Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Slc4a3 | Rat | heart disease | | ISO | SLC4A3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16844662 | |
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Slc4a3 | Rat | heart disease | | ISO | SLC4A3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16844662 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
3. | cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger. | Kudrycki KE, etal., J Biol Chem 1990 Jan 5;265(1):462-71. |
4. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
5. | Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. | Morgan PE, etal., Am J Physiol Cell Physiol. 2007 Aug;293(2):C738-48. Epub 2007 Jul 25. |
6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
7. | GOA pipeline | RGD automated data pipeline |
8. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
10. | Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. | Simon JS, etal., Mamm Genome 1996 May;7(5):380-2. |
11. | Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. | Sterling D and Casey JR, Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):221-9. |
PMID:2686841 | PMID:21608017 | PMID:22693949 | PMID:22871113 | PMID:29167417 |
Slc4a3 (Rattus norvegicus - Norway rat) |
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SLC4A3 (Homo sapiens - human) |
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Slc4a3 (Mus musculus - house mouse) |
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Slc4a3 (Chinchilla lanigera - long-tailed chinchilla) |
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SLC4A3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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SLC4A3 (Canis lupus familiaris - dog) |
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Slc4a3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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SLC4A3 (Sus scrofa - pig) |
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SLC4A3 (Chlorocebus sabaeus - green monkey) |
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Slc4a3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Slc4a3
61 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D9Bro1 |
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D9Mco24 |
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RH144096 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 43 | 9 | 2 | 2 | 66 | 20 | 32 | ||||||
Low | 3 | 17 | 8 | 19 | 8 | 8 | 11 | 8 | 15 | 9 | 11 | 8 | |
Below cutoff | 31 | 31 | 31 |
RefSeq Acc Id: | ENSRNOT00000027337 ⟹ ENSRNOP00000027337 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_017049 ⟹ NP_058745 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006245149 ⟹ XP_006245211 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017596276 ⟹ XP_017451765 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017596277 ⟹ XP_017451766 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017596279 ⟹ XP_017451768 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017596280 ⟹ XP_017451769 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039083028 ⟹ XP_038938956 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039083030 ⟹ XP_038938958 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063266648 ⟹ XP_063122718 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063266649 ⟹ XP_063122719 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063266650 ⟹ XP_063122720 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063266651 ⟹ XP_063122721 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NP_058745 ⟸ NM_017049 |
- UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006245211 ⟸ XM_006245149 |
- Peptide Label: | isoform X3 |
- Sequence: |
RefSeq Acc Id: | XP_017451769 ⟸ XM_017596280 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017451766 ⟸ XM_017596277 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017451768 ⟸ XM_017596279 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017451765 ⟸ XM_017596276 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000027337 ⟸ ENSRNOT00000027337 |
RefSeq Acc Id: | XP_038938956 ⟸ XM_039083028 |
- Peptide Label: | isoform X2 |
- UniProtKB: | P23348 (UniProtKB/Swiss-Prot) |
RefSeq Acc Id: | XP_038938958 ⟸ XM_039083030 |
- Peptide Label: | isoform X6 |
RefSeq Acc Id: | XP_063122718 ⟸ XM_063266648 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A6JW47 (UniProtKB/TrEMBL), G3V8P8 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063122719 ⟸ XM_063266649 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_063122720 ⟸ XM_063266650 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_063122721 ⟸ XM_063266651 |
- Peptide Label: | isoform X5 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P23348-F1-model_v2 | AlphaFold | P23348 | 1-1227 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:3712 | AgrOrtholog |
BioCyc Gene | G2FUF-27057 | BioCyc |
Ensembl Genes | ENSRNOG00000020138 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000027337 | ENTREZGENE |
ENSRNOT00000027337.4 | UniProtKB/TrEMBL | |
Gene3D-CATH | Helical hairpin bin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | Anion_exchange | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Anion_exchange_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Anion_exchange_CS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Band3_cytoplasmic_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
HCO3_transpt_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
HCO3_transpt_euk | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PTrfase/Anion_transptr | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:24781 | UniProtKB/Swiss-Prot |
NCBI Gene | 24781 | ENTREZGENE |
PANTHER | PTHR11453 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR11453:SF15 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Band_3_cyto | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
HCO3_cotransp | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Slc4a3 | PhenoGen |
PRINTS | ANIONEXCHNGR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ANIONEXHNGR3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
HCO3TRNSPORT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | ANION_EXCHANGER_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ANION_EXCHANGER_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000020138 | RatGTEx |
Superfamily-SCOP | SSF55804 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A6JW47 | ENTREZGENE, UniProtKB/TrEMBL |
B3A3_RAT | UniProtKB/Swiss-Prot | |
G3V8P8 | ENTREZGENE, UniProtKB/TrEMBL | |
P23348 | ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-02-24 | Slc4a3 | solute carrier family 4 member 3 | Slc4a3 | solute carrier family 4 (anion exchanger), member 3 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-02-15 | Slc4a3 | solute carrier family 4 (anion exchanger), member 3 | Slc4a3 | solute carrier family 4, member 3 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2003-04-09 | Slc4a3 | solute carrier family 4, member 3 | Solute carrier family 4, member 3, anion exchange protein 3 | Name updated | 629478 | APPROVED | |
2002-06-10 | Slc4a3 | Solute carrier family 4, member 3, anion exchange protein 3 | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_expression | mRNA expressed mostly in the heart and forestomach | 729955 |
gene_mapping | segregates on chr 4 with blood pressure in recombinant inbred rats derived by crossing SHR and BN | 1342444 |
gene_protein | predicted protein consists of 1227 aa residues and masses 135.4 kDa | 729955 |