Star (steroidogenic acute regulatory protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Star (steroidogenic acute regulatory protein) Rattus norvegicus
Analyze
Symbol: Star
Name: steroidogenic acute regulatory protein
RGD ID: 3770
Description: Predicted to enable cholesterol binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; response to glucocorticoid; and steroid metabolic process. Located in mitochondrial crista and neuronal cell body. Biomarker of hypogonadism; hypothyroidism; nephrosis; polycystic ovary syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; INTERACTS WITH (+)-pilocarpine; (-)-citrinin; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: stARD1; START domain-containing protein 1; steroidogenic acute regulatory protein, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,969,824 - 72,974,447 (-)NCBIGRCr8
mRatBN7.21666,267,094 - 66,274,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,264,807 - 66,271,672 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,545,726 - 71,550,356 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,952,036 - 74,956,666 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,191,932 - 70,196,560 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,036,204 - 71,040,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,036,204 - 71,040,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,700,880 - 70,705,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,642,580 - 70,647,203 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,640,558 - 70,647,408 (-)NCBI
Celera1664,176,969 - 64,181,592 (-)NCBICelera
RH 3.4 Map16622.1RGD
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRatCardiomegaly  IEP 4145630mRNA:increased expression:cardiac muscle tissue (rat)RGD 
StarRatcongenital adrenal hyperplasia  ISOStar (Mus musculus)4145592 RGD 
StarRatcongenital adrenal hyperplasia susceptibilityISOSTAR (Homo sapiens)1600070DNA:transversion:intron:g.IVS4-11T>A (human)RGD 
StarRatExperimental Diabetes Mellitus  IEP 4145530mRNA:decreased expression:sciatic nerve (rat)RGD 
StarRatFetal Growth Retardation  IEP 4832477mRNA:increased expression:adrenal gland and maternal (rat)RGD 
StarRatFever  IEP 4845252protein:decreased expression:testis (rat)RGD 
StarRathypogonadism  IEP 4833436mRNA:decreased expression:testis (rat)RGD 
StarRathypothyroidism  IEP 4889527mRNA:increased expression:corpus luteum (rat)RGD 
StarRatnephrosis  IEP 1599698mRNA:decreased expression:ovaryRGD 
StarRatpolycystic ovary syndrome  IEP 4145934protein:increased expression:ovary (rat)RGD 
StarRattype 2 diabetes mellitus  IEP 4889107mRNA:decreased expression:testis and Leydig cell (rat)RGD 
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRatcongenital adrenal hyperplasia  ISOSTAR (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10215405 more ...
StarRatgenetic disease  ISOSTAR (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
StarRathereditary spastic paraplegia 54  ISOSTAR (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 54ClinVarPMID:28492532
StarRathypogonadotropic hypogonadism 2 with or without anosmia  ISOSTAR (Homo sapiens)8554872ClinVar Annotator: match by term: Hypogonadotropic hypogonadism 2 with or without anosmiaClinVarPMID:12627230 more ...
StarRatLipoid Congenital Adrenal Hyperplasia  ISOSTAR (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10215405 more ...
StarRatparaplegia  ISOSTAR (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:28492532
StarRatsyndactyly-telecanthus-anogenital and renal malformations syndrome  ISOSTAR (Homo sapiens)8554872ClinVar Annotator: match by term: Syndactyly-telecanthus-anogenital and renal malformations syndromeClinVarPMID:16968793 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRatEndometrial Neoplasms  ISOSTAR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23200943
StarRatLipoid Congenital Adrenal Hyperplasia  ISOSTAR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11502818 and PMID:22028173
StarRatpolycystic ovary syndrome  ISOSTAR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21262361
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRatcongenital adrenal hyperplasia  ISSSTAR (Homo sapiens)13592920OMIM:201710 more ...MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRatLipoid Congenital Adrenal Hyperplasia  ISOSTAR (Homo sapiens)7240710 OMIM 

