Psma6 (proteasome 20S subunit alpha 6) - Rat Genome Database

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Gene: Psma6 (proteasome 20S subunit alpha 6) Heterocephalus glaber
Analyze
Symbol: Psma6
Name: proteasome 20S subunit alpha 6
RGD ID: 18899862
Description: ENCODES a protein that exhibits NF-kappaB binding (ortholog); RNA binding (ortholog); INVOLVED IN positive regulation of canonical NF-kappaB signal transduction (ortholog); regulation of inflammatory response (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); ectodermal dysplasia and immunodeficiency 2 (ortholog); human immunodeficiency virus infectious disease (ortholog); FOUND IN cilium (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proteasome subunit alpha 6; Proteasome subunit alpha type-6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,449,266 - 1,486,382 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248381,449,362 - 1,474,597 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psma6Naked Mole-RatBrain-Lung-Thyroid Syndrome  ISOPSMA6 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868
Psma6Naked Mole-Ratectodermal dysplasia and immunodeficiency 2  ISOPSMA6 (Homo sapiens)8554872ClinVar Annotator: match by term: Ectodermal dysplasia and immunodeficiency 2ClinVarPMID:28492532
Psma6Naked Mole-Ratmyocardial infarction  ISOPSMA6 (Homo sapiens)8554872ClinVar Annotator: match by term: PSMA6-related conditionClinVarPMID:16845397 and PMID:19282875
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psma6Naked Mole-Rathuman immunodeficiency virus infectious disease  ISOPSMA6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15308739
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psma6Naked Mole-Ratmyocardial infarction susceptibilityISOPSMA6 (Homo sapiens)7240710 OMIM 


Biological Process

  

Cellular Component
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psma6Naked Mole-Ratcilium located_inISOPSMA6 (Homo sapiens)9068941 HPAGO_REF:0000052
Psma6Naked Mole-Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
Psma6Naked Mole-Ratcytoplasm located_inIEAARBA:ARBA00026971150520179 UniProtGO_REF:0000117
Psma6Naked Mole-Ratcytoplasm is_active_inISOPSMA6 (Homo sapiens)9068941 PMID:34711951UniProtPMID:34711951
Psma6Naked Mole-Ratcytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
Psma6Naked Mole-Ratcytosol located_inISOPSMA6 (Homo sapiens)9068941 HPAGO_REF:0000052
Psma6Naked Mole-Ratmitochondrion located_inISOPSMA6 (Homo sapiens)9068941 HPAGO_REF:0000052
Psma6Naked Mole-Ratmyofibril located_inISOPsma6 (Rattus norvegicus)9068941PMID:15561103BHF-UCLPMID:15561103 and REF_RGD_ID:8554154
Psma6Naked Mole-Ratnuclear matrix located_inISOPsma6 (Mus musculus)9068941 PMID:10852819BHF-UCLPMID:10852819
Psma6Naked Mole-Ratnucleoplasm located_inISOPSMA6 (Homo sapiens)9068941 HPAGO_REF:0000052
Psma6Naked Mole-Ratnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
Psma6Naked Mole-Ratnucleus is_active_inISOPSMA6 (Homo sapiens)9068941 PMID:34711951UniProtPMID:34711951
Psma6Naked Mole-Ratnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
Psma6Naked Mole-RatP-body located_inISOPsma6 (Mus musculus)9068941 PMID:22078707UniProtPMID:22078707
Psma6Naked Mole-Ratproteasome complex part_ofIEAUniProtKB-KW:KW-0647150520179 UniProtGO_REF:0000043
Psma6Naked Mole-Ratproteasome core complex part_ofIEAInterPro:IPR001353150520179 InterProGO_REF:0000002
Psma6Naked Mole-Ratproteasome core complex, alpha-subunit complex part_ofIEAInterPro:IPR000426 and InterPro:IPR034642150520179 InterProGO_REF:0000002
Psma6Naked Mole-Ratproteasome core complex, alpha-subunit complex part_ofIEAUniRule:UR000416603150520179 UniProtGO_REF:0000104
Psma6Naked Mole-Ratribosome located_inISOPSMA6 (Homo sapiens)9068941 PMID:7681138BHF-UCLPMID:7681138
Psma6Naked Mole-Ratsarcomere located_inISOPsma6 (Rattus norvegicus)9068941PMID:15561103BHF-UCLPMID:15561103 and REF_RGD_ID:8554154
1 to 20 of 20 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psma6Naked Mole-RatNF-kappaB binding enablesISOUniProtKB:Q00653-29068941 PMID:14743216BHF-UCLPMID:14743216
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:O14818 and UniProtKB:P257879068941 PMID:14733938 and PMID:33961781IntActPMID:14733938 and PMID:33961781
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:P257879068941 PMID:12376572 and PMID:15887188IntActPMID:12376572 and PMID:15887188
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:P25788 more ...9068941 PMID:25416956IntActPMID:25416956
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:O14818 more ...9068941 PMID:17948026IntActPMID:17948026
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:A2RU48 more ...9068941 PMID:32296183IntActPMID:32296183
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:O14818 and UniProtKB:P257899068941 PMID:15225636IntActPMID:15225636
Psma6Naked Mole-Ratprotein binding enablesISOPR:P28063 more ...9068941 PMID:31915251MGIPMID:31915251
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:P257889068941 PMID:16169070IntActPMID:16169070
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:P257899068941 PMID:19581590IntActPMID:19581590
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:Q9Y5K59068941 PMID:16990800 more ...IntActPMID:16990800 more ...
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:O14818 more ...9068941 PMID:35271311IntActPMID:35271311
Psma6Naked Mole-Ratprotein binding enablesISOUniProtKB:P428589068941 PMID:25959826 and PMID:32814053IntActPMID:25959826 and PMID:32814053
Psma6Naked Mole-RatRNA binding enablesISOPsma6 (Mus musculus)9068941 PMID:10852819BHF-UCLPMID:10852819
Psma6Naked Mole-RatRNA binding enablesISOPSMA6 (Homo sapiens)9068941 PMID:7681138BHF-UCLPMID:7681138
1 to 15 of 15 rows

PMID:21993625   PMID:22301074   PMID:30032202  



Psma6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,449,266 - 1,486,382 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248381,449,362 - 1,474,597 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PSMA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,278,558 - 35,317,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,278,633 - 35,317,493 (+)EnsemblGRCh38hg38GRCh38
GRCh371435,747,764 - 35,786,699 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,831,325 - 34,856,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 341434,831,324 - 34,856,429NCBI
Celera1415,625,404 - 15,650,528 (+)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1415,875,787 - 15,900,913 (+)NCBIHuRef
CHM1_11435,761,317 - 35,786,430 (+)NCBICHM1_1
T2T-CHM13v2.01429,466,162 - 29,505,113 (+)NCBIT2T-CHM13v2.0
Psma6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,431,007 - 55,465,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,431,007 - 55,465,239 (+)EnsemblGRCm39 Ensembl
GRCm381255,384,222 - 55,418,459 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,384,222 - 55,418,454 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,499,812 - 56,519,446 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,317,027 - 56,336,581 (+)NCBIMGSCv36mm8
Celera1256,548,065 - 56,567,699 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1223.94NCBI
Psma6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,500,676 - 78,531,693 (+)NCBIGRCr8
mRatBN7.2672,765,534 - 72,796,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,765,473 - 72,796,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,199,417 - 73,216,739 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,505,773 - 73,523,097 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,934,448 - 72,951,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,174,460 - 76,205,429 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,174,452 - 76,205,426 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,711,990 - 85,742,474 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,649,844 - 75,667,404 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,652,972 - 75,670,527 (+)NCBI
Celera671,619,646 - 71,637,029 (+)NCBICelera
Cytogenetic Map6q23NCBI
Psma6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,750,270 - 25,787,533 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540925,751,578 - 25,787,533 (-)NCBIChiLan1.0ChiLan1.0
PSMA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,604,909 - 36,630,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11435,821,412 - 35,846,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,044,300 - 16,069,521 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,227,495 - 34,252,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1434,214,271 - 34,252,347 (+)Ensemblpanpan1.1panPan2
PSMA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,010,899 - 14,038,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,010,939 - 14,038,134 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha813,807,535 - 13,834,775 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0814,116,970 - 14,144,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,117,011 - 14,144,063 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,818,618 - 13,845,898 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,883,420 - 13,910,936 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,173,313 - 14,200,558 (+)NCBIUU_Cfam_GSD_1.0
Psma6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864045,937,259 - 45,961,803 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364949,443,176 - 9,467,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,578,243 - 64,616,491 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,578,247 - 64,603,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,487,814 - 69,525,983 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,099,804 - 12,127,477 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,099,937 - 12,127,309 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660531,062,970 - 1,090,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000000631   ⟹   ENSHGLP00000000592
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248381,449,266 - 1,475,393 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000000632   ⟹   ENSHGLP00000000593
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248381,449,527 - 1,486,382 (-)Ensembl
RefSeq Acc Id: XM_004867557   ⟹   XP_004867614
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248381,449,362 - 1,474,597 (-)NCBI
RefSeq Acc Id: XM_021246633   ⟹   XP_021102292
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248381,449,362 - 1,474,597 (-)NCBI
RefSeq Acc Id: XM_021246634   ⟹   XP_021102293
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248381,449,362 - 1,474,568 (-)NCBI
Protein RefSeqs XP_004867614 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102292 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102293 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000592
RefSeq Acc Id: XP_021102292   ⟸   XM_021246633
- Peptide Label: isoform X2
- UniProtKB: A0AAX6S2R6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867614   ⟸   XM_004867557
- Peptide Label: isoform X1
- UniProtKB: G5B117 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102293   ⟸   XM_021246634
- Peptide Label: isoform X3
- UniProtKB: A0AAX6S1A5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000593   ⟸   ENSHGLT00000000632
Ensembl Acc Id: ENSHGLP00000000592   ⟸   ENSHGLT00000000631



1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000000520 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000631 ENTREZGENE
Gene3D-CATH 3.60.20.10 UniProtKB/TrEMBL
InterPro Ntn_hydrolases_N UniProtKB/TrEMBL
  Proteasome_alpha UniProtKB/TrEMBL
  Proteasome_alpha-type UniProtKB/TrEMBL
  Proteasome_asu_N UniProtKB/TrEMBL
  Proteasome_sua/b UniProtKB/TrEMBL
  Proteasome_subunit_alpha6 UniProtKB/TrEMBL
KEGG Report hgl:101709607 UniProtKB/TrEMBL
NCBI Gene Psma6 ENTREZGENE
PANTHER PROTEASOME SUBUNIT ALPHA/BETA UniProtKB/TrEMBL
Pfam Proteasome UniProtKB/TrEMBL
  Proteasome_A_N UniProtKB/TrEMBL
PROSITE PROTEASOME_ALPHA_1 UniProtKB/TrEMBL
  PROTEASOME_ALPHA_2 UniProtKB/TrEMBL
SMART Proteasome_A_N UniProtKB/TrEMBL
Superfamily-SCOP SSF56235 UniProtKB/TrEMBL
UniProt A0AAX6S1A5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S2R6 ENTREZGENE, UniProtKB/TrEMBL
  G5B117 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows