RGD Reference Report - Dec1 and Dec2 are regulators of the mammalian molecular clock. - Rat Genome Database

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Dec1 and Dec2 are regulators of the mammalian molecular clock.

Authors: Honma, S  Kawamoto, T  Takagi, Y  Fujimoto, K  Sato, F  Noshiro, M  Kato, Y  Honma, K 
Citation: Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
RGD ID: 625726
Pubmed: PMID:12397359   (View Abstract at PubMed)
DOI: DOI:10.1038/nature01123   (Journal Full-text)

The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus. Four clock-gene families have been found to be involved in a transcription-translation feedback loop that generates the circadian rhythm at the intracellular level. The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. Protein products of Per act together with Cry proteins to inhibit Per transcription, thus closing the autoregulatory feedback loop. We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 promoter through direct protein-protein interactions with Bmal1 and/or competition for E-box elements. Dec1 and Dec2 are expressed in the suprachiasmic nucleus in a circadian fashion, with a peak in the subjective day. A brief light pulse induced Dec1 but not Dec2 expression in the suprachiasmic nucleus in a phase-dependent manner. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bhlhe40Ratcircadian rhythm involved_inIEP PMID:12397359UniProt 
Bhlhe41Ratcircadian rhythm involved_inIEP PMID:12397359UniProt 
Per2Ratnegative regulation of DNA-templated transcription involved_inIDA PMID:12397359UniProt 
Per2Ratnegative regulation of transcription by RNA polymerase II involved_inIDA PMID:12397359BHF-UCL 
Bhlhe40Ratresponse to light stimulus  IEP  RGD 
Bhlhe40Ratresponse to light stimulus involved_inIDA PMID:12397359UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Bhlhe40  (basic helix-loop-helix family, member e40)
Bhlhe41  (basic helix-loop-helix family, member e41)
Per2  (period circadian regulator 2)

Objects referenced in this article
Gene BHLHE40 basic helix-loop-helix family member e40 Homo sapiens
Gene BHLHE41 basic helix-loop-helix family member e41 Homo sapiens
Gene Bhlhe40 basic helix-loop-helix family, member e40 Mus musculus
Gene Bhlhe41 basic helix-loop-helix family, member e41 Mus musculus

Additional Information