Faim2 (Fas apoptotic inhibitory molecule 2) - Rat Genome Database

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Gene: Faim2 (Fas apoptotic inhibitory molecule 2) Mus musculus
Analyze
Symbol: Faim2
Name: Fas apoptotic inhibitory molecule 2
RGD ID: 733738
MGI Page MGI
Description: Involved in cerebellar Purkinje cell differentiation; cerebellar granular layer development; and regulation of neuron apoptotic process. Acts upstream of or within negative regulation of apoptotic signaling pathway; negative regulation of neuron apoptotic process; and response to ischemia. Located in Golgi apparatus; endoplasmic reticulum; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and white fat. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2); PARTICIPATES IN FasL mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900002L20Rik; AI854036; Lf; Lfg; Lfg2; lifeg; lifeguard; lifeguard 2; mKIAA0950; neural membrane protein 35; NMP; NMP25; Nmp35; Tmbim; Tmbim2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,394,886 - 99,432,757 (-)NCBIGRCm39mm39
GRCm39 Ensembl1599,394,893 - 99,426,046 (-)Ensembl
GRCm381599,497,005 - 99,534,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,497,012 - 99,528,165 (-)EnsemblGRCm38mm10GRCm38
MGSCv371599,327,436 - 99,358,448 (-)NCBIGRCm37mm9NCBIm37
MGSCv361599,325,039 - 99,356,051 (-)NCBImm8
Celera15101,652,607 - 101,683,625 (-)NCBICelera
Cytogenetic Map15F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12693553   PMID:14610273   PMID:15033168   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17635665  
PMID:21209208   PMID:21957071   PMID:23029562   PMID:23090999   PMID:24335530   PMID:26565411   PMID:26582200   PMID:27638043   PMID:28228635   PMID:28708137   PMID:29315561   PMID:31211943  


Genomics

Comparative Map Data
Faim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,394,886 - 99,432,757 (-)NCBIGRCm39mm39
GRCm39 Ensembl1599,394,893 - 99,426,046 (-)Ensembl
GRCm381599,497,005 - 99,534,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,497,012 - 99,528,165 (-)EnsemblGRCm38mm10GRCm38
MGSCv371599,327,436 - 99,358,448 (-)NCBIGRCm37mm9NCBIm37
MGSCv361599,325,039 - 99,356,051 (-)NCBImm8
Celera15101,652,607 - 101,683,625 (-)NCBICelera
Cytogenetic Map15F1NCBI
FAIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1249,866,896 - 49,904,217 (-)EnsemblGRCh38hg38GRCh38
GRCh381249,866,896 - 49,903,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371250,260,679 - 50,297,683 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,546,947 - 48,583,987 (-)NCBINCBI36hg18NCBI36
Build 341248,546,946 - 48,583,987NCBI
Celera1249,056,734 - 49,093,776 (-)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1247,291,842 - 47,330,172 (-)NCBIHuRef
CHM1_11250,227,016 - 50,263,951 (-)NCBICHM1_1
Faim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,632,368 - 130,659,353 (-)NCBI
Rnor_6.0 Ensembl7141,157,963 - 141,185,710 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07141,158,769 - 141,185,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X115,663,275 - 115,689,093 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,246,372 - 138,272,190 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17138,322,809 - 138,348,627 (-)NCBI
Celera7127,115,377 - 127,141,090 (-)NCBICelera
Cytogenetic Map7q36NCBI
Faim2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547466,777 - 501,490 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955547467,331 - 501,172 (-)NCBIChiLan1.0ChiLan1.0
FAIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11239,744,705 - 39,780,702 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,744,700 - 39,780,702 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01238,850,588 - 38,886,614 (+)NCBIMhudiblu_PPA_v0panPan3
FAIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,802,711 - 4,831,230 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,798,235 - 4,827,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,426,513 - 41,459,677 (-)NCBI
ROS_Cfam_1.0274,847,381 - 4,880,528 (+)NCBI
UMICH_Zoey_3.1274,813,057 - 4,846,157 (+)NCBI
UNSW_CanFamBas_1.0274,802,365 - 4,835,546 (+)NCBI
UU_Cfam_GSD_1.02741,821,388 - 41,854,554 (-)NCBI
Faim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,588,905 - 65,620,783 (+)NCBI
SpeTri2.0NW_0049365127,544,047 - 7,575,922 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,779,334 - 15,812,547 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,779,329 - 15,813,029 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FAIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,100,437 - 46,131,046 (-)NCBI
ChlSab1.1 Ensembl1146,099,895 - 46,131,155 (-)Ensembl
Vero_WHO_p1.0NW_023666037199,989,447 - 200,026,442 (+)NCBI
Faim2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248162,386,995 - 2,418,312 (+)NCBI

Position Markers
Faim2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F3UniSTS
cM Map15 UniSTS
AI854036  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,497,387 - 99,497,483UniSTSGRCm38
MGSCv371599,327,818 - 99,327,914UniSTSGRCm37
Celera15101,652,989 - 101,653,085UniSTS
Cytogenetic Map15F3UniSTS
Whitehead/MRC_RH15872.02UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156564117599641298Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567386497101386646Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577629711104043685Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78716903102993272Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578716903102993272Mouse
14928306Manh79_mmandible shape 79 (mouse)1578949676104043685Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1579000000104043685Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579265530104043685Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined80011059104043685Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580415753104043685Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580987052104043685Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580987052104043685Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82717593104043685Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585988005104043685Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585988005104043685Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585988005104043685Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585993114104043685Mouse
1301764Chab4_mcholesterol absorption 4 (mouse)Not determined1586751919104043685Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92890759103517472Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597800000103100000Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597987052102988123Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1642
Count of miRNA genes:653
Interacting mature miRNAs:842
Transcripts:ENSMUST00000023750
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001038658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_028224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF468028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ283203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000023750   ⟹   ENSMUSP00000023750
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1599,497,012 - 99,528,165 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229214
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1599,499,798 - 99,510,867 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230603
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1599,510,120 - 99,527,682 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230837
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1599,497,013 - 99,527,681 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231171   ⟹   ENSMUSP00000155195
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1599,497,016 - 99,527,712 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231211
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1599,499,513 - 99,510,677 (-)Ensembl
RefSeq Acc Id: NM_001038658   ⟹   NP_001033747
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,394,886 - 99,426,046 (-)NCBI
GRCm381599,497,005 - 99,528,165 (-)NCBI
MGSCv371599,327,436 - 99,358,448 (-)RGD
Celera15101,652,607 - 101,683,773 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_028224   ⟹   NP_082500
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,394,886 - 99,426,046 (-)NCBI
GRCm381599,497,005 - 99,528,165 (-)NCBI
MGSCv371599,327,436 - 99,358,448 (-)RGD
Celera15101,652,607 - 101,683,773 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521449   ⟹   XP_006521512
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,394,891 - 99,432,757 (-)NCBI
GRCm381599,497,010 - 99,534,880 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082500   ⟸   NM_028224
- Peptide Label: isoform 1
- UniProtKB: Q8K097 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001033747   ⟸   NM_001038658
- Peptide Label: isoform 2
- UniProtKB: Q8K097 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521512   ⟸   XM_006521449
- Peptide Label: isoform X1
- UniProtKB: Q8K097 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000155195   ⟸   ENSMUST00000231171
RefSeq Acc Id: ENSMUSP00000023750   ⟸   ENSMUST00000023750

Promoters
RGD ID:6826003
Promoter ID:MM_KWN:19691
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_001038658,   NM_028224,   UC007XPR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361599,357,971 - 99,358,471 (-)MPROMDB
RGD ID:8684992
Promoter ID:EPDNEW_M20527
Type:initiation region
Name:Faim2_1
Description:Mus musculus Fas apoptotic inhibitory molecule 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381599,527,689 - 99,527,749EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919643 AgrOrtholog
Ensembl Genes ENSMUSG00000023011 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000023750 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000155195 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023750 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000231171 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Bax_inhibitor_1-related UniProtKB/Swiss-Prot
KEGG Report mmu:72393 UniProtKB/Swiss-Prot
MGD MGI:1919643 ENTREZGENE
NCBI Gene 72393 ENTREZGENE
PANTHER PTHR23291 UniProtKB/Swiss-Prot
Pfam Bax1-I UniProtKB/Swiss-Prot
PhenoGen Faim2 PhenoGen
UniProt LFG2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TY22 UniProtKB/Swiss-Prot
  Q8K1F6 UniProtKB/Swiss-Prot
  Q9D6K4 UniProtKB/Swiss-Prot