Slc4a3 (solute carrier family 4 member 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Slc4a3 (solute carrier family 4 member 3) Rattus norvegicus
Analyze
Symbol: Slc4a3
Name: solute carrier family 4 member 3
RGD ID: 3712
Description: Enables chloride:bicarbonate antiporter activity and enzyme binding activity. Predicted to be involved in several processes, including bicarbonate transport; regulation of cardiac muscle cell action potential; and regulation of pH. Predicted to act upstream of or within cardiac conduction. Located in plasma membrane. Orthologous to human SLC4A3 (solute carrier family 4 member 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AE 3; Ae3; Aep3; anion exchange protein 3; anion exchanger 3; B3RP-3; band 3-related protein 3; neuronal band 3-like protein; solute carrier family 4 (anion exchanger), member 3; Solute carrier family 4 member 3 anion exchange protein 3; solute carrier family 4, member 3; Solute carrier family 4, member 3, anion exchange protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,484,749 - 84,497,746 (+)NCBIGRCr8
mRatBN7.2977,036,243 - 77,053,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl977,037,016 - 77,049,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,481,242 - 85,493,343 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,610,117 - 90,622,218 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,996,301 - 89,008,402 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,742,207 - 82,755,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,741,920 - 82,755,153 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,512,289 - 82,524,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,823,769 - 74,835,860 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,983,838 - 74,995,930 (+)NCBI
Celera974,606,698 - 74,618,789 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger. Kudrycki KE, etal., J Biol Chem 1990 Jan 5;265(1):462-71.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Morgan PE, etal., Am J Physiol Cell Physiol. 2007 Aug;293(2):C738-48. Epub 2007 Jul 25.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Simon JS, etal., Mamm Genome 1996 May;7(5):380-2.
11. Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. Sterling D and Casey JR, Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):221-9.
Additional References at PubMed
PMID:2686841   PMID:21608017   PMID:22693949   PMID:22871113   PMID:29167417  


Genomics

Comparative Map Data
Slc4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,484,749 - 84,497,746 (+)NCBIGRCr8
mRatBN7.2977,036,243 - 77,053,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl977,037,016 - 77,049,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,481,242 - 85,493,343 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,610,117 - 90,622,218 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,996,301 - 89,008,402 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,742,207 - 82,755,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,741,920 - 82,755,153 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,512,289 - 82,524,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,823,769 - 74,835,860 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,983,838 - 74,995,930 (+)NCBI
Celera974,606,698 - 74,618,789 (+)NCBICelera
Cytogenetic Map9q33NCBI
SLC4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,627,630 - 219,641,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,627,394 - 219,641,980 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,492,352 - 220,506,693 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,200,536 - 220,214,946 (+)NCBINCBI36Build 36hg18NCBI36
Build 342220,317,791 - 220,332,197NCBI
Celera2214,262,260 - 214,276,669 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,345,224 - 212,359,627 (+)NCBIHuRef
CHM1_12220,498,113 - 220,512,522 (+)NCBICHM1_1
T2T-CHM13v2.02220,112,359 - 220,126,699 (+)NCBIT2T-CHM13v2.0
Slc4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,522,688 - 75,536,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,522,910 - 75,538,816 (+)EnsemblGRCm39 Ensembl
GRCm38175,546,044 - 75,559,431 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,546,266 - 75,562,172 (+)EnsemblGRCm38mm10GRCm38
MGSCv37175,542,841 - 75,556,006 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36175,429,444 - 75,442,227 (+)NCBIMGSCv36mm8
Celera176,037,295 - 76,050,423 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map139.16NCBI
Slc4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,843,556 - 13,859,705 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545313,846,444 - 13,859,707 (-)NCBIChiLan1.0ChiLan1.0
