| 14372115 | dars-1 | | | | | | Roundworm | | symbol | gene, null |
| 14372118 | dars-2 | | | | | | Roundworm | | symbol | gene, null |
| 621167 | Dars1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); INVOLVED IN aspartyl-tRNA aminoacylation (ortholog); PARTICIPATES IN Canavan disease pathway; aminoacyl-tRNA biosynthetic pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Inv olvement and Leg Spasticity (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione | 13 | 42410351 | 42465467 | Rat | 151 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732389 | DARS1 | aspartyl-tRNA synthetase 1 | This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involv ement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] | 2 | 135905881 | 135985684 | Human | 177 | symbol , ensembl_gene_symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732390 | Dars1 | aspartyl-tRNA synthetase 1 | Predicted to enable RNA binding activity and aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Located in cytoplasm and synapse. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; brain; geni tourinary system; respiratory system; and sensory organ. Orthologous to human DARS1 (aspartyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 128291444 | 128345153 | Mouse | 139 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8963310 | Dars1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); INVOLVED IN aspartyl-tRNA aminoacylation (ortholog); PARTICIPATES IN Canavan disease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog ); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955440 | 3268648 | 3345808 | Chinchilla | 16 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11784673 | DARS1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation for protein translation (inferred); PARTICIPATES IN Canavan d isease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | 2B | 23876931 | 23956032 | Bonobo | 36 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12285736 | DARS1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation for protein translation (inferred); PARTICIPATES IN Canavan d isease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | 19 | 38690170 | 38751360 | Dog | 36 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12564933 | Dars1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation for protein translation (inferred); PARTICIPATES IN Canavan d isease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936469 | 39921182 | 39979297 | Squirrel | 36 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14002530 | DARS1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation for protein translation (inferred); PARTICIPATES IN Canavan d isease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol; resveratrol | | | | Pig | 38 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18767189 | DARS1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation for protein translation (inferred); PARTICIPATES IN Canavan d isease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 36 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18923554 | Dars1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation for protein translation (inferred); PARTICIPATES IN Canavan d isease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog); FOUND IN synapse (ortholog) | | | | Naked Mole-Rat | 31 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8695150 | DARS1-AS1 | DARS1 antisense RNA 1 | INTERACTS WITH acrylamide; arsenite(3-); okadaic acid | 2 | 135985176 | 136007542 | Human | 4 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 155249769 | dars1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625958340 | Dars1 | aspartyl-tRNA synthetase 1 | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); INVOLVED IN aspartyl-tRNA aminoacylation (ortholog); PARTICIPATES IN Canavan disease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog ); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1308286 | Dars2 | aspartyl-tRNA synthetase 2 (mitochondrial) | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); PARTICIPATES IN aminoacyl-tRN A biosynthetic pathway; ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene | 13 | 75842078 | 75870319 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1550719 | Dars2 | aspartyl-tRNA synthetase 2 (mitochondrial) | Predicted to enable aspartate-tRNA ligase activity; aspartate-tRNA(Asn) ligase activity; and protein homodimerization activity. Predicted to be involved in aspartyl-tRNA aminoacylation and mitochondrial asparaginyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, in cluding alimentary system; genitourinary system; integumental system; midbrain; and telencephalon. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 160868171 | 160898236 | Mouse | 130 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605663 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL ). [provided by RefSeq, Nov 2009] | 1 | 173824673 | 173858546 | Human | 238 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8868683 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH cerebellar at axia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | NW_004955406 | 13964087 | 13991691 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11711456 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | 1 | 149342301 | 149375979 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12115466 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN lysyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); AS SOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | 7 | 25378705 | 25406975 | Dog | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12618348 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | NW_004936481 | 14029478 | 14052724 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14029055 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH cerebellar at axia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrion (ortholog) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18636421 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918314 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | | | | Naked Mole-Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258161 | dars2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625850590 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH cerebellar at axia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249770 | dars1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251823 | dars1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238936 | dars2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1593553 | Dars1-ps1 | aspartyl-tRNA synthetase 1, pseudogene 1 | | 8 | 12796069 | 12814990 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |