Symbol:
Tnp1
Name:
transition protein 1
RGD ID:
3884
Description:
Predicted to enable DNA binding activity. Predicted to be involved in several processes, including nucleosome disassembly; regulation of gene expression; and spermatid nucleus differentiation. Predicted to act upstream of or within spermatogenesis. Located in male germ cell nucleus. Orthologous to human TNP1 (transition protein 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; allethrin; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
spermatid nuclear transition protein 1; STP-1; testis-specific basic protein; TP-1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TNP1 (transition protein 1)
HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Tnp1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Tnp1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TNP1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TNP1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tnp1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TNP1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
TNP1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Tnp1 (transition protein 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Tnp1 (transition protein 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
TNP1 (transition protein 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 9 82,043,669 - 82,044,278 (-) NCBI GRCr8 mRatBN7.2 9 74,594,463 - 74,595,072 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 9 74,594,466 - 74,595,274 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 9 83,049,184 - 83,049,793 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 9 88,178,079 - 88,178,688 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 9 86,564,825 - 86,565,434 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 9 80,294,837 - 80,295,446 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 80,294,840 - 80,295,446 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 9 80,066,299 - 80,066,908 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 72,397,750 - 72,398,359 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 9 72,544,732 - 72,545,341 (-) NCBI Celera 9 72,188,091 - 72,188,700 (-) NCBI Celera Cytogenetic Map 9 q33 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Biological Process
cell differentiation (IEA) chromatin remodeling (IBA,IEA,ISO,ISS) flagellated sperm motility (IEA,ISO,ISS) heterochromatin formation (IEA,ISO,ISS) negative regulation of DNA-templated transcription (IEA,ISO,ISS) nucleosome disassembly (IEA,ISO,ISS) positive regulation of protein processing (IEA,ISO,ISS) sexual reproduction (IEA,ISO,ISS) single strand break repair (IEA,ISO,ISS) sperm DNA condensation (IEA,ISO,ISS) spermatid development (IEA,ISO,ISS) spermatid nucleus elongation (IBA,IEA,ISO,ISS) spermatogenesis (IEA,ISO)
1.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
3.
Isolation of a cDNA clone for transition protein 1 (TP1), a major chromosomal protein of mammalian spermatids.
Heidaran MA and Kistler WS, Gene 1987;54(2-3):281-4.
4.
Nucleotide sequence of the Stp-1 gene coding for rat spermatid nuclear transition protein 1 (TP1): homology with protamine P1 and assignment of the mouse Stp-1 gene to chromosome 1.
Heidaran MA, etal., Gene 1989 Jan 30;75(1):39-46.
5.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
6.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.
GOA pipeline
RGD automated data pipeline
8.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
9.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Tnp1 (Rattus norvegicus - Norway rat)
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 9 82,043,669 - 82,044,278 (-) NCBI GRCr8 mRatBN7.2 9 74,594,463 - 74,595,072 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 9 74,594,466 - 74,595,274 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 9 83,049,184 - 83,049,793 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 9 88,178,079 - 88,178,688 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 9 86,564,825 - 86,565,434 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 9 80,294,837 - 80,295,446 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 80,294,840 - 80,295,446 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 9 80,066,299 - 80,066,908 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 72,397,750 - 72,398,359 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 9 72,544,732 - 72,545,341 (-) NCBI Celera 9 72,188,091 - 72,188,700 (-) NCBI Celera Cytogenetic Map 9 q33 NCBI
TNP1 (Homo sapiens - human)
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 2 216,859,458 - 216,860,064 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 2 216,859,458 - 216,860,064 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 2 217,724,181 - 217,724,787 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 2 217,432,426 - 217,433,027 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 2 217,549,689 - 217,550,288 NCBI Celera 2 211,492,069 - 211,492,670 (-) NCBI Celera Cytogenetic Map 2 q35 NCBI HuRef 2 209,578,223 - 209,578,824 (-) NCBI HuRef CHM1_1 2 217,730,235 - 217,730,836 (-) NCBI CHM1_1 T2T-CHM13v2.0 2 217,341,898 - 217,342,504 (-) NCBI T2T-CHM13v2.0
Tnp1 (Mus musculus - house mouse)
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 1 73,054,233 - 73,055,058 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 1 73,054,233 - 73,055,068 (-) Ensembl GRCm39 Ensembl GRCm38 1 73,015,074 - 73,015,899 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 1 73,015,074 - 73,015,909 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 1 73,061,648 - 73,062,473 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 1 72,948,284 - 72,949,079 (-) NCBI MGSCv36 mm8 Celera 1 73,589,038 - 73,589,863 (-) NCBI Celera Cytogenetic Map 1 C3 NCBI cM Map 1 36.94 NCBI
Tnp1 (Chinchilla lanigera - long-tailed chinchilla)
Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955453 16,387,527 - 16,388,890 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955453 16,387,897 - 16,388,513 (+) NCBI ChiLan1.0 ChiLan1.0
TNP1 (Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 13 119,489,569 - 119,490,175 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 2B 119,504,535 - 119,505,141 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 2B 104,122,748 - 104,123,349 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 2B 222,723,606 - 222,724,212 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 2B 222,723,606 - 222,724,212 (-) Ensembl panpan1.1 panPan2
TNP1 (Canis lupus familiaris - dog)
Tnp1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
TNP1 (Sus scrofa - pig)
Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 15 119,037,496 - 119,038,105 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 15 119,037,492 - 119,038,099 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 15 131,800,371 - 131,801,028 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
TNP1 (Chlorocebus sabaeus - green monkey)
Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 10 102,703,116 - 102,703,747 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 10 102,703,325 - 102,703,691 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666040 96,709,921 - 96,711,971 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Tnp1 (Heterocephalus glaber - naked mole-rat)
.
Predicted Target Of
Count of predictions: 16 Count of miRNA genes: 16 Interacting mature miRNAs: 16 Transcripts: ENSRNOT00000023769 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
7411571 Bw138 Body weight QTL 138 14.3 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 9 32535505 77535505 Rat 11353957 Bmd92 Bone mineral density QTL 92 0.01 tibia mineral mass (VT:1000283) volumetric bone mineral density (CMO:0001553) 9 46114199 91114199 Rat 61385 Edpm9 Estrogen-dependent pituitary mass QTL 9 3.43 0.05 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) 9 63869687 108869687 Rat 70218 Cm28 Cardiac mass QTL 28 8.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 9 25268044 79271759 Rat 724544 Uae9 Urinary albumin excretion QTL 9 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 9 25268044 114175309 Rat 1578760 Cm53 Cardiac mass QTL 53 3.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 9 56771635 101771635 Rat 1581580 Uae34 Urinary albumin excretion QTL 34 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 62072275 96470995 Rat 12879506 Pur33 Proteinuria QTL 33 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 9 44649921 89649921 Rat 731164 Uae25 Urinary albumin excretion QTL 25 3.5 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 25661188 100929786 Rat 10058949 Gmadr5 Adrenal mass QTL 5 2 0.014 adrenal gland mass (VT:0010420) both adrenal glands wet weight to body weight ratio (CMO:0002411) 9 42791513 87976209 Rat 1578757 Pur6 Proteinuria QTL 6 3.3 0.005 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 9 62072275 96470995 Rat 631656 Bp108 Blood pressure QTL 108 5.97 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 48598251 93598251 Rat 2303170 Bp332 Blood pressure QTL 332 3.73 0.027 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 55847841 77026453 Rat 8662828 Vetf6 Vascular elastic tissue fragility QTL 6 3.9 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) 9 36962359 92058970 Rat 61352 Bp34 Blood pressure QTL 34 5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 42495343 79271511 Rat 724515 Uae16 Urinary albumin excretion QTL 16 8 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 58163035 100929646 Rat 731171 Glom6 Glomerulus QTL 6 2.8 0.0003 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) 9 64573531 109573531 Rat 1598834 Memor11 Memory QTL 11 2.5 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) 9 36962359 77814038 Rat 70186 Niddm26 Non-insulin dependent diabetes mellitus QTL 26 3.87 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 9 22071169 86369743 Rat 7207814 Bmd91 Bone mineral density QTL 91 3.5 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 9 23754144 83851531 Rat 6903941 Pur31 Proteinuria QTL 31 0.036 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 9 40194188 85194188 Rat 2303180 Bp333 Blood pressure QTL 333 0.001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 56627713 78595166 Rat 2290450 Scl57 Serum cholesterol level QTL 57 4.15 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 9 36962359 95410867 Rat 11353949 Bp393 Blood pressure QTL 393 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 40194188 85194188 Rat 11353951 Bp394 Blood pressure QTL 394 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 44649921 89649921 Rat 10054125 Srcrt7 Stress Responsive Cort QTL 7 3.33 0.0011 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 9 1 87073594 Rat 1300134 Bp185 Blood pressure QTL 185 3.73 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 61381434 104821652 Rat 7411656 Foco26 Food consumption QTL 26 9.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 9 32535505 77535505 Rat
PMC141152P1
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 9 74,594,689 - 74,595,055 (+) MAPPER mRatBN7.2 Rnor_6.0 9 80,295,064 - 80,295,429 NCBI Rnor6.0 Rnor_5.0 9 80,066,526 - 80,066,891 UniSTS Rnor5.0 RGSC_v3.4 9 72,397,977 - 72,398,342 UniSTS RGSC3.4 Celera 9 72,188,318 - 72,188,683 UniSTS Cytogenetic Map 9 q33 UniSTS
Tnp1
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 9 74,594,689 - 74,595,055 (+) MAPPER mRatBN7.2 Rnor_6.0 9 80,295,064 - 80,295,429 NCBI Rnor6.0 Rnor_5.0 9 80,066,526 - 80,066,891 UniSTS Rnor5.0 RGSC_v3.4 9 72,397,977 - 72,398,342 UniSTS RGSC3.4 Celera 9 72,188,318 - 72,188,683 UniSTS Cytogenetic Map 9 q33 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
1
8
7
24
27
31
14
13
14
2
58
27
17
10
37
17
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000023769 ⟹ ENSRNOP00000023769
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 9 74,594,466 - 74,595,274 (-) Ensembl Rnor_6.0 Ensembl 9 80,294,840 - 80,295,446 (-) Ensembl
RefSeq Acc Id:
NM_017056 ⟹ NP_058752
RefSeq Status:
PROVISIONAL
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 9 82,043,669 - 82,044,278 (-) NCBI mRatBN7.2 9 74,594,463 - 74,595,072 (-) NCBI Rnor_6.0 9 80,294,837 - 80,295,446 (-) NCBI Rnor_5.0 9 80,066,299 - 80,066,908 (-) NCBI RGSC_v3.4 9 72,397,750 - 72,398,359 (-) RGD Celera 9 72,188,091 - 72,188,700 (-) RGD
Sequence:
TTTTGGCAGAAATTACAATGTCGACCAGCCGCAAACTAAAGACTCATGGCATGAGGAGAGGCAAGAACCGAGCTCCTCACAAGGGCGTCAAGAGAGGAGGAAGCAAGAGAAAATACCGGAAGAGCAGC CTGAAGAGTAGGAAACGGGGCGATGATGCAAGTCGCAATTACCGATCCCACTTGTAATGCGGCAATGAGCTCTAGCCTGGTGGTCTTCAAACTACACCAGGCAGCAACAAGACATCAGAGGGGGACTG CCAGAGAGATCTGAAGTTAGACCAAAGCCAGAGAAAGATCCTATCAGAGTGGGTAAAATGCCAGTTGTGACGAAATTCGGAATGTATATGTTGGCTGTTTCTCCCCAACATCTCAATAACAATTTTGA AAACAAAATAAAATTGTGAAAACTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
hide sequence
RefSeq Acc Id:
NP_058752 ⟸ NM_017056
- UniProtKB:
P02317 (UniProtKB/Swiss-Prot), A6JVR3 (UniProtKB/TrEMBL)
- Sequence:
MSTSRKLKTHGMRRGKNRAPHKGVKRGGSKRKYRKSSLKSRKRGDDASRNYRSHL
hide sequence
Ensembl Acc Id:
ENSRNOP00000023769 ⟸ ENSRNOT00000023769
RGD ID: 13696741
Promoter ID: EPDNEW_R7266
Type: multiple initiation site
Name: Tnp1_1
Description: transition protein 1
SO ACC ID: SO:0000170
Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ )
Experiment Methods: Single-end sequencing.
Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 9 80,295,458 - 80,295,518 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2002-06-10
Tnp1
Transition protein 1
Symbol and Name status set to approved
70586
APPROVED
Note Type
Note
Reference
gene_protein
protein contains 54 aa residues
729972