Bhlhe40 (basic helix-loop-helix family, member e40) - Rat Genome Database

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Gene: Bhlhe40 (basic helix-loop-helix family, member e40) Mus musculus
Analyze
Symbol: Bhlhe40
Name: basic helix-loop-helix family, member e40
RGD ID: 68660
MGI Page MGI
Description: Enables DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and E-box binding activity. Involved in circadian regulation of gene expression and entrainment of circadian clock by photoperiod. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human BHLHE40 (basic helix-loop-helix family member e40).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic helix-loop-helix domain containing, class B2; Bhlhb; Bhlhb2; C130042M06Rik; Cla; class B basic helix-loop-helix protein 2; class E basic helix-loop-helix protein 40; Clast5; CR; CR8; cytokine response gene 8; Dec1; differentially expressed in chondrocytes protein 1; E47 interaction protein 1; eip1 (E47 interaction protein 1); Sh; Sharp2; stimulated by retinoic acid gene 13 protein; Str; Stra13; Stra14
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,637,590 - 108,643,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,637,590 - 108,643,886 (+)EnsemblGRCm39 Ensembl
GRCm386108,660,629 - 108,666,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,660,629 - 108,666,925 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,610,623 - 108,616,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366108,626,406 - 108,632,702 (+)NCBIMGSCv36mm8
Celera6110,461,756 - 110,468,060 (+)NCBICelera
Cytogenetic Map6E2NCBI
cM Map649.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
buspirone  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (EXP)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
dichloromethane  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
ferric oxide  (EXP)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycine betaine  (ISO)
Heptachlor epoxide  (EXP)
hypochlorous acid  (EXP)
ifosfamide  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ketamine  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxsalen  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
phenformin  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phenylmercury acetate  (ISO)
phosgene  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
PX-866  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
styrene  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
triticonazole  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear body  (IEA,ISO)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal circadian behavior  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal lymph node germinal center morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal susceptibility to autoimmune disorder  (IAGP)
abnormal T cell activation  (IAGP)
decreased circulating calcium level  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating glycerol level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
decreased double-positive T cell number  (IAGP)
decreased fasting circulating glucose level  (IEA)
decreased interleukin-2 secretion  (IAGP)
decreased T cell proliferation  (IAGP)
delayed circadian behavior phase  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased blood urea nitrogen level  (IEA)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating chloride level  (IEA)
increased circulating fructosamine level  (IEA)
increased circulating iron level  (IEA)
increased double-negative T cell number  (IAGP)
increased heart weight  (IEA)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased spleen germinal center number  (IAGP)
increased spleen white pulp amount  (IAGP)
increased susceptibility to pharmacologically induced seizures  (IAGP)
lymph node hyperplasia  (IAGP)
spleen hyperplasia  (IAGP)
thymus hyperplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Dec1 and Dec2 are regulators of the mammalian molecular clock. Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. Pfisterer P, etal., J Biol Chem 2002 Feb 22;277(8):6637-44. Epub 2001 Dec 10.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7649373   PMID:9050988   PMID:9284045   PMID:10349636   PMID:10702671   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11313924   PMID:11668339   PMID:11879638   PMID:11890681  
PMID:12297495   PMID:12384505   PMID:12477932   PMID:12594185   PMID:12657651   PMID:14581485   PMID:14672706   PMID:15038852   PMID:15108316   PMID:15147242   PMID:15196947   PMID:15465485  
PMID:15472070   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16267380   PMID:16602821   PMID:16878149   PMID:17347673   PMID:17487425   PMID:17502421   PMID:18234890   PMID:18287559  
PMID:18342625   PMID:18411297   PMID:18648504   PMID:18665267   PMID:18799693   PMID:19029909   PMID:19032342   PMID:19208226   PMID:19620969   PMID:19679564   PMID:19786558   PMID:20059953  
PMID:20211142   PMID:20368287   PMID:20412781   PMID:21040902   PMID:21057086   PMID:21267068   PMID:21506129   PMID:21677750   PMID:21873635   PMID:22080784   PMID:22215611   PMID:22244086  
PMID:22569553   PMID:22610404   PMID:22905217   PMID:22988430   PMID:23229312   PMID:23638021   PMID:23878307   PMID:24194600   PMID:24397494   PMID:24699451   PMID:24952961   PMID:24993831  
PMID:25336743   PMID:25340473   PMID:25352248   PMID:25690852   PMID:25963661   PMID:26100875   PMID:26416771   PMID:26468276   PMID:26498531   PMID:26525672   PMID:26697751   PMID:26834156  
PMID:27100196   PMID:27178982   PMID:27226296   PMID:28067313   PMID:28250425   PMID:28408345   PMID:28734031   PMID:29277702   PMID:29438518   PMID:29715265   PMID:29773643   PMID:29773644  
PMID:29882288   PMID:29952285   PMID:30012868   PMID:30973865   PMID:31061528   PMID:31414712   PMID:31533057   PMID:31597354   PMID:31880771   PMID:31884423   PMID:31900338   PMID:31991027  
PMID:32896382   PMID:33238123   PMID:33473114   PMID:33507476   PMID:33607194   PMID:34161515   PMID:34321999   PMID:34551158   PMID:34584158   PMID:34919144   PMID:34987131   PMID:35122398  
PMID:35355710   PMID:35863637   PMID:35908202   PMID:36194917   PMID:36528755   PMID:36614058   PMID:36739947   PMID:36928215   PMID:37341148   PMID:37524711   PMID:37843306   PMID:37934060  
PMID:37990879   PMID:38166556   PMID:38271477   PMID:38355793   PMID:38402153   PMID:38448474   PMID:38619295   PMID:38683120   PMID:38807374  


Genomics

Comparative Map Data
Bhlhe40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,637,590 - 108,643,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,637,590 - 108,643,886 (+)EnsemblGRCm39 Ensembl
GRCm386108,660,629 - 108,666,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,660,629 - 108,666,925 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,610,623 - 108,616,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366108,626,406 - 108,632,702 (+)NCBIMGSCv36mm8
Celera6110,461,756 - 110,468,060 (+)NCBICelera
Cytogenetic Map6E2NCBI
cM Map649.85NCBI
BHLHE40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3834,979,437 - 4,985,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl34,979,437 - 4,985,323 (+)EnsemblGRCh38hg38GRCh38
GRCh3735,021,122 - 5,027,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3634,996,208 - 5,001,861 (+)NCBINCBI36Build 36hg18NCBI36
Build 3434,996,207 - 5,001,861NCBI
Celera34,959,047 - 4,964,811 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef34,954,421 - 4,960,188 (+)NCBIHuRef
CHM1_134,971,113 - 4,976,884 (+)NCBICHM1_1
T2T-CHM13v2.034,970,406 - 4,979,102 (+)NCBIT2T-CHM13v2.0
Bhlhe40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,174,450 - 143,180,150 (+)NCBIGRCr8
mRatBN7.24141,618,453 - 141,624,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,618,476 - 141,624,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4147,040,502 - 147,046,182 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,821,233 - 142,826,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,465,221 - 141,470,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,703,619 - 140,709,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,703,619 - 140,709,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04205,170,129 - 205,175,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,139,486 - 144,145,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14144,384,326 - 144,390,027 (+)NCBI
Celera4130,269,971 - 130,275,671 (+)NCBICelera
Cytogenetic Map4q41NCBI
Bhlhe40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554218,463,018 - 8,468,877 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554218,463,337 - 8,468,877 (-)NCBIChiLan1.0ChiLan1.0
BHLHE40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v224,985,872 - 4,991,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan134,990,663 - 4,996,646 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v034,927,487 - 4,933,215 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.135,028,217 - 5,033,968 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl35,028,515 - 5,032,470 (+)Ensemblpanpan1.1panPan2
BHLHE40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,641,872 - 12,647,519 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,642,702 - 12,647,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2012,616,237 - 12,621,884 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02012,685,779 - 12,691,425 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2012,685,620 - 12,691,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12012,390,474 - 12,396,120 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02012,731,885 - 12,737,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02012,718,100 - 12,723,747 (-)NCBIUU_Cfam_GSD_1.0
