GREM2 (gremlin 2, DAN family BMP antagonist) - Rat Genome Database

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Gene: GREM2 (gremlin 2, DAN family BMP antagonist) Chlorocebus sabaeus
Analyze
Symbol: GREM2
Name: gremlin 2, DAN family BMP antagonist
RGD ID: 18494163
Description: ENCODES a protein that exhibits BMP binding (inferred); cytokine activity (inferred); heparin binding (inferred); INVOLVED IN animal organ morphogenesis (inferred); cytokine-mediated signaling pathway (inferred); determination of dorsal identity (inferred); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); Hereditary Leiomyomatosis and Renal Cell Cancer (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gremlin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12577,600,306 - 77,724,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2577,602,803 - 77,603,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605579,707,875 - 79,832,479 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12577,600,306 - 77,724,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2577,602,803 - 77,603,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605579,707,875 - 79,832,479 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381240,489,573 - 240,612,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1240,489,573 - 240,612,155 (-)EnsemblGRCh38hg38GRCh38
GRCh371240,652,873 - 240,775,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,719,496 - 238,842,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 341236,979,833 - 237,101,430NCBI
Celera1213,908,963 - 214,031,592 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1211,110,745 - 211,233,432 (-)NCBIHuRef
CHM1_11241,924,855 - 242,047,766 (-)NCBICHM1_1
T2T-CHM13v2.01239,900,834 - 240,023,520 (-)NCBIT2T-CHM13v2.0
Grem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,661,352 - 174,749,386 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,661,351 - 174,749,385 (-)EnsemblGRCm39 Ensembl
GRCm381174,833,785 - 174,921,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,833,785 - 174,921,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv371176,763,916 - 176,851,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,670,460 - 176,758,494 (-)NCBIMGSCv36mm8
Celera1181,920,779 - 182,009,726 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.08NCBI
Grem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81389,310,897 - 89,403,856 (-)NCBIGRCr8
mRatBN7.21386,778,543 - 86,871,509 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,778,500 - 86,871,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1389,276,244 - 89,369,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,676,524 - 90,769,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,861,272 - 87,954,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,894,431 - 92,988,137 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,894,431 - 92,988,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01397,359,449 - 97,453,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41390,528,920 - 90,622,303 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1386,379,414 - 86,472,331 (-)NCBICelera
Cytogenetic Map13q24NCBI
Grem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,245,960 - 11,343,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,245,960 - 11,343,677 (+)NCBIChiLan1.0ChiLan1.0
GREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218,546,639 - 8,671,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan118,770,127 - 8,895,198 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01216,037,977 - 216,163,020 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,023,212 - 221,148,149 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,026,605 - 221,027,111 (-)Ensemblpanpan1.1panPan2
GREM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1732,048,151 - 32,157,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl732,048,183 - 32,157,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha731,588,241 - 31,697,847 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0731,872,605 - 31,982,246 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl731,870,255 - 31,981,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1731,710,419 - 31,820,007 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0731,741,770 - 31,851,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0731,980,916 - 32,090,573 (-)NCBIUU_Cfam_GSD_1.0
Grem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934444,922,948 - 45,027,019 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365269,720,335 - 9,823,370 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365269,820,276 - 9,821,907 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1011,885,280 - 11,885,780 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11011,884,198 - 11,904,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,102,376 - 14,122,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Grem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,967,542 - 10,968,048 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,965,170 - 11,072,462 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 10 60
Below cutoff 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000019462   ⟹   ENSCSAP00000018880
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2577,602,803 - 77,603,309 (-)Ensembl
RefSeq Acc Id: XM_007989925   ⟹   XP_007988116
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12577,600,306 - 77,724,090 (-)NCBI
Vero_WHO_p1.0NW_02366605579,707,875 - 79,832,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037986070   ⟹   XP_037841998
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605579,707,875 - 79,714,038 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007988116 (Get FASTA)   NCBI Sequence Viewer  
  XP_037841998 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000018880
  ENSCSAP00000018880.1
Reference Protein Sequences
RefSeq Acc Id: XP_007988116   ⟸   XM_007989925
- UniProtKB: A0A0D9SDE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000018880   ⟸   ENSCSAT00000019462
RefSeq Acc Id: XP_037841998   ⟸   XM_037986070
- UniProtKB: A0A0D9SDE1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000019372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000019462.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  DAN UniProtKB/TrEMBL
  Gremlin-1/2 UniProtKB/TrEMBL
KEGG Report csab:103230835 UniProtKB/TrEMBL
NCBI Gene GREM2 ENTREZGENE
PANTHER GREMLIN 1 UniProtKB/TrEMBL
  GREMLIN-2 UniProtKB/TrEMBL
Pfam DAN UniProtKB/TrEMBL
PIRSF Gremlin_precursor UniProtKB/TrEMBL
PROSITE CTCK_2 UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
UniProt A0A0D9SDE1 ENTREZGENE, UniProtKB/TrEMBL