Dars1 (aspartyl-tRNA synthetase 1)

Gene: Dars1 (aspartyl-tRNA synthetase 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Dars1

Name:

aspartyl-tRNA synthetase 1

RGD ID:

12564933

Description:

ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); ATP binding (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); PARTICIPATES IN Canavan disease pathway; ASSOCIATED WITH genetic disease (ortholog); Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ortholog); WHIM syndrome 1 (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aspartate--tRNA ligase, cytoplasmic; aspartyl-tRNA synthetase; aspartyl-tRNA synthetase, transcript variant X1; aspartyl-tRNA synthetase, transcript variant X2; Dars

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	101,638,433 - 101,696,530 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	39,921,120 - 39,979,323 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	39,921,182 - 39,979,297 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (ISO)

WHIM syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aspartyl-tRNA aminoacylation (IEA)

Cellular Component

aminoacyl-tRNA synthetase multienzyme complex (IEA)

cytoplasm (IEA)

cytosol (IEA)

synapse (IEA)

Molecular Function

aminoacyl-tRNA ligase activity (IEA)

aspartate-tRNA ligase activity (IEA)

ATP binding (IEA)

nucleic acid binding (IEA)

protein binding (ISO)

RNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Canavan disease pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	101,638,433 - 101,696,530 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	39,921,120 - 39,979,323 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	39,921,182 - 39,979,297 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	135,905,881 - 135,985,684 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	135,905,881 - 135,986,100 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	136,663,451 - 136,743,254 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	136,380,724 - 136,459,692 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	136,497,985 - 136,576,954	NCBI
Celera	2	130,374,979 - 130,453,946 (-)	NCBI		Celera
Cytogenetic Map	2	q21.3	NCBI
HuRef	2	128,656,738 - 128,735,990 (-)	NCBI		HuRef
CHM1_1	2	136,669,650 - 136,748,607 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	136,350,305 - 136,430,110 (-)	NCBI		T2T-CHM13v2.0

Dars1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	128,291,444 - 128,345,153 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	128,291,444 - 128,345,105 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	128,363,707 - 128,417,416 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	128,363,707 - 128,417,368 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	130,260,284 - 130,313,993 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	130,191,253 - 130,244,884 (-)	NCBI		MGSCv36	mm8
Celera	1	130,992,060 - 131,045,578 (-)	NCBI		Celera
Cytogenetic Map	1	E3	NCBI
cM Map	1	55.8	NCBI

Dars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	42,410,351 - 42,465,467 (-)	NCBI		GRCr8
mRatBN7.2	13	39,857,936 - 39,913,055 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	39,857,936 - 39,913,116 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	42,451,676 - 42,506,974 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	43,739,779 - 43,795,077 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	40,993,748 - 41,048,901 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	45,074,067 - 45,127,815 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	45,074,072 - 45,127,815 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	50,158,677 - 50,212,300 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	41,077,395 - 41,132,513 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	41,090,911 - 41,146,678 (-)	NCBI
Celera	13	40,231,977 - 40,287,207 (-)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

Dars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	3,266,821 - 3,345,808 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	3,268,648 - 3,345,808 (-)	NCBI	ChiLan1.0	ChiLan1.0

DARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	38,945,632 - 39,025,072 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	38,960,584 - 39,040,041 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	23,876,931 - 23,956,032 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	139,977,483 - 140,056,836 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	139,977,483 - 140,056,836 (-)	Ensembl	panpan1.1		panPan2

DARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	38,690,170 - 38,751,360 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	38,668,527 - 38,751,310 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	38,933,151 - 38,994,341 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	40,135,547 - 40,196,455 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	40,135,551 - 40,196,464 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	38,777,495 - 38,838,663 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	38,937,306 - 38,998,504 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	40,169,840 - 40,230,688 (-)	NCBI		UU_Cfam_GSD_1.0

DARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	15,810,618 - 15,885,706 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	15,810,497 - 15,885,706 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	18,269,726 - 18,344,247 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DARS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	20,120,999 - 20,202,019 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	20,119,914 - 20,201,991 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	2,261,198 - 2,342,266 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dars1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	35,266,830 - 35,337,645 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	35,266,830 - 35,337,610 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005315837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021720875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006306 ⟹ ENSSTOP00000005639

