Hcrtr2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity; orexin receptor activity; peptide hormone binding; INVOLVED IN feeding behavior; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH hyperglycemia; narcolepsy (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 8 | 85870279 | 85986405 | Rat | 97 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1351591 | HCRTR2 | hypocretin receptor 2 | The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that sel ectively binds orexin A. [provided by RefSeq, Jan 2009] | 6 | 55106469 | 55284713 | Human | 90 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553616 | Hcrtr2 | hypocretin (orexin) receptor 2 | Enables orexin receptor activity. Involved in locomotion. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genito urinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 76133162 | 76230905 | Mouse | 103 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8904989 | Hcrtr2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); narcolepsy (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955411 | 970892 | 1010138 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12000287 | HCRTR2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); PARTIC IPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); narcolepsy (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 6 | 54722279 | 54835963 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12143991 | HCRTR2 | hypocretin receptor 2 | ENCODES a protein that exhibits orexin receptor activity; G protein-coupled receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN neuropeptide signaling pathway; regulation of circadian sleep/wake cycle, wakefulness; regulation of cytosolic calcium ion concentration; PARTICIP ATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH narcolepsy; hyperglycemia (ortholog); FOUND IN plasma membrane | 12 | 22517482 | 22623358 | Dog | 48 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12705617 | Hcrtr2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); PARTIC IPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); narcolepsy (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936476 | 5838663 | 5933174 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14125166 | HCRTR2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); narcolepsy (ortholog); FOUND IN plasma membrane (ortholog) | | | | Pig | 46 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18675794 | HCRTR2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); PARTIC IPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); narcolepsy (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915867 | Hcrtr2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); narcolepsy (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250620 | hcrtr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626129827 | Hcrtr2 | hypocretin receptor 2 | ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); orexin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN feeding behavior (ortholog); G protein-coupled receptor signaling pathway (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); narcolepsy (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231922 | hcrtr2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249979 | hcrtr2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 733946 | CRNKL1 | crooked neck pre-mRNA splicing factor 1 | The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicin g. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013] | 20 | 20034368 | 20056046 | Human | 82 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733826 | DCXR | dicarbonyl and L-xylulose reductase | The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010] | 17 | 82035858 | 82037697 | Human | 248 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1605703 | MTMR11 | myotubularin related protein 11 | Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 149928651 | 149936879 | Human | 97 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1342496 | XAB2 | XPA binding protein 2 | Involved in DNA-templated transcription; mRNA splicing, via spliceosome; and transcription-coupled nucleotide-excision repair. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 7619525 | 7629545 | Human | 93 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1348993 | CRIP1 | cysteine rich protein 1 | Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008] | 14 | 105486886 | 105488947 | Human | 143 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732507 | CRY2 | cryptochrome circadian regulator 2 | This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodime rs to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] | 11 | 45847118 | 45883244 | Human | 201 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1604528 | VPS37A | VPS37A subunit of ESCRT-I | This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulat ed in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012] | 8 | 17246958 | 17333455 | Human | 137 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1606724 | CD200R1 | CD200 receptor 1 | This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a my eloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] | 3 | 112921205 | 112975103 | Human | 97 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314425 | CORO1C | coronin 1C | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved i n a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] | 12 | 108645109 | 108731518 | Human | 175 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1344708 | LETMD1 | LETM1 domain containing 1 | This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011] | 12 | 51048220 | 51068958 | Human | 95 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732391 | RBP1 | retinol binding protein 1 | This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants enco ding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] | 3 | 139517438 | 139539742 | Human | 275 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1606379 | C2orf68 | chromosome 2 open reading frame 68 | INTERACTS WITH 17beta-estradiol; 3-isobutyl-1-methyl-7H-xanthine; acrylamide | 2 | 85605254 | 85612066 | Human | 43 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735941 | CREM | cAMP responsive element modulator | This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and transla tion initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] | 10 | 35126846 | 35212958 | Human | 304 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737388 | DPYSL2 | dihydropyrimidinase like 2 | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone co llapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] | 8 | 26514031 | 26658175 | Human | 258 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |