DUT (deoxyuridine triphosphatase) - Rat Genome Database

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Gene: DUT (deoxyuridine triphosphatase) Homo sapiens
Analyze
Symbol: DUT
Name: deoxyuridine triphosphatase
RGD ID: 1349758
HGNC Page HGNC
Description: Enables RNA binding activity. Predicted to be involved in dUMP biosynthetic process and dUTP catabolic process. Located in nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: DUTP1   DUTP2   DUTP3   DUTP4   DUTP5   DUTP6   DUTP7   DUTP8   LOC441862  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1548,331,011 - 48,343,373 (+)EnsemblGRCh38hg38GRCh38
GRCh381548,329,991 - 48,343,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371548,623,292 - 48,635,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361546,410,913 - 46,422,862 (+)NCBINCBI36hg18NCBI36
Build 341546,411,721 - 46,422,855NCBI
Celera1525,516,088 - 25,528,037 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1525,456,621 - 25,468,570 (+)NCBIHuRef
CHM1_11548,741,653 - 48,753,602 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-methylcholine  (EXP)
2-nitrofluorene  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP)
bufalin  (EXP)
buspirone  (ISO)
butan-1-ol  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cyclosporin A  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (EXP)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
erythromycin estolate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
indole-3-methanol  (ISO)
ivermectin  (EXP)
levofloxacin  (ISO)
limonene  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
propiconazole  (ISO)
resveratrol  (EXP)
SB 431542  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
extracellular exosome  (HDA)
mitochondrion  (IEA)
nucleoplasm  (IDA,TAS)
nucleus  (ISO,TAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Colon cancer  (IAGP)
High myopia  (IAGP)
References

Additional References at PubMed
PMID:1091006   PMID:1325640   PMID:8389461   PMID:8631816   PMID:8631817   PMID:8805593   PMID:8910358   PMID:9070952   PMID:9228092   PMID:10910061   PMID:11118321   PMID:12096336  
PMID:12369926   PMID:12374095   PMID:12477932   PMID:12799180   PMID:15342556   PMID:15489334   PMID:15604093   PMID:15629463   PMID:16189514   PMID:17081983   PMID:17848562   PMID:17880943  
PMID:18464913   PMID:19015155   PMID:19060904   PMID:19302784   PMID:19403629   PMID:19879316   PMID:19968781   PMID:20458337   PMID:20560137   PMID:20877624   PMID:21145461   PMID:21780905  
PMID:21873635   PMID:22172489   PMID:22658674   PMID:22863883   PMID:22939629   PMID:22944692   PMID:23894549   PMID:24311590   PMID:25544563   PMID:25659154   PMID:25963833   PMID:26344197  
PMID:27432908   PMID:28073829   PMID:28515276   PMID:29229926   PMID:29531348   PMID:29568061   PMID:29791485   PMID:29845934   PMID:30033366   PMID:30679536   PMID:30833792   PMID:30948266  
PMID:31091453   PMID:31405213   PMID:31536960   PMID:32129710   PMID:32203420   PMID:32249768  


Genomics

Comparative Map Data
DUT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1548,331,011 - 48,343,373 (+)EnsemblGRCh38hg38GRCh38
GRCh381548,329,991 - 48,343,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371548,623,292 - 48,635,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361546,410,913 - 46,422,862 (+)NCBINCBI36hg18NCBI36
Build 341546,411,721 - 46,422,855NCBI
Celera1525,516,088 - 25,528,037 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1525,456,621 - 25,468,570 (+)NCBIHuRef
CHM1_11548,741,653 - 48,753,602 (+)NCBICHM1_1
Dut
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,089,168 - 125,100,969 (+)NCBIGRCm39mm39
GRCm39 Ensembl2125,089,110 - 125,100,528 (+)Ensembl
GRCm382125,247,248 - 125,259,049 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,247,190 - 125,258,608 (+)EnsemblGRCm38mm10GRCm38
MGSCv372125,072,984 - 125,084,785 (+)NCBIGRCm37mm9NCBIm37
MGSCv362124,938,923 - 124,950,049 (+)NCBImm8
Celera2126,491,099 - 126,502,875 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.33NCBI
Dut
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23112,498,864 - 112,509,994 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3112,498,982 - 112,510,771 (+)Ensembl
