RGD Reference Report - Bcl-XL and Bcl-2 Expression in Bilharzial Squamous Cell Carcinoma of the Urinary Bladder: Which Protein Is Prognostic? - Rat Genome Database

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Bcl-XL and Bcl-2 Expression in Bilharzial Squamous Cell Carcinoma of the Urinary Bladder: Which Protein Is Prognostic?

Authors: Hameed, DA  Abdel Raheem, AM  Mosad, E  Hammouda, HM  Kamel, NA  Abdel Aziz, MA 
Citation: Hameed DA, etal., Urology. 2008 Mar 14;.
RGD ID: 2292910
Pubmed: PMID:18342927   (View Abstract at PubMed)
DOI: DOI:10.1016/j.urology.2007.12.063   (Journal Full-text)

OBJECTIVES: Bcl-2 and Bcl-XL are the most important antiapoptotic members of the Bcl-2 family frequently overexpressed in bladder cancer. Overexpression of Bcl-XL bilharzial-related bladder cancer was associated with tumor progression. However, the negative prognostic value of Bcl-2 expression is still questionable. This work studied the expression of Bcl-XL and Bcl-2 immunohistochemically in bilharzial-related squamous cell carcinoma of the urinary bladder and determined their prognostic value in relation to recurrence after radical cystectomy. METHODS: A total of 72 patients with muscle-invasive bilharzial squamous cell carcinoma of the urinary bladder underwent radical cystectomy at our institution. The specimens were examined immunohistochemically for Bcl-XL and Bcl-2 expression. The patients were followed up for 3 years or until recurrence. The expression of Bcl-XL and Bcl-2 were related to the other prognostic indicators and patient survival. RESULTS: The expressions of both Bcl-2 and Bcl-XL were significantly different according to the grade of malignancy. Bcl-XL expression was significantly related to tumor recurrence, but Bcl-2 expression was not. CONCLUSIONS: To our knowledge, the present study is the first report of a negative prognostic value for Bcl-XL in bilharzial squamous cell carcinoma of the urinary bladder. However, this is another negative report on the prognostic value of bcl-2 in bilharzial bladder tumors.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
BCL2Humanurinary bladder cancer severityIEP  RGD 
BCL2L1Humanurinary bladder cancer disease_progressionIEP  RGD 
Bcl2Raturinary bladder cancer severityISOBCL2 (Homo sapiens) RGD 
Bcl2Mouseurinary bladder cancer severityISOBCL2 (Homo sapiens) RGD 
Bcl2l1Raturinary bladder cancer disease_progressionISOBCL2L1 (Homo sapiens) RGD 
Bcl2l1Mouseurinary bladder cancer disease_progressionISOBCL2L1 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Bcl2  (BCL2, apoptosis regulator) Bcl2l1  (Bcl2-like 1)

Genes (Mus musculus)
Bcl2  (B cell leukemia/lymphoma 2) Bcl2l1  (BCL2-like 1)

Genes (Homo sapiens)
BCL2  (BCL2 apoptosis regulator) BCL2L1  (BCL2 like 1)