Star (steroidogenic acute regulatory protein) - Rat Genome Database

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Gene: Star (steroidogenic acute regulatory protein) Heterocephalus glaber
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Symbol: Star
Name: steroidogenic acute regulatory protein
RGD ID: 18927465
Description: ENCODES a protein that exhibits cholesterol binding (inferred); cholesterol transfer activity (inferred); lipid binding (inferred); INVOLVED IN bile acid biosynthetic process (ortholog); biphenyl metabolic process (ortholog); cellular response to alkaloid (ortholog); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congenital adrenal hyperplasia (ortholog); Endometrial Neoplasms (ortholog); FOUND IN mitochondrial crista (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Steroidogenic acute regulatory protein, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,493,786 - 5,502,030 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,494,430 - 5,501,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bile acid biosynthetic process  (ISO)
biphenyl metabolic process  (ISO)
cellular response to alkaloid  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth hormone stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-alpha  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to metal ion  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to type II interferon  (ISO)
cholesterol metabolic process  (IEA)
circadian rhythm  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
estrogen biosynthetic process  (ISO)
glucocorticoid metabolic process  (ISO)
intracellular cholesterol transport  (IEA,ISO)
lipid metabolic process  (ISO)
lipid transport  (IEA)
male gonad development  (ISO)
negative regulation of neuron apoptotic process  (ISO)
organic acid metabolic process  (ISO)
phenol-containing compound metabolic process  (ISO)
phthalate metabolic process  (ISO)
positive regulation of bile acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neurogenesis  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of steroid biosynthetic process  (IEA,ISO)
response to activity  (ISO)
response to benzoic acid  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to fungicide  (ISO)
response to gonadotropin  (ISO)
response to herbicide  (ISO)
response to hydrogen peroxide  (ISO)
response to insecticide  (ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to leptin  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
response to retinoic acid  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
steroid biosynthetic process  (IEA)
testosterone biosynthetic process  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Star
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,493,786 - 5,502,030 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,494,430 - 5,501,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
STAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,142,700 - 38,150,952 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,142,700 - 38,150,992 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,000,218 - 38,008,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,119,375 - 38,127,757 (-)NCBINCBI36Build 36hg18NCBI36
Build 34838,119,374 - 38,127,757NCBI
Celera836,952,763 - 36,961,143 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,535,200 - 36,543,580 (-)NCBIHuRef
CHM1_1838,201,783 - 38,210,163 (-)NCBICHM1_1
T2T-CHM13v2.0838,419,706 - 38,427,956 (-)NCBIT2T-CHM13v2.0
Star
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,298,502 - 26,306,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,296,583 - 26,306,010 (+)EnsemblGRCm39 Ensembl
GRCm38825,808,474 - 25,815,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,806,555 - 25,815,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,918,985 - 26,926,454 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,274,058 - 27,281,527 (+)NCBIMGSCv36mm8
Celera827,276,742 - 27,284,211 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Star
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,969,824 - 72,974,447 (-)NCBIGRCr8
mRatBN7.21666,267,094 - 66,274,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,264,807 - 66,271,672 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,545,726 - 71,550,356 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,952,036 - 74,956,666 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,191,932 - 70,196,560 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,036,204 - 71,040,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,036,204 - 71,040,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,700,880 - 70,705,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,642,580 - 70,647,203 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,640,558 - 70,647,408 (-)NCBI
Celera1664,176,969 - 64,181,592 (-)NCBICelera
RH 3.4 Map16622.1RGD
Cytogenetic Map16q12.4NCBI
Star
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,760,089 - 13,765,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,760,089 - 13,765,245 (-)NCBIChiLan1.0ChiLan1.0
STAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,702,681 - 56,715,659 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,419,409 - 32,432,623 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,446,334 - 37,454,102 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,622,577 - 34,629,912 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,623,201 - 34,629,544 (-)Ensemblpanpan1.1panPan2
STAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,326,355 - 27,331,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,326,355 - 27,331,025 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,843,664 - 27,848,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,225,542 - 29,230,211 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,225,488 - 29,230,211 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,447,844 - 27,452,510 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,025,113 - 28,029,783 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,064,539 - 28,069,208 (+)NCBIUU_Cfam_GSD_1.0
Star
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,930,968 - 49,937,924 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,523,355 - 1,529,672 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,523,289 - 1,530,181 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,377,521 - 48,385,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,377,597 - 48,385,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,502,030 - 55,509,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,164,891 - 36,174,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,167,694 - 36,174,583 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,817,058 - 5,826,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000008967   ⟹   ENSHGLP00000008872
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247805,493,786 - 5,502,030 (+)Ensembl
RefSeq Acc Id: XM_004855369   ⟹   XP_004855426
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247805,494,430 - 5,501,063 (+)NCBI
RefSeq Acc Id: XM_021236813   ⟹   XP_021092472
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247805,494,430 - 5,498,976 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004855426 (Get FASTA)   NCBI Sequence Viewer  
  XP_021092472 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02715 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000008872
GenBank Protein JAN96021 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004855426   ⟸   XM_004855369
- Peptide Label: isoform X1
- UniProtKB: A0A0N8ESB9 (UniProtKB/TrEMBL),   G5B0A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092472   ⟸   XM_021236813
- Peptide Label: isoform X2
- UniProtKB: A0AAX6R4Q1 (UniProtKB/TrEMBL),   G5B0A4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000008872   ⟸   ENSHGLT00000008967


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006377 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008967 ENTREZGENE
Gene3D-CATH 3.30.530.20 UniProtKB/TrEMBL
InterPro StAR UniProtKB/TrEMBL
  StAR-like UniProtKB/TrEMBL
  START-like_dom_sf UniProtKB/TrEMBL
  START_lipid-bd_dom UniProtKB/TrEMBL
KEGG Report hgl:101708935 UniProtKB/TrEMBL
NCBI Gene Star ENTREZGENE
PANTHER PTHR46489 UniProtKB/TrEMBL
  STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam START UniProtKB/TrEMBL
PRINTS STARPROTEIN UniProtKB/TrEMBL
PROSITE START UniProtKB/TrEMBL
SMART START UniProtKB/TrEMBL
Superfamily-SCOP Bet v1-like UniProtKB/TrEMBL
UniProt A0A0N8ESB9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R4Q1 ENTREZGENE, UniProtKB/TrEMBL
  G5B0A4 ENTREZGENE, UniProtKB/TrEMBL