STAR (steroidogenic acute regulatory protein) - Rat Genome Database
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Gene: STAR (steroidogenic acute regulatory protein) Sus scrofa
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Symbol: STAR
Name: steroidogenic acute regulatory protein
RGD ID: 13966336
Description: ENCODES a protein that exhibits cholesterol binding (inferred); cholesterol transfer activity (inferred); INVOLVED IN bile acid biosynthetic process (ortholog); biphenyl metabolic process (ortholog); brain development (ortholog); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congenital adrenal hyperplasia (ortholog); Endometrial Neoplasms (ortholog); FOUND IN cytosol (ortholog); mitochondrial crista (ortholog); mitochondrial intermembrane space (ortholog); INTERACTS WITH bisphenol A; fisetin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: lipid transporter; stARD1; START domain-containing protein 1; steroidogenic acute regulator; steroidogenic acute regulatory protein, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,347,864 - 48,385,464 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,377,597 - 48,385,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,502,030 - 55,509,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)
fisetin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bile acid biosynthetic process  (ISO)
biphenyl metabolic process  (ISO)
brain development  (ISO)
cellular lipid metabolic process  (IEA,ISO)
cellular response to alkaloid  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth hormone stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-alpha  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to metal ion  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cholesterol metabolic process  (IEA)
circadian rhythm  (ISO)
circadian sleep/wake cycle, REM sleep  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
diterpenoid metabolic process  (ISO)
estrogen biosynthetic process  (ISO)
glucocorticoid metabolic process  (IEA,ISO)
insecticide metabolic process  (ISO)
intermembrane lipid transfer  (IEA)
intracellular cholesterol transport  (IBA,ISO)
male gonad development  (ISO)
negative regulation of neuron apoptotic process  (ISO)
organic acid metabolic process  (ISO)
phenol-containing compound metabolic process  (ISO)
phthalate metabolic process  (ISO)
positive regulation of bile acid biosynthetic process  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of neurogenesis  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of steroid biosynthetic process  (IBA,ISO)
response to activity  (ISO)
response to antibiotic  (ISO)
response to corticosterone  (ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to fungicide  (ISO)
response to gonadotropin  (ISO)
response to herbicide  (ISO)
response to hydrogen peroxide  (ISO)
response to insecticide  (ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to leptin  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to peptide hormone  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
steroid biosynthetic process  (IBA,IEA)
sterol transport  (IEA)
testosterone biosynthetic process  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8793057   PMID:8977433   PMID:9048613   PMID:14681463   PMID:15059951   PMID:15590903   PMID:16879365   PMID:17145712   PMID:18653717   PMID:19386723   PMID:27512005   PMID:29883844  


Genomics

Comparative Map Data
STAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,347,864 - 48,385,464 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,377,597 - 48,385,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,502,030 - 55,509,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl838,142,700 - 38,150,992 (-)EnsemblGRCh38hg38GRCh38
GRCh38838,142,700 - 38,150,952 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37838,000,218 - 38,008,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,119,375 - 38,127,757 (-)NCBINCBI36hg18NCBI36
Build 34838,119,374 - 38,127,757NCBI
Celera836,952,763 - 36,961,143 (-)NCBI
Cytogenetic Map8p11.23NCBI
HuRef836,535,200 - 36,543,580 (-)NCBIHuRef
CHM1_1838,201,783 - 38,210,163 (-)NCBICHM1_1
Star
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,298,502 - 26,306,010 (+)NCBIGRCm39mm39
GRCm39 Ensembl826,296,583 - 26,306,010 (+)Ensembl
GRCm38825,808,474 - 25,815,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,806,555 - 25,815,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,918,985 - 26,926,454 (+)NCBIGRCm37mm9NCBIm37
MGSCv36827,274,058 - 27,281,527 (+)NCBImm8
Celera827,276,742 - 27,284,211 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Star
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21666,267,094 - 66,274,368 (-)NCBI
Rnor_6.0 Ensembl1671,036,204 - 71,040,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01671,036,204 - 71,040,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,700,880 - 70,705,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,642,580 - 70,647,203 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11670,640,558 - 70,647,408 (-)NCBI
Celera1664,176,969 - 64,181,592 (-)NCBICelera
RH 3.4 Map16622.1RGD
Cytogenetic Map16q12.4NCBI
Star
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,760,089 - 13,765,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,760,089 - 13,765,245 (-)NCBIChiLan1.0ChiLan1.0
STAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1834,622,577 - 34,629,912 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,623,201 - 34,629,544 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0837,446,334 - 37,454,102 (-)NCBIMhudiblu_PPA_v0panPan3
STAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1627,326,355 - 27,331,025 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11627,326,355 - 27,331,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Star
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367101,523,289 - 1,530,181 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,164,891 - 36,174,424 (-)NCBI
ChlSab1.1 Ensembl836,167,694 - 36,174,583 (-)Ensembl
Star
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247805,494,430 - 5,501,063 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_213755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB530157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEMK02000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK234759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY800265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP565893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01026300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000039622   ⟹   ENSSSCP00000052521
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1548,347,864 - 48,359,767 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054089   ⟹   ENSSSCP00000048519
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1548,348,888 - 48,385,445 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057991   ⟹   ENSSSCP00000059533
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1548,353,114 - 48,385,464 (+)Ensembl
RefSeq Acc Id: NM_213755   ⟹   NP_998920
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11548,377,597 - 48,385,398 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_998920   ⟸   NM_213755
- Peptide Label: precursor
- UniProtKB: Q5Q0U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000052521   ⟸   ENSSSCT00000039622
RefSeq Acc Id: ENSSSCP00000048519   ⟸   ENSSSCT00000054089
RefSeq Acc Id: ENSSSCP00000059533   ⟸   ENSSSCT00000057991
Protein Domains
START


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034942 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026939 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000048519 UniProtKB/TrEMBL
  ENSSSCP00000059533 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070045796 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000054089 UniProtKB/TrEMBL
  ENSSSCT00000057991 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070054026 UniProtKB/TrEMBL
Gene3D-CATH 3.30.530.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro StAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  StAR-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START_lipid-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396597 UniProtKB/TrEMBL
NCBI Gene STAR ENTREZGENE
PANTHER PTHR46489 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STARPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AWK7_PIG UniProtKB/TrEMBL
  A0A4X1VUU5_PIG UniProtKB/TrEMBL
  Q28996 ENTREZGENE
  Q5Q0U1 ENTREZGENE, UniProtKB/TrEMBL
  STAR_PIG UniProtKB/Swiss-Prot
UniProt Secondary Q53Z33 UniProtKB/Swiss-Prot
  Q95259 UniProtKB/Swiss-Prot
VGNC ID VGNC:95522 ENTREZGENE