| 620572 | Faim | Fas apoptotic inhibitory molecule | INVOLVED IN positive regulation of canonical NF-kappaB signal transduction; positive regulation of neurogenesis; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-c hlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 8 | 108423259 | 108445365 | Rat | 87 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734131 | Faim | Fas apoptotic inhibitory molecule | Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm. Is expressed in several structures, including gonad; hemolymphoid system; intestine; liver; and retina. Orthologous to human FAIM ght:700;'>FAIM (Fas apoptotic inhibitory molecule). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 98868426 | 98884076 | Mouse | 100 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605660 | FAIM | Fas apoptotic inhibitory molecule | The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] | 3 | 138608771 | 138633376 | Human | 88 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8908814 | Faim | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog) | NW_004955501 | 447085 | 459691 | Chinchilla | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11924135 | FAIM | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytoplasm (inferred) | 3 | 135639242 | 135664449 | Bonobo | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12114447 | FAIM | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytoplasm (inferred) | 23 | 34807093 | 34822577 | Dog | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12664484 | Faim | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytoplasm (inferred) | NW_004936540 | 843463 | 863029 | Squirrel | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14228796 | FAIM | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytoplasm (inferred) | | | | Pig | 11 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18618258 | FAIM | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytoplasm (inferred) | | | | Green Monkey | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925754 | Faim | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258978 | faim | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626109745 | Faim | Fas apoptotic inhibitory molecule | INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of neurogenesis (ortholog) | | | | Black Rat | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258977 | faim.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231169 | faim.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628744 | Faim2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN cerebellar granular layer development (ortholog); cerebellar Purkinje cell differentiation (ortholog); cerebellar Purkinje cell layer development (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease; FOUND IN endoplasmic retic ulum (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 7 | 132512095 | 132539192 | Rat | 117 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733738 | Faim2 | Fas apoptotic inhibitory molecule 2 | Predicted to enable calcium channel activity. Involved in cerebellar Purkinje cell differentiation; cerebellar granular layer development; and regulation of neuron apoptotic process. Acts upstream of or within negative regulation of apoptotic signaling pathway; negative regulation of neuron apoptoti c process; and response to ischemia. Located in Golgi apparatus; endoplasmic reticulum; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and white fat. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 99394886 | 99432757 | Mouse | 111 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348169 | FAIM2 | Fas apoptotic inhibitory molecule 2 | Predicted to enable calcium channel activity. Involved in regulation of neuron apoptotic process. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in Golgi membrane and membrane raft. [provided by Alliance of Genome Resources , Jul 2025] | 12 | 49866896 | 49903900 | Human | 103 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 9049590 | Faim2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN cerebellar granular layer development (ortholog); cerebellar Purkinje cell differentiation (ortholog); cerebellar Purkinje cell layer development (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN endopl asmic reticulum (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog) | NW_004955547 | 467331 | 501172 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11945429 | FAIM2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN negative regulation of apoptotic signaling pathway (ortholog); negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi membrane (inferred) | 12 | 38850588 | 38886614 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12390222 | FAIM2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN negative regulation of apoptotic signaling pathway (ortholog); negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi membrane (inferred) | 27 | 4802711 | 4831230 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12661831 | Faim2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN negative regulation of apoptotic signaling pathway (ortholog); negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi membrane (inferred) | NW_004936512 | 7544047 | 7575922 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14024943 | FAIM2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN negative regulation of apoptotic signaling pathway (ortholog); negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18771846 | FAIM2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN negative regulation of apoptotic signaling pathway (ortholog); negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi membrane (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913741 | Faim2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN cerebellar granular layer development (ortholog); cerebellar Purkinje cell differentiation (ortholog); cerebellar Purkinje cell layer development (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN Golgi membrane (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235348 | faim2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625989991 | Faim2 | Fas apoptotic inhibitory molecule 2 | INVOLVED IN cerebellar granular layer development (ortholog); cerebellar Purkinje cell differentiation (ortholog); cerebellar Purkinje cell layer development (ortholog); PARTICIPATES IN FasL mediated signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); FOUND IN endopl asmic reticulum (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1590301 | Faiml | Fas apoptotic inhibitory molecule like | INVOLVED IN apoptotic process (inferred); negative regulation of apoptotic process (inferred); regulation of signal transduction (inferred); FOUND IN cytoplasm (inferred); INTERACTS WITH bis(2-ethylhexyl) phthalate (ortholog) | 8 | 108671391 | 108689538 | Rat | 5 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1617844 | Faiml | Fas apoptotic inhibitory molecule like | Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Is expressed in several structures, including gonad; liver; lung; muscle tissue; and spleen. Orthologous to human FAIM (Fas apoptotic inhibitory molecule). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 99111429 | 99119292 | Mouse | 9 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 155231433 | faim2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235349 | faim2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1359282 | Fcmr | Fc mu receptor | ENCODES a protein that exhibits high-affinity IgM receptor activity (ortholog); IgM binding (ortholog); polymeric immunoglobulin binding (ortholog); INVOLVED IN Fc receptor-mediated immune complex endocytosis (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); immu noglobulin transcytosis in epithelial cells (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); early endosome membrane (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 44889628 | 44903926 | Rat | 121 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1603318 | FCMR | Fc mu receptor | Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supp lied by OMIM, Jul 2010] | 1 | 206903317 | 206923196 | Human | 109 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1622299 | Fcmr | Fc fragment of IgM receptor | Enables IgM binding activity. Involved in humoral immune response mediated by circulating immunoglobulin; immunoglobulin transcytosis in epithelial cells; and regulation of B cell receptor signaling pathway. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway and negative regulation of lymphocyte apoptotic process. Located in external side of plasma membrane and trans-Golgi network membrane. Orthologous to human FCMR (Fc mu receptor). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 130793514 | 130808528 | Mouse | 141 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8898550 | Fcmr | Fc mu receptor | ENCODES a protein that exhibits high-affinity IgM receptor activity (ortholog); IgM binding (ortholog); polymeric immunoglobulin binding (ortholog); INVOLVED IN Fc receptor-mediated immune complex endocytosis (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); immu noglobulin transcytosis in epithelial cells (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); early endosome membrane (ortholog); external side of plasma membrane (ortholog) | NW_004955406 | 42438173 | 42452339 | Chinchilla | 22 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11762837 | FCMR | Fc mu receptor | ENCODES a protein that exhibits IgM binding (ortholog); INVOLVED IN humoral immune response mediated by circulating immunoglobulin (ortholog); immunoglobulin transcytosis in epithelial cells (ortholog); negative regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog) | 1 | 182506551 | 182525249 | Bonobo | 24 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12090655 | FCMR | Fc mu receptor | ENCODES a protein that exhibits high-affinity IgM receptor activity (ortholog); IgM binding (ortholog); polymeric immunoglobulin binding (ortholog); INVOLVED IN Fc receptor-mediated immune complex endocytosis (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); immu noglobulin transcytosis in epithelial cells (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); early endosome membrane (ortholog); external side of plasma membrane (ortholog) | 7 | 6046270 | 6064063 | Dog | 26 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12547405 | Fcmr | Fc mu receptor | ENCODES a protein that exhibits high-affinity IgM receptor activity (ortholog); IgM binding (ortholog); polymeric immunoglobulin binding (ortholog); INVOLVED IN Fc receptor-mediated immune complex endocytosis (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); immu noglobulin transcytosis in epithelial cells (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); early endosome membrane (ortholog); external side of plasma membrane (ortholog) | NW_004936557 | 5707138 | 5718192 | Squirrel | 22 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13957132 | FCMR | Fc mu receptor | ENCODES a protein that exhibits IgM binding (ortholog); INVOLVED IN humoral immune response mediated by circulating immunoglobulin (ortholog); immunoglobulin transcytosis in epithelial cells (ortholog); negative regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog) | | | | Pig | 25 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928901 | Fcmr | Fc mu receptor | ENCODES a protein that exhibits high-affinity IgM receptor activity (ortholog); IgM binding (ortholog); polymeric immunoglobulin binding (ortholog); INVOLVED IN Fc receptor-mediated immune complex endocytosis (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); immu noglobulin transcytosis in epithelial cells (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); early endosome membrane (ortholog); external side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 23 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |