| 620849 | Dut | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity; identical protein binding; peroxisome proliferator activated receptor binding; INVOLVED IN dUMP biosynthetic process; dUTP catabolic process; liver development; PARTICIPATES IN pyrimidine metabolic pathway; beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 132952258 | 132963433 | Rat | 227 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1349758 | DUT | deoxyuridine triphosphatase | This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for D NA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008] | 15 | 48331095 | 48343373 | Human | 251 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550877 | Dut | deoxyuridine triphosphatase | Predicted to enable several functions, including dUTP diphosphatase activity; magnesium ion binding activity; and peroxisome proliferator activated receptor binding activity. Predicted to be involved in pyrimidine deoxyribonucleotide metabolic process and regulation of protein-containing complex ass embly. Located in mitochondrion. Is expressed in central nervous system and retina. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 125089168 | 125100969 | Mouse | 229 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8797631 | Dut | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955409 | 5574810 | 5584135 | Chinchilla | 28 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 11823036 | DUT | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleus (ortholog) | 15 | 27280025 | 27292003 | Bonobo | 49 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12250878 | DUT | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | 30 | 14572766 | 14585621 | Dog | 47 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12510556 | Dut | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004936471 | 10670604 | 10681356 | Squirrel | 48 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 13854610 | DUT | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleus (ortholog) | | | | Pig | 49 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18782270 | DUT | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleus (ortholog) | | | | Green Monkey | 49 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18900941 | Dut | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 46 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 285807495 | dut | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933987 | dut | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934965 | dut | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935482 | dut | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935921 | dut | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625966189 | Dut | deoxyuridine triphosphatase | ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PART ICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); High Myopia (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 28 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 14376199 | dut-1 | | | | | | Roundworm | | symbol | gene, null |
| 287913294 | dut.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 285806636 | dut.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1587036 | Dut-ps | deoxyuridine triphosphatase pseudogene | INTERACTS WITH rotenone | 1 | 50916511 | 50917371 | Rat | 1 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 38645763 | DUT-AS1 | DUT antisense RNA 1 | ASSOCIATED WITH Growth Mental Deficiency Syndrome of Myhre | 15 | 48310468 | 48331856 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 38609546 | LOC441862 | DUT pseudogene | | 19 | 52451206 | 52452288 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16562235 | AC023355.1 | novel transcript, antisense to DUT | | | | | Human | | name | gene, lncrna |
| 16565823 | AC009027.1 | deoxyuridine triphosphatase (DUT) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 14376197 | DUT1 | | | | | | Yeast | | symbol | gene, null |
| 5131596 | DUTP1 | deoxyuridine triphosphatase pseudogene 1 | | 3 | 125310863 | 125311497 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 6481453 | DUTP2 | deoxyuridine triphosphatase pseudogene 2 | | 8 | 123352307 | 123352645 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5686985 | DUTP3 | deoxyuridine triphosphatase pseudogene 3 | | 7 | 147146272 | 147146760 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6481457 | DUTP4 | deoxyuridine triphosphatase pseudogene 4 | | X | 149817172 | 149817648 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6481456 | DUTP5 | deoxyuridine triphosphatase pseudogene 5 | | 6 | 85426602 | 85427193 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6481458 | DUTP6 | deoxyuridine triphosphatase pseudogene 6 | | 1 | 166868734 | 166869207 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6481460 | DUTP7 | deoxyuridine triphosphatase pseudogene 7 | | 4 | 51865053 | 51865535 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6481381 | DUTP8 | deoxyuridine triphosphatase pseudogene 8 | | 4 | 98048499 | 98049112 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 14376198 | dUTPase | | | | | | Fly | | symbol | gene, null |
| 62234 | Robo1 | roundabout guidance receptor 1 | Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within several processes, incl uding axon guidance; heart development; and mammary duct terminal end bud growth. Located in axolemma. Is expressed in several structures, including autopod; central nervous system; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung cancer. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus; combined or isolated pituitary hormone deficiency 8; congenital nystagmus; multiple myeloma; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 71824406 | 72844379 | Mouse | 351 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735617 | ROBO1 | roundabout guidance receptor 1 | Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immu noglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] | 3 | 78597239 | 79767998 | Human | 379 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16567992 | LINC03106 | long intergenic non-protein coding RNA 3106 | Predicted to enable dUTP diphosphatase activity and magnesium ion binding activity. Predicted to be involved in dUMP biosynthetic process and dUTP catabolic process. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 26066675 | 26118408 | Human | 5 | description | gene, ncrna, VALIDATED [RefSeq] |
| 12714781 | LOC101969523 | deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like | ENCODES a protein that exhibits dUTP diphosphatase activity (inferred); hydrolase activity (inferred); magnesium ion binding (inferred); INVOLVED IN dUMP biosynthetic process (inferred); dUTP catabolic process (inferred); nucleotide metabolic process (inferred) | NW_004936471 | 8287036 | 8287704 | Squirrel | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 12151708 | CYP2D15 | cytochrome P450 family 2 subfamily D member 15 | ENCODES a protein that exhibits arachidonate monooxygenase activity (ortholog); monooxygenase activity (ortholog); progesterone 21-hydroxylase activity (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); C21-steroid hormone metabolic process (ortholog); dopamine biosynthetic process ( ortholog); PARTICIPATES IN celecoxib pharmacodynamics pathway; celecoxib pharmacokinetics pathway; citalopram pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH Bufuralol; desipramine; dextromethorphan | 10 | 23255259 | 23259380 | Dog | 127 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
