Ect2l (epithelial cell transforming 2 like) - Rat Genome Database

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Gene: Ect2l (epithelial cell transforming 2 like) Rattus norvegicus
Analyze
Symbol: Ect2l
Name: epithelial cell transforming 2 like
RGD ID: 9246970
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human ECT2L (epithelial cell transforming 2 like); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; rotenone.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epithelial cell-transforming sequence 2 oncogene-like; NEWGENE_2319083
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,594,726 - 14,677,321 (-)NCBIGRCr8
mRatBN7.2112,775,705 - 12,857,538 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,778,922 - 12,855,449 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0113,301,918 - 13,372,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,302,256 - 13,341,952 (-)EnsemblRnor6.0rn6Rnor6.0
Celera111,234,398 - 11,301,711 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ect2lRatFamilial Behcet-Like Autoinflammatory Syndrome  ISOECT2L (Homo sapiens)8554872ClinVar Annotator: match by term: Autoinflammatory syndrome more ...ClinVarPMID:25741868

1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ect2lRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ECT2L mRNACTDPMID:30723492
Ect2lRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ECT2L mRNACTDPMID:32145629
Ect2lRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOEct2l (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of ECT2L mRNACTDPMID:21354282
Ect2lRat4,4'-sulfonyldiphenol increases expressionISOEct2l (Mus musculus)6480464bisphenol S results in increased expression of ECT2L mRNACTDPMID:30951980
Ect2lRatAflatoxin B2 alpha decreases methylationISOECT2L (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of ECT2L intronCTDPMID:30157460
Ect2lRatbis(2-ethylhexyl) phthalate decreases expressionISOECT2L (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of ECT2L mRNACTDPMID:31163220
Ect2lRatbisphenol A increases methylationISOECT2L (Homo sapiens)6480464bisphenol A results in increased methylation of ECT2L geneCTDPMID:31601247
Ect2lRatbisphenol F increases expressionISOEct2l (Mus musculus)6480464bisphenol F results in increased expression of ECT2L mRNACTDPMID:30951980
Ect2lRatbuta-1,3-diene decreases expressionISOEct2l (Mus musculus)64804641 and 3-butadiene results in decreased expression of ECT2L mRNACTDPMID:29038090
Ect2lRatozone multiple interactionsISOEct2l (Mus musculus)6480464[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ECT2L mRNACTDPMID:34911549
Ect2lRatrotenone decreases expressionEXP 6480464Rotenone results in decreased expression of ECT2L mRNACTDPMID:28374803

1 to 11 of 11 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ect2lRatguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR0002191600115GO_REF:0000002InterProGO_REF:0000002



Ect2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,594,726 - 14,677,321 (-)NCBIGRCr8
mRatBN7.2112,775,705 - 12,857,538 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,778,922 - 12,855,449 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0113,301,918 - 13,372,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,302,256 - 13,341,952 (-)EnsemblRnor6.0rn6Rnor6.0
Celera111,234,398 - 11,301,711 (-)NCBICelera
Cytogenetic Map1p12NCBI
ECT2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386138,796,087 - 138,904,070 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6138,795,911 - 138,904,070 (+)EnsemblGRCh38hg38GRCh38
GRCh376139,117,224 - 139,225,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366139,176,002 - 139,266,900 (+)NCBINCBI36Build 36hg18NCBI36
Celera6139,857,349 - 139,965,590 (+)NCBICelera
Cytogenetic Map6q24.1NCBI
HuRef6136,678,549 - 136,786,853 (+)NCBIHuRef
CHM1_16139,380,248 - 139,488,189 (+)NCBICHM1_1
T2T-CHM13v2.06139,984,635 - 140,092,615 (+)NCBIT2T-CHM13v2.0
Ect2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391018,004,123 - 18,086,575 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1018,004,651 - 18,086,638 (-)EnsemblGRCm39 Ensembl
GRCm381018,128,375 - 18,210,827 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1018,128,903 - 18,210,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv371017,848,828 - 17,921,159 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361017,848,828 - 17,921,159 (-)NCBIMGSCv36mm8
Celera1018,027,165 - 18,098,726 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map107.47NCBI
Ect2l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543620,754,934 - 20,843,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543620,754,395 - 20,843,015 (-)NCBIChiLan1.0ChiLan1.0
ECT2L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25158,762,241 - 158,868,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16156,659,827 - 156,766,511 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06136,556,048 - 136,662,697 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16140,641,624 - 140,747,937 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6140,641,624 - 140,748,058 (+)Ensemblpanpan1.1panPan2
ECT2L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,069,668 - 31,140,358 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,069,732 - 31,139,325 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,937,114 - 32,015,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0131,223,419 - 31,303,208 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl131,232,949 - 31,300,641 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1131,110,418 - 31,179,588 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0130,982,991 - 31,061,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0131,292,668 - 31,372,882 (+)NCBIUU_Cfam_GSD_1.0
Ect2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946126,111,158 - 126,199,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365605,906,220 - 5,978,849 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365605,906,173 - 5,979,080 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ECT2L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,566,954 - 25,644,277 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,566,955 - 25,644,289 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,702,374 - 28,779,562 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ECT2L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11334,489,321 - 34,594,872 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1334,491,222 - 34,576,744 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660406,660,068 - 6,768,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ect2l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475315,059,107 - 15,150,617 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475315,058,307 - 15,153,975 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ect2l
667 total Variants

