DUT (deoxyuridine triphosphatase)

Gene: DUT (deoxyuridine triphosphatase) Chlorocebus sabaeus

Analyze

Symbol:

DUT

Name:

deoxyuridine triphosphatase

RGD ID:

18782270

Description:

ENCODES a protein that exhibits dUTP diphosphatase activity (ortholog); identical protein binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN dTMP biosynthetic process (ortholog); dUMP biosynthetic process (ortholog); dUTP catabolic process (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; ASSOCIATED WITH Bloom syndrome (ortholog); Bone Marrow Failure and Diabetes Mellitus Syndrome (ortholog); Brain Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	34,941,775 - 34,954,184 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	34,940,702 - 34,953,166 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	106,175,656 - 106,187,091 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

Bone Marrow Failure and Diabetes Mellitus Syndrome (ISO)

Brain Neoplasms (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

High Myopia (ISO)

Marfan syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dTMP biosynthetic process (ISO)

dUMP biosynthetic process (IEA,ISO)

dUTP catabolic process (IEA,ISO)

liver development (ISO)

nucleotide metabolic process (IEA)

regulation of protein-containing complex assembly (ISO)

response to organic cyclic compound (ISO)

Cellular Component

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

dUTP diphosphatase activity (IEA,ISO)

hydrolase activity (IEA)

identical protein binding (ISO)

magnesium ion binding (IEA)

metal ion binding (IEA)

peroxisome proliferator activated receptor binding (ISO)

protein binding (ISO)

pyrimidine deoxyribonucleotide binding (ISO)

signaling receptor inhibitor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-ureidopropionase deficiency pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

pyrimidine metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DUT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	34,941,775 - 34,954,184 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	34,940,702 - 34,953,166 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	106,175,656 - 106,187,091 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DUT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	48,331,095 - 48,343,373 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	48,331,011 - 48,343,373 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	48,623,292 - 48,635,570 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	46,410,913 - 46,422,862 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	46,411,721 - 46,422,855	NCBI
Celera	15	25,516,088 - 25,528,037 (+)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	25,456,621 - 25,468,570 (+)	NCBI		HuRef
CHM1_1	15	48,741,653 - 48,753,602 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	46,139,356 - 46,151,634 (+)	NCBI		T2T-CHM13v2.0

Dut
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	125,089,168 - 125,100,969 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	125,089,110 - 125,100,528 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	125,247,248 - 125,259,049 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	125,247,190 - 125,258,608 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	125,072,984 - 125,084,785 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	124,938,923 - 124,950,049 (+)	NCBI		MGSCv36	mm8
Celera	2	126,491,099 - 126,502,875 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.33	NCBI

Dut
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	132,952,258 - 132,963,433 (+)	NCBI		GRCr8
mRatBN7.2	3	112,498,864 - 112,509,994 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	112,498,982 - 112,510,771 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	116,358,986 - 116,369,833 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	124,954,504 - 124,965,351 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	122,614,871 - 122,625,718 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	117,514,399 - 117,525,450 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	117,514,444 - 117,525,446 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	124,038,120 - 124,049,168 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	112,551,434 - 112,562,434 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	112,457,006 - 112,468,009 (+)	NCBI
Celera	3	111,355,479 - 111,366,436 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Dut
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	5,574,694 - 5,584,134 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	5,574,810 - 5,584,135 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	37,571,636 - 37,582,801 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	41,753,022 - 41,764,193 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	27,280,025 - 27,292,003 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	45,604,061 - 45,616,022 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	45,603,807 - 45,616,022 (+)	Ensembl	panpan1.1		panPan2

DUT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	14,572,766 - 14,585,621 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	14,572,602 - 14,585,530 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	14,494,200 - 14,507,265 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	14,706,670 - 14,719,522 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	14,706,505 - 14,719,499 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	14,629,328 - 14,642,402 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	14,744,651 - 14,757,504 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	14,856,699 - 14,869,776 (+)	NCBI		UU_Cfam_GSD_1.0

Dut
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	92,822,523 - 92,833,400 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936471	10,670,604 - 10,681,356 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	123,450,858 - 123,462,245 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	123,451,207 - 123,462,267 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	137,480,904 - 137,492,062 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Dut
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	11,378,944 - 11,388,057 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	11,378,882 - 11,388,677 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	2	42
Low		18	18
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008016712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000008572 ⟹ ENSCSAP00000006714

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	26	34,940,702 - 34,953,166 (-)	Ensembl

RefSeq Acc Id:

XM_008016712 ⟹ XP_008014903

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	34,941,775 - 34,953,086 (-)	NCBI
Vero_WHO_p1.0	NW_023666048	106,175,656 - 106,187,091 (+)	NCBI