Rnor_6.03117,514,399 - 117,525,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,514,444 - 117,525,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,038,120 - 124,049,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43112,551,434 - 112,562,434 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13112,457,006 - 112,468,009 (+)NCBI
Celera3111,355,479 - 111,366,436 (+)NCBICelera
Cytogenetic Map3q36NCBI
Dut
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554095,574,694 - 5,584,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554095,574,810 - 5,584,135 (-)NCBIChiLan1.0ChiLan1.0
DUT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11545,604,061 - 45,616,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1545,603,807 - 45,616,022 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01527,280,025 - 27,292,003 (+)NCBIMhudiblu_PPA_v0panPan3
DUT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13014,572,766 - 14,585,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3014,572,602 - 14,585,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3014,494,200 - 14,507,265 (+)NCBI
ROS_Cfam_1.03014,706,670 - 14,719,522 (+)NCBI
UMICH_Zoey_3.13014,629,328 - 14,642,402 (+)NCBI
UNSW_CanFamBas_1.03014,744,651 - 14,757,504 (+)NCBI
UU_Cfam_GSD_1.03014,856,699 - 14,869,776 (+)NCBI
Dut
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864092,822,523 - 92,833,400 (+)NCBI
SpeTri2.0NW_00493647110,670,604 - 10,681,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1123,451,212 - 123,462,232 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11123,451,207 - 123,462,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21137,480,904 - 137,492,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12634,941,775 - 34,954,184 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2634,940,702 - 34,953,166 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048106,175,656 - 106,187,091 (+)NCBIVero_WHO_p1.0
Dut
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473111,378,882 - 11,388,677 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
M89913  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371548,634,343 - 48,634,524UniSTSGRCh37
Build 361546,421,635 - 46,421,816RGDNCBI36
Celera1525,526,810 - 25,526,991RGD
Cytogenetic Map15q21.1UniSTS
HuRef1525,467,343 - 25,467,524UniSTS
Whitehead-YAC Contig Map15 UniSTS
RH92298  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371548,635,375 - 48,635,500UniSTSGRCh37
Build 361546,422,667 - 46,422,792RGDNCBI36
Celera1525,527,842 - 25,527,967RGD
Cytogenetic Map15q21.1UniSTS
HuRef1525,468,375 - 25,468,500UniSTS
GeneMap99-GB4 RH Map15168.12UniSTS
RH39501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371952,955,143 - 52,955,294UniSTSGRCh37
GRCh371548,634,222 - 48,634,377UniSTSGRCh37
Build 361546,421,514 - 46,421,669RGDNCBI36
Celera1950,005,076 - 50,005,227UniSTS
Celera1525,526,689 - 25,526,844RGD
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map19q13.41UniSTS
HuRef1949,285,381 - 49,285,532UniSTS
HuRef1525,467,222 - 25,467,377UniSTS
RH122528  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371548,622,499 - 48,622,771UniSTSGRCh37
Build 361546,409,791 - 46,410,063RGDNCBI36
Celera1525,515,004 - 25,515,276RGD
Cytogenetic Map15q21.1UniSTS
HuRef1525,455,537 - 25,455,809UniSTS
TNG Radiation Hybrid Map1515023.0UniSTS
WI-17558  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371548,634,144 - 48,634,293UniSTSGRCh37
Build 361546,421,436 - 46,421,585RGDNCBI36
Celera1525,526,611 - 25,526,760RGD
Cytogenetic Map15q21.1UniSTS
HuRef1525,467,144 - 25,467,293UniSTS
GeneMap99-GB4 RH Map15168.73UniSTS
Whitehead-RH Map15133.5UniSTS
SHGC-36316  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371548,631,261 - 48,631,360UniSTSGRCh37
Build 361546,418,553 - 46,418,652RGDNCBI36
Celera1525,523,728 - 25,523,827RGD
Cytogenetic Map15q21.1UniSTS
HuRef1525,464,261 - 25,464,360UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2123
Count of miRNA genes:608
Interacting mature miRNAs:678
Transcripts:ENST00000331200, ENST00000455976, ENST00000558367, ENST00000558472, ENST00000558813, ENST00000558978, ENST00000559416, ENST00000559540, ENST00000559852, ENST00000559935, ENST00000561350
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2428 2352 1618 520 1441 362 4083 1800 3545 402 1453 1608 174 1 1204 2514 6 2
Low 11 638 108 104 509 103 274 397 189 17 6 5 1 274
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_931760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB049113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC023355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY935242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF697257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG505144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG532018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI257870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP208983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M89913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000331200   ⟹   ENSP00000370376
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,331,429 - 48,343,373 (+)Ensembl
RefSeq Acc Id: ENST00000455976   ⟹   ENSP00000405160
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,332,103 - 48,343,369 (+)Ensembl
RefSeq Acc Id: ENST00000558367   ⟹   ENSP00000453683
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,332,406 - 48,342,033 (+)Ensembl
RefSeq Acc Id: ENST00000558472   ⟹   ENSP00000452749
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,331,456 - 48,342,052 (+)Ensembl
RefSeq Acc Id: ENST00000558813   ⟹   ENSP00000453717
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,331,405 - 48,342,293 (+)Ensembl
RefSeq Acc Id: ENST00000558978   ⟹   ENSP00000452814
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,331,473 - 48,342,395 (+)Ensembl
RefSeq Acc Id: ENST00000559416   ⟹   ENSP00000454183
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,331,095 - 48,342,137 (+)Ensembl
RefSeq Acc Id: ENST00000559540   ⟹   ENSP00000454041
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,332,210 - 48,342,395 (+)Ensembl
RefSeq Acc Id: ENST00000559852
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,341,136 - 48,342,062 (+)Ensembl
RefSeq Acc Id: ENST00000559935   ⟹   ENSP00000453667
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,331,011 - 48,341,495 (+)Ensembl
RefSeq Acc Id: ENST00000561350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1548,334,445 - 48,340,236 (+)Ensembl
RefSeq Acc Id: NM_001025248   ⟹   NP_001020419
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,331,429 - 48,343,373 (+)NCBI
GRCh371548,623,215 - 48,635,570 (+)NCBI
Build 361546,410,913 - 46,422,862 (+)NCBI Archive
HuRef1525,456,621 - 25,468,570 (+)ENTREZGENE
CHM1_11548,741,653 - 48,753,602 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001025249   ⟹   NP_001020420
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,331,424 - 48,343,373 (+)NCBI
GRCh371548,623,215 - 48,635,570 (+)NCBI
Build 361546,410,913 - 46,422,862 (+)NCBI Archive
HuRef1525,456,621 - 25,468,570 (+)ENTREZGENE
CHM1_11548,741,653 - 48,753,602 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001330286   ⟹   NP_001317215
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,331,095 - 48,343,373 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001948   ⟹   NP_001939
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,332,197 - 48,343,373 (+)NCBI
GRCh371548,623,215 - 48,635,570 (+)NCBI
Build 361546,411,657 - 46,422,862 (+)NCBI Archive
HuRef1525,456,621 - 25,468,570 (+)ENTREZGENE
CHM1_11548,742,397 - 48,753,602 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017021988   ⟹   XP_016877477
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,331,438 - 48,340,456 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001751125
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,329,991 - 48,342,562 (+)NCBI
Sequence:
RefSeq Acc Id: XR_931760
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,331,438 - 48,342,562 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001020419 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020420 (Get FASTA)   NCBI Sequence Viewer  
  NP_001317215 (Get FASTA)   NCBI Sequence Viewer  
  NP_001939 (Get FASTA)   NCBI Sequence Viewer  
  XP_016877477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36801 (Get FASTA)   NCBI Sequence Viewer  
  AAA58444 (Get FASTA)   NCBI Sequence Viewer  
  AAB71393 (Get FASTA)   NCBI Sequence Viewer  
  AAB71394 (Get FASTA)   NCBI Sequence Viewer  
  AAB93866 (Get FASTA)   NCBI Sequence Viewer  
  AAB93867 (Get FASTA)   NCBI Sequence Viewer  
  AAB94642 (Get FASTA)   NCBI Sequence Viewer  
  AAC50418 (Get FASTA)   NCBI Sequence Viewer  
  AAC51123 (Get FASTA)   NCBI Sequence Viewer  
  AAH70339 (Get FASTA)   NCBI Sequence Viewer  
  AAI10378 (Get FASTA)   NCBI Sequence Viewer  
  AAX14045 (Get FASTA)   NCBI Sequence Viewer  
  BAB13724 (Get FASTA)   NCBI Sequence Viewer  
  BAF84204 (Get FASTA)   NCBI Sequence Viewer  
  BAG35058 (Get FASTA)   NCBI Sequence Viewer  
  BAG60677 (Get FASTA)   NCBI Sequence Viewer  
  CAG46521 (Get FASTA)   NCBI Sequence Viewer  
  CAG46580 (Get FASTA)   NCBI Sequence Viewer  
  EAW77349 (Get FASTA)   NCBI Sequence Viewer  
  EAW77350 (Get FASTA)   NCBI Sequence Viewer  
  EAW77351 (Get FASTA)   NCBI Sequence Viewer  
  EAW77352 (Get FASTA)   NCBI Sequence Viewer  
  P33316 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001020419   ⟸   NM_001025248
- Peptide Label: isoform 1 precursor
- UniProtKB: P33316 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001020420   ⟸   NM_001025249
- Peptide Label: isoform 3
- UniProtKB: P33316 (UniProtKB/Swiss-Prot),   A0A0C4DGL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001939   ⟸   NM_001948
- Peptide Label: isoform 2
- UniProtKB: P33316 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016877477   ⟸   XM_017021988
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001317215   ⟸   NM_001330286
- Peptide Label: isoform 4
- UniProtKB: P33316 (UniProtKB/Swiss-Prot),   H0YNW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000370376   ⟸   ENST00000331200
RefSeq Acc Id: ENSP00000452749   ⟸   ENST00000558472
RefSeq Acc Id: ENSP00000453683   ⟸   ENST00000558367
RefSeq Acc Id: ENSP00000452814   ⟸   ENST00000558978
RefSeq Acc Id: ENSP00000453717   ⟸   ENST00000558813
RefSeq Acc Id: ENSP00000454041   ⟸   ENST00000559540
RefSeq Acc Id: ENSP00000454183   ⟸   ENST00000559416
RefSeq Acc Id: ENSP00000453667   ⟸   ENST00000559935
RefSeq Acc Id: ENSP00000405160   ⟸   ENST00000455976
Protein Domains
dUTPase

Promoters
RGD ID:6792223
Promoter ID:HG_KWN:21321
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000249783,   NM_001025248,   NM_001025249,   NM_001948,   UC001ZWU.1,   UC001ZWV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361546,410,916 - 46,411,787 (+)MPROMDB
RGD ID:6853008
Promoter ID:EP74325
Type:initiation region
Name:HS_DUT
Description:DUTP pyrophosphatase.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361546,411,672 - 46,411,732EPD
RGD ID:7229421
Promoter ID:EPDNEW_H20457
Type:initiation region
Name:DUT_3
Description:deoxyuridine triphosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20458  EPDNEW_H20459  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,331,098 - 48,331,158EPDNEW
RGD ID:7229425
Promoter ID:EPDNEW_H20458
Type:initiation region
Name:DUT_1
Description:deoxyuridine triphosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20457  EPDNEW_H20459  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,331,429 - 48,331,489EPDNEW
RGD ID:7229427
Promoter ID:EPDNEW_H20459
Type:initiation region
Name:DUT_2
Description:deoxyuridine triphosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20457  EPDNEW_H20458  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381548,332,197 - 48,332,257EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q21.1-21.3(chr15:46042302-54195828)x1 copy number loss See cases [RCV000051619] Chr15:46042302..54195828 [GRCh38]
Chr15:46334500..54488025 [GRCh37]
Chr15:44121792..52275317 [NCBI36]
Chr15:15q21.1-21.3
pathogenic
GRCh38/hg38 15q21.1-21.2(chr15:47460844-52494222)x1 copy number loss See cases [RCV000135639] Chr15:47460844..52494222 [GRCh38]
Chr15:47753041..52786419 [GRCh37]
