Klhl24 (kelch-like family member 24) - Rat Genome Database

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Gene: Klhl24 (kelch-like family member 24) Rattus norvegicus
Analyze
Symbol: Klhl24
Name: kelch-like family member 24
RGD ID: 727971
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in intermediate filament organization; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in adherens junction and desmosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and familial hypertrophic cardiomyopathy. Orthologous to human KLHL24 (kelch like family member 24); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dre1; kainate receptor-interacting protein for GluR6; kelch-like 24; kelch-like 24 (Drosophila); kelch-like protein 24; KRIP6; MGC105289
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,348,024 - 94,382,085 (-)NCBIGRCr8
mRatBN7.21180,843,621 - 80,877,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,846,755 - 80,877,636 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,566,617 - 89,597,436 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,219,965 - 82,250,790 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,281,103 - 81,311,931 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,613,101 - 84,643,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,615,760 - 84,633,504 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,675,249 - 87,705,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41183,094,560 - 83,126,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11183,152,149 - 83,184,206 (-)NCBI
Celera1179,681,696 - 79,711,857 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl24Rat3-methylcrotonyl-CoA carboxylase 1 deficiency  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: 3 Alpha methylcrotonylglycinuria 1ClinVarPMID:11181649 more ...
Klhl24Ratcardiomyopathy  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: CardiomyopathyClinVarPMID:25741868 more ...
Klhl24Ratcongenital disorder of glycosylation Id  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type 1DClinVarPMID:11181649 more ...
Klhl24RatCurrarino syndrome  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: Currarino triadClinVarPMID:21681106 and PMID:27549440
Klhl24Ratepidermolysis bullosa simplex generalized type  ISOKLHL24 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Klhl24RatGeneralized Epidermolysis Bullosa Simplex 1B  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: Epidermolysis bullosa simplex and Koebner typeClinVarPMID:25741868 more ...
Klhl24RatGeneralized Epidermolysis Bullosa Simplex 6 with Scarring and Hair Loss  ISOKLHL24 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Klhl24Ratgenetic disease  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Klhl24Rathypertrophic cardiomyopathy  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:25741868 more ...
Klhl24RatHypertrophic Cardiomyopathy 29  ISOKLHL24 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Klhl24Ratvitamin D-dependent rickets type 1A  ISOKLHL24 (Homo sapiens)8554872ClinVar Annotator: match by term: VITAMIN D DEPENDENCY and TYPE 1ClinVarPMID:25741868 more ...
1 to 11 of 11 rows

1 to 20 of 182 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl24Rat(-)-alpha-phellandrene increases expressionISOKLHL24 (Homo sapiens)6480464alpha phellandrene results in increased expression of KLHL24 mRNACTDPMID:25075043
Klhl24Rat(-)-demecolcine increases expressionISOKLHL24 (Homo sapiens)6480464Demecolcine results in increased expression of KLHL24 mRNACTDPMID:23649840
Klhl24Rat1,2-dichloroethane decreases expressionISOKlhl24 (Mus musculus)6480464ethylene dichloride results in decreased expression of KLHL24 mRNACTDPMID:28189721 and PMID:28960355
Klhl24Rat1,2-dimethylhydrazine decreases expressionISOKlhl24 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of KLHL24 mRNACTDPMID:22206623
Klhl24Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of KLHL24 mRNACTDPMID:29097150
Klhl24Rat17beta-estradiol multiple interactionsISOKLHL24 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of KLHL24 mRNACTDPMID:20660070
Klhl24Rat17beta-estradiol decreases expressionISOKLHL24 (Homo sapiens)6480464Estradiol results in decreased expression of KLHL24 mRNACTDPMID:31614463
Klhl24Rat17beta-estradiol decreases expressionISOKlhl24 (Mus musculus)6480464Estradiol results in decreased expression of KLHL24 mRNACTDPMID:39298647
Klhl24Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of KLHL24 mRNACTDPMID:32145629
Klhl24Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOKLHL24 (Homo sapiens)64804642 more ...CTDPMID:19095052
Klhl24Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of KLHL24 mRNACTDPMID:21215274
Klhl24Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of KLHL24 mRNACTDPMID:23238561 and PMID:32109520
Klhl24Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOKlhl24 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of KLHL24 mRNACTDPMID:23238561
Klhl24Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOKlhl24 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of KLHL24 mRNACTDPMID:21570461
Klhl24Rat2-hydroxypropanoic acid increases expressionISOKLHL24 (Homo sapiens)6480464Lactic Acid results in increased expression of KLHL24 mRNACTDPMID:30851411
Klhl24Rat3,3',4,4'-tetrachlorobiphenyl affects expressionISOKLHL24 (Homo sapiens)64804643 more ...CTDPMID:20638727
Klhl24Rat3,4-dichloroaniline increases expressionEXP 64804643 and 4-dichloroaniline results in increased expression of KLHL24 mRNACTDPMID:24172598
Klhl24Rat4,4'-sulfonyldiphenol decreases expressionISOKlhl24 (Mus musculus)6480464bisphenol S results in decreased expression of KLHL24 mRNACTDPMID:39298647
Klhl24Rat4-hydroxyphenyl retinamide increases expressionISOKlhl24 (Mus musculus)6480464Fenretinide results in increased expression of KLHL24 mRNACTDPMID:28973697
Klhl24Rat4-hydroxyphenyl retinamide decreases expressionISOKlhl24 (Mus musculus)6480464Fenretinide results in decreased expression of KLHL24 mRNACTDPMID:28973697

1 to 20 of 182 rows

Biological Process
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl24Ratintermediate filament organization involved_inIEAUniProtKB:Q6TFL4 and ensembl:ENSP000002428101600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl24Ratintermediate filament organization involved_inISOKLHL24 (Homo sapiens)1624291 PMID:27889062RGDPMID:27889062
Klhl24Ratintermediate filament organization involved_inISSUniProtKB:Q6TFL41600115GO_REF:0000024UniProtGO_REF:0000024
Klhl24Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Klhl24Ratprotein autoubiquitination involved_inISSUniProtKB:Q6TFL41600115GO_REF:0000024UniProtGO_REF:0000024
Klhl24Ratprotein autoubiquitination involved_inISOKLHL24 (Homo sapiens)1624291 PMID:27798626RGDPMID:27798626
Klhl24Ratprotein autoubiquitination involved_inIEAUniProtKB:Q6TFL4 and ensembl:ENSP000002428101600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl24Ratprotein ubiquitination involved_inISSUniProtKB:Q6TFL41600115GO_REF:0000024UniProtGO_REF:0000024
Klhl24Ratprotein ubiquitination involved_inIEAUniProtKB:Q6TFL4 and ensembl:ENSP000002428101600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl24Ratprotein ubiquitination involved_inISOKLHL24 (Homo sapiens)1624291 PMID:27798626RGDPMID:27798626
1 to 10 of 10 rows

Cellular Component
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl24Ratadherens junction located_inIEAUniProtKB:Q6TFL4 and ensembl:ENSP000002428101600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl24Ratadherens junction located_inIEAUniProtKB-SubCell:SL-00091600115GO_REF:0000044UniProtGO_REF:0000044
Klhl24Ratadherens junction located_inISOKLHL24 (Homo sapiens)1624291 PMID:27889062RGDPMID:27889062
Klhl24Ratadherens junction located_inISSUniProtKB:Q6TFL41600115GO_REF:0000024UniProtGO_REF:0000024
Klhl24Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Klhl24Rataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
Klhl24Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Klhl24RatCul3-RING ubiquitin ligase complex part_ofISSUniProtKB:Q6TFL41600115GO_REF:0000024UniProtGO_REF:0000024
Klhl24RatCul3-RING ubiquitin ligase complex part_ofIEAUniProtKB:Q6TFL4 and ensembl:ENSP000002428101600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl24RatCul3-RING ubiquitin ligase complex part_ofIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Klhl24RatCul3-RING ubiquitin ligase complex part_ofISOKLHL24 (Homo sapiens)1624291 PMID:27798626RGDPMID:27798626
Klhl24Ratcytoplasm located_inISSUniProtKB:Q6TFL41600115GO_REF:0000024UniProtGO_REF:0000024
Klhl24Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Klhl24Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Klhl24Ratcytoplasm is_active_inIBAMGI:1858732 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Klhl24Ratcytoplasm located_inISOKLHL24 (Homo sapiens)1624291 PMID:27889062RGDPMID:27889062
Klhl24Ratcytoplasm located_inIEAUniProtKB:Q6TFL4 and ensembl:ENSP000002428101600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl24Ratdesmosome located_inIEAUniProtKB:Q6TFL4 and ensembl:ENSP000002428101600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl24Ratdesmosome located_inIEAUniProtKB-SubCell:SL-00921600115GO_REF:0000044UniProtGO_REF:0000044
Klhl24Ratdesmosome located_inISOKLHL24 (Homo sapiens)1624291 PMID:27889062RGDPMID:27889062
1 to 20 of 22 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl24Ratprotein binding enablesISOKLHL24 (Homo sapiens)1624291UniProtKB:O43639 more ...RGDPMID:27798626 more ...
Klhl24Ratubiquitin-like ligase-substrate adaptor activity enablesIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:15489334   PMID:17254796   PMID:21873635   PMID:27798626   PMID:27889062  



Klhl24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,348,024 - 94,382,085 (-)NCBIGRCr8
mRatBN7.21180,843,621 - 80,877,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,846,755 - 80,877,636 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,566,617 - 89,597,436 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,219,965 - 82,250,790 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,281,103 - 81,311,931 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,613,101 - 84,643,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,615,760 - 84,633,504 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,675,249 - 87,705,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41183,094,560 - 83,126,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11183,152,149 - 83,184,206 (-)NCBI
Celera1179,681,696 - 79,711,857 (-)NCBICelera
Cytogenetic Map11q23NCBI
KLHL24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,635,623 - 183,684,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3183,635,610 - 183,684,519 (+)EnsemblGRCh38hg38GRCh38
GRCh373183,353,411 - 183,402,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363184,836,105 - 184,885,001 (+)NCBINCBI36Build 36hg18NCBI36
Celera3181,794,950 - 181,843,839 (+)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3180,759,268 - 180,810,190 (+)NCBIHuRef
CHM1_13183,317,525 - 183,366,726 (+)NCBICHM1_1
T2T-CHM13v2.03186,445,098 - 186,493,998 (+)NCBIT2T-CHM13v2.0
Klhl24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391619,916,286 - 19,947,976 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1619,916,292 - 19,947,971 (+)EnsemblGRCm39 Ensembl
GRCm381620,097,553 - 20,129,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,097,542 - 20,129,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv371620,097,627 - 20,127,817 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,011,097 - 20,041,287 (+)NCBIMGSCv36mm8
Celera1620,661,389 - 20,691,296 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.36NCBI
Klhl24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,700,035 - 23,735,301 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,700,030 - 23,733,021 (-)NCBIChiLan1.0ChiLan1.0
KLHL24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22181,505,763 - 181,569,697 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13181,510,545 - 181,574,403 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03180,669,767 - 180,731,186 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13188,837,980 - 188,888,933 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3188,839,457 - 188,885,385 (+)Ensemblpanpan1.1panPan2
KLHL24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,583,683 - 16,625,778 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,590,368 - 16,621,041 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,671,915 - 20,713,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,491,764 - 16,533,422 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,491,815 - 16,533,348 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,530,507 - 16,572,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,517,530 - 16,559,186 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03416,755,202 - 16,797,365 (+)NCBIUU_Cfam_GSD_1.0
Klhl24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602120,024,263 - 120,061,122 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365786,116,068 - 6,151,297 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365786,116,117 - 6,151,244 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13121,570,591 - 121,608,139 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113121,564,833 - 121,608,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,001,698 - 131,061,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,732,347 - 5,780,154 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,732,928 - 5,780,143 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,515,358 - 14,565,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,807,780 - 72,844,190 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,803,070 - 72,843,627 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Klhl24
215 total Variants

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:78
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000052120
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat

1 to 10 of 18 rows
AI104888  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,873,771 - 80,874,021 (+)MAPPERmRatBN7.2
Rnor_6.01184,639,747 - 84,639,996NCBIRnor6.0
Rnor_5.01187,701,895 - 87,702,144UniSTSRnor5.0
RGSC_v3.41183,122,223 - 83,122,472UniSTSRGSC3.4
Celera1179,708,017 - 79,708,266UniSTS
RH 3.4 Map11686.4UniSTS
Cytogenetic Map11q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000052120   ⟹   ENSRNOP00000050815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,846,755 - 80,877,636 (-)Ensembl
Rnor_6.0 Ensembl1184,615,760 - 84,633,504 (-)Ensembl
RefSeq Acc Id: NM_001394229   ⟹   NP_001381158
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,351,157 - 94,382,050 (-)NCBI
mRatBN7.21180,846,754 - 80,877,649 (-)NCBI
RefSeq Acc Id: NM_181473   ⟹   NP_852138
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,351,157 - 94,382,050 (-)NCBI
mRatBN7.21180,846,754 - 80,877,649 (-)NCBI
Rnor_6.01184,613,101 - 84,643,674 (-)NCBI
Rnor_5.01187,675,249 - 87,705,822 (-)NCBI
RGSC_v3.41183,094,560 - 83,126,617 (-)RGD
Celera1179,681,696 - 79,711,857 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088275   ⟹   XP_038944203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,348,024 - 94,381,998 (-)NCBI
mRatBN7.21180,843,621 - 80,876,680 (-)NCBI
RefSeq Acc Id: XM_039088276   ⟹   XP_038944204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,348,024 - 94,381,374 (-)NCBI
mRatBN7.21180,843,621 - 80,876,889 (-)NCBI
RefSeq Acc Id: XM_063270469   ⟹   XP_063126539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,348,024 - 94,381,998 (-)NCBI
RefSeq Acc Id: XM_063270470   ⟹   XP_063126540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,348,024 - 94,381,962 (-)NCBI
RefSeq Acc Id: XM_063270471   ⟹   XP_063126541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,348,024 - 94,381,937 (-)NCBI
RefSeq Acc Id: XM_063270472   ⟹   XP_063126542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,348,024 - 94,382,085 (-)NCBI
RefSeq Acc Id: XM_063270473   ⟹   XP_063126543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,348,024 - 94,381,998 (-)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_852138   ⟸   NM_181473
- UniProtKB: Q812D9 (UniProtKB/Swiss-Prot),   Q56A24 (UniProtKB/Swiss-Prot),   A6JSC2 (UniProtKB/TrEMBL),   F1LNL5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050815   ⟸   ENSRNOT00000052120
RefSeq Acc Id: XP_038944204   ⟸   XM_039088276
- Peptide Label: isoform X1
- UniProtKB: Q56A24 (UniProtKB/Swiss-Prot),   Q812D9 (UniProtKB/Swiss-Prot),   A6JSC2 (UniProtKB/TrEMBL),   F1LNL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944203   ⟸   XM_039088275
- Peptide Label: isoform X1
- UniProtKB: Q56A24 (UniProtKB/Swiss-Prot),   Q812D9 (UniProtKB/Swiss-Prot),   A6JSC2 (UniProtKB/TrEMBL),   F1LNL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381158   ⟸   NM_001394229
- UniProtKB: Q56A24 (UniProtKB/Swiss-Prot),   Q812D9 (UniProtKB/Swiss-Prot),   A6JSC2 (UniProtKB/TrEMBL),   F1LNL5 (UniProtKB/TrEMBL)
BACK   BTB

Name Modeler Protein Id AA Range Protein Structure
AF-Q56A24-F1-model_v2 AlphaFold Q56A24 1-600 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20711 BioCyc
Ensembl Genes ENSRNOG00000033372 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000052120 ENTREZGENE
  ENSRNOT00000052120.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot
  2.120.10.80 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312023 IMAGE-MGC_LOAD
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  KLHL24 UniProtKB/Swiss-Prot
  KLHL24_BACK UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:303803 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105289 IMAGE-MGC_LOAD
NCBI Gene 303803 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/Swiss-Prot
  PTHR24412:SF215 UniProtKB/Swiss-Prot
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
PhenoGen Klhl24 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033372 RatGTEx
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot
UniProt A6JSC2 ENTREZGENE, UniProtKB/TrEMBL
  F1LNL5 ENTREZGENE, UniProtKB/TrEMBL
  KLH24_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q812D9 ENTREZGENE
UniProt Secondary Q812D9 UniProtKB/Swiss-Prot
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Klhl24  kelch-like family member 24  Klhl24  kelch-like 24 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Klhl24  kelch-like 24 (Drosophila)  Dre1  Dre1 protein  Symbol and Name updated 1299863 APPROVED
2005-07-08 Dre1  Dre1 protein      Symbol and Name status set to approved 1299863 APPROVED