Mcemp1 (mast cell-expressed membrane protein 1) - Rat Genome Database

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Gene: Mcemp1 (mast cell-expressed membrane protein 1) Rattus norvegicus
Analyze
Symbol: Mcemp1
Name: mast cell-expressed membrane protein 1
RGD ID: 1565374
Description: Predicted to enable identical protein binding activity. Predicted to be located in membrane. Orthologous to human MCEMP1 (mast cell expressed membrane protein 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498128; LOC498128; RGD1565374; similar to hypothetical protein LOC199675; uncharacterized protein LOC498128
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,519,709 - 6,523,880 (+)NCBIGRCr8
mRatBN7.2121,721,781 - 1,727,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,388,866 - 2,392,478 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,012,436 - 3,016,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,783,441 - 1,787,053 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,211,970 - 2,217,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,213,471 - 2,217,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,372,176 - 4,379,103 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,486,267 - 2,489,878 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera123,578,197 - 3,581,808 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:31104315  


Genomics

Comparative Map Data
Mcemp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,519,709 - 6,523,880 (+)NCBIGRCr8
mRatBN7.2121,721,781 - 1,727,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,388,866 - 2,392,478 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,012,436 - 3,016,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,783,441 - 1,787,053 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,211,970 - 2,217,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,213,471 - 2,217,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,372,176 - 4,379,103 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,486,267 - 2,489,878 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera123,578,197 - 3,581,808 (+)NCBICelera
Cytogenetic Map12p12NCBI
MCEMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,677,090 - 7,679,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,677,088 - 7,679,829 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,741,976 - 7,744,715 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,647,943 - 7,650,719 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,613,125 - 7,615,901 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,411,723 - 7,414,497 (+)NCBIHuRef
CHM1_1197,741,698 - 7,744,472 (+)NCBICHM1_1
T2T-CHM13v2.0197,677,976 - 7,680,714 (+)NCBIT2T-CHM13v2.0
Mcemp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,715,754 - 3,718,916 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,715,754 - 3,719,259 (+)EnsemblGRCm39 Ensembl
GRCm3883,665,762 - 3,668,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,665,754 - 3,669,259 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,665,762 - 3,668,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,665,754 - 3,669,259 (+)NCBIMGSCv36mm8
Celera83,896,091 - 3,899,234 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Mcemp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555631,602,193 - 1,604,836 (-)NCBIChiLan1.0ChiLan1.0
MCEMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,344,290 - 12,351,281 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,461,856 - 11,468,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,966,022 - 6,969,354 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,821,152 - 7,823,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,821,177 - 7,827,590 (+)Ensemblpanpan1.1panPan2
MCEMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,440,815 - 52,443,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,441,384 - 52,443,488 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,245,403 - 52,248,087 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,970,684 - 52,973,370 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12052,174,393 - 52,177,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,618,010 - 52,620,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,849,244 - 52,851,928 (+)NCBIUU_Cfam_GSD_1.0
Mcemp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,121,876 - 213,124,406 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365884,710,910 - 4,714,691 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCEMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1271,473,384 - 71,476,126 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,880,712 - 71,883,444 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCEMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,163,068 - 7,166,861 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,163,591 - 7,166,561 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081694,901 - 697,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcemp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624828740,146 - 742,922 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcemp1
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:64
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000031653
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat

Markers in Region
RH141039  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,725,654 - 1,725,871 (+)MAPPERmRatBN7.2
Rnor_6.0122,216,671 - 2,216,887NCBIRnor6.0
Rnor_5.0124,378,769 - 4,378,985UniSTSRnor5.0
RGSC_v3.4122,486,382 - 2,486,598UniSTSRGSC3.4
Celera123,581,477 - 3,581,693UniSTS
Cytogenetic Map12p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 1 2 10
Low 1 32 21 18 21 2 12 1
Below cutoff 33 23 18 18 8 9 14 31 21 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031653   ⟹   ENSRNOP00000030516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)Ensembl
Rnor_6.0 Ensembl122,213,705 - 2,217,002 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084431   ⟹   ENSRNOP00000071318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)Ensembl
Rnor_6.0 Ensembl122,213,471 - 2,217,433 (+)Ensembl
RefSeq Acc Id: NM_001134602   ⟹   NP_001128074
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,520,267 - 6,523,880 (+)NCBI
mRatBN7.2121,722,376 - 1,725,989 (+)NCBI
Rnor_6.0122,213,705 - 2,217,002 (+)NCBI
Rnor_5.0124,372,176 - 4,379,103 (+)NCBI
RGSC_v3.4122,486,267 - 2,489,878 (-)RGD
Celera123,578,197 - 3,581,808 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598421   ⟹   XP_017453910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,519,709 - 6,523,878 (+)NCBI
mRatBN7.2121,721,781 - 1,727,350 (+)NCBI
Rnor_6.0122,213,177 - 2,217,005 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089664   ⟹   XP_038945592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,519,757 - 6,523,878 (+)NCBI
mRatBN7.2121,721,864 - 1,727,350 (+)NCBI
RefSeq Acc Id: XM_039089666   ⟹   XP_038945594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,519,762 - 6,523,878 (+)NCBI
mRatBN7.2121,721,868 - 1,727,350 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001128074 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453910 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945592 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945594 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL74955 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030516.5
  ENSRNOP00000071318.1
Reference Protein Sequences
RefSeq Acc Id: NP_001128074   ⟸   NM_001134602
- Sequence:
RefSeq Acc Id: XP_017453910   ⟸   XM_017598421
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000030516   ⟸   ENSRNOT00000031653
RefSeq Acc Id: ENSRNOP00000071318   ⟸   ENSRNOT00000084431
RefSeq Acc Id: XP_038945592   ⟸   XM_039089664
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K062 (UniProtKB/TrEMBL),   A6KQ30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945594   ⟸   XM_039089666
- Peptide Label: isoform X3
- UniProtKB: A6KQ30 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K062-F1-model_v2 AlphaFold A0A0G2K062 1-213 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698375
Promoter ID:EPDNEW_R8900
Type:single initiation site
Name:Mcemp1_1
Description:mast cell-expressed membrane protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,213,706 - 2,213,766EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565374 AgrOrtholog
BioCyc Gene G2FUF-20384 BioCyc
Ensembl Genes ENSRNOG00000028259 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031653.5 UniProtKB/TrEMBL
  ENSRNOT00000084431.2 UniProtKB/TrEMBL
Gene3D-CATH Designed four-helix bundle protein UniProtKB/TrEMBL
InterPro MCEMP1 UniProtKB/TrEMBL
KEGG Report rno:498128 UniProtKB/TrEMBL
NCBI Gene 498128 ENTREZGENE
PANTHER MAST CELL-EXPRESSED MEMBRANE PROTEIN 1 UniProtKB/TrEMBL
  PTHR37856 UniProtKB/TrEMBL
Pfam Lectin_N UniProtKB/TrEMBL
PhenoGen Mcemp1 PhenoGen
RatGTEx ENSRNOG00000028259 RatGTEx
UniProt A0A0G2K062 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ30 ENTREZGENE, UniProtKB/TrEMBL
  D4A545_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-23 Mcemp1  mast cell-expressed membrane protein 1  RGD1565374  similar to hypothetical protein LOC199675  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565374  similar to hypothetical protein LOC199675   RGD1565374_predicted  similar to hypothetical protein LOC199675 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565374_predicted  similar to hypothetical protein LOC199675 (predicted)  LOC498128  similar to hypothetical protein LOC199675  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498128  similar to hypothetical protein LOC199675      Symbol and Name status set to provisional 70820 PROVISIONAL