1 to 20 of 705 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRat(+)-dexrazoxane multiple interactionsISOStar (Mus musculus)6480464[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of STAR mRNACTDPMID:26873546
StarRat(+)-pilocarpine increases localizationEXP 6480464Pilocarpine results in increased localization of STAR proteinCTDPMID:20609383
StarRat(-)-anisomycin multiple interactionsISOStar (Mus musculus)6480464Anisomycin promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA] and Anisomycin results in increased expression of and results in increased stability of STAR mRNACTDPMID:15713539
StarRat(-)-citrinin decreases expressionEXP 6480464Citrinin results in decreased expression of STAR proteinCTDPMID:22564900
StarRat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOStar (Mus musculus)648046427-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] more ...CTDPMID:20083572 and PMID:23362264
StarRat(25R)-cholest-5-ene-3beta,26-diol increases expressionISOStar (Mus musculus)648046427-hydroxycholesterol results in increased expression of STAR mRNA and 27-hydroxycholesterol results in increased expression of STAR proteinCTDPMID:23362264
StarRat(25R)-cholest-5-ene-3beta,26-diol increases abundanceISOSTAR (Homo sapiens)6480464STAR protein results in increased abundance of 27-hydroxycholesterolCTDPMID:15863358
StarRat(25R)-cholest-5-ene-3beta,26-diol increases abundanceEXP 6480464STAR protein results in increased abundance of 27-hydroxycholesterolCTDPMID:12368294
StarRat(25R)-cholest-5-ene-3beta,26-diol increases expressionISOSTAR (Homo sapiens)648046427-hydroxycholesterol results in increased expression of STAR proteinCTDPMID:15863358
StarRat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOSTAR (Homo sapiens)648046427-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]CTDPMID:9804848
StarRat(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one increases expressionEXP 6480464cyclopiazonic acid results in increased expression of STAR proteinCTDPMID:22001352
StarRat(E)-thiamethoxam decreases expressionEXP 6480464Thiamethoxam results in decreased expression of STAR mRNACTDPMID:34181816
StarRat(E)-thiamethoxam multiple interactionsEXP 6480464Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]CTDPMID:34181816
StarRat(R)-carnitine multiple interactionsEXP 6480464Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR mRNA] and Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR protein]CTDPMID:33965443
StarRat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA]CTDPMID:28070105
StarRat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of STAR mRNACTDPMID:14618266
StarRat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of STAR mRNA]CTDPMID:32134168
StarRat(S)-nicotine multiple interactionsISOSTAR (Homo sapiens)6480464trichostatin A inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]CTDPMID:24709674
StarRat(S)-nicotine decreases expressionISOStar (Mus musculus)6480464Nicotine results in decreased expression of STAR mRNA and Nicotine results in decreased expression of STAR proteinCTDPMID:31846720
StarRat(S)-nicotine multiple interactionsISOStar (Mus musculus)6480464LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR mRNA] more ...CTDPMID:31846720

1 to 20 of 705 rows

Biological Process
1 to 20 of 72 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRatbile acid biosynthetic process  IDA 1600081 RGD 
StarRatbiphenyl metabolic process  IEP 4768197Aroclor 1254RGD 
StarRatcellular response to alkaloid  IEP 4145624evodiamine and rutaecarpineRGD 
StarRatcellular response to antibiotic  IEP 4777466TriclosanRGD 
StarRatcellular response to cadmium ion  IEP 4835171 RGD 
StarRatcellular response to cAMP  IEP 4145594 RGD 
StarRatcellular response to dexamethasone stimulus  IEP 4145599 RGD 
StarRatcellular response to epinephrine stimulus  IEP 4145763 RGD 
StarRatcellular response to fibroblast growth factor stimulus  IEP 4145611FGF2RGD 
StarRatcellular response to fibroblast growth factor stimulus  IEP 2289861FGF-9RGD 
StarRatcellular response to follicle-stimulating hormone stimulus  IEP 4145531 RGD 
StarRatcellular response to glucose stimulus  IEP 4785271 RGD 
StarRatcellular response to gonadotropin stimulus  IEP 4145716 RGD 
StarRatcellular response to growth hormone stimulus  IEP 4891987 RGD 
StarRatcellular response to insulin stimulus  IEP 1600072 RGD 
StarRatcellular response to interferon-alpha  IMP 4145607 RGD 
StarRatcellular response to lipopolysaccharide  IEP 4145535 RGD 
StarRatcellular response to luteinizing hormone stimulus  IEP 1600071 RGD 
StarRatcellular response to metal ion  IEP 4890967hexavalent chromiumRGD 
StarRatcellular response to transforming growth factor beta stimulus  IEP 4781450FSH-stimulated granulosa cellsRGD 
1 to 20 of 72 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
StarRatmitochondrial crista  IDA 4889558 RGD 
StarRatmitochondrion located_inIEAUniProtKB:P51557 and ensembl:ENSMUSP000000339791600115GO_REF:0000107EnsemblGO_REF:0000107
StarRatmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
StarRatmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
StarRatmitochondrion located_inISOStar (Mus musculus)1624291 PMID:7961770RGDPMID:7961770
StarRatmitochondrion located_inIEAInterPro:IPR0298661600115GO_REF:0000002InterProGO_REF:0000002
StarRatneuronal cell body  IDA 4145616 RGD 

