Sp7 (Sp7 transcription factor) - Rat Genome Database

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Gene: Sp7 (Sp7 transcription factor) Rattus norvegicus
Analyze
Symbol: Sp7
Name: Sp7 transcription factor
RGD ID: 631377
Description: Predicted to enable DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to zinc ion starvation and response to insulin. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor); INTERACTS WITH 5-formyltetrahydrofolic acid; ammonium chloride; arsenous acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: osterix; Osx; Transcription factor Sp7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,363,193 - 135,373,376 (-)NCBIGRCr8
mRatBN7.27133,484,609 - 133,494,788 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,484,609 - 133,494,847 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,247,146 - 135,255,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,476,525 - 137,485,150 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,461,680 - 137,470,323 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,957,316 - 143,967,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,958,858 - 143,967,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,753,826 - 141,762,790 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,109,771 - 141,118,397 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,186,207 - 141,194,213 (-)NCBI
Celera7129,919,226 - 129,927,844 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
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Reference
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Original Reference(s)
Sp7Rataortic valve stenosis severityISOSP7 (Homo sapiens)267010069 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Sp7Ratosteogenesis imperfecta  ISOSP7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Sp7Ratosteogenesis imperfecta type 12  ISOSP7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:20579626 more ...
Object Symbol
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Original Reference(s)
Sp7Ratosteogenesis imperfecta type 12  ISOSP7 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Original Reference(s)
Sp7Rat1,2-dichloroethane increases expressionISOSp7 (Mus musculus)6480464ethylene dichloride results in increased expression of SP7 mRNACTDPMID:28960355
Sp7Rat17beta-estradiol increases expressionISOSP7 (Homo sapiens)6480464Estradiol results in increased expression of SP7 mRNACTDPMID:17689939
Sp7Rat17beta-estradiol multiple interactionsISOSP7 (Homo sapiens)6480464fulvestrant inhibits the reaction [Estradiol results in increased expression of SP7 mRNA]CTDPMID:17689939
Sp7Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOSp7 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNACTDPMID:28836330
Sp7Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOSP7 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of SP7 mRNACTDPMID:30203000 and PMID:31887333
Sp7Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOSp7 (Mus musculus)6480464actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA]CTDPMID:28836330
Sp7Rat2,4-di-tert-butylphenol multiple interactionsISOSP7 (Homo sapiens)6480464[SAG compound co-treated with 2 and 4-di-tert-butylphenol co-treated with Fibroblast Growth Factor 2 co-treated with Ascorbic Acid co-treated with alpha-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of SP7 mRNACTDPMID:36682590
Sp7Rat2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid multiple interactionsISOSP7 (Homo sapiens)6480464anacardic acid inhibits the reaction [Tretinoin results in increased expression of SP7 mRNA]CTDPMID:24819975
Sp7Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOSp7 (Mus musculus)6480464tetrabromobisphenol A results in decreased expression of SP7 mRNACTDPMID:25777084
Sp7Rat3,3',5,5'-tetrabromobisphenol A multiple interactionsISOSp7 (Mus musculus)6480464tetrabromobisphenol A inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]CTDPMID:32473317
Sp7Rat3-methyladenine multiple interactionsISOSp7 (Mus musculus)64804643-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of SP7 protein]CTDPMID:36402210
Sp7Rat4,4'-sulfonyldiphenol increases expressionISOSP7 (Homo sapiens)6480464bisphenol S results in increased expression of SP7 proteinCTDPMID:36565802
Sp7Rat5-azacytidine increases expressionISOSp7 (Mus musculus)6480464Azacitidine results in increased expression of SP7 mRNACTDPMID:17085970
Sp7Rat5-formyltetrahydrofolic acid multiple interactionsEXP 6480464[Methotrexate co-treated with Leucovorin] results in increased expression of SP7 mRNACTDPMID:25187349
Sp7RatActein multiple interactionsISOSp7 (Mus musculus)6480464actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA]CTDPMID:28836330
Sp7Rataldehydo-D-glucose multiple interactionsISOSP7 (Homo sapiens)6480464[EPO protein co-treated with Glucose] results in increased expression of SP7 mRNA and [EPO protein co-treated with Glucose] results in increased expression of SP7 proteinCTDPMID:30894315
Sp7Rataldehydo-D-glucose multiple interactionsISOSp7 (Mus musculus)6480464[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Herbicides] results in decreased expression of SP7 mRNACTDPMID:37567420
Sp7Ratall-trans-retinoic acid multiple interactionsISOSP7 (Homo sapiens)6480464anacardic acid inhibits the reaction [Tretinoin results in increased expression of SP7 mRNA] and ginkgolic acid inhibits the reaction [Tretinoin results in increased expression of SP7 mRNA]CTDPMID:24819975
Sp7Ratall-trans-retinoic acid multiple interactionsISOSp7 (Mus musculus)6480464Tretinoin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]CTDPMID:32473317
Sp7Ratall-trans-retinoic acid increases expressionISOSP7 (Homo sapiens)6480464Tretinoin results in increased expression of SP7 mRNACTDPMID:24819975

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Biological Process
1 to 20 of 25 rows

  
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Original Reference(s)
Sp7Ratcellular response to zinc ion starvation  IEP 151667428 RGD 
Sp7Ratcementum mineralization involved_inISOSp7 (Mus musculus)1624291MGI:1915401 more ...RGDPMID:31059863
Sp7Ratcementum mineralization involved_inIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratdiphosphate metabolic process involved_inIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratdiphosphate metabolic process involved_inISOSp7 (Mus musculus)1624291MGI:3608932 PMID:31059863RGDPMID:31059863
Sp7Ratgene expression involved_inISOSp7 (Mus musculus)1624291MGI:3608932 PMID:31059863RGDPMID:31059863
Sp7Ratgene expression involved_inIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Rathematopoietic stem cell differentiation involved_inISOSP7 (Homo sapiens)1624291 PMID:18932205RGDPMID:18932205
Sp7Rathematopoietic stem cell differentiation involved_inIEAUniProtKB:Q8TDD2 and ensembl:ENSP000004438271600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratosteoblast differentiation involved_inISOSP7 (Homo sapiens)1624291 PMID:18932205RGDPMID:18932205
Sp7Ratosteoblast differentiation acts_upstream_of_or_withinIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratosteoblast differentiation involved_inIEAUniProtKB:Q8TDD2 and ensembl:ENSP000004438271600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratosteoblast differentiation acts_upstream_of_or_withinISOSp7 (Mus musculus)1624291MGI:2159411 PMID:11792318RGDPMID:11792318
Sp7Ratpositive regulation of stem cell differentiation involved_inISOSP7 (Homo sapiens)1624291 PMID:18932205RGDPMID:18932205
Sp7Ratpositive regulation of stem cell differentiation involved_inIEAUniProtKB:Q8TDD2 and ensembl:ENSP000004438271600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratpositive regulation of transcription by RNA polymerase II involved_inISOSp7 (Mus musculus)1624291 PMID:16041384 and PMID:30026585RGDPMID:16041384 and PMID:30026585
Sp7Ratpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q8TDD2 and ensembl:ENSP000004438271600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratpositive regulation of transcription by RNA polymerase II involved_inISOSP7 (Homo sapiens)1624291 PMID:18932205RGDPMID:18932205
Sp7Ratregulation of hydrolase activity involved_inISOSp7 (Mus musculus)1624291MGI:3608932 PMID:31059863RGDPMID:31059863
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Cellular Component
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Original Reference(s)
Sp7Ratcytoplasm located_inISOSP7 (Homo sapiens)1624291 PMID:18471237RGDPMID:18471237
Sp7Ratcytoplasm located_inIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratcytoplasm located_inIEAUniProtKB:Q8TDD2 and ensembl:ENSP000004438271600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratcytoplasm located_inISOSp7 (Mus musculus)1624291 PMID:22886301RGDPMID:22886301
Sp7Ratnucleus located_inISOSP7 (Homo sapiens)1624291 PMID:18471237RGDPMID:18471237
Sp7Ratnucleus located_inIEAUniProtKB:Q8TDD2 and ensembl:ENSP000004438271600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Sp7Ratnucleus located_inISOSp7 (Mus musculus)1624291 PMID:11792318RGDPMID:11792318
Sp7Ratnucleus located_inIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
1 to 13 of 13 rows

