Hnrnpl (heterogeneous nuclear ribonucleoprotein L) - Rat Genome Database

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Gene: Hnrnpl (heterogeneous nuclear ribonucleoprotein L) Rattus norvegicus
Analyze
Symbol: Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
RGD ID: 71059
Description: Enables mRNA 3'-UTR binding activity and mRNA CDS binding activity. Involved in several processes, including cellular response to amino acid starvation; circadian rhythm; and regulation of gene expression. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heterogenous nuclear ribonucleoprotein L; hnrnp-L; Hnrpl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,226,373 - 93,239,084 (+)NCBIGRCr8
mRatBN7.2184,098,558 - 84,111,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,510,654 - 89,521,604 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,969,995 - 97,980,674 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,266,512 - 91,277,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,994,090 - 87,006,776 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,174,400 - 88,187,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,919,015 - 83,929,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,005,781 - 84,007,795 (+)NCBI
Celera178,491,204 - 78,501,887 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
HnrnplRatbrain cancer susceptibilityISOHNRNPL (Homo sapiens)10002773associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma and mRNA:decreased expression:bone marrow (human)RGD 
HnrnplRathepatocellular carcinoma  ISOHNRNPL (Homo sapiens)9999429associated with Hepatitis BRGD 
HnrnplRatlung cancer severityISOHNRNPL (Homo sapiens)9999427human gene in a mouse modelRGD 
HnrnplRatSertoli cell-only syndrome  ISOHNRNPL (Homo sapiens)9999426protein:decreased expression:testis (human)RGD 
HnrnplRatsystemic scleroderma  ISOHNRNPL (Homo sapiens)9999440 RGD 
Object Symbol
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Original Reference(s)
HnrnplRatmaturity-onset diabetes of the young type 1  ISOHNRNPL (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVarPMID:28492532
HnrnplRattype 2 diabetes mellitus  ISOHNRNPL (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVarPMID:28492532
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Original Reference(s)
HnrnplRatBreast Neoplasms  ISOHNRNPL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21466612
HnrnplRatDisease Progression  ISOHNRNPL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21364753
HnrnplRatStomach Neoplasms  ISOHNRNPL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21364753

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Original Reference(s)
HnrnplRat(S)-nicotine decreases expressionISOHnrnpl (Mus musculus)6480464Nicotine results in decreased expression of HNRNPL mRNACTDPMID:21955143
HnrnplRat1,2-dimethylhydrazine multiple interactionsISOHnrnpl (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HNRNPL mRNACTDPMID:22206623
HnrnplRat17alpha-ethynylestradiol multiple interactionsISOHnrnpl (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPL mRNACTDPMID:17942748
HnrnplRat17alpha-ethynylestradiol decreases expressionISOHnrnpl (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of HNRNPL mRNACTDPMID:17942748
HnrnplRat17alpha-ethynylestradiol affects expressionISOHnrnpl (Mus musculus)6480464Ethinyl Estradiol affects the expression of HNRNPL mRNACTDPMID:17555576
HnrnplRat17beta-estradiol increases expressionISOHnrnpl (Mus musculus)6480464Estradiol results in increased expression of HNRNPL mRNACTDPMID:39298647
HnrnplRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:21394737
HnrnplRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOHnrnpl (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPL mRNACTDPMID:17942748
HnrnplRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of HNRNPL mRNACTDPMID:34747641
HnrnplRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHnrnpl (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HNRNPL mRNACTDPMID:21570461
HnrnplRat2,6-dimethoxyphenol multiple interactionsISOHNRNPL (Homo sapiens)6480464[pyrogallol 1 and 3-dimethyl ether co-treated with Furaldehyde] results in increased expression of and affects the localization of HNRNPL proteinCTDPMID:38598786
HnrnplRat2-hydroxypropanoic acid increases expressionISOHNRNPL (Homo sapiens)6480464Lactic Acid results in increased expression of HNRNPL mRNACTDPMID:30851411