Chr15:45540333..50573711 [NCBI36]
Chr15:15q21.1-21.2
pathogenic
GRCh37/hg19 15q21.1(chr15:48606170-48732716)x3 copy number gain See cases [RCV000447342] Chr15:48606170..48732716 [GRCh37]
Chr15:15q21.1
uncertain significance
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q15.2-21.2(chr15:42850434-49592633)x1 copy number loss See cases [RCV000447035] Chr15:42850434..49592633 [GRCh37]
Chr15:15q15.2-21.2
pathogenic
GRCh37/hg19 15q21.1-21.2(chr15:47574384-50369056)x1 copy number loss See cases [RCV000447640] Chr15:47574384..50369056 [GRCh37]
Chr15:15q21.1-21.2
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q15.1-21.2(chr15:41689327-52446981)x1 copy number loss See cases [RCV000448968] Chr15:41689327..52446981 [GRCh37]
Chr15:15q15.1-21.2
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q15.3-21.3(chr15:43759773-53252240)x1 copy number loss not provided [RCV000683686] Chr15:43759773..53252240 [GRCh37]
Chr15:15q15.3-21.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
NC_000015.10:g.(?_48134288)_(48644779_?)del deletion Marfan syndrome [RCV001032801] Chr15:48426485..48936976 [GRCh37]
Chr15:15q21.1
pathogenic
NM_001025248.2(DUT):c.298C>T (p.Pro100Ser) single nucleotide variant Severe Myopia [RCV000785702] Chr15:48332285 [GRCh38]
Chr15:48624482 [GRCh37]
Chr15:15q21.1
uncertain significance
GRCh37/hg19 15q21.1-22.2(chr15:48000433-60747551)x3 copy number gain not provided [RCV000845891] Chr15:48000433..60747551 [GRCh37]
Chr15:15q21.1-22.2
pathogenic
Single allele deletion Marfan syndrome [RCV000824957] Chr15:48051994..48830007 [GRCh37]
Chr15:15q21.1
pathogenic
GRCh37/hg19 15q21.1-21.2(chr15:47192561-50819726)x1 copy number loss not provided [RCV001006685] Chr15:47192561..50819726 [GRCh37]
Chr15:15q21.1-21.2
pathogenic
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3078 AgrOrtholog
COSMIC DUT COSMIC
Ensembl Genes ENSG00000128951 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000370376 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000405160 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000452749 UniProtKB/TrEMBL
  ENSP00000452814 UniProtKB/TrEMBL
  ENSP00000453667 UniProtKB/TrEMBL
  ENSP00000453683 UniProtKB/TrEMBL
  ENSP00000453717 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000454041 UniProtKB/TrEMBL
  ENSP00000454183 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000331200 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000455976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000558367 UniProtKB/TrEMBL
  ENST00000558472 UniProtKB/TrEMBL
  ENST00000558813 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000558978 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000559416 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000559540 UniProtKB/TrEMBL
  ENST00000559935 UniProtKB/TrEMBL
Gene3D-CATH 2.70.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000128951 GTEx
HGNC ID HGNC:3078 ENTREZGENE
Human Proteome Map DUT Human Proteome Map
InterPro dUTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dUTPase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dUTPase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dUTPase_trimeric UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1854 UniProtKB/Swiss-Prot
NCBI Gene 1854 ENTREZGENE
OMIM 601266 OMIM
PANTHER PTHR11241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam dUTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA151 PharmGKB
Superfamily-SCOP SSF51283 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs dut UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0C4DGL3 ENTREZGENE, UniProtKB/TrEMBL
  DUT_HUMAN UniProtKB/Swiss-Prot
  H0YKC5_HUMAN UniProtKB/TrEMBL
  H0YKI0_HUMAN UniProtKB/TrEMBL
  H0YMM5_HUMAN UniProtKB/TrEMBL
  H0YMP1_HUMAN UniProtKB/TrEMBL
  H0YNJ9_HUMAN UniProtKB/TrEMBL
  H0YNW5 ENTREZGENE, UniProtKB/TrEMBL
  P33316 ENTREZGENE
UniProt Secondary A8K650 UniProtKB/Swiss-Prot
  B4DPR5 UniProtKB/Swiss-Prot
  O14785 UniProtKB/Swiss-Prot
  Q16708 UniProtKB/Swiss-Prot
  Q16860 UniProtKB/Swiss-Prot
  Q6FHN1 UniProtKB/Swiss-Prot
  Q6NSA3 UniProtKB/Swiss-Prot
  Q96Q81 UniProtKB/Swiss-Prot