Fbxo11 (F-box protein 11) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fbxo11 (F-box protein 11) Rattus norvegicus
Analyze
Symbol: Fbxo11
Name: F-box protein 11
RGD ID: 727935
Description: Predicted to enable protein-arginine N-methyltransferase activity; ubiquitin-like ligase-substrate adaptor activity; and ubiquitin-protein transferase activity. Involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel and positive regulation of protein catabolic process. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box only protein 11; F-box only protein 11-like; LOC103689957; Vit1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,240,348 - 12,316,223 (+)NCBIGRCr8
mRatBN7.266,486,761 - 6,562,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,486,015 - 6,562,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx66,820,525 - 6,844,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,129,930 - 7,154,210 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,657,075 - 6,681,355 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,662,356 - 11,737,427 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,662,356 - 11,686,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,634,305 - 21,709,376 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0621,398,929 - 21,414,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4611,542,561 - 11,566,829 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1611,542,560 - 11,566,829 (-)NCBI
Celera66,301,914 - 6,326,193 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11Ratbreast carcinoma amelioratesISOFBXO11 (Homo sapiens)152025262human constructs and cell line in a mouse modelRGD 
Fbxo11Rathepatitis B  ISOFBXO11 (Homo sapiens)9068941associated with hepatocellular carcinoma and protein:increased expression:liver (human)RGDPMID:29603830 and REF_RGD_ID:152025266
Fbxo11Rathepatocellular carcinoma exacerbatesISOFBXO11 (Homo sapiens)152025259mRNA:increased expression:liver (human)RGD 
Fbxo11Rathepatocellular carcinoma amelioratesISOFBXO11 (Homo sapiens)9068941mRNA:increased expression:liver (human)RGDPMID:32657545 and REF_RGD_ID:152025263
Fbxo11Ratlung non-small cell carcinoma treatmentISOFBXO11 (Homo sapiens)152025265 RGD 
Fbxo11Ratstomach cancer  ISOFBXO11 (Homo sapiens)152025261protein:increased expression:stomach (human)RGD 
Fbxo11Ratstomach cancer exacerbatesISOFBXO11 (Homo sapiens)152025260mRNA and protein:increased expression:stomach (human)RGD 
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11RatDevelopmental Disease  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868 and PMID:28492532
Fbxo11Ratgenetic disease  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24728327 more ...
Fbxo11RatHereditary Neoplastic Syndromes  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:19250818 more ...
Fbxo11Rathereditary nonpolyposis colorectal cancer type 5  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Colorectal cancer more ...ClinVarPMID:19250818 more ...
Fbxo11RatINTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND BEHAVIORAL ABNORMALITIES  ISOFBXO11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
Fbxo11Ratintellectual disability  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868 and PMID:28492532
Fbxo11RatLynch syndrome  ISOFBXO11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14520694 more ...
Fbxo11RatMarfanoid Mental Retardation Syndrome, Autosomal  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Marfanoid habitus and intellectual disabilityClinVarPMID:25741868 more ...
Fbxo11RatNeurodevelopmental Disorders  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:24728327 more ...
