RGD Reference Report - Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. - Rat Genome Database

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Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis.

Authors: Garcia-Rodriguez, S  Arias-Santiago, S  Perandres-Lopez, R  Castellote, L  Zumaquero, E  Navarro, P  Buendia-Eisman, A  Ruiz, JC  Orgaz-Molina, J  Sancho, J  M, ZUBIAUR 
Citation: Garcia-Rodriguez S, etal., J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50.
RGD ID: 7777173
Pubmed: PMID:23457721   (View Abstract at PubMed)

BACKGROUND: A role for the innate immune system in driving the autoimmune T cell cascade in psoriasis has been proposed. Toll-like receptors-(TLR)-2 and -4 play a role in inflammation, atherosclerosis, and their specific role in psoriasis remains unclear. OBJECTIVE: To evaluate TLR2 and TLR4 gene expression levels in peripheral blood mononuclear cells from psoriatic patients. METHODS: Changes in TLR2 4 gene expressions were evaluated using quantitative real-time reverse transcription polymerase chain reaction in peripheral blood mononuclear cells, from twenty-one patients with severe psoriasis, and analysed whether there was any correlation with cytokine plasma levels (T-helper 0-, T-helper 1-, T-helper 2- or regulatory T cells-type), or Calprotectin and with S100A8 and S100A9 gene expression levels. Eleven non-psoriatic healthy controls were analysed. RESULTS: A clear increase in TLR4 gene expression was observed (3.84 +/- 0.93, n = 21) together with a moderate increase in TLR2 expression (1.522 +/- 0.31, n = 21). Both TLR4 and TLR2 gene expressions were significantly augmented in psoriatic patients compared with controls (all P < 0.001). Correlations between TLR2 and S100A9 gene expressions (r = 0.5145, P = 0.0170, n = 21); and between TLR2 expression and plasma interleukin-2 (r = 0.5667, P = 0.0074); interleukin-4 (r = 0.4766, P = 0.0289), interleukin-10 (r = 0.4355, P = 0.0484) and interleukin-13 (r = 0.4603, P = 0.0358), were found. When patients with atheroma plaque were considered (n = 7), both TLR4 (3.47 +/- 0.99, P = 0.0156) and TLR2 (1.63 +/- 0.31, P = 0.0156) expressions were significantly increased vs. controls and correlated with plasma TNF-a (r = 0.8929, P = 0.0123, in both cases). CONCLUSION: Differential TLR4 2 gene expressions on psoriatic peripheral blood mononuclear cells and correlations with regulatory and or proinflammatory cytokines and or damage-associated molecular pattern molecule S100A9 emphasize innate immune response role in psoriasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR2HumanPlaque, Atherosclerotic  IEP associated with Plaque more ...RGD 
TLR4HumanPlaque, Atherosclerotic  IEP associated with Plaque more ...RGD 
Tlr2MousePlaque, Atherosclerotic  ISOTLR2 (Homo sapiens)associated with Plaque more ...RGD 
Tlr2RatPlaque, Atherosclerotic  ISOTLR2 (Homo sapiens)associated with Plaque more ...RGD 
Tlr4RatPlaque, Atherosclerotic  ISOTLR4 (Homo sapiens)associated with Plaque more ...RGD 
Tlr4MousePlaque, Atherosclerotic  ISOTLR4 (Homo sapiens)associated with Plaque more ...RGD 
TLR2Humanpsoriasis  IEP mRNA:increased expression:mononuclear cell:RGD 
TLR4Humanpsoriasis  IEP mRNA:increased expression:mononuclear cell:RGD 
Tlr2Ratpsoriasis  ISOTLR2 (Homo sapiens)mRNA:increased expression:mononuclear cell:RGD 
Tlr2Mousepsoriasis  ISOTLR2 (Homo sapiens)mRNA:increased expression:mononuclear cell:RGD 
Tlr4Ratpsoriasis  ISOTLR4 (Homo sapiens)mRNA:increased expression:mononuclear cell:RGD 
Tlr4Mousepsoriasis  ISOTLR4 (Homo sapiens)mRNA:increased expression:mononuclear cell:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)
TLR4  (toll like receptor 4)


Additional Information