SLC4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213122,257,661 - 122,272,044 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B122,272,628 - 122,287,010 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,884,750 - 106,899,143 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,475,148 - 225,489,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,475,148 - 225,489,189 (+)Ensemblpanpan1.1panPan2
SLC4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13726,136,589 - 26,149,312 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3726,136,412 - 26,149,312 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,962,037 - 26,974,762 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03726,151,769 - 26,167,414 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3726,151,769 - 26,165,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13726,055,607 - 26,068,323 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,991,659 - 26,004,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03726,012,382 - 26,025,125 (+)NCBIUU_Cfam_GSD_1.0
Slc4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,650,060 - 175,662,989 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,992,814 - 2,008,800 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,992,850 - 2,005,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,630,316 - 121,643,539 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,629,794 - 121,643,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,528,845 - 105,543,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,529,093 - 105,543,405 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604093,858,750 - 93,872,999 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,439,336 - 5,453,801 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248235,440,213 - 5,453,683 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc4a3
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:41
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000027337
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat

Markers in Region
D9Bro1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2977,026,343 - 77,026,453 (+)MAPPERmRatBN7.2
Rnor_6.0982,732,357 - 82,732,466NCBIRnor6.0
Rnor_5.0982,501,618 - 82,501,727UniSTSRnor5.0
RGSC_v3.4974,813,098 - 74,813,207UniSTSRGSC3.4
RGSC_v3.4974,813,097 - 74,813,207RGDRGSC3.4
RGSC_v3.1974,973,168 - 74,973,277RGD
RH 3.4 Map9757.3RGD
RH 3.4 Map9757.3UniSTS
Cytogenetic Map9q33UniSTS
Cytogenetic Map9q34UniSTS
D9Mco24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2977,044,883 - 77,045,128 (+)MAPPERmRatBN7.2
Rnor_6.0982,750,896 - 82,751,142NCBIRnor6.0
Rnor_5.0982,520,157 - 82,520,403UniSTSRnor5.0
RGSC_v3.4974,831,637 - 74,831,883UniSTSRGSC3.4
Celera974,614,566 - 74,614,812UniSTS
Cytogenetic Map9q34UniSTS
RH144096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2977,047,808 - 77,048,901 (+)MAPPERmRatBN7.2
Rnor_6.0982,753,823 - 82,754,915NCBIRnor6.0
Rnor_5.0982,523,084 - 82,524,176UniSTSRnor5.0
RGSC_v3.4974,834,564 - 74,835,656UniSTSRGSC3.4
Celera974,617,493 - 74,618,585UniSTS
RH 3.4 Map9766.3UniSTS
Cytogenetic Map9q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 9 2 2 66 20 32
Low 3 17 8 19 8 8 11 8 15 9 11 8
Below cutoff 31 31 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000027337   ⟹   ENSRNOP00000027337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl977,037,016 - 77,049,105 (+)Ensembl
Rnor_6.0 Ensembl982,741,920 - 82,755,153 (+)Ensembl
RefSeq Acc Id: NM_017049   ⟹   NP_058745
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,485,655 - 84,497,746 (+)NCBI
mRatBN7.2977,037,016 - 77,049,105 (+)NCBI
Rnor_6.0982,743,028 - 82,755,119 (+)NCBI
Rnor_5.0982,512,289 - 82,524,380 (+)NCBI
RGSC_v3.4974,823,769 - 74,835,860 (+)RGD
Celera974,606,698 - 74,618,789 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245149   ⟹   XP_006245211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,488,351 - 84,497,746 (+)NCBI
mRatBN7.2977,039,690 - 77,053,940 (+)NCBI
Rnor_6.0982,745,232 - 82,755,119 (+)NCBI
Rnor_5.0982,512,289 - 82,524,380 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596276   ⟹   XP_017451765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,485,232 - 84,497,746 (+)NCBI
mRatBN7.2977,036,595 - 77,053,940 (+)NCBI
Rnor_6.0982,742,591 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596277   ⟹   XP_017451766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,484,880 - 84,497,746 (+)NCBI
mRatBN7.2977,036,243 - 77,053,940 (+)NCBI
Rnor_6.0982,742,207 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596279   ⟹   XP_017451768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,484,749 - 84,497,746 (+)NCBI
mRatBN7.2977,036,243 - 77,053,940 (+)NCBI