  
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Original Reference(s)
Sp7RatDEAD/H-box RNA helicase binding enablesISOSp7 (Mus musculus)1624291UniProtKB:Q08211 and PMID:17303075RGDPMID:17303075
Sp7RatDEAD/H-box RNA helicase binding enablesIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7RatDNA binding enablesIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7RatDNA binding enablesISOSp7 (Mus musculus)1624291 PMID:11792318RGDPMID:11792318
Sp7RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOSp7 (Mus musculus)1624291 PMID:16041384 and PMID:30026585RGDPMID:16041384 and PMID:30026585
Sp7RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000233 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sp7Ratprotein binding enablesISOSP7 (Homo sapiens)1624291UniProtKB:O95995 more ...RGDPMID:32296183
Sp7Ratprotein binding enablesISOSp7 (Mus musculus)1624291UniProtKB:Q9H6W3 more ...RGDPMID:19927124
Sp7RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOSp7 (Mus musculus)1624291 PMID:16041384RGDPMID:16041384
Sp7RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q8VI67 and ensembl:ENSMUSP000000775961600115GO_REF:0000107EnsemblGO_REF:0000107
Sp7RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:1277166 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sp7Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
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1 to 11 of 11 rows
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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression and function of osteogenic genes runt-related transcription factor 2 and osterix in orthodontic tooth movement in rats. Han J and He H, Int J Clin Exp Pathol. 2015 Sep 1;8(9):11895-900. eCollection 2015.
3. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
4. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Nakashima K, etal., Cell 2002 Jan 11;108(1):17-29.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. [Histopathologic features of degenerative aortic valve and its mechanisms]. Sun J, etal., Zhonghua Yi Xue Za Zhi. 2013 Jan 22;93(4):280-4.
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PMID:14604442   PMID:16041384   PMID:16610234   PMID:17303075   PMID:18270471   PMID:18272339   PMID:18471237   PMID:18932205   PMID:19124839   PMID:19822991   PMID:21806466   PMID:22009963  
PMID:22886301   PMID:23354182   PMID:25823394   PMID:26253417   PMID:28107808   PMID:30026585   PMID:30912295   PMID:32910396   PMID:33187585   PMID:34245724  



Sp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,363,193 - 135,373,376 (-)NCBIGRCr8
mRatBN7.27133,484,609 - 133,494,788 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,484,609 - 133,494,847 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,247,146 - 135,255,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,476,525 - 137,485,150 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,461,680 - 137,470,323 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,957,316 - 143,967,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,958,858 - 143,967,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,753,826 - 141,762,790 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,109,771 - 141,118,397 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,186,207 - 141,194,213 (-)NCBI
Celera7129,919,226 - 129,927,844 (-)NCBICelera
Cytogenetic Map7q36NCBI
SP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,326,575 - 53,344,793 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,326,575 - 53,345,315 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,720,359 - 53,738,577 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,006,626 - 52,015,804 (-)NCBINCBI36Build 36hg18NCBI36
Build 341252,006,628 - 52,015,804NCBI
Celera1253,369,632 - 53,379,307 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,761,885 - 50,771,562 (-)NCBIHuRef
CHM1_11253,687,545 - 53,697,201 (-)NCBICHM1_1
T2T-CHM13v2.01253,292,290 - 53,310,533 (-)NCBIT2T-CHM13v2.0
Sp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,265,038 - 102,275,498 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,265,041 - 102,275,617 (-)EnsemblGRCm39 Ensembl
GRCm3815102,356,603 - 102,367,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,356,606 - 102,367,182 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715102,187,608 - 102,196,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,184,644 - 102,194,367 (-)NCBIMGSCv36mm8
Celera15104,514,244 - 104,523,282 (-)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.51NCBI
Sp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458583,981 - 602,856 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955458583,981 - 602,856 (-)NCBIChiLan1.0ChiLan1.0
SP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,849,740 - 40,859,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,846,505 - 40,856,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,409,055 - 35,427,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,191,091 - 36,209,494 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,199,673 - 36,209,494 (+)Ensemblpanpan1.1panPan2
SP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,878,612 - 1,887,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,880,424 - 1,887,679 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,365,530 - 44,382,281 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,871,509 - 1,888,303 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1271,889,794 - 1,906,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,874,976 - 1,891,740 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,766,164 - 44,782,966 (-)NCBIUU_Cfam_GSD_1.0
Sp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,544,586 - 62,554,293 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,612,060 - 10,619,628 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,610,542 - 10,613,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,543,534 - 18,565,776 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,541,368 - 18,566,668 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,978,684 - 19,002,387 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,436,976 - 49,456,741 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037196,611,275 - 196,624,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,436,115 - 1,456,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,436,390 - 1,444,996 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Sp7
24 total Variants

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:77
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000018828
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat

1 to 10 of 15 rows
D7Mit1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,371,291 - 135,371,468 (+)Marker Load Pipeline
mRatBN7.27133,492,707 - 133,492,884 (+)MAPPERmRatBN7.2
Rnor_6.07143,965,415 - 143,965,591NCBIRnor6.0
Rnor_5.07141,760,721 - 141,760,897UniSTSRnor5.0
RGSC_v3.47141,116,327 - 141,116,504RGDRGSC3.4
RGSC_v3.47141,116,328 - 141,116,504UniSTSRGSC3.4
RGSC_v3.17141,192,765 - 141,192,941RGD
Celera7129,925,775 - 129,925,951UniSTS
RH 3.4 Map71065.7UniSTS
RH 3.4 Map71065.7RGD
RH 2.0 Map7799.2RGD
Cytogenetic Map7q36UniSTS
PMC151001P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,486,386 - 133,486,584 (+)MAPPERmRatBN7.2
Rnor_6.07143,959,094 - 143,959,291NCBIRnor6.0
Rnor_5.07141,754,402 - 141,754,599UniSTSRnor5.0
RGSC_v3.47141,110,007 - 141,110,204UniSTSRGSC3.4
Celera7129,919,462 - 129,919,659UniSTS
Cytogenetic Map7q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 2 12 104 40 37 23 9 23 5 94 31 93 32 50 14



Ensembl Acc Id: ENSRNOT00000018828   ⟹   ENSRNOP00000018828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,484,953 - 133,494,156 (-)Ensembl
Rnor_6.0 Ensembl7143,958,858 - 143,966,863 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081758   ⟹   ENSRNOP00000074457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,484,609 - 133,494,847 (-)Ensembl
Rnor_6.0 Ensembl7143,958,858 - 143,967,484 (-)Ensembl
RefSeq Acc Id: NM_001037632   ⟹   NP_001032721
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,364,735 - 135,373,361 (-)NCBI
mRatBN7.27133,486,151 - 133,494,777 (-)NCBI
Rnor_6.07143,958,858 - 143,967,484 (-)NCBI
Rnor_5.07141,753,826 - 141,762,790 (-)NCBI
RGSC_v3.47141,109,771 - 141,118,397 (-)RGD
Celera7129,919,226 - 129,927,844 (-)RGD
Sequence:
RefSeq Acc Id: NM_181374   ⟹   NP_852039
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,364,735 - 135,372,740 (-)NCBI
mRatBN7.27133,486,151 - 133,494,156 (-)NCBI
Rnor_6.07143,958,858 - 143,966,863 (-)NCBI
Rnor_5.07141,753,826 - 141,762,790 (-)NCBI
RGSC_v3.47141,109,771 - 141,118,397 (-)RGD
Celera7129,919,226 - 129,927,223 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594791   ⟹   XP_017450280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,363,193 - 135,373,376 (-)NCBI
mRatBN7.27133,484,609 - 133,494,788 (-)NCBI
Rnor_6.07143,957,316 - 143,967,488 (-)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_001032721 (Get FASTA)   NCBI Sequence Viewer  
  NP_852039 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450280 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO18647 (Get FASTA)   NCBI Sequence Viewer  
  DAA01455 (Get FASTA)   NCBI Sequence Viewer  
  DAA01456 (Get FASTA)   NCBI Sequence Viewer  
  EDL86842 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018828.2
  ENSRNOP00000074457
  ENSRNOP00000074457.1
1 to 10 of 10 rows
RefSeq Acc Id: NP_001032721   ⟸   NM_001037632
- Peptide Label: isoform 1
- UniProtKB: Q6IMK1 (UniProtKB/TrEMBL),   Q811U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_852039   ⟸   NM_181374
- Peptide Label: isoform 2
- UniProtKB: Q6IMK2 (UniProtKB/TrEMBL),   F7EYG4 (UniProtKB/TrEMBL),   Q811U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450280   ⟸   XM_017594791
- Peptide Label: isoform X1
- UniProtKB: Q6IMK2 (UniProtKB/TrEMBL),   F7EYG4 (UniProtKB/TrEMBL),   Q811U1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018828   ⟸   ENSRNOT00000018828
Ensembl Acc Id: ENSRNOP00000074457   ⟸   ENSRNOT00000081758
C2H2-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q6IMK2-F1-model_v2 AlphaFold Q6IMK2 1-428 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695698
Promoter ID:EPDNEW_R6223
Type:multiple initiation site
Name:Sp7_1
Description:Sp7 transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,967,469 - 143,967,529EPDNEW


1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31938 BioCyc
Ensembl Genes ENSRNOG00000014082 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018828.4 UniProtKB/TrEMBL
  ENSRNOT00000081758 ENTREZGENE
  ENSRNOT00000081758.2 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:300260 UniProtKB/TrEMBL
NCBI Gene 300260 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR SP7 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Sp7 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014082 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt F7EYG4 ENTREZGENE, UniProtKB/TrEMBL
  Q6IMK1 ENTREZGENE, UniProtKB/TrEMBL
  Q6IMK2 ENTREZGENE, UniProtKB/TrEMBL
  Q811U1 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Sp7  Sp7 transcription factor      Symbol and Name status set to approved 625702 APPROVED