HnrnplRat3',5'-cyclic UMP affects bindingISOHNRNPL (Homo sapiens)6480464HNRNPL protein binds to cyclic 3' and 5'-uridine monophosphateCTDPMID:30528433
HnrnplRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOHNRNPL (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HNRNPL mRNACTDPMID:28628672
HnrnplRat4,4'-sulfonyldiphenol affects expressionISOHnrnpl (Mus musculus)6480464bisphenol S affects the expression of HNRNPL mRNACTDPMID:39298647
HnrnplRat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of HNRNPL mRNACTDPMID:36041667
HnrnplRat4,4'-sulfonyldiphenol increases expressionISOHNRNPL (Homo sapiens)6480464bisphenol S results in increased expression of HNRNPL proteinCTDPMID:34186270
HnrnplRat4,4'-sulfonyldiphenol decreases methylationISOHnrnpl (Mus musculus)6480464bisphenol S results in decreased methylation of HNRNPL exonCTDPMID:33297965
HnrnplRat5-fluorouracil multiple interactionsISOHNRNPL (Homo sapiens)6480464TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPL mRNA]CTDPMID:15016801
HnrnplRatacrolein multiple interactionsISOHNRNPL (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HNRNPL mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of HNRNPL mRNACTDPMID:32699268

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Biological Process
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Cellular Component
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Original Reference(s)
HnrnplRatchromatin located_inISSUniProtKB:P148661600115GO_REF:0000024UniProtGO_REF:0000024
HnrnplRatchromatin located_inISOHNRNPL (Homo sapiens)1624291 PMID:33174841RGDPMID:33174841
HnrnplRatcytoplasm located_inISOHNRNPL (Homo sapiens)1624291 PMID:33174841RGDPMID:33174841
HnrnplRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
HnrnplRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
HnrnplRatnucleoplasm located_inISSUniProtKB:P148661600115GO_REF:0000024UniProtGO_REF:0000024
HnrnplRatnucleoplasm located_inIEAUniProtKB-SubCell:SL-01901600115GO_REF:0000044UniProtGO_REF:0000044
HnrnplRatnucleoplasm located_inISOHNRNPL (Homo sapiens)1624291 PMID:2687284RGDPMID:2687284
HnrnplRatnucleoplasm located_inISOHNRNPL (Homo sapiens) more ...1624291 RGDGO_REF:0000052
HnrnplRatnucleus located_inIEAInterPro:IPR0065361600115GO_REF:0000002InterProGO_REF:0000002
HnrnplRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
HnrnplRatnucleus is_active_inIBAMGI:104816 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HnrnplRatnucleus located_inISOHNRNPL (Homo sapiens)1624291 PMID:15798186 and PMID:33174841RGDPMID:15798186 and PMID:33174841
HnrnplRatperinuclear region of cytoplasm  IDA 9999434 RGD 
HnrnplRatpronucleus located_inISOHnrnpl (Mus musculus)1624291 PMID:7768196RGDPMID:7768196
HnrnplRatribonucleoprotein complex part_ofISSUniProtKB:P148661600115GO_REF:0000024UniProtGO_REF:0000024
HnrnplRatribonucleoprotein complex part_ofIEAUniProtKB-KW:KW-06871600115GO_REF:0000043UniProtGO_REF:0000043
HnrnplRatribonucleoprotein complex part_ofISOHNRNPL (Homo sapiens)1624291 PMID:17289661 more ...RGDPMID:17289661 more ...
HnrnplRatribonucleoprotein granule located_inISSUniProtKB:P148661600115GO_REF:0000024UniProtGO_REF:0000024
HnrnplRatribonucleoprotein granule located_inISOHNRNPL (Homo sapiens)1624291 PMID:17289661RGDPMID:17289661
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Molecular Function
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Object Symbol
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Original Reference(s)
HnrnplRatmRNA 3'-UTR binding  IDA 9854643 RGD 
HnrnplRatmRNA binding enablesIBAFB:FBgn0011224 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HnrnplRatmRNA CDS binding  IDA 10058976 RGD 
HnrnplRatnucleic acid binding enablesIEAInterPro:IPR0359791600115GO_REF:0000002InterProGO_REF:0000002
HnrnplRatpre-mRNA intronic binding enablesISSUniProtKB:P148661600115GO_REF:0000024UniProtGO_REF:0000024
HnrnplRatpre-mRNA intronic binding enablesISOHNRNPL (Homo sapiens)1624291 PMID:25623890RGDPMID:25623890
HnrnplRatprotein binding  IPIElavl1 (Rattus norvegicus)9999434 RGD 
HnrnplRatprotein binding enablesISOHnrnpl (Mus musculus)1624291PR:Q61990 PMID:8871564RGDPMID:8871564
HnrnplRatprotein binding enablesISOHNRNPL (Homo sapiens) and UniProtKB:P14866-11624291UniProtKB:P22626 and PMID:23976881RGDPMID:23976881
HnrnplRatprotein binding enablesISOHNRNPL (Homo sapiens) and UniProtKB:P14866-11624291UniProtKB:Q12906 and PMID:23976881RGDPMID:23976881
HnrnplRatprotein binding enablesISOHNRNPL (Homo sapiens)1624291UniProtKB:P22626 more ...RGDPMID:11809897 more ...
HnrnplRatRNA binding enablesIEAUniRule:UR0004146191600115GO_REF:0000104UniProtGO_REF:0000104
HnrnplRatRNA binding enablesISOHnrnpl (Mus musculus)1624291 PMID:27315481RGDPMID:27315481
HnrnplRatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
HnrnplRatRNA binding enablesIEAInterPro:IPR000504 and InterPro:IPR0065361600115GO_REF:0000002InterProGO_REF:0000002
HnrnplRattranscription cis-regulatory region binding enablesISSUniProtKB:P148661600115GO_REF:0000024UniProtGO_REF:0000024
HnrnplRattranscription cis-regulatory region binding enablesISOHNRNPL (Homo sapiens)1624291 PMID:11809897RGDPMID:11809897
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
HnrnplRatspliceosome pathway   ISOHNRNPL (Homo sapiens)9686091 RGD 

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Reference Title
Reference Citation
1. Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor beta pathway in patients with systemic sclerosis. Bussone G, etal., Arthritis Res Ther. 2011 May 13;13(3):R74. doi: 10.1186/ar3336.
2. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
3. PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. Costain WJ and Mishra RK, Peptides 2003 Jan;24(1):137-46.
4. Lymphoid gene expression as a predictor of risk of secondary brain tumors. Edick MJ, etal., Genes Chromosomes Cancer. 2005 Feb;42(2):107-16.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. Goehe RW, etal., J Clin Invest. 2010 Nov;120(11):3923-39. doi: 10.1172/JCI43552. Epub 2010 Oct 25.
8. hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. Hamilton BJ, etal., Biochem Biophys Res Commun. 1999 Aug 11;261(3):646-51.
9. Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation. Kim TD, etal., Mol Cell Biol. 2005 Apr;25(8):3232-46.
10. HnRNPL as a key factor in spermatogenesis: Lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome. Li J, etal., J Proteomics. 2012 Jun 6;75(10):2879-91. doi: 10.1016/j.jprot.2011.12.040. Epub 2012 Jan 10.
11. A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels. Liu G, etal., J Biol Chem. 2012 Jun 29;287(27):22709-16. doi: 10.1074/jbc.M112.357343. Epub 2012 May 8.
12. The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation. Majumder M, etal., Mol Cell Biol. 2009 May;29(10):2899-912. doi: 10.1128/MCB.01774-08. Epub 2009 Mar 9.
13. Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes. Matsui K, etal., Hepatology. 2008 Feb;47(2):686-97.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. An exonic splicing silencer is involved in the regulated splicing of glucose 6-phosphate dehydrogenase mRNA. Szeszel-Fedorowicz W, etal., J Biol Chem. 2006 Nov 10;281(45):34146-58. Epub 2006 Sep 15.
20. Autoantibody recognition of an N-terminal epitope of hnRNP L marks the risk for developing HBV-related hepatocellular carcinoma. Yau WY, etal., J Proteomics. 2013 Dec 6;94:346-58. doi: 10.1016/j.jprot.2013.10.003. Epub 2013 Oct 11.
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PMID:2687284   PMID:7768196   PMID:11809897   PMID:12477932   PMID:15798186   PMID:17289661   PMID:19056867   PMID:19946888   PMID:22082260   PMID:22215678   PMID:22523384   PMID:22658674  
PMID:22681889   PMID:24625528   PMID:25623890   PMID:27315481   PMID:35352799  



Hnrnpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,226,373 - 93,239,084 (+)NCBIGRCr8
mRatBN7.2184,098,558 - 84,111,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,510,654 - 89,521,604 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,969,995 - 97,980,674 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,266,512 - 91,277,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,994,090 - 87,006,776 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,174,400 - 88,187,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,919,015 - 83,929,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,005,781 - 84,007,795 (+)NCBI
Celera178,491,204 - 78,501,887 (+)NCBICelera
Cytogenetic Map1q21NCBI
HNRNPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,836,370 - 38,852,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,836,370 - 38,852,347 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,327,010 - 39,342,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,018,868 - 44,034,819 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,018,868 - 44,032,457NCBI
Celera1936,129,470 - 36,145,420 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,773,794 - 35,789,557 (-)NCBIHuRef
CHM1_11939,327,480 - 39,343,450 (-)NCBICHM1_1
T2T-CHM13v2.01941,640,403 - 41,656,404 (-)NCBIT2T-CHM13v2.0
Hnrnpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,507,971 - 28,521,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,507,966 - 28,521,691 (+)EnsemblGRCm39 Ensembl
GRCm38728,808,546 - 28,822,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,808,541 - 28,822,266 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,595,909 - 29,607,285 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,519,673 - 28,531,004 (+)NCBIMGSCv36mm8
Celera723,371,763 - 23,383,139 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.93NCBI
Hnrnpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468670,559 - 683,540 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468668,177 - 683,540 (+)NCBIChiLan1.0ChiLan1.0
HNRNPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,140,619 - 45,158,142 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,011,145 - 47,027,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,943,720 - 35,959,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,493,832 - 44,509,183 (-)NCBIpanpan1.1PanPan1.1panPan2
HNRNPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,267,195 - 114,279,107 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,267,210 - 114,278,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,668,694 - 113,682,944 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,867,366 - 114,881,619 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,869,714 - 114,881,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,424,849 - 114,439,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,060,575 - 114,072,464 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,054,052 - 115,068,304 (+)NCBIUU_Cfam_GSD_1.0
Hnrnpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,365,722 - 13,378,495 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,793,801 - 1,806,579 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,793,791 - 1,806,564 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,643,566 - 47,657,833 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,643,561 - 47,655,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,180,634 - 43,194,945 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,452,705 - 33,469,070 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,452,852 - 33,466,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,466,361 - 11,483,112 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,206,252 - 12,218,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,206,278 - 12,220,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hnrnpl
67 total Variants

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:189
Interacting mature miRNAs:215
Transcripts:ENSRNOT00000027425, ENSRNOT00000027494, ENSRNOT00000057034
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat

1 to 10 of 38 rows
WI-13808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,105,765 - 84,105,895 (+)MAPPERmRatBN7.2
Rnor_6.0187,000,974 - 87,001,103NCBIRnor6.0
Rnor_5.0188,181,592 - 88,181,721UniSTSRnor5.0
RGSC_v3.4183,923,896 - 83,924,025UniSTSRGSC3.4
Celera178,496,085 - 78,496,214UniSTS
Cytogenetic Map1q21UniSTS
AI599652  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,238,316 - 93,238,819 (+)Marker Load Pipeline
mRatBN7.288,601,113 - 8,601,258 (+)MAPPERmRatBN7.2
mRatBN7.2184,110,800 - 84,111,303 (+)MAPPERmRatBN7.2
Rnor_6.089,673,364 - 9,673,508NCBIRnor6.0
Rnor_6.0187,006,009 - 87,006,511NCBIRnor6.0
Rnor_5.089,647,369 - 9,647,513UniSTSRnor5.0
Rnor_5.0188,186,627 - 88,187,129UniSTSRnor5.0
RGSC_v3.4183,928,931 - 83,929,433UniSTSRGSC3.4