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936469	39,921,120 - 39,979,323 (+)	Ensembl

RefSeq Acc Id:

XM_005315837 ⟹ XP_005315894

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	101,638,433 - 101,696,530 (-)	NCBI
SpeTri2.0	NW_004936469	39,921,182 - 39,979,297 (+)	NCBI

Sequence:

show sequence

GACGGCGCTCTGCTGCTGGCCTTTCGGCGCTTCGGAATCTCGAGAGAGCTGGAAGTCTCGCGAT
CTTTCCGAAGCCGAAGTTCCACGCGGAGTCCGAGCGCGTGTACCAAGGCAGGAGGGCCGGGAGG
GCGGAGACTGTGCGGGAGGGAGAAGCCCCTTGGCTTGCTCTTACAGACGCCTGCGAGGAAGAGT
GGTGTCCACTCCCCGATTCAGTGTCTCGATGCCCAGCGCCAGCGCCAGTCGCAAGAGTCAGGAG
AAGCCGCGGGAGATCATGGACGCGGCGGAAGATTATGCTAAAGAAAGATATGGAATATCTTCAA
TGATACAATCACAGGAAAAACCAGATCGAATTTTGGTTTTGGTAAGAGACTTGACAGTACAAAG
AGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTGCATACAAGTAGAGCTAAAGGGAAACAATGC
TTCTTAGTTCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCTGTGGGAGACCATGCAA
GCAAGCAGATGGTTAAATTTGCTGCCAACATCAACAAGGAAAGCATCGTAGATGTAGAAGGCGT
TGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAGGATGTTGAGTTACATGTTCAG
AAGATTTATGTGATCAGTTTGGCTGAACCCCGCCTGCCCCTGCAGCTGGATGATGCCATTCGGC
CTGAGGTGGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAAGATACAAGATTAGACAACAG
AGTCATTGATCTCCGGACATCAACTAGTCAGGCAATCTTCCGTCTGCAGTCTGGCATCTGCCAT
CTTTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAGACTCCTAAAATTATTTCAG
CTGCCAGTGAAGGAGGAGCCAATGTATTCACTGTATCATATTTTAAAAATAATGCATACCTAGC
TCAGTCTCCACAGCTGTATAAGCAAATGTGCATTTGTGCTGATTTTGAGAAGGTGTTCTGTATT
GGACCAGTTTTCAGAGCTGAAGACTCTAATACCCACAGACATCTGACTGAATTTGTTGGTCTAG
ACATTGAAATGGCTTTTAATTATCATTATCATGAAGTTTTAGAAGAAATTGCTGACACCTTGGT
ACAAATATTCAAAGGACTTCAAGAAAGGTTTCAGACTGAAATTCAAACCGTGAATAAACAGTTC
CCTTGTGAACCCTTCAAATTTTTGGAACCAACTTTAAGACTAGAGTATTGTGAAGCTTTGGCTA
TGCTTAGAGAAGCTGGAGTTGAAATGGGAGATGAAGAAGATCTGAGTACACCAAATGAAAAACT
ATTGGGTCGTTTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTG
GCTGTAAGACCTTTCTATACCATGCCTGACCCAAGAAATCCTAAACACTCCAACTCTTATGATA
TGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAGCTGCTAAC
AGAGAGAGCCTTACATCATGGAATTGATTTGGAGAAAATCAAGGCTTACATTGATTCCTTCCGT
TTTGGAGCCCCTCCTCATGCTGGTGGAGGCATTGGATTGGAACGCGTGACTATGCTGTTTTTGG
GATTGCATAATGTGCGTCAGACCTCGATGTTCCCTCGTGACCCTAAACGACTCACTCCTTAAAG
CCACCATGCTCCTTACTCTTTTCAGGAAGTTACTATTGATCAGGTTGTACCTTAGGTACTTAAA
ATATGCAATAGAATAATTGTCTTATCTAAAGTGCCACAGTTGTTTTTTAATTAATTCAGTATAG
GTTAATTTAGAACAGAAGATTTTTATAACTTCAGACATACTTCAGTAGGAAATGCTTGAACGTT
TTAAAAAGAAGTTCATATAGTTTATTAAAAAATCATATTCCATTACTACAATAAATGTTAACAA
GAGTTTTAAACAGTTATGATTGTGAACATTTTTTCTGTTCTATATTACGGTGGCCCCAGTATTA
ACATCTTAAATTTTCAATATTTGAACTTACTTTTTTAACTTTTGACATTAAGAACAATTGGAAA
AATACCCAAGATTTTAACAAGTATATAACTGGCATCTCATGAAAAATTAGTATCAATTCTTAAA
AGTTATATCCAGAAATCATGTAAAGTGGGTAAAAATACTAGCTAGAAAATAATCAAAATAATGC
TATATTAAATTGTTAAATGCTAAGTCTGAATTTCAATAAATTTTAAAGCTAATTAAAGTTTG

hide sequence

RefSeq Acc Id:

XM_021720875 ⟹ XP_021576550

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	101,638,433 - 101,696,528 (-)	NCBI
SpeTri2.0	NW_004936469	39,921,183 - 39,979,297 (+)	NCBI

Sequence:

show sequence

ACGGCGCTCTGCTGCTGGCCTTTCGGCGCTTCGGAATCTCGAGAGAGCTGGAAGTCTCGCGATC
TTTCCGAAGCCGAAGTTCCACGCGGAGTCCGAGCGCGTGTACCAAGGCAGGAGGGCCGGGAGGG
CGGAGACTGTGCGGGAGGGAGAAGCCCCTTGGCTTGCTCTTACAGACGCCTGCGAGGAAGAGTG
GTGTCCACTCCCCGATTCAGTGTCTCGATGCCCAGCGCCAGCGCCAGTCGCAAGAGTCAGGAGA
AGCCGCGGGAGATCATGGACGCGGCGGAAATCGAATTTTGGTTTTGGTAAGAGACTTGACAGTA
CAAAGAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTGCATACAAGTAGAGCTAAAGGGAAAC
AATGCTTCTTAGTTCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCTGTGGGAGACCA
TGCAAGCAAGCAGATGGTTAAATTTGCTGCCAACATCAACAAGGAAAGCATCGTAGATGTAGAA
GGCGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAGGATGTTGAGTTACATG
TTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGCCTGCCCCTGCAGCTGGATGATGCCAT
TCGGCCTGAGGTGGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAAGATACAAGATTAGAC
AACAGAGTCATTGATCTCCGGACATCAACTAGTCAGGCAATCTTCCGTCTGCAGTCTGGCATCT
GCCATCTTTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAGACTCCTAAAATTAT
TTCAGCTGCCAGTGAAGGAGGAGCCAATGTATTCACTGTATCATATTTTAAAAATAATGCATAC
CTAGCTCAGTCTCCACAGCTGTATAAGCAAATGTGCATTTGTGCTGATTTTGAGAAGGTGTTCT
GTATTGGACCAGTTTTCAGAGCTGAAGACTCTAATACCCACAGACATCTGACTGAATTTGTTGG
TCTAGACATTGAAATGGCTTTTAATTATCATTATCATGAAGTTTTAGAAGAAATTGCTGACACC
TTGGTACAAATATTCAAAGGACTTCAAGAAAGGTTTCAGACTGAAATTCAAACCGTGAATAAAC
AGTTCCCTTGTGAACCCTTCAAATTTTTGGAACCAACTTTAAGACTAGAGTATTGTGAAGCTTT
GGCTATGCTTAGAGAAGCTGGAGTTGAAATGGGAGATGAAGAAGATCTGAGTACACCAAATGAA
AAACTATTGGGTCGTTTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATC
CATTGGCTGTAAGACCTTTCTATACCATGCCTGACCCAAGAAATCCTAAACACTCCAACTCTTA
TGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAGCTG
CTAACAGAGAGAGCCTTACATCATGGAATTGATTTGGAGAAAATCAAGGCTTACATTGATTCCT
TCCGTTTTGGAGCCCCTCCTCATGCTGGTGGAGGCATTGGATTGGAACGCGTGACTATGCTGTT
TTTGGGATTGCATAATGTGCGTCAGACCTCGATGTTCCCTCGTGACCCTAAACGACTCACTCCT
TAAAGCCACCATGCTCCTTACTCTTTTCAGGAAGTTACTATTGATCAGGTTGTACCTTAGGTAC
TTAAAATATGCAATAGAATAATTGTCTTATCTAAAGTGCCACAGTTGTTTTTTAATTAATTCAG
TATAGGTTAATTTAGAACAGAAGATTTTTATAACTTCAGACATACTTCAGTAGGAAATGCTTGA
ACGTTTTAAAAAGAAGTTCATATAGTTTATTAAAAAATCATATTCCATTACTACAATAAATGTT
AACAAGAGTTTTAAACAGTTATGATTGTGAACATTTTTTCTGTTCTATATTACGGTGGCCCCAG
TATTAACATCTTAAATTTTCAATATTTGAACTTACTTTTTTAACTTTTGACATTAAGAACAATT
GGAAAAATACCCAAGATTTTAACAAGTATATAACTGGCATCTCATGAAAAATTAGTATCAATTC
TTAAAAGTTATATCCAGAAATCATGTAAAGTGGGTAAAAATACTAGCTAGAAAATAATCAAAAT
AATGCTATATTAAATTGTTAAATGCTAAGTCTGAATTTCAATAAATTTTAAAGCTAATTAAAGT
TTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005315894	(Get FASTA)	NCBI Sequence Viewer
	XP_021576550	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000005639.3
GenBank Protein	KAG3274404	(Get FASTA)	NCBI Sequence Viewer
	KAG3274405	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005315894 ⟸ XM_005315837
- Peptide Label:	isoform X1
- UniProtKB:	I3M7N3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRILVLVRDLTVQRADEVVWVRA RVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIG SCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEEGRATVNQDTRLDNRVIDLRTSTS QAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQM CICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVLEEIADTLVQIFKGLQER FQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKY DTDFYILDKYPLAVRPFYTMPDPRNPKHSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGID LEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP hide sequence

RefSeq Acc Id:

XP_021576550 ⟸ XM_021720875

- Peptide Label:

isoform X2

- Sequence:

show sequence

MVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEV
EGEEEGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAAS
EGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIE
MAFNYHYHEVLEEIADTLVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLR
EAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKHSNSYDMFM
RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLH
NVRQTSMFPRDPKRLTP

hide sequence

RefSeq Acc Id:

ENSSTOP00000005639 ⟸ ENSSTOT00000006306

Protein Domains

Aminoacyl-transfer RNA synthetases class-II family

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006292	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006306.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.140	UniProtKB/TrEMBL
InterPro	Aa-tRNA-synt_II	UniProtKB/TrEMBL
	aa-tRNA-synth_II	UniProtKB/TrEMBL
	aa-tRNA-synth_II/BPL/LPL	UniProtKB/TrEMBL
	Asp-tRNA_synthase_2	UniProtKB/TrEMBL
	Asp/Asn-tRNA-synth_IIb	UniProtKB/TrEMBL
	NA-bd_OB-fold	UniProtKB/TrEMBL
	NA-bd_OB_tRNA	UniProtKB/TrEMBL
NCBI Gene	Dars	ENTREZGENE
PANTHER	ASPARTATE--TRNA LIGASE, CYTOPLASMIC	UniProtKB/TrEMBL
	PTHR43450	UniProtKB/TrEMBL
Pfam	tRNA-synt_2	UniProtKB/TrEMBL
	tRNA_anti-codon	UniProtKB/TrEMBL
PRINTS	TRNASYNTHASP	UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_II	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50249	UniProtKB/TrEMBL
	SSF55681	UniProtKB/TrEMBL
UniProt	I3M7N3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-07-23	Dars1	aspartyl-tRNA synthetase 1	Dars	aspartyl-tRNA synthetase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB