| 1304619 | Ago1 | argonaute RISC component 1 | ENCODES a protein that exhibits core promoter sequence-specific DNA binding (ortholog); double-stranded RNA binding (ortholog); miRNA binding (ortholog); INVOLVED IN regulation of mRNA stability; miRNA metabolic process (ortholog); miRNA processing (ortholog); PARTICIPATES IN microRNA pathway; ASSOC IATED WITH alcohol dependence (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic ribonucleoprotein granule (ortholog); cytosol (ortholog); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 17beta-estradiol | 5 | 144006618 | 144064740 | Rat | 148 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312163 | AGO1 | argonaute RISC component 1 | This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] | 1 | 35869761 | 35930532 | Human | 217 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312164 | Ago1 | argonaute RISC catalytic subunit 1 | This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] | 4 | 126328805 | 126362500 | Mouse | 158 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 11711288 | AGO1 | argonaute RISC component 1 | ENCODES a protein that exhibits RNA endonuclease activity (ortholog); INVOLVED IN miRNA metabolic process (ortholog); miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alcohol depende nce (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); cytosol (inferred) | 1 | 35148984 | 35196252 | Bonobo | 78 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12328735 | AGO1 | argonaute RISC component 1 | ENCODES a protein that exhibits RNA endonuclease activity (ortholog); INVOLVED IN miRNA metabolic process (ortholog); miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alcohol depende nce (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); cytosol (inferred) | 15 | 6258359 | 6294911 | Dog | 80 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14144693 | AGO1 | argonaute RISC component 1 | ENCODES a protein that exhibits core promoter sequence-specific DNA binding (ortholog); double-stranded RNA binding (ortholog); RNA endonuclease activity (ortholog); INVOLVED IN miRNA processing (ortholog); miRNA-mediated gene silencing by mRNA destabilization (ortholog); negative regulation of angi ogenesis (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alcohol dependence (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic ribonucleoprotein granule (ortholog); RISC-loading complex (ortholog) | | | | Pig | 69 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |