KDM8 (lysine demethylase 8) - Rat Genome Database

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Pathways
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Gene: KDM8 (lysine demethylase 8) Homo sapiens
Analyze
Symbol: KDM8
Name: lysine demethylase 8
RGD ID: 1602684
HGNC Page HGNC:25840
Description: Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; methylated histone binding activity; and peptidase activity. Involved in G2/M transition of mitotic cell cycle; protein destabilization; and regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: arginyl C3-hydroxylase KDM8; bifunctional peptidase and arginyl-hydroxylase JMJD5; FLJ13798; JmjC arginyl-hydroxylase; jmjC domain-containing protein 5; JMJD5; jumonji C domain-containing protein 5; jumonji domain containing 5; jumonji domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8; lysine (K)-specific demethylase 8; lysine-specific demethylase 8
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381627,203,526 - 27,221,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1627,203,508 - 27,221,768 (+)EnsemblGRCh38hg38GRCh38
GRCh371627,214,847 - 27,233,089 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361627,122,317 - 27,140,544 (+)NCBINCBI36Build 36hg18NCBI36
Celera1625,993,442 - 26,011,724 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1625,303,702 - 25,321,984 (+)NCBIHuRef
CHM1_11628,226,511 - 28,244,793 (+)NCBICHM1_1
T2T-CHM13v2.01627,482,139 - 27,500,381 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
cytosol  (IDA,TAS)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Hsia DA, etal., Proc Natl Acad Sci U S A. 2010 May 25;107(21):9671-6. doi: 10.1073/pnas.1000401107. Epub 2010 May 10.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:12477932   PMID:14702039   PMID:16189514   PMID:16344560   PMID:16858412   PMID:17909537   PMID:21115819   PMID:21873635   PMID:22375008   PMID:22851697   PMID:23251661  
PMID:23948433   PMID:24100311   PMID:24344305   PMID:24740926   PMID:24981860   PMID:26025680   PMID:26186194   PMID:26261525   PMID:26710852   PMID:26760772   PMID:26792738   PMID:26871637  
PMID:27715397   PMID:28514442   PMID:28700943   PMID:28847961   PMID:28982940   PMID:29459673   PMID:29563586   PMID:29676528   PMID:30072740   PMID:30500822   PMID:30551455   PMID:31280863  
PMID:32296183   PMID:32678829   PMID:32747552   PMID:33536335   PMID:33961781   PMID:34373451   PMID:35176452   PMID:35906200   PMID:37813845  


Genomics

Comparative Map Data
KDM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381627,203,526 - 27,221,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1627,203,508 - 27,221,768 (+)EnsemblGRCh38hg38GRCh38
GRCh371627,214,847 - 27,233,089 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361627,122,317 - 27,140,544 (+)NCBINCBI36Build 36hg18NCBI36
Celera1625,993,442 - 26,011,724 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1625,303,702 - 25,321,984 (+)NCBIHuRef
CHM1_11628,226,511 - 28,244,793 (+)NCBICHM1_1
T2T-CHM13v2.01627,482,139 - 27,500,381 (+)NCBIT2T-CHM13v2.0
Kdm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,043,788 - 125,062,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7125,043,848 - 125,061,441 (+)EnsemblGRCm39 Ensembl
GRCm387125,444,620 - 125,463,651 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7125,444,676 - 125,462,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv377132,588,190 - 132,605,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367125,235,824 - 125,253,407 (+)NCBIMGSCv36mm8
Celera7125,303,361 - 125,320,954 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.85NCBI
Kdm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81189,444,527 - 189,459,507 (+)NCBIGRCr8
mRatBN7.21180,013,969 - 180,028,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,020,656 - 180,028,841 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,350,526 - 188,365,400 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01195,536,557 - 195,551,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01188,219,849 - 188,234,719 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01196,838,460 - 196,854,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1196,839,321 - 196,854,180 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01203,825,823 - 203,840,790 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,510,173 - 184,525,036 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,666,742 - 184,674,917 (+)NCBI
Celera1177,684,363 - 177,699,127 (+)NCBICelera
Cytogenetic Map1q36NCBI
Kdm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554935,437,090 - 5,462,294 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554935,437,344 - 5,462,849 (+)NCBIChiLan1.0ChiLan1.0
KDM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21828,602,178 - 28,620,254 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11633,142,252 - 33,160,327 (+)NCBINHGRI_mPanPan1
PanPan1.11627,577,230 - 27,595,164 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1627,577,230 - 27,595,164 (+)Ensemblpanpan1.1panPan2
KDM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1619,366,813 - 19,390,082 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl619,366,331 - 19,380,257 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha620,948,051 - 20,971,318 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0619,509,426 - 19,532,710 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl619,509,438 - 19,532,685 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1619,307,285 - 19,330,551 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0619,220,623 - 19,244,109 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0619,567,219 - 19,590,503 (-)NCBIUU_Cfam_GSD_1.0
Kdm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344122,834,703 - 122,855,523 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650110,933,671 - 10,951,707 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650110,932,541 - 10,955,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl319,653,402 - 19,676,148 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1319,653,396 - 19,676,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2319,871,955 - 19,945,912 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KDM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1524,907,345 - 24,927,028 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl524,907,657 - 24,928,995 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660684,770,483 - 4,789,136 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdm8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478211,884,631 - 11,903,947 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478211,884,847 - 11,903,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KDM8
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.11-12.1(chr16:14954894-28306843)x3 copy number gain See cases [RCV000051828] Chr16:14954894..28306843 [GRCh38]
Chr16:15048751..28318164 [GRCh37]
Chr16:14956252..28225665 [NCBI36]
Chr16:16p13.11-12.1		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21463739-29249579)x3 copy number gain See cases [RCV000051829] Chr16:21463739..29249579 [GRCh38]
Chr16:21475060..29260900 [GRCh37]
Chr16:21382561..29168401 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21602183-29314373)x3 copy number gain See cases [RCV000051842] Chr16:21602183..29314373 [GRCh38]
Chr16:21613504..29325694 [GRCh37]
Chr16:21521005..29233195 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23047969-30632245)x3 copy number gain See cases [RCV000052401] Chr16:23047969..30632245 [GRCh38]
Chr16:23059290..30643566 [GRCh37]
Chr16:22966791..30551067 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.2-12.1(chr16:21600992-28323344)x1 copy number loss See cases [RCV000052519] Chr16:21600992..28323344 [GRCh38]
Chr16:21612313..28334665 [GRCh37]
Chr16:21519814..28242166 [NCBI36]
Chr16:16p12.2-12.1		 pathogenic
GRCh38/hg38 16p12.1(chr16:26966063-28234594)x3 copy number gain See cases [RCV000053861] Chr16:26966063..28234594 [GRCh38]
Chr16:26977384..28245915 [GRCh37]
Chr16:26884885..28153416 [NCBI36]
Chr16:16p12.1		 uncertain significance
NC_000016.9:g.21530207_29332245del deletion not provided [RCV001030428] Chr16:21530207..29332245 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2		 pathogenic
GRCh38/hg38 16p12.1(chr16:26485169-27400746)x3 copy number gain See cases [RCV000133835] Chr16:26485169..27400746 [GRCh38]
Chr16:26496490..27412067 [GRCh37]
Chr16:26403991..27319568 [NCBI36]
Chr16:16p12.1		 uncertain significance
GRCh38/hg38 16p12.2-11.2(chr16:22634385-29227323)x3 copy number gain See cases [RCV000135594] Chr16:22634385..29227323 [GRCh38]
Chr16:22645706..29238644 [GRCh37]
Chr16:22553207..29146145 [NCBI36]
Chr16:16p12.2-11.2		 likely pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21350622-29202837)x3 copy number gain See cases [RCV000140235] Chr16:21350622..29202837 [GRCh38]
Chr16:21361943..29214158 [GRCh37]
Chr16:21269444..29121659 [NCBI36]
Chr16:16p12.2-11.2		 likely pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23752047-31943755)x3 copy number gain See cases [RCV000141141] Chr16:23752047..31943755 [GRCh38]
Chr16:23763368..31955076 [GRCh37]
Chr16:23670869..31862577 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.1(chr16:26495864-27278367)x3 copy number gain See cases [RCV000143396] Chr16:26495864..27278367 [GRCh38]
Chr16:26507185..27289688 [GRCh37]
Chr16:26414686..27197189 [NCBI36]
Chr16:16p12.1		 uncertain significance
GRCh38/hg38 16p12.1(chr16:26505797-27234282)x3 copy number gain See cases [RCV000143258] Chr16:26505797..27234282 [GRCh38]
Chr16:26517118..27245603 [GRCh37]
Chr16:26424619..27153104 [NCBI36]
Chr16:16p12.1		 likely benign|uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:19590412-29814175)x3 copy number gain Breast ductal adenocarcinoma [RCV000207226] Chr16:19590412..29814175 [GRCh37]
Chr16:16p12.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p12.3-11.2(chr16:19424115-30142220)x3 copy number gain See cases [RCV000449403] Chr16:19424115..30142220 [GRCh37]
Chr16:16p12.3-11.2		 pathogenic
GRCh37/hg19 16p12.1(chr16:26457088-27431415)x3 copy number gain See cases [RCV000446796] Chr16:26457088..27431415 [GRCh37]
Chr16:16p12.1		 likely benign
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p12.1(chr16:26457597-27283271)x3 copy number gain See cases [RCV000511665] Chr16:26457597..27283271 [GRCh37]
Chr16:16p12.1		 likely benign
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:22718350-28858721)x4 copy number gain See cases [RCV000511587] Chr16:22718350..28858721 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p12.1(chr16:25900524-27489837)x3 copy number gain See cases [RCV000511134] Chr16:25900524..27489837 [GRCh37]
Chr16:16p12.1		 uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:21596299-30399167)x1 copy number loss See cases [RCV000511271] Chr16:21596299..30399167 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_024773.3(KDM8):c.278G>A (p.Arg93Gln) single nucleotide variant Inborn genetic diseases [RCV003252181] Chr16:27210401 [GRCh38]
Chr16:27221722 [GRCh37]
Chr16:16p12.1		 likely benign
GRCh37/hg19 16p12.2-11.2(chr16:21475039-29043958)x1 copy number loss Chromosome 16p12.2-p11.2 deletion syndrome [RCV003315282] Chr16:21475039..29043958 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:18238275-30177240)x3 copy number gain See cases [RCV000512428] Chr16:18238275..30177240 [GRCh37]
Chr16:16p12.3-11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21379628-29351826)x3 copy number gain See cases [RCV000512478] Chr16:21379628..29351826 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21379628-29379768)x1 copy number loss not provided [RCV000683786] Chr16:21379628..29379768 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_024773.3(KDM8):c.1080G>A (p.Thr360=) single nucleotide variant not provided [RCV000882473] Chr16:27220479 [GRCh38]
Chr16:27231800 [GRCh37]
Chr16:16p12.1		 likely benign
NM_024773.3(KDM8):c.-32+506G>C single nucleotide variant Inborn genetic diseases [RCV003270700] Chr16:27204142 [GRCh38]
Chr16:27215463 [GRCh37]
Chr16:16p12.1		 uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:21312200-29646379)x3 copy number gain not provided [RCV001249228] Chr16:21312200..29646379 [GRCh37]
Chr16:16p12.2-11.2		 not provided
NM_024773.3(KDM8):c.289A>G (p.Ile97Val) single nucleotide variant not provided [RCV000881820] Chr16:27210412 [GRCh38]
Chr16:27221733 [GRCh37]
Chr16:16p12.1		 likely benign
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21576802-29351826)x3 copy number gain not provided [RCV001006786] Chr16:21576802..29351826 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic|likely pathogenic
GRCh37/hg19 16p12.1(chr16:26457597-27420153)x3 copy number gain not provided [RCV001258625] Chr16:26457597..27420153 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.368G>A (p.Cys123Tyr) single nucleotide variant Coffin-Siris syndrome [RCV001267725] Chr16:27210491 [GRCh38]
Chr16:27221812 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.1086+14_1086+21del deletion Coffin-Siris syndrome [RCV001267726] Chr16:27220493..27220500 [GRCh38]
Chr16:27231814..27231821 [GRCh37]
Chr16:16p12.1		 uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:21594997-29625302)x1 copy number loss not provided [RCV001795549] Chr16:21594997..29625302 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
NM_024773.3(KDM8):c.461C>T (p.Pro154Leu) single nucleotide variant Inborn genetic diseases [RCV003279631] Chr16:27210584 [GRCh38]
Chr16:27221905 [GRCh37]
Chr16:16p12.1		 uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:21576803-30177240)x3 copy number gain not provided [RCV002474541] Chr16:21576803..30177240 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
NM_024773.3(KDM8):c.-27G>A single nucleotide variant Inborn genetic diseases [RCV002969399] Chr16:27210097 [GRCh38]
Chr16:27221418 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.466C>T (p.Arg156Cys) single nucleotide variant Inborn genetic diseases [RCV002817536] Chr16:27210589 [GRCh38]
Chr16:27221910 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.5C>A (p.Ala2Asp) single nucleotide variant Inborn genetic diseases [RCV002733870] Chr16:27210128 [GRCh38]
Chr16:27221449 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.1192T>C (p.Tyr398His) single nucleotide variant Inborn genetic diseases [RCV002752713] Chr16:27220671 [GRCh38]
Chr16:27231992 [GRCh37]
Chr16:16p12.1		 likely benign
NM_024773.3(KDM8):c.-20A>C single nucleotide variant Inborn genetic diseases [RCV002883219] Chr16:27210104 [GRCh38]
Chr16:27221425 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.80C>T (p.Pro27Leu) single nucleotide variant Inborn genetic diseases [RCV002974396] Chr16:27210203 [GRCh38]
Chr16:27221524 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.680A>G (p.Gln227Arg) single nucleotide variant Inborn genetic diseases [RCV002997075] Chr16:27214890 [GRCh38]
Chr16:27226211 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.1028C>T (p.Pro343Leu) single nucleotide variant Inborn genetic diseases [RCV002765028] Chr16:27220427 [GRCh38]
Chr16:27231748 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.83A>G (p.His28Arg) single nucleotide variant Inborn genetic diseases [RCV002826633] Chr16:27210206 [GRCh38]
Chr16:27221527 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.-28C>A single nucleotide variant Inborn genetic diseases [RCV002804497] Chr16:27210096 [GRCh38]
Chr16:27221417 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.-32+523C>G single nucleotide variant Inborn genetic diseases [RCV002935679] Chr16:27204159 [GRCh38]
Chr16:27215480 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.811G>A (p.Gly271Arg) single nucleotide variant Inborn genetic diseases [RCV002672949] Chr16:27215957 [GRCh38]
Chr16:27227278 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.1063C>T (p.His355Tyr) single nucleotide variant Inborn genetic diseases [RCV003208342] Chr16:27220462 [GRCh38]
Chr16:27231783 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.698G>A (p.Arg233Gln) single nucleotide variant Inborn genetic diseases [RCV003193749] Chr16:27214908 [GRCh38]
Chr16:27226229 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.98T>A (p.Leu33Gln) single nucleotide variant Inborn genetic diseases [RCV003374892] Chr16:27210221 [GRCh38]
Chr16:27221542 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.1120C>T (p.Pro374Ser) single nucleotide variant Inborn genetic diseases [RCV003363533] Chr16:27220599 [GRCh38]
Chr16:27231920 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_024773.3(KDM8):c.1004G>T (p.Arg335Met) single nucleotide variant not provided [RCV003457249] Chr16:27220403 [GRCh38]
Chr16:27231724 [GRCh37]
Chr16:16p12.1		 uncertain significance
GRCh37/hg19 16p12.1(chr16:25900524-27489837)x3 copy number gain not specified [RCV003987163] Chr16:25900524..27489837 [GRCh37]
Chr16:16p12.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5082
Count of miRNA genes:1050
Interacting mature miRNAs:1334
Transcripts:ENST00000286096, ENST00000380948, ENST00000441782, ENST00000562269, ENST00000562733, ENST00000563571, ENST00000563881, ENST00000564961, ENST00000567366, ENST00000567735, ENST00000567785, ENST00000568792, ENST00000568965, ENST00000569329, ENST00000569592
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 42 1 306 300 108 300 3 1 21 24 3
Low 2394 2869 1419 324 1776 165 4347 2141 3698 419 1435 1609 174 1 1204 2782 6 2
Below cutoff 3 120 1 65 7 55 15 1 1 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC092725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC106739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY345239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ022832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA497245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000286096   ⟹   ENSP00000286096
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,203,526 - 27,221,768 (+)Ensembl
RefSeq Acc Id: ENST00000441782   ⟹   ENSP00000398410
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,203,975 - 27,220,859 (+)Ensembl
RefSeq Acc Id: ENST00000562269
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,203,517 - 27,213,642 (+)Ensembl
RefSeq Acc Id: ENST00000562733   ⟹   ENSP00000454215
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,203,996 - 27,210,483 (+)Ensembl
RefSeq Acc Id: ENST00000563571
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,214,576 - 27,219,063 (+)Ensembl
RefSeq Acc Id: ENST00000563881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,204,078 - 27,204,444 (+)Ensembl
RefSeq Acc Id: ENST00000564961
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,203,508 - 27,211,715 (+)Ensembl
RefSeq Acc Id: ENST00000567366
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,214,620 - 27,220,667 (+)Ensembl
RefSeq Acc Id: ENST00000567735   ⟹   ENSP00000455463
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,214,971 - 27,221,194 (+)Ensembl
RefSeq Acc Id: ENST00000567785
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,214,612 - 27,221,084 (+)Ensembl
RefSeq Acc Id: ENST00000568792
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,214,638 - 27,216,134 (+)Ensembl
RefSeq Acc Id: ENST00000568965   ⟹   ENSP00000456901
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,210,124 - 27,221,722 (+)Ensembl
RefSeq Acc Id: ENST00000569329   ⟹   ENSP00000456107
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,203,803 - 27,210,612 (+)Ensembl
RefSeq Acc Id: ENST00000569592
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1627,220,318 - 27,220,902 (+)Ensembl
RefSeq Acc Id: NM_001145348   ⟹   NP_001138820
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,203,975 - 27,221,768 (+)NCBI
GRCh371627,214,807 - 27,233,089 (+)RGD
Celera1625,993,442 - 26,011,724 (+)RGD
HuRef1625,303,702 - 25,321,984 (+)RGD
CHM1_11628,227,000 - 28,244,793 (+)NCBI
T2T-CHM13v2.01627,482,588 - 27,500,381 (+)NCBI
Sequence:
RefSeq Acc Id: NM_024773   ⟹   NP_079049
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,203,526 - 27,221,768 (+)NCBI
GRCh371627,214,807 - 27,233,089 (+)RGD
Build 361627,122,317 - 27,140,544 (+)NCBI Archive
Celera1625,993,442 - 26,011,724 (+)RGD
HuRef1625,303,702 - 25,321,984 (+)RGD
CHM1_11628,226,511 - 28,244,793 (+)NCBI
T2T-CHM13v2.01627,482,139 - 27,500,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023676   ⟹   XP_016879165
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,203,526 - 27,221,768 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047434654   ⟹   XP_047290610
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,203,526 - 27,221,768 (+)NCBI
RefSeq Acc Id: XM_047434655   ⟹   XP_047290611
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,203,526 - 27,220,478 (+)NCBI
RefSeq Acc Id: XM_047434656   ⟹   XP_047290612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,211,146 - 27,221,768 (+)NCBI
RefSeq Acc Id: XM_047434657   ⟹   XP_047290613
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,211,148 - 27,221,768 (+)NCBI
RefSeq Acc Id: XM_047434658   ⟹   XP_047290614
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,214,603 - 27,221,768 (+)NCBI
RefSeq Acc Id: XM_054313952   ⟹   XP_054169927
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01627,482,139 - 27,500,381 (+)NCBI
RefSeq Acc Id: XM_054313953   ⟹   XP_054169928
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01627,482,139 - 27,500,381 (+)NCBI
RefSeq Acc Id: XM_054313954   ⟹   XP_054169929
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01627,482,139 - 27,499,091 (+)NCBI
RefSeq Acc Id: XM_054313955   ⟹   XP_054169930
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01627,489,759 - 27,500,381 (+)NCBI
RefSeq Acc Id: XM_054313956   ⟹   XP_054169931
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01627,489,761 - 27,500,381 (+)NCBI
RefSeq Acc Id: XM_054313957   ⟹   XP_054169932
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01627,493,203 - 27,500,381 (+)NCBI
RefSeq Acc Id: XM_054313958   ⟹   XP_054169933
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01627,489,167 - 27,500,381 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001138820 (Get FASTA)   NCBI Sequence Viewer  
  NP_079049 (Get FASTA)   NCBI Sequence Viewer  
  XP_016879165 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290610 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290611 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290612 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290613 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290614 (Get FASTA)   NCBI Sequence Viewer  
  XP_054169927 (Get FASTA)   NCBI Sequence Viewer  
  XP_054169928 (Get FASTA)   NCBI Sequence Viewer  
  XP_054169929 (Get FASTA)   NCBI Sequence Viewer  
  XP_054169930 (Get FASTA)   NCBI Sequence Viewer  
  XP_054169931 (Get FASTA)   NCBI Sequence Viewer  
  XP_054169932 (Get FASTA)   NCBI Sequence Viewer  
  XP_054169933 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH27911 (Get FASTA)   NCBI Sequence Viewer  
  AAQ23080 (Get FASTA)   NCBI Sequence Viewer  
  ALQ34243 (Get FASTA)   NCBI Sequence Viewer  
  ALQ34244 (Get FASTA)   NCBI Sequence Viewer  
  ALQ34245 (Get FASTA)   NCBI Sequence Viewer  
  BAB14706 (Get FASTA)   NCBI Sequence Viewer  
  BAG59661 (Get FASTA)   NCBI Sequence Viewer  
  BAG60638 (Get FASTA)   NCBI Sequence Viewer  
  EAW55759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000286096
  ENSP00000286096.5
  ENSP00000398410
  ENSP00000398410.2
  ENSP00000454215.1
  ENSP00000455463.1
  ENSP00000456107.1
  ENSP00000456901.1
GenBank Protein Q8N371 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_079049   ⟸   NM_024773
- Peptide Label: isoform 2
- UniProtKB: Q6VAK5 (UniProtKB/Swiss-Prot),   B4DLU9 (UniProtKB/Swiss-Prot),   Q9H8B1 (UniProtKB/Swiss-Prot),   Q8N371 (UniProtKB/Swiss-Prot),   A0A0S2Z5T1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138820   ⟸   NM_001145348
- Peptide Label: isoform 1
- UniProtKB: Q8N371 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016879165   ⟸   XM_017023676
- Peptide Label: isoform X1
- UniProtKB: A0A0S2Z5P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000398410   ⟸   ENST00000441782