Fbxo11Ratobesity  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: ObesityClinVar 
Fbxo11RatPitt-Hopkins-like syndrome 2  ISOFBXO11 (Homo sapiens)8554872ClinVar Annotator: match by term: Pitt-Hopkins-like syndrome 2ClinVarPMID:28492532
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11Ratotitis media  ISSFbxo11 (Mus musculus)13592920OMIM:166760MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11RatINTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND BEHAVIORAL ABNORMALITIES  ISOFBXO11 (Homo sapiens)7240710 OMIM 

1 to 20 of 65 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11Rat1,2-dimethylhydrazine multiple interactionsISOFbxo11 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FBXO11 mRNACTDPMID:22206623
Fbxo11Rat1,2-dimethylhydrazine decreases expressionISOFbxo11 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of FBXO11 mRNACTDPMID:22206623
Fbxo11Rat17alpha-ethynylestradiol affects expressionISOFbxo11 (Mus musculus)6480464Ethinyl Estradiol affects the expression of FBXO11 mRNACTDPMID:17555576
Fbxo11Rat17beta-estradiol affects expressionISOFBXO11 (Homo sapiens)6480464Estradiol affects the expression of FBXO11 mRNACTDPMID:22574217
Fbxo11Rat17beta-estradiol multiple interactionsISOFBXO11 (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FBXO11 mRNACTDPMID:20823114
Fbxo11Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of FBXO11 mRNACTDPMID:33387578
Fbxo11Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of FBXO11 mRNACTDPMID:21346803
Fbxo11Ratacetylsalicylic acid increases expressionISOFBXO11 (Homo sapiens)6480464Aspirin results in increased expression of FBXO11 mRNACTDPMID:15928584
Fbxo11Rataflatoxin B1 decreases methylationISOFBXO11 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of FBXO11 geneCTDPMID:27153756
Fbxo11Rataflatoxin M1 decreases expressionISOFBXO11 (Homo sapiens)6480464Aflatoxin M1 results in decreased expression of FBXO11 mRNACTDPMID:30928695
Fbxo11Ratantirheumatic drug increases expressionISOFBXO11 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of FBXO11 mRNACTDPMID:24449571
Fbxo11Rataristolochic acid A decreases expressionISOFBXO11 (Homo sapiens)6480464aristolochic acid I results in decreased expression of FBXO11 mRNACTDPMID:33212167
Fbxo11Ratarsane multiple interactionsISOFBXO11 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FBXO11 mRNACTDPMID:39836092
Fbxo11Ratarsenic atom multiple interactionsISOFBXO11 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FBXO11 mRNACTDPMID:39836092
Fbxo11Ratatrazine increases expressionISOFBXO11 (Homo sapiens)6480464Atrazine results in increased expression of FBXO11 mRNACTDPMID:22378314
Fbxo11Ratbenzo[a]pyrene diol epoxide I decreases expressionISOFBXO11 (Homo sapiens)64804647 more ...CTDPMID:19150397 and PMID:20018196
Fbxo11Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of FBXO11 mRNACTDPMID:25181051
Fbxo11Ratbisphenol A decreases expressionISOFbxo11 (Mus musculus)6480464bisphenol A results in decreased expression of FBXO11 mRNACTDPMID:33221593
Fbxo11Ratbucladesine multiple interactionsISOFBXO11 (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FBXO11 mRNACTDPMID:20823114
Fbxo11Ratcadmium dichloride decreases methylationEXP 6480464Cadmium Chloride results in decreased methylation of FBXO11 promoterCTDPMID:22457795

1 to 20 of 65 rows

Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11Ratnegative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  IMP 152176655 RGD 
Fbxo11Ratnegative regulation of epithelial to mesenchymal transition involved_inISSUniProtKB:Q86XK21600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo11Ratnegative regulation of epithelial to mesenchymal transition involved_inIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratnegative regulation of epithelial to mesenchymal transition involved_inISOFBXO11 (Homo sapiens)1624291 PMID:25827072RGDPMID:25827072
Fbxo11Ratpositive regulation of protein catabolic process  IMP 152176655 RGD 
Fbxo11Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inISSUniProtKB:Q86XK21600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo11Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inISOFBXO11 (Homo sapiens)1624291 PMID:25827072 and PMID:29059170RGDPMID:25827072 and PMID:29059170
Fbxo11Ratprotein modification process involved_inIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratprotein modification process involved_inISOFBXO11 (Homo sapiens)1624291 PMID:16487488RGDPMID:16487488
Fbxo11Ratprotein ubiquitination involved_inIEAUniPathway:UPA001431600115GO_REF:0000041UniProtGO_REF:0000041
Fbxo11Ratregulation of apoptotic process involved_inIBAPANTHER:PTN000542389 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fbxo11Ratsensory perception of sound involved_inISOFbxo11 (Mus musculus)1624291 PMID:17035249RGDPMID:17035249
Fbxo11Ratsensory perception of sound acts_upstream_of_or_withinISOFbxo11 (Mus musculus)1624291MGI:1861993 PMID:10932191RGDPMID:10932191
Fbxo11Ratsensory perception of sound acts_upstream_of_or_withinIEAUniProtKB:Q7TPD1 and ensembl:ENSMUSP000001212061600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratubiquitin-dependent protein catabolic process involved_inIBAPANTHER:PTN000542389 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 16 of 16 rows

Cellular Component
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11Ratchromosome located_inIEAUniProtKB-SubCell:SL-04681600115GO_REF:0000044UniProtGO_REF:0000044
Fbxo11Ratchromosome located_inIEAUniProtKB-KW:KW-01581600115GO_REF:0000043UniProtGO_REF:0000043
Fbxo11Ratcytoplasm located_inIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratcytoplasm located_inISOFBXO11 (Homo sapiens)1624291 PMID:16487488RGDPMID:16487488
Fbxo11Ratnucleolus located_inISOFBXO11 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Fbxo11Ratnucleolus located_inIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratnucleoplasm located_inIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratnucleoplasm located_inISOFBXO11 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Fbxo11Ratnucleus is_active_inISOFBXO11 (Homo sapiens)1624291 PMID:25827072RGDPMID:25827072
Fbxo11Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Fbxo11Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Fbxo11Ratnucleus located_inIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratnucleus located_inISOFBXO11 (Homo sapiens)1624291 PMID:16487488RGDPMID:16487488
1 to 13 of 13 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Fbxo11Ratprotein binding enablesISOFBXO11 (Homo sapiens)1624291UniProtKB:O95863 more ...RGDPMID:17098746 more ...
