Faim (Fas apoptotic inhibitory molecule) - Rat Genome Database
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Gene: Faim (Fas apoptotic inhibitory molecule) Mus musculus
Analyze
Symbol: Faim
Name: Fas apoptotic inhibitory molecule
RGD ID: 734131
MGI Page MGI
Description: Involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to localize to cytoplasm. Is expressed in several structures, including face; gonad; hemolymphoid system; intestine; and retina. Orthologous to human FAIM (Fas apoptotic inhibitory molecule); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Fai; fas apoptotic inhibitory molecule 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,868,426 - 98,884,076 (+)NCBIGRCm39mm39
GRCm38998,986,373 - 99,002,019 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl998,986,373 - 99,002,021 (+)EnsemblGRCm38mm10GRCm38
MGSCv37998,886,792 - 98,902,438 (+)NCBIGRCm37mm9NCBIm37
MGSCv36998,795,725 - 98,811,370 (+)NCBImm8
Celera998,524,144 - 98,539,790 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11043772   PMID:11076861   PMID:11483211   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17942717  
PMID:19168072   PMID:19300454   PMID:19592656   PMID:19843941   PMID:20178987   PMID:21267068   PMID:21873635   PMID:23341629   PMID:24071998   PMID:24565867   PMID:26866272   PMID:27767058  


Genomics

Comparative Map Data
Faim
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,868,426 - 98,884,076 (+)NCBIGRCm39mm39
GRCm38998,986,373 - 99,002,019 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl998,986,373 - 99,002,021 (+)EnsemblGRCm38mm10GRCm38
MGSCv37998,886,792 - 98,902,438 (+)NCBIGRCm37mm9NCBIm37
MGSCv36998,795,725 - 98,811,370 (+)NCBImm8
Celera998,524,144 - 98,539,790 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
FAIM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3138,608,606 - 138,633,376 (+)EnsemblGRCh38hg38GRCh38
GRCh383138,608,099 - 138,633,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373138,327,613 - 138,352,218 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh373138,327,542 - 138,352,218 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,810,232 - 139,834,908 (+)NCBINCBI36hg18NCBI36
Celera3136,752,476 - 136,777,527 (+)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3135,702,306 - 135,726,894 (+)NCBIHuRef
CHM1_13138,291,316 - 138,316,081 (+)NCBICHM1_1
Faim
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2899,543,877 - 99,569,499 (+)NCBI
Rnor_6.0 Ensembl8106,816,152 - 106,827,580 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,225,212 - 107,241,224 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08107,225,119 - 107,247,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08106,649,714 - 106,671,537 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.489,522,803 - 9,539,269 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18103,854,182 - 103,869,924 (+)NCBI
Celera898,949,776 - 98,965,494 (+)NCBICelera
Cytogenetic Map8q31NCBI
Faim
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501447,094 - 461,396 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955501447,085 - 459,691 (-)NCBIChiLan1.0ChiLan1.0
FAIM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13143,243,585 - 143,267,787 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3143,243,675 - 143,267,787 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03135,639,242 - 135,664,449 (+)NCBIMhudiblu_PPA_v0panPan3
FAIM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2334,807,249 - 34,822,244 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12334,807,093 - 34,822,577 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Faim
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936540843,463 - 863,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAIM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1379,397,319 - 79,411,913 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11379,397,647 - 79,411,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21387,082,125 - 87,092,596 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAIM
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11551,906,832 - 51,932,145 (-)NCBI
ChlSab1.1 Ensembl1551,905,188 - 51,921,162 (-)Ensembl
Faim
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473015,114,558 - 15,145,027 (+)NCBI

Position Markers
D9Mit356  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38998,989,258 - 98,989,373UniSTSGRCm38
MGSCv37998,889,677 - 98,889,792UniSTSGRCm37
Celera998,527,029 - 98,527,144UniSTS
Cytogenetic Map9E3.3UniSTS
cM Map953.0UniSTS
Whitehead/MRC_RH91008.82UniSTS
BE112969  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38998,992,131 - 98,992,559UniSTSGRCm38
MGSCv37998,892,550 - 98,892,978UniSTSGRCm37
Celera998,529,902 - 98,530,330UniSTS
Cytogenetic Map9E3.3UniSTS
Faim  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9E3.3UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir133bmmu-miR-133b-5pOncomiRDBexternal_infoNANA22532850

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:81
Interacting mature miRNAs:82
Transcripts:ENSMUST00000035038, ENSMUST00000112911
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035038   ⟹   ENSMUSP00000035038
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl998,986,373 - 99,002,021 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112911   ⟹   ENSMUSP00000108532
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl998,986,374 - 99,001,749 (+)Ensembl
RefSeq Acc Id: ENSMUST00000185472   ⟹   ENSMUSP00000140627
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl998,991,831 - 99,001,688 (+)Ensembl
RefSeq Acc Id: ENSMUST00000186837
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl998,986,407 - 98,993,238 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187211
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl998,986,401 - 98,990,662 (+)Ensembl
RefSeq Acc Id: NM_001122851   ⟹   NP_001116323
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39998,868,426 - 98,884,072 (+)NCBI
GRCm38998,986,373 - 99,002,019 (+)ENTREZGENE
MGSCv37998,886,792 - 98,902,438 (+)RGD
Celera998,524,144 - 98,539,790 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011810   ⟹   NP_035940
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39998,868,426 - 98,884,072 (+)NCBI
GRCm38998,986,373 - 99,002,019 (+)ENTREZGENE
MGSCv37998,886,792 - 98,902,438 (+)RGD
Celera998,524,144 - 98,539,790 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036154930   ⟹   XP_036010823
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39998,869,096 - 98,884,076 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_035940   ⟸   NM_011810
- Peptide Label: isoform Faim-S
- UniProtKB: Q9WUD8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001116323   ⟸   NM_001122851
- Peptide Label: isoform Faim-L
- UniProtKB: Q9WUD8 (UniProtKB/Swiss-Prot),   D3Z3C1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035038   ⟸   ENSMUST00000035038
RefSeq Acc Id: ENSMUSP00000140627   ⟸   ENSMUST00000185472
RefSeq Acc Id: ENSMUSP00000108532   ⟸   ENSMUST00000112911
RefSeq Acc Id: XP_036010823   ⟸   XM_036154930
- Peptide Label: isoform X1

Promoters
RGD ID:6844514
Promoter ID:MM_KWN:58478
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001122851,   NM_011810,   UC009RDS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36998,886,451 - 98,886,951 (+)MPROMDB
RGD ID:8670554
Promoter ID:EPDNEW_M13303
Type:initiation region
Name:Faim_1
Description:Mus musculus Fas apoptotic inhibitory molecule , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38998,986,404 - 98,986,464EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344387 AgrOrtholog
Ensembl Genes ENSMUSG00000032463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035038 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000108532 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000140627 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035038 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000112911 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000185472 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAIM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAIM1_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23873 UniProtKB/Swiss-Prot
MGD MGI:1344387 ENTREZGENE
NCBI Gene 23873 ENTREZGENE
PANTHER PTHR13088 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAIM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Faim PhenoGen
UniProt A0A087WRH2_MOUSE UniProtKB/TrEMBL
  D3Z3C1 ENTREZGENE, UniProtKB/TrEMBL
  FAIM1_MOUSE UniProtKB/Swiss-Prot
  Q3U119_MOUSE UniProtKB/TrEMBL
  Q9WUD8 ENTREZGENE
UniProt Secondary Q9DAK6 UniProtKB/Swiss-Prot