Sequence:

show sequence

CCTGGTGGACTCTCGGAAAAATGGGGGCCCGAGCAAACAAGAAGAGCGAGGGCAAGAGGCGTAG
GCACCCGGAGGCGGCAGCAAGACTCAGAACGCCAAGGGCACCGTCTTCCTAGTGCCCCAGGGCC
TGCGCCGCCTCTCCACGCCCCTCGCACGGCGGCGACTGCTTCCGAGGTCATGTTCCGGGACGCG
CGCGTCTTCAGGGTGGAAGCCTGGCGCACGTCCGGAGGTGCCGAGAAGCCAACCAGCCCAAACT
CTGGGGGAAATGACTCTCCTCTGCCCTCGCCCCGCGCTCTGCTACCATTTCCTTCCGTCTCTGC
TTCGCTCAGCGATGCAAAACGCGCGAGGCGCACGGCAGAGGGCCGAGGCCGCGGGACTCTCCGC
GCCAGGCCCGCCCCTCGGCCGCGCAGCGCAGCACGGGACGCCCTGGCCGCTGTCCAGCGCTGGC
AGTCTGAGCCGAGGCTGTCGCGGAGCCAGTACAGCCGGGGCCGCGGGCTGGAAGGGCGAGCTTC
CTAAGCCGGGGGGATGCCCGGCGCCCGGGCAGGAGACACCCGCCATTTCACCCAGTAAGCGGCC
CCGGCCTGCAGAGGAGGGCGGCATGCAGCTCCGCTTTGCCCGGCTCTCCGAGCACGCCACGGCC
CCCACCCGGGGCTCCGCGCGGGCCGCGGGTTACGACCTGTACAGTGCCTATGATTACACAATAC
CACCTATGGAGAAAACTCTTGTGAAAACGGACATTCAGATAGCGCTCCCTTCTGGGTGTTATGG
AAGAGTAGCTCCACGGTCAGGCTTGGCTGCAAAACACTTTATTGATGTAGGAGCTGGTGTCATA
GATGAAGATTATAGAGGAAATGTTGGTGTTGTACTGTTTAATTTTGGCAAAGACAAGTTTGAAG
TCAAAAAGGGTGATCGAATTGCACAGCTCATTTGCGAACAGATTTTTTATCCAGAAATAGAAGA
AGTTCAAGCTTTGGATGACACCGAAAGGGGTTCAGGCGGTTTTGGTTCCACTGGAAAGAATTAA
AATTTATGCCAAGAACAGAAAACGAGAAGTCATACGTTTTTCTTAAAAAAAAAAAAAAAGTTTT
TGCTTAAAGTGTTTTGGTGTTTTGCACTTCTGTAAACTTACTAGCTTCACCTTAGAAAAGTACT
GCATTTTTTACTTTTTTTTTTTTTTTTATGGTCAAGGAAGAGATCATAAAAAAATAAAACACAA
AGCTTTTTGTGTTTGGATCAAAAAGAAACTTTGTTTTTCTGCAATTGATGGTTGTATGTAAATC
TGCTTTGTGGTGACCTGATGTAAAGTGTCTTCTTAAAGTCAAATGTACATCAATTACAGATTTA
AAAAAAAAAAACCTGTATTTAACTCAAATGATCCCCCTTCAGCAACTTATTTTGCTTTAATTCC
TTTAAATCTTAAGCAATATTTTGTATTCAGTAAACTTAAATTCTTACACAAGGTACAAAATCTT
GCATAAGCTGAACTAAAAGAAAATGAAATGAAAAGGAGAGATTAAAGGTATTCCTTGTTCTTCC
TTGTCTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008014903	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006714.1

RefSeq Acc Id:	XP_008014903 ⟸ XM_008016712
- UniProtKB:	A0A0D9RDM5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000006714 ⟸ ENSCSAT00000008572

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000010486	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008572.1	UniProtKB/TrEMBL
Gene3D-CATH	2.70.40.10	UniProtKB/TrEMBL
InterPro	dUTPase-like	UniProtKB/TrEMBL
	dUTPase-like_sf	UniProtKB/TrEMBL
	dUTPase_1	UniProtKB/TrEMBL
	dUTPase_trimeric	UniProtKB/TrEMBL
KEGG Report	csab:103245674	UniProtKB/TrEMBL
NCBI Gene	DUT	ENTREZGENE
PANTHER	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE	UniProtKB/TrEMBL
	PTHR11241	UniProtKB/TrEMBL
Pfam	dUTPase	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51283	UniProtKB/TrEMBL
UniProt	A0A0D9RDM5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB