Ftl1l2 (ferritin light chain 1 like 2) - Rat Genome Database

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Gene: Ftl1l2 (ferritin light chain 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ftl1l2 (Ensembl: Ftl1-ps14)
Name: ferritin light chain 1 like 2 (Ensembl:ferritin light chain 1, pseudogene 14)
RGD ID: 2325062
Description: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular iron ion homeostasis and iron ion transport. Predicted to be located in autolysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain); INTERACTS WITH cadmium atom.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ferritin light chain 1-like; ferritin light chain 2; LOC100359668
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,977,712 - 78,987,254 (-)NCBIGRCr8
mRatBN7.2673,242,612 - 73,243,527 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl673,242,608 - 73,253,291 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl261,543,323 - 61,578,556 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0676,652,033 - 76,652,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,652,206 - 76,652,757 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0686,184,248 - 86,185,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4676,152,983 - 76,153,826 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera672,075,615 - 72,076,557 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ftl1l2Ratcadmium atom decreases expressionEXP 6480464Cadmium results in decreased expression of FTL1L2 mRNACTDPMID:39025289


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ftl1l2Ratintracellular iron ion homeostasis involved_inIEAUniProtKB-KW:KW-04091600115GO_REF:0000043UniProtGO_REF:0000043
Ftl1l2Ratintracellular iron ion homeostasis involved_inIEAInterPro:IPR0015191600115GO_REF:0000002InterProGO_REF:0000002
Ftl1l2Ratiron ion transport involved_inIEAInterPro:IPR0015191600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ftl1l2Ratautolysosome located_inIEAUniProtKB-SubCell:SL-05351600115GO_REF:0000044UniProtGO_REF:0000044
Ftl1l2Ratcytoplasm is_active_inIBAFB:FBgn0015221 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ftl1l2Ratferric iron binding enablesIBAPANTHER:PTN000153092 and UniProtKB:P0A9981600115GO_REF:0000033GO_CentralGO_REF:0000033
Ftl1l2Ratferric iron binding enablesIEAInterPro:IPR001519 and InterPro:IPR0083311600115GO_REF:0000002InterProGO_REF:0000002
Ftl1l2Ratferrous iron binding enablesIBAFB:FBgn0015221 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ftl1l2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Ftl1l2
2 total Variants

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:49
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000042177
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat

1 to 10 of 27 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 32 70 74 73 48 17 48 6 165 68 52 39 53 25



Ensembl Acc Id: ENSRNOT00000042177   ⟹   ENSRNOP00000042311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl673,242,618 - 73,252,261 (-)Ensembl
Rnor_6.0 Ensembl676,652,206 - 76,652,757 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096014   ⟹   ENSRNOP00000090717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl261,543,323 - 61,578,556 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106144   ⟹   ENSRNOP00000095589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl673,242,608 - 73,253,291 (-)Ensembl
RefSeq Acc Id: XM_039113181   ⟹   XP_038969109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,977,712 - 78,987,254 (-)NCBI
mRatBN7.2673,242,612 - 73,243,527 (-)NCBI
Protein RefSeqs XP_038969109 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042311.3
  ENSRNOP00000090717.1
  ENSRNOP00000095589.1
  ENSRNOP00000103057
Ensembl Acc Id: ENSRNOP00000042311   ⟸   ENSRNOT00000042177
RefSeq Acc Id: XP_038969109   ⟸   XM_039113181
- UniProtKB: F1M5T1 (UniProtKB/TrEMBL),   A0A8I6GIG4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095589   ⟸   ENSRNOT00000106144
Ensembl Acc Id: ENSRNOP00000090717   ⟸   ENSRNOT00000096014
Ferritin-like diiron

Name Modeler Protein Id AA Range Protein Structure
AF-F1M5T1-F1-model_v2 AlphaFold F1M5T1 1-183 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-37482 BioCyc
Ensembl Genes ENSRNOG00000033776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000065602 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042177.4 UniProtKB/TrEMBL
  ENSRNOT00000096014.1 UniProtKB/TrEMBL
  ENSRNOT00000106144.1 UniProtKB/TrEMBL
  ENSRNOT00000170958 ENTREZGENE
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/TrEMBL
  Ferritin-like_SF UniProtKB/TrEMBL
  Ferritin-rel UniProtKB/TrEMBL
  Ferritin_CS UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/TrEMBL
NCBI Gene 100359668 ENTREZGENE
PANTHER FERRITIN LIGHT CHAIN UniProtKB/TrEMBL
  PTHR11431 UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PhenoGen Ftl1l2 PhenoGen
PROSITE FERRITIN_1 UniProtKB/TrEMBL
  FERRITIN_2 UniProtKB/TrEMBL
  FERRITIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033776 RatGTEx
  ENSRNOG00000065602 RatGTEx
Superfamily-SCOP Ferritin/RR_like UniProtKB/TrEMBL
UniProt A0A8I6GIG4 ENTREZGENE, UniProtKB/TrEMBL
  F1M5T1 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ftl1l2  ferritin light chain 1 like 2  LOC100359668  ferritin light chain 2  Symbol and Name Changed 1299863 APPROVED
2010-05-20 LOC100359668  ferritin light chain 2      Symbol and Name status set to provisional 70820 PROVISIONAL