Rnor_6.0982,742,207 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596280   ⟹   XP_017451769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,484,880 - 84,497,746 (+)NCBI
mRatBN7.2977,036,243 - 77,053,940 (+)NCBI
Rnor_6.0982,742,207 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083028   ⟹   XP_038938956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,486,051 - 84,497,746 (+)NCBI
mRatBN7.2977,037,415 - 77,053,940 (+)NCBI
RefSeq Acc Id: XM_039083030   ⟹   XP_038938958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,490,425 - 84,497,746 (+)NCBI
mRatBN7.2977,041,785 - 77,053,940 (+)NCBI
RefSeq Acc Id: XM_063266648   ⟹   XP_063122718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,485,458 - 84,497,746 (+)NCBI
RefSeq Acc Id: XM_063266649   ⟹   XP_063122719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,486,051 - 84,497,746 (+)NCBI
RefSeq Acc Id: XM_063266650   ⟹   XP_063122720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,486,084 - 84,497,746 (+)NCBI
RefSeq Acc Id: XM_063266651   ⟹   XP_063122721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,490,406 - 84,497,746 (+)NCBI
RefSeq Acc Id: NP_058745   ⟸   NM_017049
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245211   ⟸   XM_006245149
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017451769   ⟸   XM_017596280
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451766   ⟸   XM_017596277
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451768   ⟸   XM_017596279
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451765   ⟸   XM_017596276
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027337   ⟸   ENSRNOT00000027337
RefSeq Acc Id: XP_038938956   ⟸   XM_039083028
- Peptide Label: isoform X2
- UniProtKB: P23348 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038938958   ⟸   XM_039083030
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063122718   ⟸   XM_063266648
- Peptide Label: isoform X1
- UniProtKB: A6JW47 (UniProtKB/TrEMBL),   G3V8P8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122719   ⟸   XM_063266649
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122720   ⟸   XM_063266650
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122721   ⟸   XM_063266651
- Peptide Label: isoform X5
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23348-F1-model_v2 AlphaFold P23348 1-1227 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3712 AgrOrtholog
BioCyc Gene G2FUF-27057 BioCyc
Ensembl Genes ENSRNOG00000020138 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027337 ENTREZGENE
  ENSRNOT00000027337.4 UniProtKB/TrEMBL
Gene3D-CATH Helical hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Anion_exchange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anion_exchange_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anion_exchange_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band3_cytoplasmic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTrfase/Anion_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24781 UniProtKB/Swiss-Prot
NCBI Gene 24781 ENTREZGENE
PANTHER PTHR11453 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11453:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_3_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_cotransp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc4a3 PhenoGen
PRINTS ANIONEXCHNGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANIONEXHNGR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3TRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANION_EXCHANGER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANION_EXCHANGER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020138 RatGTEx
Superfamily-SCOP SSF55804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JW47 ENTREZGENE, UniProtKB/TrEMBL
  B3A3_RAT UniProtKB/Swiss-Prot
  G3V8P8 ENTREZGENE, UniProtKB/TrEMBL
  P23348 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc4a3  solute carrier family 4 member 3  Slc4a3  solute carrier family 4 (anion exchanger), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Slc4a3  solute carrier family 4 (anion exchanger), member 3  Slc4a3  solute carrier family 4, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Slc4a3  solute carrier family 4, member 3    Solute carrier family 4, member 3, anion exchange protein 3  Name updated 629478 APPROVED
2002-06-10 Slc4a3  Solute carrier family 4, member 3, anion exchange protein 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed mostly in the heart and forestomach 729955
gene_mapping segregates on chr 4 with blood pressure in recombinant inbred rats derived by crossing SHR and BN 1342444
gene_protein predicted protein consists of 1227 aa residues and masses 135.4 kDa 729955