Molecular Function
1 to 11 of 11 rows

  
1 to 11 of 11 rows

RGD Manual Annotations


  

1 to 20 of 94 rows
#
Reference Title
Reference Citation
1. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Adamsson A, etal., Int J Androl. 2009 Oct;32(5):575-85. Epub 2008 Jul 9.
2. Parabens inhibit the early phase of folliculogenesis and steroidogenesis in the ovaries of neonatal rats. Ahn HJ, etal., Mol Reprod Dev. 2012 Sep;79(9):626-36. doi: 10.1002/mrd.22070. Epub 2012 Jul 26.
3. Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats. Almog B, etal., Mol Cell Endocrinol. 2001 Oct 25;183(1-2):179-91.
4. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Banu SK, etal., Toxicol Appl Pharmacol. 2008 Oct 15;232(2):180-9. Epub 2008 Jun 17.
5. Expression of steroidogenic acute regulatory protein in cultured Schwann cells and its regulation by cAMP. Benmessahel Y, etal., Ann N Y Acad Sci 2002 Nov;973:83-7.
6. Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: mechanisms and reversal by exogenous ACTH. Boyd KN, etal., J Neurochem. 2010 Oct;115(1):142-52. doi: 10.1111/j.1471-4159.2010.06904.x. Epub 2010 Jul 30.
7. Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis. Brokken LJ, etal., Endocrinology. 2009 Jan;150(1):445-51. Epub 2008 Sep 4.
8. Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats. Campbell JE, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R168-76. Epub 2010 Apr 14.
9. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Caron KM, etal., Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11540-5.
10. Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy. Cermenati G, etal., J Neurosci. 2010 Sep 8;30(36):11896-901.
11. Effects of high levels of glucose on the steroidogenesis and the expression of adiponectin receptors in rat ovarian cells. Chabrolle C, etal., Reprod Biol Endocrinol. 2008 Mar 19;6:11.
12. Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat. Chen M, etal., Exp Toxicol Pathol. 2007 Nov;59(3-4):245-51. Epub 2007 Sep 19.
13. Protein kinase Cmu mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. Chen YC, etal., FEBS Lett. 2010 Nov 5;584(21):4442-8. Epub 2010 Oct 13.
14. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Chen YJ, etal., Endocrinology. 2008 Sep;149(9):4658-68. Epub 2008 May 29.
15. The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. Cheng J, etal., Toxicology 2003 May 3;187(2-3):139-48.
16. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. Cherradi N, etal., J Biol Chem. 1997 Mar 21;272(12):7899-907.
17. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Colon E, etal., Endocrinology. 2007 Jan;148(1):128-39. Epub 2006 Oct 5.
18. Effect of restraint stress on 2,3,7,8 tetrachloro dibenzo-p-dioxin induced testicular and epididymal toxicity in rats. Dhanabalan S, etal., Hum Exp Toxicol. 2010 Jul 7.
19. Fibroblast growth factor-9, a local regulator of ovarian function. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
20. Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Elumalai P, etal., Reprod Toxicol. 2009 Jan;27(1):41-5. Epub 2008 Nov 24.
1 to 20 of 94 rows
PMID:7626524   PMID:7961770   PMID:9015355   PMID:9328229   PMID:9516465   PMID:12477932   PMID:12530640   PMID:12697693   PMID:12958217   PMID:12959973   PMID:14651853   PMID:14694755  
PMID:15342684   PMID:15358680   PMID:15489334   PMID:15713539   PMID:16039847   PMID:16175571   PMID:16239298   PMID:16682116   PMID:17242178   PMID:17526944   PMID:17702849   PMID:17927664  
PMID:18004794   PMID:18403318   PMID:18425351   PMID:18614015   PMID:18800309   PMID:18990246   PMID:20039971   PMID:20568448   PMID:20609383   PMID:20924043   PMID:21076439   PMID:21153110  
PMID:21153282   PMID:21608230   PMID:22226148   PMID:22425774   PMID:22674924   PMID:22960446   PMID:23332974   PMID:23831818   PMID:24713504   PMID:24728861   PMID:24877623   PMID:27511375  
PMID:29859221   PMID:30884106   PMID:31028793   PMID:33526603   PMID:33670702   PMID:35871495   PMID:38517482   PMID:39094930  



Star
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,969,824 - 72,974,447 (-)NCBIGRCr8
mRatBN7.21666,267,094 - 66,274,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,264,807 - 66,271,672 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,545,726 - 71,550,356 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,952,036 - 74,956,666 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,191,932 - 70,196,560 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,036,204 - 71,040,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,036,204 - 71,040,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,700,880 - 70,705,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,642,580 - 70,647,203 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,640,558 - 70,647,408 (-)NCBI
Celera1664,176,969 - 64,181,592 (-)NCBICelera
RH 3.4 Map16622.1RGD
Cytogenetic Map16q12.4NCBI
STAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,142,700 - 38,150,952 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,142,700 - 38,150,992 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,000,218 - 38,008,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,119,375 - 38,127,757 (-)NCBINCBI36Build 36hg18NCBI36
Build 34838,119,374 - 38,127,757NCBI
Celera836,952,763 - 36,961,143 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,535,200 - 36,543,580 (-)NCBIHuRef
CHM1_1838,201,783 - 38,210,163 (-)NCBICHM1_1
T2T-CHM13v2.0838,419,706 - 38,427,956 (-)NCBIT2T-CHM13v2.0
Star
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,298,502 - 26,306,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,296,583 - 26,306,010 (+)EnsemblGRCm39 Ensembl
GRCm38825,808,474 - 25,815,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,806,555 - 25,815,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,918,985 - 26,926,454 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,274,058 - 27,281,527 (+)NCBIMGSCv36mm8
Celera827,276,742 - 27,284,211 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Star
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,760,089 - 13,765,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,760,089 - 13,765,245 (-)NCBIChiLan1.0ChiLan1.0
STAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,702,681 - 56,715,659 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,419,409 - 32,432,623 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,446,334 - 37,454,102 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,622,577 - 34,629,912 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,623,201 - 34,629,544 (-)Ensemblpanpan1.1panPan2
STAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,326,355 - 27,331,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,326,355 - 27,331,025 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,843,664 - 27,848,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,225,542 - 29,230,211 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,225,488 - 29,230,211 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,447,844 - 27,452,510 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,025,113 - 28,029,783 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,064,539 - 28,069,208 (+)NCBIUU_Cfam_GSD_1.0
Star
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,930,968 - 49,937,924 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,523,355 - 1,529,672 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,523,289 - 1,530,181 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,377,521 - 48,385,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,377,597 - 48,385,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,502,030 - 55,509,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,164,891 - 36,174,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,167,694 - 36,174,583 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,817,058 - 5,826,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Star
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,493,786 - 5,502,030 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,494,430 - 5,501,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Star
7 total Variants

Predicted Target Of
Summary Value
Count of predictions:462
Count of miRNA genes:244
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000020606
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 14 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat

1 to 10 of 14 rows
RH143429  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,269,932 - 66,270,083 (+)MAPPERmRatBN7.2
Rnor_6.01671,039,043 - 71,039,193NCBIRnor6.0
Rnor_5.01670,703,719 - 70,703,869UniSTSRnor5.0
RGSC_v3.41670,645,419 - 70,645,569UniSTSRGSC3.4
Celera1664,179,808 - 64,179,958UniSTS
RH 3.4 Map16623.6UniSTS
Cytogenetic Map16q12.4UniSTS
RH128847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,267,090 - 66,267,281 (+)MAPPERmRatBN7.2
Rnor_6.01671,036,201 - 71,036,391NCBIRnor6.0
Rnor_5.01670,700,877 - 70,701,067UniSTSRnor5.0
RGSC_v3.41670,642,577 - 70,642,767UniSTSRGSC3.4
Celera1664,176,966 - 64,177,156UniSTS
RH 3.4 Map16624.3UniSTS
Cytogenetic Map16q12.4UniSTS
RH142227  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,271,657 - 66,271,812 (+)MAPPERmRatBN7.2
Rnor_6.01671,040,788 - 71,040,942NCBIRnor6.0
Rnor_5.01670,705,464 - 70,705,618UniSTSRnor5.0
RGSC_v3.41670,647,144 - 70,647,298UniSTSRGSC3.4
Celera1664,181,533 - 64,181,687UniSTS
RH 3.4 Map16622.1UniSTS
Cytogenetic Map16q12.4UniSTS
RH140293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,265,087 - 66,265,296 (+)MAPPERmRatBN7.2
Rnor_6.01671,034,198 - 71,034,406NCBIRnor6.0
Rnor_5.01670,698,874 - 70,699,082UniSTSRnor5.0
RGSC_v3.41670,640,574 - 70,640,782UniSTSRGSC3.4
Celera1664,174,963 - 64,175,171UniSTS
RH 3.4 Map16623.6UniSTS
Cytogenetic Map16q12.4UniSTS
MARC_35058-35059:1074713892:4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81672,970,968 - 72,971,615 (+)Marker Load Pipeline
mRatBN7.21666,268,238 - 66,268,885 (+)MAPPERmRatBN7.2
Rnor_6.01671,037,349 - 71,037,995NCBIRnor6.0
Rnor_5.01670,702,025 - 70,702,671UniSTSRnor5.0
RGSC_v3.41670,643,725 - 70,644,371UniSTSRGSC3.4
Celera1664,178,114 - 64,178,760UniSTS
Cytogenetic Map16q12.4UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000020606   ⟹   ENSRNOP00000020606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,264,807 - 66,271,672 (-)Ensembl
Rnor_6.0 Ensembl1671,036,204 - 71,040,847 (-)Ensembl
RefSeq Acc Id: NM_031558   ⟹   NP_113746
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,969,824 - 72,974,447 (-)NCBI
mRatBN7.21666,267,094 - 66,271,717 (-)NCBI
Rnor_6.01671,036,204 - 71,040,847 (-)NCBI
Rnor_5.01670,700,880 - 70,705,523 (-)NCBI
RGSC_v3.41670,642,580 - 70,647,203 (-)RGD
Celera1664,176,969 - 64,181,592 (-)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_113746 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC02528 (Get FASTA)   NCBI Sequence Viewer  
  AAH88859 (Get FASTA)   NCBI Sequence Viewer  
  AAU84904 (Get FASTA)   NCBI Sequence Viewer  
  ABK88261 (Get FASTA)   NCBI Sequence Viewer  
  BAA19245 (Get FASTA)   NCBI Sequence Viewer  
  BAA34737 (Get FASTA)   NCBI Sequence Viewer  
  EDM09070 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020606
  ENSRNOP00000020606.2
GenBank Protein P97826 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_113746   ⟸   NM_031558
- Peptide Label: precursor
- UniProtKB: P97628 (UniProtKB/Swiss-Prot),   P97826 (UniProtKB/Swiss-Prot),   A6IW02 (UniProtKB/TrEMBL),   Q5XUN6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020606   ⟸   ENSRNOT00000020606
START

Name Modeler Protein Id AA Range Protein Structure
AF-P97826-F1-model_v2 AlphaFold P97826 1-284 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700165
Promoter ID:EPDNEW_R10689
Type:single initiation site
Name:Star_1
Description:steroidogenic acute regulatory protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01671,040,810 - 71,040,870EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-10977 BioCyc
Ensembl Genes ENSRNOG00000015052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020606 ENTREZGENE
  ENSRNOT00000020606.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.530.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7311249 IMAGE-MGC_LOAD
InterPro StAR UniProtKB/Swiss-Prot
  StAR-like UniProtKB/Swiss-Prot
  START-like_dom_sf UniProtKB/Swiss-Prot
  START_lipid-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:25557 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105401 IMAGE-MGC_LOAD
NCBI Gene 25557 ENTREZGENE
PANTHER PTHR46489 UniProtKB/Swiss-Prot
  STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam START UniProtKB/Swiss-Prot
PhenoGen Star PhenoGen
PRINTS STARPROTEIN UniProtKB/Swiss-Prot
PROSITE START UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015052 RatGTEx
SMART START UniProtKB/Swiss-Prot
Superfamily-SCOP Bet v1-like UniProtKB/Swiss-Prot
UniProt A6IW02 ENTREZGENE, UniProtKB/TrEMBL
  P97628 ENTREZGENE
  P97826 ENTREZGENE
  Q5XUN6 ENTREZGENE, UniProtKB/TrEMBL
  STAR_RAT UniProtKB/Swiss-Prot
UniProt Secondary P97628 UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Star  Steroidogenic acute regulatory protein      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_process involved in cholesterol transport to inner mitochondrial membrane and steroid biosynthesis 1299054
gene_regulation activation of MAP kinase cascade suppresses expression in preovulatory granulosa cells 1299055
gene_regulation expression in primary Leydig cells is induced by human chorionic gonadotropin and this effect is suppressed by manganese chloride 1299056
gene_regulation transcription is inhibited by transcription factor Yin Yang 1 634518
gene_transcript two different mRNA transcripts expressed in central nervous system and adrenal gland 1299054