Fbxo11Ratprotein binding enablesISOFbxo11 (Mus musculus)1624291UniProtKB:P41183 and PMID:22113614RGDPMID:22113614
Fbxo11Ratprotein-arginine N-methyltransferase activity enablesIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratprotein-arginine N-methyltransferase activity enablesISOFBXO11 (Homo sapiens)1624291 PMID:16487488RGDPMID:16487488
Fbxo11Ratubiquitin-like ligase-substrate adaptor activity enablesISOFBXO11 (Homo sapiens)1624291 PMID:25827072RGDPMID:25827072
Fbxo11Ratubiquitin-like ligase-substrate adaptor activity enablesIEAUniProtKB:Q86XK2 and ensembl:ENSP000003848231600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratubiquitin-like ligase-substrate adaptor activity enablesISSUniProtKB:Q86XK21600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo11Ratubiquitin-protein transferase activity enablesIEAUniProtKB:Q7TPD1 and ensembl:ENSMUSP000001212061600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo11Ratubiquitin-protein transferase activity enablesISOFbxo11 (Mus musculus)1624291 PMID:22113614RGDPMID:22113614
Fbxo11Ratzinc ion binding enablesIEAInterPro:IPR0031261600115GO_REF:0000002InterProGO_REF:0000002
Fbxo11Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
1 to 12 of 12 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo11Ratp53 signaling pathway   ISOFBXO11 (Homo sapiens)6484113 PIDPID:200206

1 to 12 of 12 rows
#
Reference Title
Reference Citation
1. miR-324-5p upregulation potentiates resistance to cisplatin by targeting FBXO11 signalling in non-small cell lung cancer cells. Ba Z, etal., J Biochem. 2019 Dec 1;166(6):517-527. doi: 10.1093/jb/mvz066.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Modulation of Ca2+-induced Ca2+ release by ubiquitin protein ligase E3 component n-recognin UBR3 and 6 in cardiac myocytes. Ma XE, etal., Channels (Austin). 2020 Dec;14(1):326-335. doi: 10.1080/19336950.2020.1824957.
4. The tumor suppressive miR-26a regulation of FBXO11 inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. Ma Y, etal., Biomed Pharmacother. 2018 May;101:648-655. doi: 10.1016/j.biopha.2018.02.118. Epub 2018 Mar 22.
5. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT. Sun C, etal., Biomed Pharmacother. 2018 Feb;98:416-423. doi: 10.1016/j.biopha.2017.12.088. Epub 2017 Dec 27.
11. LINC01436, regulating miR-585 and FBXO11, is an oncogenic lncRNA in the progression of gastric cancer. Zhang Y, etal., Cell Biol Int. 2020 Mar;44(3):882-893. doi: 10.1002/cbin.11287. Epub 2020 Jan 8.
12. PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. Zheng H, etal., Cancer Cell. 2014 Sep 8;26(3):358-373. doi: 10.1016/j.ccr.2014.07.022.