RGSC_v3.488,436,039 - 8,436,183UniSTSRGSC3.4
Celera810,109,633 - 10,109,777UniSTS
Celera178,501,120 - 78,501,622UniSTS
RH 3.4 Map1844.0UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map8q11UniSTS
D6S1116E  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,235,556 - 93,235,815 (+)Marker Load Pipeline
mRatBN7.2184,108,040 - 84,108,299 (+)MAPPERmRatBN7.2
Rnor_6.0187,003,249 - 87,003,507NCBIRnor6.0
Rnor_5.0188,183,867 - 88,184,125UniSTSRnor5.0
RGSC_v3.4183,926,171 - 83,926,429UniSTSRGSC3.4
Celera178,498,360 - 78,498,618UniSTS
Cytogenetic Map1q21UniSTS
UniSTS:479127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.235,939,834 - 5,940,272 (+)MAPPERmRatBN7.2
Rnor_6.03261,494 - 261,931NCBIRnor6.0
Rnor_5.03257,367 - 257,804UniSTSRnor5.0
RGSC_v3.431,378,472 - 1,378,909UniSTSRGSC3.4
Celera3778,564 - 779,001UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000027425   ⟹   ENSRNOP00000027425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)Ensembl
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000027494   ⟹   ENSRNOP00000027494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,879 - 84,111,553 (+)Ensembl
Rnor_6.0 Ensembl186,996,093 - 87,006,776 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057034   ⟹   ENSRNOP00000053867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,100,911 - 84,111,549 (+)Ensembl
Rnor_6.0 Ensembl187,000,093 - 87,006,753 (+)Ensembl
RefSeq Acc Id: NM_001134760   ⟹   NP_001128232
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,228,401 - 93,239,084 (+)NCBI
mRatBN7.2184,100,885 - 84,111,568 (+)NCBI
Rnor_6.0186,996,093 - 87,006,776 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
RGSC_v3.4183,919,015 - 83,929,698 (+)RGD
Celera178,491,204 - 78,501,887 (+)RGD
Sequence:
RefSeq Acc Id: NM_032619   ⟹   NP_116008
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,228,401 - 93,239,084 (+)NCBI
mRatBN7.2184,100,885 - 84,111,568 (+)NCBI
Rnor_6.0186,996,093 - 87,006,776 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
RGSC_v3.4183,919,015 - 83,929,698 (+)RGD
Celera178,491,204 - 78,501,887 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228691   ⟹   XP_006228753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,226,373 - 93,239,070 (+)NCBI
mRatBN7.2184,098,558 - 84,111,557 (+)NCBI
Rnor_6.0186,994,090 - 87,006,765 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228692   ⟹   XP_006228754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,226,377 - 93,239,070 (+)NCBI
mRatBN7.2184,098,558 - 84,111,554 (+)NCBI
Rnor_6.0186,994,091 - 87,006,765 (+)NCBI
Rnor_5.0188,174,400 - 88,187,394 (+)NCBI
Sequence:
RefSeq Acc Id: NP_116008   ⟸   NM_032619
- Peptide Label: isoform b
- UniProtKB: A6J9L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001128232   ⟸   NM_001134760
- Peptide Label: isoform a
- UniProtKB: F1LPP9 (UniProtKB/Swiss-Prot),   Q5U1Y5 (UniProtKB/Swiss-Prot),   F1LQ48 (UniProtKB/TrEMBL),   A0A8L2QEL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228753   ⟸   XM_006228691
- Peptide Label: isoform X1
- UniProtKB: A6J9L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228754   ⟸   XM_006228692
- Peptide Label: isoform X2
- UniProtKB: A6J9L3 (UniProtKB/TrEMBL),   A6J9L2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053867   ⟸   ENSRNOT00000057034
RRM

Name Modeler Protein Id AA Range Protein Structure
AF-F1LQ48-F1-model_v2 AlphaFold F1LQ48 1-623 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689886
Promoter ID:EPDNEW_R410
Type:initiation region
Name:Hnrnpl_1
Description:heterogeneous nuclear ribonucleoprotein L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,996,119 - 86,996,179EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60214 BioCyc
Ensembl Genes ENSRNOG00000020235 Ensembl
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro HnRNP-L/PTB UniProtKB/Swiss-Prot
  hnRNP-L_RRM3 UniProtKB/Swiss-Prot
  HNRNPL_RRM UniProtKB/Swiss-Prot
  hnRNPL_RRM1 UniProtKB/Swiss-Prot
  hnRNPL_RRM2 UniProtKB/Swiss-Prot
  hnRNPL_RRM4 UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PTBP1_RRM UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:80846 UniProtKB/Swiss-Prot
NCBI Gene 80846 ENTREZGENE
PANTHER MATRIN 3/NUCLEAR PROTEIN 220-RELATED UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
  RRM_10 UniProtKB/Swiss-Prot
  RRM_5 UniProtKB/Swiss-Prot
  RRM_8 UniProtKB/Swiss-Prot
PhenoGen Hnrnpl PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020235 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8L2QEL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QQ13_RAT UniProtKB/TrEMBL
  A6J9L2 ENTREZGENE, UniProtKB/TrEMBL
  A6J9L3 ENTREZGENE, UniProtKB/TrEMBL
  B5DFG2_RAT UniProtKB/TrEMBL
  F1LPP9 ENTREZGENE
  F1LQ48 ENTREZGENE
  F2Z3R2_RAT UniProtKB/TrEMBL
  HNRPL_RAT UniProtKB/Swiss-Prot
  Q5U1Y5 ENTREZGENE
UniProt Secondary F1LPP9 UniProtKB/Swiss-Prot
  Q5U1Y5 UniProtKB/Swiss-Prot
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Hnrnpl  heterogeneous nuclear ribonucleoprotein L  Hnrpl  heterogeneous nuclear ribonucleoprotein L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Hnrpl  heterogeneous nuclear ribonucleoprotein L      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference