Pramel38l1 (PRAME like 38 like 1) - Rat Genome Database

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Gene: Pramel38l1 (PRAME like 38 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Pramel38l1
Name: PRAME like 38 like 1
RGD ID: 2323210
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human PRAMEF15 (PRAME family member 15); PRAMEF20 (PRAME family member 20); and PRAMEF4 (PRAME family member 4).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100363333; LOC501897; LOC685667; oogenesin-3-like; PRAME family member 12; PRAME family member 12-like; PRAME family member 18-like; PRAME family member 8-like; similar to PRAME family member DJ1198H6.2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81414,521,939 - 14,524,609 (+)NCBIGRCr8
mRatBN7.21414,510,526 - 14,513,196 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1414,510,526 - 14,512,848 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01415,949,174 - 15,951,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1415,949,171 - 15,952,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01415,876,857 - 15,879,527 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41415,607,799 - 15,610,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1413,828,320 - 13,830,994 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pramel38l1Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIBAPANTHER:PTN000368795 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pramel38l1RatCul2-RING ubiquitin ligase complex part_ofIBAPANTHER:PTN000368795 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pramel38l1Ratcytoplasm is_active_inIBAMGI:1890541 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pramel38l1Ratubiquitin-like ligase-substrate adaptor activity enablesIBAPANTHER:PTN000368795 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Pramel38l1
73 total Variants

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000041124
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat

1 to 10 of 16 rows



mesenchyme
renal system
reproductive system
2 2 3



Ensembl Acc Id: ENSRNOT00000041124   ⟹   ENSRNOP00000049773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1415,949,171 - 15,952,083 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083237   ⟹   ENSRNOP00000074015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1415,459,950 - 15,462,861 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100203   ⟹   ENSRNOP00000076777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1414,510,526 - 14,512,848 (+)Ensembl
RefSeq Acc Id: XM_006250717   ⟹   XP_006250779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81414,521,939 - 14,524,609 (+)NCBI
mRatBN7.21414,510,526 - 14,513,196 (+)NCBI
Rnor_6.01415,949,174 - 15,951,844 (+)NCBI
Rnor_5.01415,876,857 - 15,879,527 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092554   ⟹   XP_038948482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81414,521,939 - 14,524,609 (+)NCBI
mRatBN7.21414,510,526 - 14,513,196 (+)NCBI
RefSeq Acc Id: XM_039092555   ⟹   XP_038948483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81414,521,939 - 14,524,609 (+)NCBI
mRatBN7.21414,510,526 - 14,513,196 (+)NCBI
RefSeq Acc Id: XM_063273874   ⟹   XP_063129944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81414,521,939 - 14,524,176 (+)NCBI
Protein RefSeqs XP_006250779 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948482 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948483 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129944 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076777.1
  ENSRNOP00000108931
RefSeq Acc Id: XP_006250779   ⟸   XM_006250717
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000049773   ⟸   ENSRNOT00000041124
RefSeq Acc Id: XP_038948482   ⟸   XM_039092554
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948483   ⟸   XM_039092555
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000074015   ⟸   ENSRNOT00000083237

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K710-F1-model_v2 AlphaFold A0A0G2K710 1-479 view protein structure
AF-D3ZIJ6-F1-model_v2 AlphaFold D3ZIJ6 1-487 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16295 BioCyc
Ensembl Genes ENSRNOG00000032647 Ensembl
  ENSRNOG00000053903 Ensembl
  ENSRNOG00000062477 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000083237 ENTREZGENE
Ensembl Transcript ENSRNOT00000100203.1 UniProtKB/TrEMBL
  ENSRNOT00000127285 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro LRR_dom_sf UniProtKB/TrEMBL
  PRAME_domain UniProtKB/TrEMBL
NCBI Gene 100363333 ENTREZGENE
PANTHER D5ERTD577E PROTEIN-RELATED UniProtKB/TrEMBL
  SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 UniProtKB/TrEMBL
PhenoGen Pramel38l1 PhenoGen
RatGTEx ENSRNOG00000032647 RatGTEx
  ENSRNOG00000053903 RatGTEx
  ENSRNOG00000062477 RatGTEx
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt A0A8I5Y4Z4_RAT UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Pramel38l1  PRAME like 38 like 1  LOC100363333  PRAME family member 12  Symbol and Name Changed 1299863 APPROVED
2021-03-09 LOC100363333  PRAME family member 12  LOC685667  similar to PRAME family member DJ1198H6.2  Data merged from RGD:1591346 737654 PROVISIONAL
2010-05-06 LOC100363333  PRAME family member 12      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC685667  similar to PRAME family member DJ1198H6.2  RGD1560086_predicted  similar to DNA segment, Chr 5, ERATO Doi 577, expressed (predicted)  Data merged from RGD:1560086 1643240 APPROVED
2006-11-20 LOC685667  similar to PRAME family member DJ1198H6.2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1560086_predicted  similar to DNA segment, Chr 5, ERATO Doi 577, expressed (predicted)  LOC501897  similar to DNA segment, Chr 5, ERATO Doi 577, expressed  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501897  similar to DNA segment, Chr 5, ERATO Doi 577, expressed      Symbol and Name status set to provisional 70820 PROVISIONAL