1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat

1 to 10 of 26 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 25 113 91 90 59 25 59 6 192 72 93 44 60 31



Ensembl Acc Id: ENSRNOT00000079531   ⟹   ENSRNOP00000069585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl112,778,922 - 12,844,615 (-)Ensembl
Rnor_6.0 Ensembl113,302,256 - 13,341,952 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106421   ⟹   ENSRNOP00000076783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl112,778,922 - 12,855,449 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111146   ⟹   ENSRNOP00000096956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl112,778,922 - 12,855,449 (-)Ensembl
RefSeq Acc Id: XM_063276198   ⟹   XP_063132268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276201   ⟹   XP_063132271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276203   ⟹   XP_063132273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276207   ⟹   XP_063132277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276216   ⟹   XP_063132286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276225   ⟹   XP_063132295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276233   ⟹   XP_063132303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276240   ⟹   XP_063132310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XM_063276242   ⟹   XP_063132312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,637,586 (-)NCBI
RefSeq Acc Id: XM_063276245   ⟹   XP_063132315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,618,467 - 14,677,321 (-)NCBI
RefSeq Acc Id: XR_010058838
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
RefSeq Acc Id: XR_010058839
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,594,726 - 14,677,321 (-)NCBI
1 to 5 of 13 rows
1 to 5 of 13 rows
Ensembl Acc Id: ENSRNOP00000069585   ⟸   ENSRNOT00000079531
Ensembl Acc Id: ENSRNOP00000076783   ⟸   ENSRNOT00000106421
Ensembl Acc Id: ENSRNOP00000096956   ⟸   ENSRNOT00000111146
RefSeq Acc Id: XP_063132273   ⟸   XM_063276203
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJA2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132271   ⟸   XM_063276201
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJA2 (UniProtKB/TrEMBL)
DH

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVR2-F1-model_v2 AlphaFold A0A0G2JVR2 1-846 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-62278 BioCyc
Ensembl Genes ENSRNOG00000055142 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079531 ENTREZGENE
  ENSRNOT00000079531.2 UniProtKB/TrEMBL
  ENSRNOT00000106421 ENTREZGENE
  ENSRNOT00000106421.1 UniProtKB/TrEMBL
  ENSRNOT00000111146 ENTREZGENE
  ENSRNOT00000111146.1 UniProtKB/TrEMBL
  ENSRNOT00000137614 ENTREZGENE
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  DUF4347 UniProtKB/TrEMBL
  F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  GEF_Ubiquitin-Prot_Reg UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Ect2l ENTREZGENE
PANTHER EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE UniProtKB/TrEMBL
  EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE UniProtKB/TrEMBL
Pfam DUF4347 UniProtKB/TrEMBL
  F-box-like UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PhenoGen Ect2l PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055142 RatGTEx
SMART FBOX UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF81383 UniProtKB/TrEMBL
UniProt A0A0G2JVR2_RAT UniProtKB/TrEMBL
  A0A8I5ZJA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AR56_RAT UniProtKB/TrEMBL
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ect2l  epithelial cell transforming 2 like  NEWGENE_2319083  epithelial cell transforming 2 like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED