Grem2 (gremlin 2, DAN family BMP antagonist) - Rat Genome Database

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Gene: Grem2 (gremlin 2, DAN family BMP antagonist) Rattus norvegicus
Analyze
Symbol: Grem2
Name: gremlin 2, DAN family BMP antagonist
RGD ID: 1560008
Description: Predicted to enable several functions, including BMP binding activity; heparin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including determination of dorsal identity; embryonic body morphogenesis; and regulation of signal transduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gremlin 2; gremlin 2 homolog, cysteine knot superfamily; gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) ; gremlin 2, cysteine knot superfamily, homolog; gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-2; LOC289264; RGD1560008; similar to PRDC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81389,310,897 - 89,403,856 (-)NCBIGRCr8
mRatBN7.21386,778,543 - 86,871,509 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,778,500 - 86,871,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1389,276,244 - 89,369,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,676,524 - 90,769,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,861,272 - 87,954,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,894,431 - 92,988,137 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,894,431 - 92,988,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01397,359,449 - 97,453,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41390,528,920 - 90,622,303 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1386,379,414 - 86,472,331 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Grem2Ratgastrointestinal stromal tumor  ISOGREM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Grem2RatHereditary Leiomyomatosis and Renal Cell Cancer  ISOGREM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary leiomyomatosis and renal cell cancerClinVarPMID:29909963
Grem2RatNeurodevelopmental Disorders  ISOGREM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Grem2Ratparathyroid carcinoma  ISOGREM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Grem2RatSelective Tooth Agenesis 9  ISOGREM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Tooth agenesis more ...ClinVarPMID:23401279 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Grem2RatSelective Tooth Agenesis 9  ISOGREM2 (Homo sapiens)7240710 OMIM 

1 to 20 of 99 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Grem2Rat17beta-estradiol increases expressionISOGrem2 (Mus musculus)6480464Estradiol results in increased expression of GREM2 mRNACTDPMID:19484750
Grem2Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of GREM2 mRNACTDPMID:32145629
Grem2Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
Grem2Rat2,2',5,5'-tetrachlorobiphenyl increases expressionISOGREM2 (Homo sapiens)64804642 more ...CTDPMID:36804509
Grem2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOGrem2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of GREM2 mRNACTDPMID:19770486
Grem2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of GREM2 mRNACTDPMID:32109520
Grem2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOGrem2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of GREM2 mRNACTDPMID:28922406
Grem2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOGREM2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of GREM2 mRNACTDPMID:21998131 and PMID:36370075
Grem2Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Grem2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionISOGREM2 (Homo sapiens)64804642 more ...CTDPMID:26705709
Grem2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOGrem2 (Mus musculus)64804642 more ...CTDPMID:38648751
Grem2Rat2-palmitoylglycerol increases expressionISOGREM2 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of GREM2 mRNACTDPMID:37199045
Grem2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOGREM2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GREM2 mRNACTDPMID:28628672
Grem2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of GREM2 mRNACTDPMID:30047161
Grem2Rat8-Br-cAMP increases expressionISOGREM2 (Homo sapiens)64804648-Bromo Cyclic Adenosine Monophosphate results in increased expression of GREM2 mRNACTDPMID:20147733 and PMID:22079614
Grem2Ratacrylamide affects expressionEXP 6480464Acrylamide affects the expression of GREM2 mRNACTDPMID:28959563
Grem2Rataflatoxin B1 decreases expressionISOGrem2 (Mus musculus)6480464Aflatoxin B1 results in decreased expression of GREM2 mRNACTDPMID:19770486
Grem2Rataflatoxin B1 decreases methylationISOGREM2 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of GREM2 geneCTDPMID:27153756
Grem2Rataldehydo-D-glucose multiple interactionsISOGrem2 (Mus musculus)6480464[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of GREM2 mRNACTDPMID:37567420
Grem2Ratall-trans-retinoic acid increases expressionISOGREM2 (Homo sapiens)6480464Tretinoin results in increased expression of GREM2 mRNACTDPMID:23724009

1 to 20 of 99 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Grem2Ratextracellular space located_inISOGrem2 (Mus musculus)1624291 PMID:23063586RGDPMID:23063586
Grem2Ratextracellular space is_active_inIBAMGI:1344337 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:23063586   PMID:23850456   PMID:24614542   PMID:34049478  



Grem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81389,310,897 - 89,403,856 (-)NCBIGRCr8
mRatBN7.21386,778,543 - 86,871,509 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,778,500 - 86,871,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1389,276,244 - 89,369,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,676,524 - 90,769,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,861,272 - 87,954,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,894,431 - 92,988,137 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,894,431 - 92,988,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01397,359,449 - 97,453,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41390,528,920 - 90,622,303 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1386,379,414 - 86,472,331 (-)NCBICelera
Cytogenetic Map13q24NCBI
GREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381240,489,573 - 240,612,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1240,489,573 - 240,612,155 (-)EnsemblGRCh38hg38GRCh38
GRCh371240,652,873 - 240,775,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,719,496 - 238,842,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 341236,979,833 - 237,101,430NCBI
Celera1213,908,963 - 214,031,592 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1211,110,745 - 211,233,432 (-)NCBIHuRef
CHM1_11241,924,855 - 242,047,766 (-)NCBICHM1_1
T2T-CHM13v2.01239,900,834 - 240,023,520 (-)NCBIT2T-CHM13v2.0
Grem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,661,352 - 174,749,386 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,661,351 - 174,749,385 (-)EnsemblGRCm39 Ensembl
GRCm381174,833,785 - 174,921,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,833,785 - 174,921,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv371176,763,916 - 176,851,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,670,460 - 176,758,494 (-)NCBIMGSCv36mm8
Celera1181,920,779 - 182,009,726 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.08NCBI
Grem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,245,960 - 11,343,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,245,960 - 11,343,677 (+)NCBIChiLan1.0ChiLan1.0
GREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218,546,639 - 8,671,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan118,770,127 - 8,895,198 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01216,037,977 - 216,163,020 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,023,212 - 221,148,149 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,026,605 - 221,027,111 (-)Ensemblpanpan1.1panPan2
GREM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1732,048,151 - 32,157,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl732,048,183 - 32,157,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha731,588,241 - 31,697,847 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0731,872,605 - 31,982,246 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl731,870,255 - 31,981,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1731,710,419 - 31,820,007 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0731,741,770 - 31,851,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0731,980,916 - 32,090,573 (-)NCBIUU_Cfam_GSD_1.0
Grem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934444,922,948 - 45,027,019 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365269,720,335 - 9,823,370 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365269,820,276 - 9,821,907 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1011,885,280 - 11,885,780 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11011,884,198 - 11,904,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,102,376 - 14,122,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12577,600,306 - 77,724,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2577,602,803 - 77,603,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605579,707,875 - 79,832,479 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,967,542 - 10,968,048 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,965,170 - 11,072,462 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Grem2
492 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
13 90532122 90532123 T G snv SR/JrHsd (MCW) View more Information


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
13 97362651 97362652 T G snv SR/JrHsd (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:699
Count of miRNA genes:292
Interacting mature miRNAs:386
Transcripts:ENSRNOT00000004803
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat

1 to 10 of 21 rows
D13Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81389,333,129 - 89,333,251 (+)Marker Load Pipeline
mRatBN7.21386,800,776 - 86,800,898 (+)MAPPERmRatBN7.2
Rnor_6.01392,916,662 - 92,916,783NCBIRnor6.0
Rnor_5.01397,381,680 - 97,381,801UniSTSRnor5.0
RGSC_v3.41390,551,150 - 90,551,272RGDRGSC3.4
RGSC_v3.41390,551,151 - 90,551,272UniSTSRGSC3.4
RGSC_v3.11390,740,035 - 90,740,156RGD
Celera1386,401,644 - 86,401,765UniSTS
RH 3.4 Map13573.9UniSTS
RH 3.4 Map13573.9RGD
RH 2.0 Map13638.1RGD
SHRSP x BN Map1340.7498RGD
Cytogenetic Map13q24UniSTS
RH127350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,778,737 - 86,778,951 (+)MAPPERmRatBN7.2
Rnor_6.01392,894,626 - 92,894,839NCBIRnor6.0
Rnor_5.01397,359,644 - 97,359,857UniSTSRnor5.0
RGSC_v3.41390,529,115 - 90,529,328UniSTSRGSC3.4
Celera1386,379,609 - 86,379,822UniSTS
RH 3.4 Map13585.8UniSTS
Cytogenetic Map13q24UniSTS
BF388208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,779,656 - 86,779,872 (+)MAPPERmRatBN7.2
Rnor_6.01392,895,545 - 92,895,760NCBIRnor6.0
Rnor_5.01397,360,563 - 97,360,778UniSTSRnor5.0
RGSC_v3.41390,530,034 - 90,530,249UniSTSRGSC3.4
Celera1386,380,528 - 86,380,743UniSTS
RH 3.4 Map13583.4UniSTS
Cytogenetic Map13q24UniSTS
BE110247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,812,758 - 86,812,910 (+)MAPPERmRatBN7.2
Rnor_6.01392,928,642 - 92,928,793NCBIRnor6.0
Rnor_5.01397,393,660 - 97,393,811UniSTSRnor5.0
RGSC_v3.41390,563,132 - 90,563,283UniSTSRGSC3.4
Celera1386,413,621 - 86,413,772UniSTS
RH 3.4 Map13584.6UniSTS
Cytogenetic Map13q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 43 113 91 90 59 25 59 6 212 91 93 45 60 31


RefSeq Transcripts NM_001105974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004803   ⟹   ENSRNOP00000004803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,778,500 - 86,871,615 (-)Ensembl
Rnor_6.0 Ensembl1392,894,431 - 92,988,137 (-)Ensembl
RefSeq Acc Id: NM_001105974   ⟹   NP_001099444
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81389,310,897 - 89,403,856 (-)NCBI
mRatBN7.21386,778,543 - 86,871,509 (-)NCBI
Rnor_6.01392,894,431 - 92,988,137 (-)NCBI
Rnor_5.01397,359,449 - 97,453,188 (-)NCBI
RGSC_v3.41390,528,920 - 90,622,303 (-)RGD
Celera1386,379,414 - 86,472,331 (-)RGD
Sequence:
Protein RefSeqs NP_001099444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94766 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004803.4
RefSeq Acc Id: NP_001099444   ⟸   NM_001105974
- Peptide Label: precursor
- UniProtKB: D3ZXD0 (UniProtKB/TrEMBL),   A6JGB0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004803   ⟸   ENSRNOT00000004803
CTCK

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXD0-F1-model_v2 AlphaFold D3ZXD0 1-168 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699040
Promoter ID:EPDNEW_R9563
Type:multiple initiation site
Name:Grem2_1
Description:gremlin 2, DAN family BMP antagonist
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01392,988,138 - 92,988,198EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17247 BioCyc
Ensembl Genes ENSRNOG00000003616 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004803.6 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  DAN UniProtKB/TrEMBL
  Gremlin_precursor UniProtKB/TrEMBL
KEGG Report rno:289264 UniProtKB/TrEMBL
NCBI Gene 289264 ENTREZGENE
PANTHER GREMLIN 1 UniProtKB/TrEMBL
  GREMLIN-2 UniProtKB/TrEMBL
Pfam DAN UniProtKB/TrEMBL
PhenoGen Grem2 PhenoGen
PIRSF Gremlin_precursor UniProtKB/TrEMBL
PROSITE CTCK_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003616 RatGTEx
SMART SM00041 UniProtKB/TrEMBL
UniProt A6JGB0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXD0 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Grem2  gremlin 2, DAN family BMP antagonist  Grem2  gremlin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Grem2  gremlin 2  Grem2  gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Grem2  gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)  Grem2  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Grem2  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)   Grem2_predicted  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Grem2_predicted  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) (predicted)  RGD1560008_predicted  similar to PRDC (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560008_predicted  similar to PRDC (predicted)  LOC289264  similar to PRDC  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289264  similar to PRDC      Symbol and Name status set to provisional 70820 PROVISIONAL