Igll1 (immunoglobulin lambda-like polypeptide 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Igll1 (immunoglobulin lambda-like polypeptide 1) Rattus norvegicus
Analyze
Symbol: Igll1
Name: immunoglobulin lambda-like polypeptide 1
RGD ID: 2321140
Description: Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be part of IgG immunoglobulin complex. Human ortholog(s) of this gene implicated in agammaglobulinemia 2. Orthologous to several human genes including IGLL1 (immunoglobulin lambda like polypeptide 1) and IGLL5 (immunoglobulin lambda like polypeptide 5); INTERACTS WITH bisphenol A (ortholog); crocidolite asbestos (ortholog); diuron (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Immunoglobulin lambda-like polypeptide 1-like; immunoglobulin lambda-like polypeptide 5; LOC100360919
RGD Orthologs
Human
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,643,059 - 97,646,441 (+)NCBIGRCr8
mRatBN7.21184,138,847 - 84,142,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,138,910 - 84,142,216 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,863,043 - 92,866,028 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,524,170 - 85,527,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,577,768 - 84,580,753 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,388,378 - 88,391,524 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,388,378 - 88,391,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,443,556 - 91,446,702 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,159,013 - 86,162,005 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1182,893,848 - 82,896,756 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23533145  


Genomics

Comparative Map Data
Igll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,643,059 - 97,646,441 (+)NCBIGRCr8
mRatBN7.21184,138,847 - 84,142,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,138,910 - 84,142,216 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,863,043 - 92,866,028 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,524,170 - 85,527,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,577,768 - 84,580,753 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,388,378 - 88,391,524 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,388,378 - 88,391,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,443,556 - 91,446,702 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,159,013 - 86,162,005 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1182,893,848 - 82,896,756 (+)NCBICelera
Cytogenetic Map11q23NCBI
IGLL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,887,816 - 22,896,111 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,887,780 - 22,896,111 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,229,996 - 23,238,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera227,044,543 - 7,052,595 (+)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef226,197,809 - 6,205,863 (+)NCBIHuRef
CHM1_12223,242,250 - 23,250,304 (+)NCBICHM1_1
T2T-CHM13v2.02223,310,731 - 23,319,020 (+)NCBIT2T-CHM13v2.0
IGLL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22332,563,069 - 32,725,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12235,357,083 - 35,533,238 (-)NCBINHGRI_mPanPan1
PanPan1.12221,510,540 - 21,518,611 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC100687054
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,793,360 - 28,804,589 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,866,346 - 27,877,439 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,198,265 - 30,211,125 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12628,279,681 - 28,292,353 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,897,421 - 27,908,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,885,493 - 28,898,314 (-)NCBIUU_Cfam_GSD_1.0
LOC100523213
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11449,951,542 - 49,960,517 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,393,870 - 53,403,011 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Igll1
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000029851
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 10 17 17 3 17 6 3 2
Below cutoff 2 4 10 8 4 8 1 1 16 12 13 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029851   ⟹   ENSRNOP00000031750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,138,910 - 84,142,216 (+)Ensembl
Rnor_6.0 Ensembl1188,388,378 - 88,391,370 (+)Ensembl
RefSeq Acc Id: NM_001190341   ⟹   NP_001177270
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,643,187 - 97,646,438 (+)NCBI
mRatBN7.21184,138,982 - 84,142,233 (+)NCBI
Rnor_6.01188,388,378 - 88,391,370 (+)NCBI
Rnor_5.01191,443,556 - 91,446,702 (+)NCBI
Celera1182,893,848 - 82,896,756 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248656   ⟹   XP_006248718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,643,059 - 97,646,441 (+)NCBI
mRatBN7.21184,138,847 - 84,142,238 (+)NCBI
Rnor_6.01188,388,378 - 88,391,524 (+)NCBI
Rnor_5.01191,443,556 - 91,446,702 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001177270 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248718 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA92268 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031750
  ENSRNOP00000031750.4
Reference Protein Sequences
RefSeq Acc Id: NP_001177270   ⟸   NM_001190341
- Peptide Label: precursor
- UniProtKB: F1MAM7 (UniProtKB/TrEMBL),   A0NA94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248718   ⟸   XM_006248656
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000031750   ⟸   ENSRNOT00000029851
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAM7-F1-model_v2 AlphaFold F1MAM7 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321140 AgrOrtholog
BioCyc Gene G2FUF-20560 BioCyc
Ensembl Genes ENSRNOG00000025990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029851 ENTREZGENE
  ENSRNOT00000029851.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
KEGG Report rno:100360919 UniProtKB/TrEMBL
NCBI Gene 100360919 ENTREZGENE
PANTHER IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
PhenoGen Igll1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025990 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0NA94 ENTREZGENE, UniProtKB/TrEMBL
  F1MAM7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-09 Igll1  immunoglobulin lambda-like polypeptide 1  LOC100360919  Immunoglobulin lambda-like polypeptide 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100360919  Immunoglobulin lambda-like polypeptide 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL