| 61913 | Gas6 | growth arrest specific 6 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); phosphatidylserine binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN activation of protein kinase B activity; animal organ regeneration; cellular response to glucose stimulus; PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH glomerulonephritis; Neointima; acute kidney failure (ortholog); FOUND IN extracellular space; cytoplasm (ortholog); INTERACTS WITH 11-deoxycorticosterone; 17alpha-ethynylestradiol; 17beta-estradiol | 16 | 82747676 | 82778090 | Rat | 411 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62206 | Gas6 | growth arrest specific 6 | Enables receptor ligand activity. Involved in negative regulation of apoptotic process. Acts upstream of or within several processes, including blood coagulation; negative regulation of apoptotic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and limb. Orthologous to human GAS6 (growth arrest specific 6). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 13515374 | 13544535 | Mouse | 443 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736280 | GAS6 | growth arrest specific 6 | This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014] | 13 | 113820549 | 113864076 | Human | 345 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8988003 | Gas6 | growth arrest specific 6 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); phosphatidylserine binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog) | NW_004955404 | 276397 | 303864 | Chinchilla | 90 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12340481 | GAS6 | growth arrest specific 6 | ENCODES a protein that exhibits calcium ion binding (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); metal ion binding (inferred); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | 22 | 60975196 | 61005869 | Dog | 105 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12723767 | Gas6 | growth arrest specific 6 | ENCODES a protein that exhibits calcium ion binding (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); metal ion binding (inferred); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936472 | 27116 | 57158 | Squirrel | 98 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18492767 | GAS6 | growth arrest specific 6 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); phosphatidylserine binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog) | | | | Green Monkey | 90 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 626049608 | Gas6 | growth arrest specific 6 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); phosphatidylserine binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog) | | | | Black Rat | 90 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18906927 | Gas6 | growth arrest specific 6 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); phosphatidylserine binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 90 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 20867361 | GAS6 | growth arrest specific 6 | ENCODES a protein that exhibits calcium ion binding (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); phosphatidylserine binding (inferred); INVOLVED IN apoptotic cell clearance (inferred); B cell chemotaxis (inferred); calcium ion transmembrane tra nsport (inferred); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 46 | symbol | gene, protein-coding |
| 14129144 | GAS6 | growth arrest specific 6 | ENCODES a protein that exhibits calcium ion binding (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); metal ion binding (inferred); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 105 | symbol , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 329346341 | GAS6 | growth arrest specific 6 | ENCODES a protein that exhibits calcium ion binding (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); phosphatidylserine binding (inferred); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apopto tic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Bonobo | 89 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 155246821 | gas6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155255845 | gas6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247527 | gas6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7247504 | GAS6-DT | GAS6 divergent transcript | INTERACTS WITH aristolochic acid A; benzo[a]pyrene; Didecyldimethylammonium | 13 | 113864177 | 113866832 | Human | 8 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 6483935 | GAS6-AS1 | GAS6 antisense RNA 1 | INTERACTS WITH aflatoxin B1; Bufotalin; cadmium atom | 13 | 113815610 | 113842841 | Human | 12 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 6480348 | SWINGN | SWI/SNF complex interacting GAS6 enhancer non-coding RNA | INTERACTS WITH aristolochic acid A | 13 | 113926514 | 113928991 | Human | 1 | name | gene, ncrna, VALIDATED [RefSeq] |
| 620028 | Axl | Axl receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding; phosphatidylinositol 3-kinase binding; phosphatidylserine binding (ortholog); INVOLVED IN animal organ regeneration; cell differentiation; cellular response to hydrogen peroxide; PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH glomerulonephritis; Neointima; amenorrhea (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 90392864 | 90424123 | Rat | 304 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1323764 | AXL | AXL receptor tyrosine kinase | The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021] | 19 | 41219223 | 41261766 | Human | 337 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 8790519 | Axl | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN < span style='font-weight:700;'>Gas6 - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | NW_004955555 | 189445 | 218509 | Chinchilla | 87 | description | gene, protein-coding, MODEL [RefSeq] |
| 11712364 | AXL | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Gas6 n> - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog) | 19 | 38211555 | 38254464 | Bonobo | 118 | description | gene, protein-coding, MODEL [RefSeq] |
| 12328928 | AXL | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Gas6 n> - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog) | 1 | 112699679 | 112727434 | Dog | 118 | description | gene, protein-coding, MODEL [RefSeq] |
| 12708726 | Axl | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Gas6 n> - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog) | NW_004936661 | 3658140 | 3687290 | Squirrel | 118 | description | gene, protein-coding, MODEL [RefSeq] |
| 14280814 | AXL | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Gas6 n> - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog) | | | | Pig | 119 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626109505 | Axl | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN < span style='font-weight:700;'>Gas6 - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | | | | Black Rat | 87 | description | gene, protein-coding, MODEL [RefSeq] |
| 18934634 | Axl | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN < span style='font-weight:700;'>Gas6 - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 117 | description | gene, protein-coding, MODEL [RefSeq] |
| 18597783 | AXL | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Gas6 n> - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog) | | | | Green Monkey | 118 | description | gene, protein-coding, MODEL [RefSeq] |