1 to 12 of 12 rows
PMID:10932191   PMID:16487488   PMID:17035249   PMID:19028597   PMID:22113614  



Fbxo11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,240,348 - 12,316,223 (+)NCBIGRCr8
mRatBN7.266,486,761 - 6,562,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,486,015 - 6,562,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx66,820,525 - 6,844,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,129,930 - 7,154,210 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,657,075 - 6,681,355 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,662,356 - 11,737,427 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,662,356 - 11,686,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,634,305 - 21,709,376 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0621,398,929 - 21,414,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4611,542,561 - 11,566,829 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1611,542,560 - 11,566,829 (-)NCBI
Celera66,301,914 - 6,326,193 (+)NCBICelera
Cytogenetic Map6q12NCBI
FBXO11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,806,920 - 47,906,498 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,789,316 - 47,906,498 (-)EnsemblGRCh38hg38GRCh38
GRCh37248,034,059 - 48,133,637 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,887,563 - 47,986,318 (-)NCBINCBI36Build 36hg18NCBI36
Build 34247,957,375 - 48,044,465NCBI
Celera247,873,581 - 47,972,357 (-)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef247,770,542 - 47,869,544 (-)NCBIHuRef
CHM1_1247,964,454 - 48,063,258 (-)NCBICHM1_1
T2T-CHM13v2.0247,812,869 - 47,912,466 (-)NCBIT2T-CHM13v2.0
Fbxo11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,298,287 - 88,373,473 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,298,287 - 88,372,719 (-)EnsemblGRCm39 Ensembl
GRCm381787,990,859 - 88,066,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,990,859 - 88,065,291 (-)EnsemblGRCm38mm10GRCm38
MGSCv371788,390,199 - 88,464,625 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361787,899,185 - 87,973,611 (-)NCBIMGSCv36mm8
Celera1792,401,160 - 92,425,975 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
Fbxo11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544114,471,283 - 14,553,916 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544114,471,283 - 14,495,508 (-)NCBIChiLan1.0ChiLan1.0
FBXO11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,478,591 - 78,577,716 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A78,482,579 - 78,582,236 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,926,629 - 48,026,245 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,849,746 - 48,948,007 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,830,780 - 48,886,300 (-)Ensemblpanpan1.1panPan2
FBXO11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,838,003 - 49,864,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,838,776 - 49,925,064 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,693,555 - 49,780,653 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01050,711,840 - 50,799,252 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,711,894 - 50,799,655 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,419,057 - 50,506,412 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,705,887 - 50,793,282 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,893,652 - 50,980,961 (-)NCBIUU_Cfam_GSD_1.0
Fbxo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,194,074 - 33,280,085 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,685,595 - 4,708,694 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,622,695 - 4,708,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl392,696,441 - 92,792,616 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1392,696,402 - 92,792,623 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2398,680,348 - 98,710,235 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11459,276,380 - 59,375,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1459,276,447 - 59,374,442 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604552,468,631 - 52,568,736 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,108,809 - 29,191,368 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473829,108,759 - 29,190,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Fbxo11
184 total Variants

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:96
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000021998
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat

1 to 10 of 22 rows
RH126790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.266,562,426 - 6,562,642 (-)MAPPERmRatBN7.2
Rnor_6.0611,662,378 - 11,662,593NCBIRnor6.0
Rnor_5.0621,634,327 - 21,634,542UniSTSRnor5.0
RGSC_v3.4611,542,581 - 11,542,796UniSTSRGSC3.4
Celera66,325,958 - 6,326,173UniSTS
Cytogenetic Map6q12UniSTS
RH140511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.266,562,226 - 6,562,406 (-)MAPPERmRatBN7.2
Rnor_6.0611,662,614 - 11,662,793NCBIRnor6.0
Rnor_5.0621,634,563 - 21,634,742UniSTSRnor5.0
RGSC_v3.4611,542,817 - 11,542,996UniSTSRGSC3.4
Celera66,325,758 - 6,325,937UniSTS
Cytogenetic Map6q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000021998   ⟹   ENSRNOP00000021998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl66,486,015 - 6,562,662 (+)Ensembl
Rnor_6.0 Ensembl611,662,356 - 11,686,682 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl611,663,240 - 11,663,788 (-)Ensembl
RefSeq Acc Id: NM_181631   ⟹   NP_853662
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,291,942 - 12,316,221 (+)NCBI
mRatBN7.266,538,383 - 6,562,662 (+)NCBI
Rnor_6.0611,662,358 - 11,686,682 (-)NCBI
Rnor_5.0621,634,305 - 21,709,376 (-)NCBI
RGSC_v3.4611,542,561 - 11,566,829 (-)RGD
Celera66,301,914 - 6,326,193 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594113   ⟹   XP_017449602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,240,683 - 12,316,223 (+)NCBI
mRatBN7.266,487,135 - 6,562,664 (+)NCBI
Rnor_6.0611,662,356 - 11,737,427 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112126   ⟹   XP_038968054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,240,348 - 12,316,223 (+)NCBI
mRatBN7.266,486,761 - 6,562,664 (+)NCBI
RefSeq Acc Id: XM_039112127   ⟹   XP_038968055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,240,348 - 12,316,223 (+)NCBI
mRatBN7.266,486,761 - 6,562,664 (+)NCBI
RefSeq Acc Id: XM_063261802   ⟹   XP_063117872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,240,905 - 12,316,223 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_853662 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449602 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968054 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968055 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP42075 (Get FASTA)   NCBI Sequence Viewer  
  EDM02630 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021998
  ENSRNOP00000110764
GenBank Protein Q7TSL3 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_853662   ⟸   NM_181631
- UniProtKB: Q7TSL3 (UniProtKB/Swiss-Prot),   A6H9C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449602   ⟸   XM_017594113
- Peptide Label: isoform X4
- UniProtKB: Q7TSL3 (UniProtKB/Swiss-Prot),   A6H9C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021998   ⟸   ENSRNOT00000021998
RefSeq Acc Id: XP_038968054   ⟸   XM_039112126
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QBJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968055   ⟸   XM_039112127
- Peptide Label: isoform X2
F-box   UBR-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSL3-F1-model_v2 AlphaFold Q7TSL3 1-843 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38751 BioCyc
Ensembl Genes ENSRNOG00000016396 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021998 ENTREZGENE
  ENSRNOT00000165520 ENTREZGENE
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
  2.160.20.10 UniProtKB/Swiss-Prot
InterPro Beta_helix UniProtKB/Swiss-Prot
  Carb-bd_sugar_hydrolysis-dom UniProtKB/Swiss-Prot
  F-box-like_dom_sf UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  F-box_FBXO11 UniProtKB/Swiss-Prot
  FBXO11_UBR-box UniProtKB/Swiss-Prot
  NosD_dom UniProtKB/Swiss-Prot
  Para_beta_helix_rpt-2 UniProtKB/Swiss-Prot
  PbH1 UniProtKB/Swiss-Prot
  Pectin_lyas_fold UniProtKB/Swiss-Prot
  Pectin_lyase_fold/virulence UniProtKB/Swiss-Prot
  SCF-Subunits/Alg-Epimerases UniProtKB/Swiss-Prot
  Znf_UBR UniProtKB/Swiss-Prot
KEGG Report rno:301674 UniProtKB/Swiss-Prot
NCBI Gene 301674 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN UniProtKB/Swiss-Prot
  PTHR22990:SF20 UniProtKB/Swiss-Prot
Pfam Beta_helix UniProtKB/Swiss-Prot
  F-box-like UniProtKB/Swiss-Prot
  NosD UniProtKB/Swiss-Prot
  zf-UBR UniProtKB/Swiss-Prot
PhenoGen Fbxo11 PhenoGen
PROSITE FBOX UniProtKB/Swiss-Prot
  ZF_UBR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016396 RatGTEx
SMART CASH UniProtKB/Swiss-Prot
  FBOX UniProtKB/Swiss-Prot
  PbH1 UniProtKB/Swiss-Prot
  ZnF_UBR1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51126 UniProtKB/Swiss-Prot
  SSF81383 UniProtKB/Swiss-Prot
UniProt A0A8L2QBJ7 ENTREZGENE, UniProtKB/TrEMBL
  A6H9C5 ENTREZGENE, UniProtKB/TrEMBL
  FBX11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fbxo11  F-box protein 11  LOC103689957  F-box only protein 11-like  Data merged from RGD:9197316 737654 PROVISIONAL
2014-08-25 LOC103689957  F-box only protein 11-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Fbxo11  F-box protein 11  Fbxo11  F-box only protein 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Fbxo11        Symbol and Name status set to provisional 70820 PROVISIONAL