Bhlhe40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494211,360,673 - 11,365,809 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365774,315,977 - 4,322,032 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365774,316,099 - 4,321,193 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHLHE40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,526,116 - 61,533,674 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11361,526,121 - 61,533,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21367,830,821 - 67,836,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BHLHE40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12241,049,673 - 41,055,365 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2241,049,712 - 41,055,360 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041125,612,281 - 125,617,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhlhe40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477315,413,365 - 15,420,123 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477315,413,400 - 15,418,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bhlhe40
342 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1640
Count of miRNA genes:698
Interacting mature miRNAs:897
Transcripts:ENSMUST00000032194, ENSMUST00000163617, ENSMUST00000166346
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686783787113521563Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92584287111981699Mouse
1357793Pnhdlc1_mplasma non-HDL cholesterol 1 (mouse)Not determined6105541783114345810Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse
12910776Hcga4b_mhome cage activity 4b (mouse)6104480321110937026Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032194   ⟹   ENSMUSP00000032194
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6108,637,590 - 108,643,886 (+)Ensembl
GRCm38.p6 Ensembl6108,660,629 - 108,666,925 (+)Ensembl
Ensembl Acc Id: ENSMUST00000163617   ⟹   ENSMUSP00000132157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6108,637,835 - 108,639,660 (+)Ensembl
GRCm38.p6 Ensembl6108,660,874 - 108,662,699 (+)Ensembl
Ensembl Acc Id: ENSMUST00000166346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6108,637,760 - 108,638,295 (+)Ensembl
GRCm38.p6 Ensembl6108,660,799 - 108,661,334 (+)Ensembl
Ensembl Acc Id: ENSMUST00000204550
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6108,640,007 - 108,642,626 (+)Ensembl
GRCm38.p6 Ensembl6108,663,046 - 108,665,665 (+)Ensembl
RefSeq Acc Id: NM_011498   ⟹   NP_035628
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396108,637,590 - 108,643,886 (+)NCBI
GRCm386108,660,629 - 108,666,925 (+)ENTREZGENE
MGSCv376108,610,623 - 108,616,919 (+)RGD
Celera6110,461,756 - 110,468,060 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035628   ⟸   NM_011498
- UniProtKB: O35185 (UniProtKB/Swiss-Prot),   P97289 (UniProtKB/Swiss-Prot),   Q542A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000032194   ⟸   ENSMUST00000032194
Ensembl Acc Id: ENSMUSP00000132157   ⟸   ENSMUST00000163617
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35185-F1-model_v2 AlphaFold O35185 1-411 view protein structure

Promoters
RGD ID:6838988
Promoter ID:MM_KWN:47106
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B4,   MEF_B6
Transcripts:NM_011498
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366108,609,656 - 108,610,802 (+)MPROMDB
RGD ID:6890586
Promoter ID:EPDNEW_M8744
Type:initiation region
Name:Bhlhe40_1
Description:Mus musculus basic helix-loop-helix family, member e40 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386108,660,663 - 108,660,723EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1097714 AgrOrtholog
Ensembl Genes ENSMUSG00000030103 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032194 ENTREZGENE
  ENSMUST00000032194.11 UniProtKB/Swiss-Prot
  ENSMUST00000163617.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HES_HEY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orange_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20893 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1097714 ENTREZGENE
NCBI Gene 20893 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bhlhe40 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BHE40_MOUSE UniProtKB/Swiss-Prot
  E9Q2C3_MOUSE UniProtKB/TrEMBL
  O35185 ENTREZGENE
  P97289 ENTREZGENE
  Q52L58_MOUSE UniProtKB/TrEMBL
  Q542A5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97289 UniProtKB/Swiss-Prot