RefSeq Acc Id: ENSP00000286096   ⟸   ENST00000286096
RefSeq Acc Id: ENSP00000454215   ⟸   ENST00000562733
RefSeq Acc Id: ENSP00000455463   ⟸   ENST00000567735
RefSeq Acc Id: ENSP00000456901   ⟸   ENST00000568965
RefSeq Acc Id: ENSP00000456107   ⟸   ENST00000569329
RefSeq Acc Id: XP_047290610   ⟸   XM_047434654
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047290611   ⟸   XM_047434655
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047290612   ⟸   XM_047434656
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047290613   ⟸   XM_047434657
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047290614   ⟸   XM_047434658
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054169927   ⟸   XM_054313952
- Peptide Label: isoform X1
- UniProtKB: A0A0S2Z5P8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054169928   ⟸   XM_054313953
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054169929   ⟸   XM_054313954
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054169933   ⟸   XM_054313958
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054169930   ⟸   XM_054313955
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054169931   ⟸   XM_054313956
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054169932   ⟸   XM_054313957
- Peptide Label: isoform X5
Protein Domains
JmjC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N371-F1-model_v2 AlphaFold Q8N371 1-416 view protein structure

Promoters
RGD ID:6793048
Promoter ID:HG_KWN:23366
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000380948,   NM_001145348,   NM_024773,   UC010BXV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361627,122,176 - 27,122,727 (+)MPROMDB
RGD ID:7231659
Promoter ID:EPDNEW_H21575
Type:initiation region
Name:KDM8_1
Description:lysine demethylase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21576  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,203,526 - 27,203,586EPDNEW
RGD ID:7231667
Promoter ID:EPDNEW_H21576
Type:initiation region
Name:KDM8_2
Description:lysine demethylase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21575  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381627,214,606 - 27,214,666EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25840 AgrOrtholog
COSMIC KDM8 COSMIC
Ensembl Genes ENSG00000155666 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000286096 ENTREZGENE
  ENST00000286096.9 UniProtKB/Swiss-Prot
  ENST00000441782 ENTREZGENE
  ENST00000441782.6 UniProtKB/Swiss-Prot
  ENST00000562733.1 UniProtKB/TrEMBL
  ENST00000567735.1 UniProtKB/TrEMBL
  ENST00000568965.1 UniProtKB/Swiss-Prot
  ENST00000569329.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
  Cupin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000155666 GTEx
HGNC ID HGNC:25840 ENTREZGENE
Human Proteome Map KDM8 Human Proteome Map
InterPro Cupin_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JmjC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
KEGG Report hsa:79831 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79831 ENTREZGENE
OMIM 611917 OMIM
PANTHER BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cupin_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA143485510 PharmGKB
PROSITE JMJC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART JmjC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0S2Z5P8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2Z5T1 ENTREZGENE, UniProtKB/TrEMBL
  B4DLU9 ENTREZGENE
  H3BM39_HUMAN UniProtKB/TrEMBL
  H3BPT5_HUMAN UniProtKB/TrEMBL
  H3BR76_HUMAN UniProtKB/TrEMBL
  KDM8_HUMAN UniProtKB/Swiss-Prot
  Q6VAK5 ENTREZGENE
  Q8N371 ENTREZGENE
  Q9H8B1 ENTREZGENE
UniProt Secondary B4DLU9 UniProtKB/Swiss-Prot
  Q6VAK5 UniProtKB/Swiss-Prot
  Q9H8B1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-16 KDM8  lysine demethylase 8  KDM8  lysine (K)-specific demethylase 8  Symbol and/or name change 5135510 APPROVED
2012-04-03 KDM8  lysine (K)-specific demethylase 8  JMJD5  jumonji domain containing 5  Symbol and/or name change 5135510 APPROVED