Psma6 (proteasome 20S subunit alpha 6) - Rat Genome Database

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Gene: Psma6 (proteasome 20S subunit alpha 6) Rattus norvegicus
Analyze
Symbol: Psma6
Name: proteasome 20S subunit alpha 6
RGD ID: 61849
Description: Predicted to enable NF-kappaB binding activity and RNA binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in sarcomere. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: macropain iota chain; MGC72876; multicatalytic endopeptidase complex iota chain; proteasome (prosome, macropain) subunit, alpha type 6; proteasome alpha 6 subunit; proteasome iota chain; proteasome subunit alpha 6; proteasome subunit alpha type-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Psma6-ps1   Psma6-ps5  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,500,676 - 78,531,693 (+)NCBIGRCr8
mRatBN7.2672,765,534 - 72,796,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,765,473 - 72,796,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,199,417 - 73,216,739 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,505,773 - 73,523,097 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,934,448 - 72,951,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,174,460 - 76,205,429 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,174,452 - 76,205,426 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,711,990 - 85,742,474 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,649,844 - 75,667,404 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,652,972 - 75,670,527 (+)NCBI
Celera671,619,646 - 71,637,029 (+)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lovastatin  (ISO)
menadione  (ISO)
methidathion  (ISO)
methimazole  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
quercitrin  (ISO)
resveratrol  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
myofibril  (IDA)
nuclear matrix  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
P-body  (IEA,ISO,ISS)
proteasome complex  (ISO)
proteasome core complex  (ISO,ISS)
proteasome core complex, alpha-subunit complex  (IBA,IEA,ISO,ISS)
ribosome  (IEA,ISO,ISS)
sarcomere  (IDA)

Molecular Function
NF-kappaB binding  (IEA,ISO)
protein binding  (ISO)
RNA binding  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteasomes are tightly associated to myofibrils in mature skeletal muscle. Bassaglia Y, etal., Exp Cell Res. 2005 Jan 15;302(2):221-32.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Molecular cloning of cDNAs for rat proteasomes: deduced primary structures of four other subunits. Tamura T, etal., J Biochem (Tokyo) 1992 Oct;112(4):530-4.
Additional References at PubMed
PMID:7681138   PMID:9096325   PMID:9688553   PMID:10852819   PMID:12477932   PMID:14743216   PMID:15489334   PMID:16845397   PMID:16857966   PMID:17323924   PMID:20458337   PMID:20498273  
PMID:21630459   PMID:22078707   PMID:22793692   PMID:22871113   PMID:23376485   PMID:29867124   PMID:30133132   PMID:30287505   PMID:30361391  


Genomics

Comparative Map Data
Psma6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,500,676 - 78,531,693 (+)NCBIGRCr8
mRatBN7.2672,765,534 - 72,796,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,765,473 - 72,796,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,199,417 - 73,216,739 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,505,773 - 73,523,097 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,934,448 - 72,951,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,174,460 - 76,205,429 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,174,452 - 76,205,426 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,711,990 - 85,742,474 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,649,844 - 75,667,404 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,652,972 - 75,670,527 (+)NCBI
Celera671,619,646 - 71,637,029 (+)NCBICelera
Cytogenetic Map6q23NCBI
PSMA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,278,558 - 35,317,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,278,633 - 35,317,493 (+)EnsemblGRCh38hg38GRCh38
GRCh371435,747,764 - 35,786,699 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,831,325 - 34,856,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 341434,831,324 - 34,856,429NCBI
Celera1415,625,404 - 15,650,528 (+)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1415,875,787 - 15,900,913 (+)NCBIHuRef
CHM1_11435,761,317 - 35,786,430 (+)NCBICHM1_1
T2T-CHM13v2.01429,466,162 - 29,505,113 (+)NCBIT2T-CHM13v2.0
Psma6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,431,007 - 55,465,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,431,007 - 55,465,239 (+)EnsemblGRCm39 Ensembl
GRCm381255,384,222 - 55,418,459 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,384,222 - 55,418,454 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,499,812 - 56,519,446 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,317,027 - 56,336,581 (+)NCBIMGSCv36mm8
Celera1256,548,065 - 56,567,699 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1223.94NCBI
Psma6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,750,270 - 25,787,533 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540925,751,578 - 25,787,533 (-)NCBIChiLan1.0ChiLan1.0
PSMA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,604,909 - 36,630,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11435,821,412 - 35,846,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,044,300 - 16,069,521 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,227,495 - 34,252,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1434,214,271 - 34,252,347 (+)Ensemblpanpan1.1panPan2
PSMA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,010,899 - 14,038,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,010,939 - 14,038,134 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha813,807,535 - 13,834,775 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0814,116,970 - 14,144,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,117,011 - 14,144,063 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,818,618 - 13,845,898 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,883,420 - 13,910,936 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,173,313 - 14,200,558 (+)NCBIUU_Cfam_GSD_1.0
Psma6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864045,937,259 - 45,961,803 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364949,443,176 - 9,467,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,578,243 - 64,616,491 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,578,247 - 64,603,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,487,814 - 69,525,983 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,099,804 - 12,127,477 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,099,937 - 12,127,309 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660531,062,970 - 1,090,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psma6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,449,266 - 1,486,382 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248381,449,362 - 1,474,597 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Psma6
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:91
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000009666
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)67222764181132889Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009666   ⟹   ENSRNOP00000009666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl672,779,123 - 72,796,553 (+)Ensembl
Rnor_6.0 Ensembl676,188,083 - 76,205,426 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084062   ⟹   ENSRNOP00000071403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl672,765,473 - 72,796,554 (+)Ensembl
Rnor_6.0 Ensembl676,174,452 - 76,205,426 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096468   ⟹   ENSRNOP00000085716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl672,786,733 - 72,796,554 (+)Ensembl
RefSeq Acc Id: NM_017283   ⟹   NP_058979
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,514,347 - 78,531,693 (+)NCBI
mRatBN7.2672,779,206 - 72,796,554 (+)NCBI
Rnor_6.0676,188,083 - 76,205,429 (+)NCBI
Rnor_5.0685,711,990 - 85,742,474 (+)NCBI
RGSC_v3.4675,649,844 - 75,667,404 (+)RGD
Celera671,619,646 - 71,637,029 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240098   ⟹   XP_006240160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,500,676 - 78,531,693 (+)NCBI
mRatBN7.2672,765,534 - 72,796,554 (+)NCBI
Rnor_6.0676,174,460 - 76,205,429 (+)NCBI
Rnor_5.0685,711,990 - 85,742,474 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058979   ⟸   NM_017283
- UniProtKB: P60901 (UniProtKB/Swiss-Prot),   A6HBM1 (UniProtKB/TrEMBL),   A0A8I6GE69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240160   ⟸   XM_006240098
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0D7 (UniProtKB/TrEMBL),   A0A8I6GE69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009666   ⟸   ENSRNOT00000009666
RefSeq Acc Id: ENSRNOP00000071403   ⟸   ENSRNOT00000084062
RefSeq Acc Id: ENSRNOP00000085716   ⟸   ENSRNOT00000096468
Protein Domains
Proteasome alpha-type subunits

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60901-F1-model_v2 AlphaFold P60901 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694608
Promoter ID:EPDNEW_R5129
Type:initiation region
Name:Psma6_2
Description:proteasome subunit alpha 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5130  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0676,174,472 - 76,174,532EPDNEW
RGD ID:13694605
Promoter ID:EPDNEW_R5130
Type:initiation region
Name:Psma6_1
Description:proteasome subunit alpha 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5129  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0676,188,071 - 76,188,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61849 AgrOrtholog
BioCyc Gene G2FUF-37488 BioCyc
Ensembl Genes ENSRNOG00000007114 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013444 UniProtKB/Swiss-Prot
  ENSRNOG00060020304 UniProtKB/Swiss-Prot
  ENSRNOG00065005071 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009666 ENTREZGENE
  ENSRNOT00000009666.7 UniProtKB/Swiss-Prot
  ENSRNOT00000084062.2 UniProtKB/TrEMBL
  ENSRNOT00000096468.1 UniProtKB/TrEMBL
  ENSRNOT00055023043 UniProtKB/Swiss-Prot
  ENSRNOT00060035234 UniProtKB/Swiss-Prot
  ENSRNOT00065007447 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6888689 IMAGE-MGC_LOAD
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_alpha-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_asu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_sua/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_subunit_alpha6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29673 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72876 IMAGE-MGC_LOAD
NCBI Gene 29673 ENTREZGENE
PANTHER PROTEASOME SUBUNIT ALPHA TYPE-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASOME SUBUNIT ALPHA/BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Proteasome UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_A_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Psma6 PhenoGen
PROSITE PROTEASOME_ALPHA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASOME_ALPHA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007114 RatGTEx
  ENSRNOG00055013444 RatGTEx
  ENSRNOG00060020304 RatGTEx
  ENSRNOG00065005071 RatGTEx
SMART Proteasome_A_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0D7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GE69 ENTREZGENE, UniProtKB/TrEMBL
  A6HBM1 ENTREZGENE, UniProtKB/TrEMBL
  P60901 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P34062 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Psma6  proteasome 20S subunit alpha 6  Psma6  proteasome subunit alpha 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-19 Psma6  proteasome subunit alpha 6  Psma6  proteasome (prosome, macropain) subunit, alpha type 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psma6  proteasome (prosome, macropain) subunit, alpha type 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference